Not placebo. I have not had a hormone profile done for quite some time, but I had tests done regularly when I was younger from early 20's to mid 30's. I always had low T/free T, high E/SHBG. Never done a cycle, but I've had gyno in the past when I was younger. The most I've tried is clomid, nolva, exemestane, anastrozole and combinations of them. But I still prefer to find and use natural alternatives. I still get gyno symptoms from certain supplements that can raise estrogen or increase aromatization of T to E and symptoms always include sore, itchy, puffy nips, water retention/bloat, estrogen flush etc. I've researched and tried everything possible to manage things long term without going pharmaceutical or at least delaying the pharmaceutical optional as long as I possibly can.