brundel
Board Sponsor
- Awards
- 3
Let’s discuss what is happening and what we can do to protect ourselves.
As everyone knows, the world has been hit hard by COVID-19.
Global panic, economic meltdown, thousands of deaths, and counting.
Our whole nation is locked down and we don't really know when this will let up.
What we do know is COVID-19, is exceptionally contagious. It is already clogging up medical facilities, as well as global supply chains and emergency services. Emergency status has been declared pretty much worldwide.
What can we do to protect ourselves?
In an effort to do my part to help, I have been working on trying to find a way (supplement wise) to protect us from the virus. I think I have a pretty good idea how to do this. Below are links to some research. Please read through, so you understand what we are doing. Keep in mind, this is far from exhaustive data but it's enough to give you an idea why we are doing what we are doing. I have about 100 units of an antiviral that will be ready in a couple of days.
I want to be 100% clear here=
THIS IS NOT A CURE AND I CANNOT MAKE ANY PROMISES OR GUARANTEES. Please read through the data below, so you understand why we use what we did. I can tell you that all of my family is presently taking this, as am I, and pretty much everyone close to me.
In addition, this is not intended to treat or cure, but is an additional defense. You must absolutely still adhere to proper pandemic protocol.
THIS IS NOT MEANT TO MAKE YOU INVINCIBLE and able to do whatever. Instead, this is meant to help protect you and those you love, the best we can presently with dietary supplementation.
These are ready now but we need labels so maybe 2 to 3 days. I'll begin listing tomorrow.
They consist of quercetin niacin co crystals, elderberry berry extract, and zinc.
Before you rush out to buy quercetin, keep in mind that quercetin has about a 1% oral bioavailability. This is why we use the co crystals.
We can increase bioavailability up to 40x in some cases but I would expect 10x min and 25x average.
It looks like several companies are working on therapies and drugs based off of quercetin.
DATA
To make this simple, viruses are like tiny keys. They cannot replicate on their own; they need a host cell.
If you use the key analogy, then the virus is like a biological key that fits into the cell lock.
More on Viruses at the very bottom.
Quercetin/Niacin co crystals
Antiviral
Protease inhibitor
Calpain inhibitor
www.macleans.ca
www.ncbi.nlm.nih.gov
virologyj.biomedcentral.com
www.ncbi.nlm.nih.gov
nypost.com
Quercetin-Protease inhibitor.
Viral protease Protease inhibitors (lopinavir/ritonavir* and nelfinavir) Quercetin
www.macleans.ca
Quercetin-calpain inhibitor
============
sambucus-Neuraminidase inhibitor
www.sentinelassam.com
www.sciencedirect.com
==============ZINC
www.researchgate.net
FURTHER
Function
The primary role of the virus or virion is to deliver its DNA or RNA genome into the host cell so that the genome can be expressed (transcribed and translated) by the host cell, according to "Medical Microbiology."
First, viruses need to access the inside of a host’s body. Respiratory passages and open wounds can act as gateways for viruses. Sometimes insects provide the mode of entry. Certain viruses will hitch a ride in an insect's saliva and enter the host’s body after the insect bites. According to the authors of Molecular Biology of the Cell, 4th E (Garland Science, 2002) such viruses, can replicate inside both insect and host cells, ensuring a smooth transition from one to the other. Examples include: the viruses that cause yellow fever and dengue fever.
Viruses will then attach themselves to host cell surfaces. They do so by recognizing and binding to cell surface receptors, like two interlocking puzzle pieces. Many different viruses can bind to the same receptor and a single virus can bind different cell surface receptors. While viruses use them to their advantage, cell surface receptors are actually designed to serve the cell.
After a virus binds to the surface of the host cell, it can start to move across the outer covering or membrane of the host cell. There are many different modes of entry. HIV, a virus with an envelope, fuses with the membrane and is pushed through. Another enveloped virus, the influenza virus, is engulfed by the cell. Some non-enveloped viruses, such as the polio virus, create a porous channel of entry and burrow through the membrane.
Once inside, viruses release their genomes and also disrupt or hijack various parts of the cellular machinery. Viral genomes direct host cells to ultimately produce viral proteins (many times halting the synthesis of any RNA and proteins that the host cell can use). Ultimately, viruses stack the deck in their favor, both inside the host cell and within the host itself by creating conditions that allow for them to spread. For example, when suffering from the common cold, one sneeze emits 20,000 droplets containing rhinovirus or coronavirus particles, according to "Molecular Biology of the Cell." Touching or breathing those droplets in, is all it takes for a cold to spread.
As everyone knows, the world has been hit hard by COVID-19.
Global panic, economic meltdown, thousands of deaths, and counting.
Our whole nation is locked down and we don't really know when this will let up.
What we do know is COVID-19, is exceptionally contagious. It is already clogging up medical facilities, as well as global supply chains and emergency services. Emergency status has been declared pretty much worldwide.
What can we do to protect ourselves?
In an effort to do my part to help, I have been working on trying to find a way (supplement wise) to protect us from the virus. I think I have a pretty good idea how to do this. Below are links to some research. Please read through, so you understand what we are doing. Keep in mind, this is far from exhaustive data but it's enough to give you an idea why we are doing what we are doing. I have about 100 units of an antiviral that will be ready in a couple of days.
I want to be 100% clear here=
THIS IS NOT A CURE AND I CANNOT MAKE ANY PROMISES OR GUARANTEES. Please read through the data below, so you understand why we use what we did. I can tell you that all of my family is presently taking this, as am I, and pretty much everyone close to me.
In addition, this is not intended to treat or cure, but is an additional defense. You must absolutely still adhere to proper pandemic protocol.
THIS IS NOT MEANT TO MAKE YOU INVINCIBLE and able to do whatever. Instead, this is meant to help protect you and those you love, the best we can presently with dietary supplementation.
These are ready now but we need labels so maybe 2 to 3 days. I'll begin listing tomorrow.
They consist of quercetin niacin co crystals, elderberry berry extract, and zinc.
Before you rush out to buy quercetin, keep in mind that quercetin has about a 1% oral bioavailability. This is why we use the co crystals.
We can increase bioavailability up to 40x in some cases but I would expect 10x min and 25x average.
It looks like several companies are working on therapies and drugs based off of quercetin.
DATA
To make this simple, viruses are like tiny keys. They cannot replicate on their own; they need a host cell.
If you use the key analogy, then the virus is like a biological key that fits into the cell lock.
More on Viruses at the very bottom.
Quercetin/Niacin co crystals
Antiviral
Protease inhibitor
Calpain inhibitor
A made-in-Canada solution to the coronavirus outbreak? - Macleans.ca
The best hope for an antiviral drug may come from Michel Chrétien's Montreal lab
Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here the screening of Chinese herbal medicine-based, novel small molecules that bind avidly with the surface spike protein of SARS-CoV and thus can interfere with...
jvi.asm.org
Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry
Influenza A viruses (IAVs) cause seasonal pandemics and epidemics with high morbidity and mortality, which calls for effective anti-IAV agents. The glycoprotein hemagglutinin of influenza virus plays a crucial role in the initial stage of virus infection, ...
www.ncbi.nlm.nih.gov
Inhibition of enterovirus 71 replication and viral 3C protease by quercetin - Virology Journal
Background Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease (HFMD), which is sometimes associated with severe central nervous system disease in children. There is currently no specific medication for EV71 infection. Quercetin, one of the most widely...
virologyj.biomedcentral.com
Quercetin, Inflammation and Immunity
In vitro and some animal models have shown that quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities; as well as attenuating lipid peroxidation, platelet ...
www.ncbi.nlm.nih.gov
Scientists believe they’ve made a huge breakthrough in coronavirus vaccine effort
A team of Canadian scientists has successfully isolated and grown copies of the coronavirus — bringing the world a step closer to finding a vaccine to fight the deadly illness. Researchers from the…
nypost.com
Quercetin-Protease inhibitor.
Viral protease Protease inhibitors (lopinavir/ritonavir* and nelfinavir) Quercetin
Coronavirus Treatment
Traditionally, there were no effective antiviral agents for coronaviruses and initial efforts focused on the use of currently available drugs
www.sinobiological.com
A made-in-Canada solution to the coronavirus outbreak? - Macleans.ca
The best hope for an antiviral drug may come from Michel Chrétien's Montreal lab
Quercetin-calpain inhibitor
============
sambucus-Neuraminidase inhibitor
Elderberry and interferon could cure Novel Coronavirus (2019-nCoV) infection
Debojit Acharjee (The writer is Software engineer/writer. He can be contacted at [email protected]) A coronavirus is known to cause infections in animal
Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63
Human coronavirus NL63 (HCoV-NL63), one of the main circulating HCoVs worldwide, causes respiratory tract illnesses like runny nose, cough, bronchioli…
www.sciencedirect.com
==============ZINC
(PDF) Zn Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture
PDF | Increasing the intracellular Zn(2+) concentration with zinc-ionophores like pyrithione (PT) can efficiently impair the replication of a variety of... | Find, read and cite all the research you need on ResearchGate
www.researchgate.net
FURTHER
Function
The primary role of the virus or virion is to deliver its DNA or RNA genome into the host cell so that the genome can be expressed (transcribed and translated) by the host cell, according to "Medical Microbiology."
First, viruses need to access the inside of a host’s body. Respiratory passages and open wounds can act as gateways for viruses. Sometimes insects provide the mode of entry. Certain viruses will hitch a ride in an insect's saliva and enter the host’s body after the insect bites. According to the authors of Molecular Biology of the Cell, 4th E (Garland Science, 2002) such viruses, can replicate inside both insect and host cells, ensuring a smooth transition from one to the other. Examples include: the viruses that cause yellow fever and dengue fever.
Viruses will then attach themselves to host cell surfaces. They do so by recognizing and binding to cell surface receptors, like two interlocking puzzle pieces. Many different viruses can bind to the same receptor and a single virus can bind different cell surface receptors. While viruses use them to their advantage, cell surface receptors are actually designed to serve the cell.
After a virus binds to the surface of the host cell, it can start to move across the outer covering or membrane of the host cell. There are many different modes of entry. HIV, a virus with an envelope, fuses with the membrane and is pushed through. Another enveloped virus, the influenza virus, is engulfed by the cell. Some non-enveloped viruses, such as the polio virus, create a porous channel of entry and burrow through the membrane.
Once inside, viruses release their genomes and also disrupt or hijack various parts of the cellular machinery. Viral genomes direct host cells to ultimately produce viral proteins (many times halting the synthesis of any RNA and proteins that the host cell can use). Ultimately, viruses stack the deck in their favor, both inside the host cell and within the host itself by creating conditions that allow for them to spread. For example, when suffering from the common cold, one sneeze emits 20,000 droplets containing rhinovirus or coronavirus particles, according to "Molecular Biology of the Cell." Touching or breathing those droplets in, is all it takes for a cold to spread.
