EvoMuse BRITE™ Writeup

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Would BRITE work well with PES Erase? Planning to run a bottle and read that joint stiffness is a side effect so was going to use krill oil caps.
 
GNO said:
Would BRITE work well with PES Erase? Planning to run a bottle and read that joint stiffness is a side effect so was going to use krill oil caps.
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Erase is a great product. I don't know that these two would necessarily be synergistic (standing by for dsade or someone else to clarify that for sure), but there's no reason that they couldn't be combined that I can think of. I never noticed any joint problems from Erase and I dosed up to the 3 caps/day. But for purely joint issues, I'd stack something like good fish oil (or krill like you mentioned) and possibly some good ol' cissus.
 
Any thoughts of using this while taking a ARA supplement? Reduced effectiveness of the ARA? Started taking ARA again preworkout only with L-carnitine L tartate and gms
 
donk said:
Any thoughts of using this while taking a ARA supplement? Reduced effectiveness of the ARA? Started taking ARA again preworkout only with L-carnitine L tartate and gms
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It's too early to give a very educated recommendation yet.
 
donk said:
Any thoughts of using this while taking a ARA supplement? Reduced effectiveness of the ARA? Started taking ARA again preworkout only with L-carnitine L tartate and gms
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Can't speak to BRITE, but I've been using 1g ArA pre-workout for quite a while now and it's a really nice combination with MyoSynergy.
 
Truly amazing science here, Matt. Very excited to give this a try. Especially liking the long term use, rather than having to break from it.
 
Oh, I'd also be willing to donate my body to the good of your research on this product. Lol.
 
The LAST Brite ingredient will be shipping on Monday. I will, hopefully, have the betas ready to ship by Friday.
 
How can I get a hold of a sample?
 
If im understanding the mechanisms of this supplement, it could be a significant benefit to athletes who have repeatedly dieted down to comp levels then binged post comp in restoring correct leptin response and feelings of satiety. Would like to hear your thoughts...
 
NoAddedHmones said:
If im understanding the mechanisms of this supplement, it could be a significant benefit to athletes who have repeatedly dieted down to comp levels then binged post comp in restoring correct leptin response and feelings of satiety. Would like to hear your thoughts...
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It'll also help those who are not so lean.

Here's a cool article on the all trans

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Amazing ingredient

Formula as a whole is stellar. Would even work well on a caloric surplus with myosynergy to keep the gains and repress adipose accretion. It's seriously unbelievable what Matt has been able to do and accomplish with his most recent formulas.
 
For those that are just sub'd here and haven't been checking in on our subforum, there's a log opportunity in there for 3 lucky individuals.
 
T-Bone said:
This looks like something I'd be interested in. Would it be beneficial if I switched this product with my regular fish oil?. Or would it be better to keep the fish oil and just stack this with it?. I don't know, it's gotta be pretty affordable if I choose to run it indefinitely.
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I have 3 Brites on the way. In line with this question, should fish oil be reduced? I remember with sesamin/fish oil the PPAR-A had issues for those wanting to gain muscle due to decreased androgen synthesis as well as increase corticoid synthesis and PPAR-alpha ligands increase the producton of branched chain alpha-ketoacid dehydrogenase complex which increases BCAA oxidation (per Spook).



Cant wait to try it and will be stacking with the Antaeus product, however I know sometime too mcuh of a good thing can be bad at times. Should we back off the Fish Oil or would it be additive to the intended results. My main goal is non androgen assisted fat loss.
 
Asmodean said:
I have 3 Brites on the way. In line with this question, should fish oil be reduced? I remember with sesamin/fish oil the PPAR-A had issues for those wanting to gain muscle due to decreased androgen synthesis as well as increase corticoid synthesis and PPAR-alpha ligands increase the producton of branched chain alpha-ketoacid dehydrogenase complex which increases BCAA oxidation (per Spook).



Cant wait to try it and will be stacking with the Antaeus product, however I know sometime too mcuh of a good thing can be bad at times. Should we back off the Fish Oil or would it be additive to the intended results. My main goal is non androgen assisted fat loss.
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How many grams a day are you taking?
 
Asmodean said:
I have 3 Brites on the way. In line with this question, should fish oil be reduced? I remember with sesamin/fish oil the PPAR-A had issues for those wanting to gain muscle due to decreased androgen synthesis as well as increase corticoid synthesis and PPAR-alpha ligands increase the producton of branched chain alpha-ketoacid dehydrogenase complex which increases BCAA oxidation (per Spook).

Cant wait to try it and will be stacking with the Antaeus product, however I know sometime too mcuh of a good thing can be bad at times. Should we back off the Fish Oil or would it be additive to the intended results. My main goal is non androgen assisted fat loss.
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I don't think sesamin is, in practice, a PPARa agonist since it has low bioavailability due to being metabolised overwhelmingly to the lignans enterolactone and enterodiol (which are, in fact, estrogenic).
The assertion that "PPAR-alpha ligands increase the production of branched chain alpha-ketoacid dehydrogenase complex which increases BCAA oxidation" appears to come from Invalid Link Removed, which tenuously implies a relationship (based on observations with fibrates, which have complex pharmacology beyond PPARa agonism) but does not demonstrate any causality. Bear in mind that at the time of the study, and of Spook and Par's writing (2004), these things were very much less well understood.
 
Asmodean said:
Taking ~5.4 Grams of actual EPA/DHA (from 8.4G Fish Oil) and 2 X a day Krillipid Balance. Thanks for the info All.
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Actually, it looks as though it would be beneficial to keep it.
[h=1]Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes[/h]
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DOI: 10.1016/j.bbrc.2014.07.010Invalid Link Removed
[h=2]Highlights[/h]•Chronic treatment of EPA induces the recruitment of brown-like adipocytes in inguinal SV cell cultures.
•EPA enhances mitochondrial function, glucose and fatty acid oxidation.
•EPA increases lipid storage and decreases lipolysis in inguinal adipocyte.

[h=2]Abstract[/h]In this study, we determined if eicosapentaenoic acid (EPA) promotes beneficial metabolic activities of subcutaneous adipocytes. Stromal-vascular (SV) cells were isolated from inguinal adipose tissue of C57BL/6 mice and induced to differentiate into adipocytes. EPA effect on thermogenic and mitochondrial gene expression and oxidative metabolism were assessed in inguinal adipocytes. When added to SV cell cultures during 8 day differentiation, EPA significantly increased the expression of thermogenic genes UCP1-3, CIDEA and VEGFα. Moreover, EPA increased mitochondrial DNA content and the expression of genes involved in mitochondrial biogenesis including PGC1α, Nrf1 and COXiv. However, this effect was not perceived when EPA was added to mature inguinal adipocytes for 24 h, suggesting that EPA exerts its browning effect via recruiting brite adipocytes. Consistently, long-term EPA treatment also upregulated AMPKα phosphorylation and CPT1 expression and increased glucose uptake and GLUT4 mRNA expression, suggesting improved mitochondrial oxidation. Additionally, EPA-treated adipocytes had enlarged lipid droplets and increased expression of triglyceride synthesis genes GPAT1 and GPAT3, while significantly decreased glycerol release and down-regulation of HSL and ATGL gene expression. We conclude that EPA enhances energy dissipation capacity by recruiting brite adipocytes to stimulate oxidative metabolism and reduces fatty acid release by facilitating fatty acid storage in subcutaneous adipocytes.



[h=2]rown adipose but not white adipose accumulate DHA in cultured cells provided with alpha-linolenic acid[/h]
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Xia Qin, ; J. Thomas Brenna, ; Kumar S. Kothapalli, ; Peter Lawrence, ; Lei Liu, ; Hiu Gyu Park, ; Jimmie Zhang, ;
Introduction. Adipose tissue has recently been recognized as a complex endocrine organ which coordinates numerous crucial biological functions including fatty acid metabolism, glucose metabolism, energy homeostasis, and immune function. White adipose tissue (WAT) stores energy, while brown adipose tissue (BAT) dissipates energy while producing heat. Our aim was to compare the fatty acid profiles of undifferentiated and differentiated WAT and BAT/Beige transformed adipocytes provided with alpha-linolenic acid.
Methods. Murine 3T3 L1 fibroblasts (preWAT) or pre-BAT cells were grown in regular media to confluence, and differentiation were then induced to either WAT or BAT. At days 10, 12 and 14, cell were supplemented with 50 μM of albumin bound alpha-linolenic acid (ALA). Cells with no ALA supplementation were additional controls. Twenty-four hours after supplementation, fatty acid profiles of the cells were analyzed by GC and structural mass spectrometry.
Results and DIscussion. ALA supplementation caused an increase in cellular eicosapentaenoic acid (EPA, 20:5n-3) with no change in docosahexaenoic acid (DHA, 22:6n-3) levels in undifferentiated cells. WAT cells accumulated more EPA. Similarly, BAT cells accumulated EPA, however in contrast differentiated BAT cells also accumulate significant amounts of DHA when compared to undifferentiated preBAT cells. BAT adipocytes are characterized by a vast increase in mitochondria which require highly unsaturated fatty acids. DHA may be required for their function.
Conclusion. When provided with ALA, WAT cells accumulate EPA with no change in DHA; BATcells accumulate EPA and DHA. If BAT function similarly in vivo, they may serve as a source of DHA for other tissues.
 
I will have the updated beta/final liquid here in 2 weeks or so.

We are close to picking up some funding to go ahead an knock out the softgels.
 
Hey dsade any thoughts on this from the ergo log. Are they talking about ATP? Or some other form of Adenosine? I can't tell from this.

The Press said:
<img src="http://anabolicminds.com/forum/attachment.php?attachmentid=108465"/> From Science Daily Researchers at the University of Bonn have discovered a new signaling pathway to combat excess body weight. The number of overweight persons is greatly increasing worldwide -- and as a result is the risk of suffering a heart attack, stroke, diabetes or Alzheimer's disease. For this reason, many people dream of an efficient method for losing weight. An international team of researchers led by Professor Alexander Pfeifer from the University Hospital Bonn, have now come one step closer to this goal. The scientists discovered a new way to stimulate brown fat and thus burn energy from food: The body's own adenosine activates brown fat and "browns" white fat. "Not all fat is equal," says Professor Alexander Pfeifer from the Institute of Pharmacology and Toxicology of the University Hospital Bonn. Humans have two different types of fat: undesirable white fat cells which form bothersome "love handles," for example, as well as brown fat cells, which act like a desirable heater to convert excess energy into heat. "If we are able to activate brown fat cells or to convert white fat cells into brown ones, it might be possible to simply melt excess fat away" reports the pharmacologist. The group of Prof. Pfeifer together with an international team from Sweden, Denmark, Finland, as well as from the Helmholtz-Center Dresden-Rossendorf and the University of Düsseldorf now discovered a new signalling molecule capable of activating brown fat cells: adenosine. Adenosine is typically released during stress. Crucial for transmitting the adenosine signal is the adenosine receptor A2A. Adenosine activates brown adipose tissue "If adenosine binds to this receptor in brown fat cells, fat burning is significantly stimulated," reports Dr. Thorsten Gnad from Prof. Pfeifer's team. It was previously thought not possible for adenosine to activate brown fat. Several studies with rats and hamsters demonstrated that adenosine blocks brown fat. However, the researchers from the University of Bonn were not mislead by these previous findings. In contrast, using brown fat cells removed from humans during surgery, the scientists investigated the signaling pathway for fat activation using adenosine. The results showed that rats and hamsters react differently than humans in this regard. "The brown fat in mice on the other hand behaves just as in humans," summarizes Prof. Pfeifer. "Browning" of white fat by adenosine In addition, the research team investigated the possibility that adenosine transforms white fat cells into brown fat cells -- a process termed "browning." White fat cells normally cannot be induced to burn excess fat by adenosine, as they simply lack the A2A receptor. For this reason, the team of scientists transferred the A2A receptor gene from brown fat cells to white fat cells in mice. Consequently, the white fat cells also have A2A receptors and start browning and burning energy. Clinical application is still far off As a result, it was possible for the researchers from the University of Bonn to comprehend the significance of adenosine for brown cells in mice and humans for the first time. "Through the administration of adenosine-like substances, the mice actually lost weight," reports Prof. Pfeifer. However, many questions in this regard still need to be investigated. For this reason, clinical application is still far off. Story Source: The above story is based on materials provided by University of Bonn. Note: Materials may be edited for content and length. Journal Reference: Thorsten Gnad, Saskia Scheibler, Ivar von Kügelgen, Camilla Scheele, Ana Kili?, Anja Glöde, Linda S. Hoffmann, Laia Reverte-Salisa, Philipp Horn, Samet Mutlu, Ali El-Tayeb, Mathias Kranz, Winnie Deuther-Conrad, Peter Brust, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Schrader, Gennady G. Yegutkin, Christa E. Müller, Alexander Pfeifer. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature, 2014; DOI: 10.1038/nature13816 Source: Invalid Link Removed
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Hoping next week.
 
halfhuman said:
Capped?
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No. Beta version 2. The softgell version has a minimum of over 500k softgels. We wont even consider that until everything is dialed in.
 
dsade said:
No. Beta version 2. The softgell version has a minimum of over 500k softgels. We wont even consider that until everything is dialed in.
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Got it. Looking forward to this one. Hopefully it treats me better
 
vujade said:
whats the word on Brite...?
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Pretty sure we have a Beta 2 version in the works which hopes to clear up a few of the issues we had with the first one. Stay tuned to our facebook and here. We have a few things in line first.
 
Geoforce said:
Pretty sure we have a Beta 2 version in the works which hopes to clear up a few of the issues we had with the first one. Stay tuned to our facebook and here. We have a few things in line first.
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I hope so. I honestly ended up in the emergency walk in over the original beta. I have never been i n that much pain for 2 weeks until I discovered what was the culprit. I hates throwing out 2 bottles but my wife made me after I for that sick. I want to believe it can work though.
 
Will we see Brite V2 soon?
 
Asmodean said:
I hope so. I honestly ended up in the emergency walk in over the original beta. I have never been i n that much pain for 2 weeks until I discovered what was the culprit. I hates throwing out 2 bottles but my wife made me after I for that sick. I want to believe it can work though.
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That's kinda scary! What caused your issues?
 
looking forward to the new version. Started my last bottle of the original and hoping this will last me long enough until v2 is released.
 
bigk81 said:
Did the BRITE orders from earlier in May get shipped?
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The last of the May orders will finish up shipping today and tomorrow.

Did you get your gift card issued?
 
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