It's true. Watch your blood sugars. This will/can make you pre-diabetic/ diabetic over long term use.
Untrue. No offense intended, but ignorant statements such as this completely neglect to take into consideration the dozens of relevant variables that impact insuoin senstivity, while simultaneously misleading the members. It's as incorrect as making the absolute statement "injectable GH will make you diabetic". While exo. GH can indeed cause diabetes, it requires high doses...and even then it doesn't always do so. MK-677 can't elevate GH/IGF-1 to the same degree as high-dose GH, so the potential for causing serious BG regulation issues is even lower. In fact, I would say impossible under normal circumstances. More explanation is in order.
All GH peptides/secretagogues will reduce insulin sensitivity, but there is a big difference between saying MK-677 will reduce insulin senstivity and saying it will make you diabetic. Basically, diabetes is nothing more than having very poor insulin senstivity. So, the question that needs to be asked is "to what degree can MK-677 decrease insulin senstivity"....and the answer is "NOWHERE NEAR enough to cause diabetes".
Now, can MK-677 CONTRIBUTE to diabetes? OF COURSE! So can GH, IGF-1, eating too much sugar, not getting enough exercise, being too damn fat, and about a dozen other things! The more pressing question is "can MK-677 cause diabetes in a person with good or even normal insulin senstivity?" HELL NO!
In reality, bodybuilders and fitness athletes who don't use injectable GH or insulin FREQUENTLY have some of the best insulin senstivity on the planet! Their above average amount of muscle mass, weight training, cardio, clean eating and low bodyfat levels all make these individuals EXTREMELY likely to have GREAT insulin senstivity! Even bodybuilders who use low to moderate doses of GH and insulin, such as 3-5 iu of GH/daily and 10-20 iu of insulin 3-4 tmes weekly, typically have good insulin senstivity as well.
Adding MK-677 into the lives of these individuals will, at worst, leave them with normal to slightly below normal insulin senstivity (nowhere near being clinically diabetic). Now, if you add MK-677 into the life of someone who is already pre-diabetic or close to it because of their poor lifestyle choices and/or heath issues, then MK may be the thing that pushes them over the edge into pre-diabetes/diabetes, but in this case the MK would only be ONE of many factors--the straw the broke the camel's back, so to speak. Putting all the blame on MK alone and say "it will make you diabetic" is just plain wrong.
I should also mention that taking a solid insulin sensitsizer, such as berberine, can completely (or near completely) reverse any decrease in insulin sensitivity that an MK user might experience, bringing them back to where they started (with good insulin senstivity) before MK. So, not only does MK only have mild to moderate effects on insulin senstivity, it is very easily corrected with the proper supplementation.
