Lets talk COVID-19

[brundel]

@brundel no shipping to Canada?

try now

 

[ironkill]

try now

Cheers, you’re the best man

 

[ironkill]

@brundel is it advisable to take the viral defence as well as follidrone together? I have 3 bottles I’m hoping to dig into but can wait if it’s too much quercetin

 

[3clipseGT]

Quercetin in general is amazing for allergies and this new possible protection or defense, if you will, makes it that much better. Add to it the extra absorption and the price with the discount is a steal!

 

[manifesto]

Order in!!!

This should be taken right away for prevention, correct?

Or does it only work if you're already sick?

 

[ValiantThor08]

@brundel is it advisable to take the viral defence as well as follidrone together? I have 3 bottles I’m hoping to dig into but can wait if it’s too much quercetin

It shouldn't be too much. You can take both together.

 

[ValiantThor08]

Order in!!!

This should be taken right away for prevention, correct?

Or does it only work if you're already sick?

It will be beneficial preventative, and it you happen to get COVID19.

 

[manifesto]

Is it ok to still take high doses of Vitmain C with this??

 

[ValiantThor08]

Is it ok to still take high doses of Vitmain C with this??

Yes. Shouldn't be interference.

 

[brundel]

@brundel is it advisable to take the viral defence as well as follidrone together? I have 3 bottles I’m hoping to dig into but can wait if it’s too much quercetin

This will depend on your personal tolerance.
Quercetin is not recommended over 1000mg.
200mg of ours easily hits that. Indont think it will harm you but if you experience gastrointestinal issues or something just drop back to 200.

 

[brundel]

Order in!!!

This should be taken right away for prevention, correct?

Or does it only work if you're already sick?

I have my whole family and everyone at blr taking 2 per day presently

 

[brundel]

Is it ok to still take high doses of Vitmain C with this??

Yes sir

 

[manifesto]

I have my whole family and everyone at blr taking 2 per day presently

Awesome. Got 3 bottles coming. For myself and my family

 

[HIT4ME]

https://pubs.acs.org/doi/10.1021/acsomega.8b01002

hydroxychloroquine inhibits protease activity with an inhibition constant (K i) of 92.34 ± 11.91 μM

Hydroxychloroquine Inhibits Zika Virus NS2B-NS3 Protease - PubMed

Zika virus is a mosquito-transmitted flavivirus that causes devastating fetal outcomes in the context of maternal infection during pregnancy. An important target for drugs combatting Zika virus pathogenicity is NS2B-NS3 protease, which plays an essential role in hydrolysis and maturation of the...

www.ncbi.nlm.nih.gov

Comparison of Lopinavir/Ritonavir or Hydroxychloroquine in Patients With Mild Coronavirus Disease (COVID-19) - Full Text View - ClinicalTrials.gov

Comparison of Lopinavir/Ritonavir or Hydroxychloroquine in Patients With Mild Coronavirus Disease (COVID-19) - Full Text View.

clinicaltrials.gov

Clinical trial studying it as a protease inhibitor

Again, this isn't to be argumentative but for discussion and my own learning and interest.

That first study shows it MIGHT have some protease inhibitor properties and I it looks pretty good. I should have read that more closely but given it was about Zika I kept skipping over it. Good call.

The clinical trial pairs with known protease inhibitors which is common, and I am not getting that it is, itself, a PI.

Still, I do like the quercetin angle and it hits a lot of pathways. Just curiosity and I think there may be, possibly, another angle.

 

[brundel]

Again, this isn't to be argumentative but for discussion and my own learning and interest.

That first study shows it MIGHT have some protease inhibitor properties and I it looks pretty good. I should have read that more closely but given it was about Zika I kept skipping over it. Good call.

The clinical trial pairs with known protease inhibitors which is common, and I am not getting that it is, itself, a PI.

Still, I do like the quercetin angle and it hits a lot of pathways. Just curiosity and I think there may be, possibly, another angle.

Of course. The good news is we are not relying on protease inhibition alone. Protease inhibition helps prevent viral replication. But we are also blocking the ACE receptors which prevents the virus from entering the cell.
And calpain inhibition among other things.

Viral targets	Currently available drugs for human use	Investigational agents
Viral entry and fusion	Chloroquine	Convalescent plasma*, monoclonal antibodies, peptides representing different regions of ACE2, luteolin, other small molecules, peptides targeting S protein
Viral replication	Chloroquine	Calpain inhibitors
Viral protease	Protease inhibitors (lopinavir/ritonavir* and nelfinavir)	Quercetin
Viral RNA synthesis and gene expression	Ribavirin* and indomethacin	siRNA
Immunomodulation	Interferon alfacon-1*	Interferon-α and interferon-β
Unknown or other mechanisms	Nitric oxide*, niclosamide and reserpine	Glycyrrhizin, baicalin, valinomycin, nitric oxide donors (e.g. S-nitroso-N-acetylpenicillamine)

 

[HIT4ME]

Of course. The good news is we are not relying on protease inhibition alone. Protease inhibition helps prevent viral replication. But we are also blocking the ACE receptors which prevents the virus from entering the cell.
And calpain inhibition among other things.

Viral targets	Currently available drugs for human use	Investigational agents
Viral entry and fusion	Chloroquine	Convalescent plasma*, monoclonal antibodies, peptides representing different regions of ACE2, luteolin, other small molecules, peptides targeting S protein
Viral replication	Chloroquine	Calpain inhibitors
Viral protease	Protease inhibitors (lopinavir/ritonavir* and nelfinavir)	Quercetin
Viral RNA synthesis and gene expression	Ribavirin* and indomethacin	siRNA
Immunomodulation	Interferon alfacon-1*	Interferon-α and interferon-β
Unknown or other mechanisms	Nitric oxide*, niclosamide and reserpine	Glycyrrhizin, baicalin, valinomycin, nitric oxide donors (e.g. S-nitroso-N-acetylpenicillamine)

Yeah, chloroquine seems to interfere with cell maturity (and thus replication) by preventing the acidification of endosomes.

I am wondering if Rhodiola may have a similar function, but not sure how powerful it would be.

Glycyrrhizin keeps coming up too, and I know more men are dying from this than women. I am wondering if there may be link here...

 

[GreenMachineX]

Glycyrrhizin keeps coming up too, and I know more men are dying from this than women. I am wondering if there may be link here...

What kind of link? What do you mean?

 

[HIT4ME]

What kind of link? What do you mean?

Big logical jump on my end. Glycyrrhizin keeps popping up in my research as being a potential ingredient for numerous pathways being investigated. But it is supposedly anti-androgenic and esteogenic. So I am just making some leaps here that maybe it would play on some pathway since Covid appears to be more fatal to men than women according to a couple articles I read.

 

[banjobounce]

I'm thinking olive leaf extract and oregano extract.

We just did a show on dihydro hinokiol on SHR, and Dr. Seeds feels that it will inhibit viral replication even in retroviruses such as covid19.

 

[patrick25]

Discount code was mentioned?

 

[ValiantThor08]

Discount code was mentioned?

MADMARCH all caps may still be working, and that is 30 percent off.

 

[patrick25]

Getting more in stock soon?

 

[love2liftkat]

Getting more in stock soon?

He’s reordering supplies to make more.

 

[megadeth]

Sold out. Will you have more?

 

[ValiantThor08]

Sold out. Will you have more?

There should be more next week.

 

[brundel]

Yeah, chloroquine seems to interfere with cell maturity (and thus replication) by preventing the acidification of endosomes.

I am wondering if Rhodiola may have a similar function, but not sure how powerful it would be.

Glycyrrhizin keeps coming up too, and I know more men are dying from this than women. I am wondering if there may be link here...

I dont think we will know until we can get research Grant's and start really digging into it. Hoping to get a grant to continue working.
If so I'll make sure to post progress as we make it.

I have 11% salidroside rhodiola I can list today if people want.

 

[brundel]

I'm thinking olive leaf extract and oregano extract.

We just did a show on dihydro hinokiol on SHR, and Dr. Seeds feels that it will inhibit viral replication even in retroviruses such as covid19.

I gargle twice per day with 80% carvacrol. Oregano extract. Been doing it for a long time. Totally cured my gingivitis.

 

[brundel]

We should have more by wed.

 

[manifesto]

I gargle twice per day with 80% carvacrol. Oregano extract. Been doing it for a long time. Totally cured my gingivitis.

Where do you find the Carvacol rinse @brundel

 

[HIT4ME]

I dont think we will know until we can get research Grant's and start really digging into it. Hoping to get a grant to continue working.
If so I'll make sure to post progress as we make it.

I have 11% salidroside rhodiola I can list today if people want.

It isn't the salidrosides I was looking at...but some other compounds.

There is also this:

https://www.researchgate.net/publication/12663831_Inhibitory_effect_of_Ephedrae_Herba_an_oriental_traditional_medicine_on_the_growth_of_influenza_APR8_virus_in_MDCK_cells

 

[drseuss6969]

Will definitely buy Wednesday
Please post when it is up

 

[manifesto]

Is there any interactions between Selenium and Quercetin?

I know they both help to eliminate free radicals...

Should I discontinue Selenium when I receive the BLR immune product?

 

[GreenMachineX]

Is there any interactions between Selenium and Quercetin?

I know they both help to eliminate free radicals...

Should I discontinue Selenium when I receive the BLR immune product?

I’ve been using 100mg selenium in my multis for years and taking Follidrone and DCP, both of which have quercetin, for months. No issues.

 

[brundel]

Where do you find the Carvacol rinse @brundel

This one

 

[brundel]

It isn't the salidrosides I was looking at...but some other compounds.

There is also this:

https://www.researchgate.net/publication/12663831_Inhibitory_effect_of_Ephedrae_Herba_an_oriental_traditional_medicine_on_the_growth_of_influenza_APR8_virus_in_MDCK_cells

I think it's important to look at how each virus is making entry, replicating etc.
Not all are the same so something that works for hiv may not work for influenza or covid.
Which makes researchers work so much harder

 

[manifesto]

Do you mix it with water or just swish the oil around?

 

[brundel]

Is there any interactions between Selenium and Quercetin?

I know they both help to eliminate free radicals...

Should I discontinue Selenium when I receive the BLR immune product?

I do not know of any interactions

 

[HIT4ME]

I think it's important to look at how each virus is making entry, replicating etc.
Not all are the same so something that works for hiv may not work for influenza or covid.
Which makes researchers work so much harder

Yes, the proposed MOA for chloroquinone is through the prevention of acidification of the endosome...so, yes, this is how the virus is proposed to be making entry into the cells - not protease inhibition (like the Zika virus). But it does appear there is evidence this inhibition of acidification benefits protease inhibitors. It looks like ephedra extract is similar.

 

[HIT4ME]

Posting this here and in another thread....

Here is a list of the drugs under investigation. Please don't take any drugs off this list - it states right in the report that some in the list may make it better, or may make it worse. We just don't know yet.

I found it interesting that in addition to hydroxychloroquine, the list includes metformin, lisinipril, mycophenolic acid, haloperidol and rapamycin. Not interesting for any specific reason, mostly just that they are familiar maybe.

https://www.biorxiv.org/content/10.1101/2020.03.22.002386v1.full.pdf+html

 

[Bigmatt57]

So to dumb this down a little a bit, the Quercentin crystals potentially make the covid virus harder to infect the body?

 

[manifesto]

So to dumb this down a little a bit, the Quercentin crystals potentially make the covid virus harder to infect the body?

I always love lamens terms...some very smart people in here, and stuff often goes right over my head.

 

[brundel]

Yes, the proposed MOA for chloroquinone is through the prevention of acidification of the endosome...so, yes, this is how the virus is proposed to be making entry into the cells - not protease inhibition (like the Zika virus). But it does appear there is evidence this inhibition of acidification benefits protease inhibitors. It looks like ephedra extract is similar.

To be clear. Protease is not how it makes entry. Proteases are key enzymes in viral propagation. So a protease inhibitor would be employed specifically to stop viral replication.
ACE is how its making entry. This is why in the paper you posted they talk about lisinopril which is an ace inhibitor.
Calpain of course is a specific calcium-dependent cysteine protease.
This is why I think its important that any candidate cover all the bases.

HydroxyChloroquinone still hasnt been proven to work and any potential vaccines will have to pass clinical trials so we would be looking at 18 months absolute minimum. Too long.
This is why we are looking specifically at natural small molecules that are already FDA approved.
Can be made and deployed rapidly.

My hope is SOMEBODY finds something that we can rely on 100% or even 80%, soon because things are getting out of hand.

 

[brundel]

So to dumb this down a little a bit, the Quercentin crystals potentially make the covid virus harder to infect the body?

Keeping in mind that I absolutely am not promising anything.


Data implies that quercetin works in multiple ways but 2 stand out.
ACE inhibition which prevents the virus from binding and entering the cells.
Protease inhibition which prevents viral propagation. Stops it from replicating and growing.
Elderberry and zinc also play a part. I linked some stuff at the beginning of the thread on both.

 

[manifesto]

Should zinc supplementation discontinue when starting the BLR product?

 

[ValiantThor08]

Should zinc supplementation discontinue when starting the BLR product?

You could have more zinc, for example some ZMA products have 30mg of zinc. You may want a couple mg of copper to go with the extra zinc.

 

[brundel]

Should zinc supplementation discontinue when starting the BLR product?

Too much zinc can be harmful.
Do not exceed 30mg total.

 

[brundel]

Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection - PubMed

Ebola outbreaks occur on a frequent basis, with the 2014-2015 outbreak in West Africa being the largest one ever recorded. This outbreak has resulted in over 11,000 deaths in four African countries and has received international attention and intervention. Although there are currently no...

pubmed.ncbi.nlm.nih.gov

 

[brundel]

Optical imaging of luciferage gene expression has become a powerful tool to track cells and viruses in vivo in small animal models. Luciferase imaging has been used to study the location of infection by replication-defective and replication-competent viruses and to track changes in the distribution of viruses in mouse models.

 

[justhere4comm]

Lucifer-age gene? Someone with a sense of humor named that.

 

[dollar662]

Are you still on target for this to be restocked and available today?

Thanks for all you do