EvoMuse BMP Writeup (UPDATED)

Word as of last night is that BMP (and BRITE, I only have 5 left) ingredients will be shipping next week. I'm trying to get the new ingredient out here in time, but so far timing goes then I might have to put it off until the next run of capsules.

Evid Based Complement Alternat Med. 2011; 2011: 796723.
Published online 2011 Aug 22. doi: 10.1093/ecam/nep167
PMCID: PMC3163074
Role of Bone Morphogenetic Proteins-7 (BMP-7) in the Renal Improvement Effect of DangGui (Angelica sinensis) in Type-1 Diabetic Rats
Ching-Hua Yeh, 1, 2, 3 Chen-Kuei Chang, 4 Kai-Chun Cheng, 5 Ying-Xiao Li, 6 Ying Wen Zhang, 6 and Juei-Tang Cheng 1, 2, 3 *
Author information ► Article notes ► Copyright and License information ►
This article has been cited by other articles in PMC.
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Abstract

Hyperglycemia induced reactive oxygen species (ROS) generation is believed as major factors leading to diabetic nephropathy (DN). DangGui (Angelica sinensis) is mentioned to show renal protective effect in combination with other herbs. Bone morphogenetic proteins-7 (BMP-7) is produced merit in protection of DN. The role of BMP-7 in DangGui-induced renal improvement is not clear. The present study investigated the effects of DangGui on renal functions, BMP-7 expression and the levels of ROS in streptozotocin (STZ)-induced diabetic rats and high glucose-exposed rat mesangial cells (RMCs). After 1- or 4-week treatment, DangGui improved renal functions and increased renal BMP-7 expression in diabetic rats. The BMP-7 expression in RMCs was reduced by high glucose treatment and this could be reversed by DangGui. Moreover, RMCs exposed to high glucose were expired by BMP-7 RNAi transfection but those cells remained alive by scramble transfection. Thus, we employed regular RMCs to knock down BMP-7 with RNAi and we found that DangGui increased BMP-7 expression in these RMCs. Direct activation of BMP-7 expression by DangGui could be considered. The results of DPPH assay, DHE stain and lucigenin assay indicated that DangGui could inhibit high glucose-induced ROS in RMCs. These results suggest that DangGui has an ability to improve renal functions in STZ-diabetic rats through increasing endogenous BMP-7 expression and decreasing oxidative stress in kidney. The present study suggest that DangGui could be applied to improve renal functions in diabetic disorders.
 
dsade said:
Word as of last night is that BMP (and BRITE, I only have 5 left) ingredients will be shipping next week. I'm trying to get the new ingredient out here in time, but so far timing goes then I might have to put it off until the next run of capsules.

Evid Based Complement Alternat Med. 2011; 2011: 796723.
Published online 2011 Aug 22. doi: 10.1093/ecam/nep167
PMCID: PMC3163074
Role of Bone Morphogenetic Proteins-7 (BMP-7) in the Renal Improvement Effect of DangGui (Angelica sinensis) in Type-1 Diabetic Rats
Ching-Hua Yeh, 1, 2, 3 Chen-Kuei Chang, 4 Kai-Chun Cheng, 5 Ying-Xiao Li, 6 Ying Wen Zhang, 6 and Juei-Tang Cheng 1, 2, 3 *
Author information ► Article notes ► Copyright and License information ►
This article has been cited by other articles in PMC.
Go to:
Abstract

Hyperglycemia induced reactive oxygen species (ROS) generation is believed as major factors leading to diabetic nephropathy (DN). DangGui (Angelica sinensis) is mentioned to show renal protective effect in combination with other herbs. Bone morphogenetic proteins-7 (BMP-7) is produced merit in protection of DN. The role of BMP-7 in DangGui-induced renal improvement is not clear. The present study investigated the effects of DangGui on renal functions, BMP-7 expression and the levels of ROS in streptozotocin (STZ)-induced diabetic rats and high glucose-exposed rat mesangial cells (RMCs). After 1- or 4-week treatment, DangGui improved renal functions and increased renal BMP-7 expression in diabetic rats. The BMP-7 expression in RMCs was reduced by high glucose treatment and this could be reversed by DangGui. Moreover, RMCs exposed to high glucose were expired by BMP-7 RNAi transfection but those cells remained alive by scramble transfection. Thus, we employed regular RMCs to knock down BMP-7 with RNAi and we found that DangGui increased BMP-7 expression in these RMCs. Direct activation of BMP-7 expression by DangGui could be considered. The results of DPPH assay, DHE stain and lucigenin assay indicated that DangGui could inhibit high glucose-induced ROS in RMCs. These results suggest that DangGui has an ability to improve renal functions in STZ-diabetic rats through increasing endogenous BMP-7 expression and decreasing oxidative stress in kidney. The present study suggest that DangGui could be applied to improve renal functions in diabetic disorders.
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Hoping soon. I'm On my last bottle of brite
 
dsade said:
Evid Based Complement Alternat Med. 2011; 2011: 796723.
Published online 2011 Aug 22. doi: 10.1093/ecam/nep167
PMCID: PMC3163074
Role of Bone Morphogenetic Proteins-7 (BMP-7) in the Renal Improvement Effect of DangGui (Angelica sinensis) in Type-1 Diabetic Rats
Ching-Hua Yeh, 1, 2, 3 Chen-Kuei Chang, 4 Kai-Chun Cheng, 5 Ying-Xiao Li, 6 Ying Wen Zhang, 6 and Juei-Tang Cheng 1, 2, 3 *
Author information ► Article notes ► Copyright and License information ►
This article has been cited by other articles in PMC.
Go to:
Abstract

Hyperglycemia induced reactive oxygen species (ROS) generation is believed as major factors leading to diabetic nephropathy (DN). DangGui (Angelica sinensis) is mentioned to show renal protective effect in combination with other herbs. Bone morphogenetic proteins-7 (BMP-7) is produced merit in protection of DN. The role of BMP-7 in DangGui-induced renal improvement is not clear. The present study investigated the effects of DangGui on renal functions, BMP-7 expression and the levels of ROS in streptozotocin (STZ)-induced diabetic rats and high glucose-exposed rat mesangial cells (RMCs). After 1- or 4-week treatment, DangGui improved renal functions and increased renal BMP-7 expression in diabetic rats. The BMP-7 expression in RMCs was reduced by high glucose treatment and this could be reversed by DangGui. Moreover, RMCs exposed to high glucose were expired by BMP-7 RNAi transfection but those cells remained alive by scramble transfection. Thus, we employed regular RMCs to knock down BMP-7 with RNAi and we found that DangGui increased BMP-7 expression in these RMCs. Direct activation of BMP-7 expression by DangGui could be considered. The results of DPPH assay, DHE stain and lucigenin assay indicated that DangGui could inhibit high glucose-induced ROS in RMCs. These results suggest that DangGui has an ability to improve renal functions in STZ-diabetic rats through increasing endogenous BMP-7 expression and decreasing oxidative stress in kidney. The present study suggest that DangGui could be applied to improve renal functions in diabetic disorders.
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Very interested in this...
 
Just waiting for tracking. Chinese New Year is over so...
 
dsade said:
There is some crossover, but BMP 2, 4, and 7 (mostly 2 and 7) influence bone and muscle development. Once things calm down a little more here and I am really able to dig into the highly complex world of BMP/SMAD complexes then I'm going to start work on the EvoMuse joint formula.
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Sorry if I'm ignorant but why does the average guy with strong bones care much about bone development? I can understand older women benefiting but most guys? I'd think tendon/ligament development would be helpful but I'm not aware of bones being a weak-link for most people.
 
Ray Donovan said:
Sorry if I'm ignorant but why does the average guy with strong bones care much about bone development? I can understand older women benefiting but most guys? I'd think tendon/ligament development would be helpful but I'm not aware of bones being a weak-link for most people.
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Bone is in a constant state of turnover. Osteoclasts cause bone resorption (stealing minerals from bones) while osteoblasts go on to form healthy bone tissue. BMP makes sure that the balance is tweaked towards osteoblasts and not osteoclasts.

That's not to say, however, that bone resorption isn't important for overall bone health - just that we want the balance tilted towards osteoblasts.

EDIT: Hitting different BMPs is what I'm working on right now for joints, ligaments, tendons, etc - so expect a cutting edge joint formula from EvoMuse sometime later this year.
 
dsade said:
Bone is in a constant state of turnover. Osteoclasts cause bone resorption (stealing minerals from bones) while osteoblasts go on to form healthy bone tissue. BMP makes sure that the balance is tweaked towards osteoblasts and not osteoclasts.

That's not to say, however, that bone resorption isn't important for overall bone health - just that we want the balance tilted towards osteoblasts.

EDIT: Hitting different BMPs is what I'm working on right now for joints, ligaments, tendons, etc - so expect a cutting edge joint formula from EvoMuse sometime later this year.
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Awesom info. I'd be very interested in the joint formula after having tendinosis is both shoulders last year. Tendons were almost 50% frayed.
 
dsade said:
Bone is in a constant state of turnover. Osteoclasts cause bone resorption (stealing minerals from bones) while osteoblasts go on to form healthy bone tissue. BMP makes sure that the balance is tweaked towards osteoblasts and not osteoclasts.

That's not to say, however, that bone resorption isn't important for overall bone health - just that we want the balance tilted towards osteoblasts.

EDIT: Hitting different BMPs is what I'm working on right now for joints, ligaments, tendons, etc - so expect a cutting edge joint formula from EvoMuse sometime later this year.
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Would definitely purchase. I often wonder how many joint products on the market simply alleviate the pain and don't provide any actual benefit to the joints or tendons. Would love to have something that was more than just a pain relief pill.
 
Max32 said:
if you have not already, look into Dry Needling therapy for severe tendon issues
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Will look into it, thanks! The good news is my shoulders are doing great today. Went to PT and did some rotator cuff exercises with bands, stretches, face pulls, electrical-muscle stimulation and massage. Before that my shoulders were wrecked for a year, I was worried I'd never be okay. Probably from doing a Helladrol/Beastrol cycle and adding 40 pounds to my 5RM on bench in 5 weeks, heh. I was throwing up 355 for 5 at 210 body weight on the beast. :D
 
andrewski48 said:
Would definitely purchase. I often wonder how many joint products on the market simply alleviate the pain and don't provide any actual benefit to the joints or tendons. Would love to have something that was more than just a pain relief pill.
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All we need is some prescriptions for var, deca and eq.....joint's and tendon's best friends.
 
Ray Donovan said:
Will look into it, thanks! The good news is my shoulders are doing great today. Went to PT and did some rotator cuff exercises with bands, stretches, face pulls, electrical-muscle stimulation and massage. Before that my shoulders were wrecked for a year, I was worried I'd never be okay. Probably from doing a Helladrol/Beastrol cycle and adding 40 pounds to my 5RM on bench in 5 weeks, heh. I was throwing up 355 for 5 at 210 body weight on the beast. :D
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Ray Donovan said:
What are you doing for recovery? Read my above post. Oh yea and don't ever do side-arm raises above parallel. One more thing that can cause impingement.
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Yeah, I'm doing the same as you without the electrical stimulation and massage. I went to PT for 3 or 4 weeks without any improvement so I'm doing it my way now. I don't do any lateral raises at all anymore.
 
StatePlan1425 said:
dsade question related to this comment. Recombinant BMP-7 has been shown in some animal studies to slow and even reverse kidney fibrosis in both acute and CKD. For nearly two decades various pharma companies have bought and sold the patents. Each time with press release about how this could revolutionize CKD treatment. And the after a few years it's sold yet again. Think this may be because each time they figure out high doses can cause cancer so they sell it to the next guy? Or maybe they do the math and figure out more money made in transplants and a lifetime of immunosuppressants?

At any rate. I'm fascinated with BMPs especially BMP-7 and have been following your product as a natural way to increase expression. Curious of your thoughts (after you get some rest of course)
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Bit of a bump on this question.
 
StatePlan1425 said:
Bit of a bump on this question.
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I spoke in somewhat detail with my spine surgeon about this (they used BMP-2 applied to the split open portion of my vetebrae where they were trying to get the transplanted bone to fuse in) and yeah, it basically comes down to massive, exogenous doses they used to see any kind of carcinogenesis. Now why one of the companies wouldn't keep pursuing, I have no idea.

There's always a huge difference between exogenous dosing at ridiculous amounts and increasing natural expression.
 
Looks like we are zeroing in on why BMP makes our muscles feel "full" all the time.

Invalid Link Removed

Biofactors. 2017 Feb 10. doi: 10.1002/biof.1334. [Epub ahead of print]
Bone morphogenetic protein-7 (BMP-7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway.
Chattopadhyay T1, Singh RR1, Gupta S1, Surolia A1,2.
Author information
Abstract

A direct link between development of insulin resistance and the presence of chronic inflammation, in case of obesity exists, with cytokines playing an important role in glucose metabolism. Members of TGF-β superfamily, including bone morphogenetic proteins (BMPs), have been shown to be involved in islet morphogenesis, establishment of β-cell mass and adipose cell fate determination. Here, we demonstrate a novel and direct role of BMP-4 and -7 in the regulation of glucose homeostasis and insulin resistance. An age-dependent increase in serum BMP-4 and decrease in serum BMP-7 levels was observed in animal models of type II diabetes. In this study, BMP-7 and -4 have been demonstrated to have antagonistic effects on insulin signaling and thereby on glucose homeostasis. BMP-7 augmented glucose uptake in the insulin sensitive tissues such as the adipose and muscle by increasing Glut4 translocation to the plasma membrane through phosphorylation and activation of PDK1 and Akt, and phosphorylation and translocation of FoxO1 to the cytoplasm in liver/HepG2 cells. Restoration of BMP-7 levels in serum of diabetic animals resulted in decreased blood glucose levels in contrast to age matched untreated control groups, opening up a new therapeutic avenue for diabetes. On the contrary, BMP-4 inhibited insulin signaling through activation of PKC-θ isoform, and resulted in insulin resistance through the attenuation of insulin signaling. BMP-7 therefore is an attractive candidate for tackling a multifaceted disease such as diabetes, since it not only reduces body fat, but also strengthens insulin signaling, causing improved glucose uptake and ameliorating peripheral insulin resistance. © 2017 BioFactors, 2017.

© 2017 International Union of Biochemistry and Molecular Biology.
 
Matt, I've got roughly 33 grams left of the BMP you sent me last year in a ziplock. This is the scoop that came with it. If I remember correctly, the directions were to take 1 scoop preworkout, and then 1 scoop later in the day. Is this still accurate?

Invalid Link Removed
 
Yessir...should be a heaping scoop.
 
New study...this shot up to first priority.

Connect Tissue Res. 2017 Jan 19. doi: 10.1080/03008207.2017.1282951. [Epub ahead of print]
Bone morphogenetic protein -2 and -7 mediate the anabolic function of nucleus pulposus cells with discrete mechanisms.
Leung VY1, Zhou L1, Tam WK1, Sun Y1, Lv F1, Zhou G2, Cheung KM1.
Author information
Abstract

Bone morphogenetic proteins (BMPs) play roles in promoting cell anabolism, especially extracellular matrix production. The difference between BMP members in their capacity to modulate intervertebral disc cell activity is yet to be defined. BMP-7/OP-1 has been shown to retard disc degeneration. We compared the activity of BMP-7 with BMP-2 on nucleus pulposus (NP) cell phenotype and function, and investigated how they differentially affect the gene expression profiles of signaling cascade components in human NP cells under degenerative states. We found that while both BMP-2 and BMP-7 enhanced matrix production of bovine NP cells, BMP-7 is more potent than BMP-2 at various dosages (50 - 800 ng/ml). BMP-7 exerted a relatively stronger stimulation on sulfated glycosaminoglycan production and proliferation in human NP cells. Degenerated NP cells showed an overall weaker response to the BMPs than non-degenerated cells, and were more sensitive to BMP-7 than BMP-2 stimulation. Comparing to BMP-2, BMP-7 not only induced the gene expression of canonical BMP components, but also evoked changes in MAPKs as well as CREB1 and EP300 gene expression in degenerated NP cells, suggesting potential activation of the cAMP dependent protein kinase related pathways. In contrast to BMP-2, BMP-7 concomitantly inhibited the expression of profibrotic genes. We propose that BMP-2 and BMP-7, and likely other BMPs, may operate multifaceted but discrete molecular machineries that give rise to their different capacity in regulating NP cell phenotype. Further investigations into such differential capacity may possibly derive alternative cues important for IVD repair or engineering.
KEYWORDS:

BMP-7 degeneration; Bone morphogenetic protein; Nucleus pulposus; intervertebral disc

PMID:
2810271
 
One of my favorite apps science daily just had a nice article about bmp9 and regrowth of scull fracture in mice.
 
patrick25 said:
One of my favorite apps science daily just had a nice article about bmp9 and regrowth of scull fracture in mice.
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BMP 9 and 14 are not highly studied, but BMP 14 is the direction I want to go with the joint formula - looks HIGHLY promising along with 7.
 
This looks to have been directly applied to the scull. Getting these compounds to work by digesting it is the hard part.
 
patrick25 said:
This looks to have been directly applied to the scull. Getting these compounds to work by digesting it is the hard part.
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We aren't ingesting the actual compounds, but compounds that increase expression of the BMP proteins.

There's not so much research, again, on 9 and 14, but if 9 works as you said and I can find a few ingredients - combined with something like Cissus, we can speed up the healing of fractures. We could get massive sales in the professional sports fields.
 
For example we already have, in the BMP formula, compounds the increase BMP2....now I need to look at BMP 9 and find something herbal to increase expression.

Clin Oral Investig. 2017 Feb 14. doi: 10.1007/s00784-017-2069-3. [Epub ahead of print]
Comparison of the effects of recombinant human bone morphogenetic protein-2 and -9 on bone formation in rat calvarial critical-size defects.
Nakamura T1, Shirakata Y1, Shinohara Y1, Miron RJ2, Hasegawa-Nakamura K1, Fujioka-Kobayashi M3,4, Noguchi K5.
Author information
Abstract
OBJECTIVES:

Among bone morphogenetic protein (BMP) family members, BMP-2 and BMP-9 have demonstrated potent osteoinductive potential. However, in vivo differences in their potential for bone regeneration remain unclear. The present study aimed to compare the effects of recombinant human (rh) BMP-2 and rhBMP-9 on bone formation in rat calvarial critical-size defects (CSD).
MATERIALS AND METHODS:

Twenty-eight Wistar rats surgically received two calvarial defects bilaterally in each parietal bone. Defects (n = 56) were allocated into four groups: absorbable collagen sponge (ACS) alone, rhBMP-2 with ACS (rhBMP-2/ACS), rhBMP-9/ACS, or sham surgery (control), on the condition that the treatments of rhBMP-2/ACS and rhBMP-9/ACS, or the same treatments were not included in the same animal. Animals were sacrificed at 2 and 8 weeks post-surgery. The calvarial defects were analyzed for bone volume (BV) by micro-computed tomography and for percentages of defect closure (DC/DL), newly formed bone area (NBA/TA), bone marrow area (BMA/NBA), adipose tissue area (ATA/NBA), central bone height (CBH), and marginal bone height (MBH) by histomorphometric analysis.
RESULTS:

The BV in the rhBMP-2/ACS group (5.44 ± 3.65 mm3, n = 7) was greater than the other groups at 2 weeks post-surgery, and the rhBMP-2/ACS and rhBMP-9/ACS groups (18.17 ± 2.51 and 16.30 ± 2.46 mm3, n = 7, respectively) demonstrated significantly greater amounts of BV compared with the control and ACS groups (6.02 ± 2.90 and 9.30 ± 2.75 mm3, n = 7, respectively) at 8 weeks post-surgery. The rhBMP-2/ACS and rhBMP-9/ACS groups significantly induced new bone formation compared to the control and ACS groups at 8 weeks post-surgery. However, there were no statistically significant differences found between the rhBMP-2/ACS and rhBMP-9/ACS groups in any of the histomorphometric parameters. The ATA/NBA in the rhBMP-2/ACS group (9.24 ± 3.72%, n = 7) was the highest among the treatment groups at 8 weeks post-surgery.
CONCLUSIONS:

Within the limits of this study, it can be concluded that rhBMP-2/ACS induced a slight early increase in new bone formation at 2 weeks and that rhBMP-9/ACS provided comparable new bone formation to rhBMP-2/ACS with less adipose tissues after a healing period of 8 weeks in rat CSD.
CLINICAL RELEVANCE:

RhBMP-9/ACS treatment provided new bone formation with less adipose tissues compared with rhBMP-2/ACS.
KEYWORDS:

Bone morphogenetic protein-2; Bone morphogenetic protein-9; Bone regeneration; Collagen; Growth factor

PMID:
28197731
DOI:
10.1007/s00784-017-2069-3
 
I believe in these products and believe your on the cusp of something major enjoy your writing and waiting on your innovation.
 
patrick25 said:
I believe in these products and believe your on the cusp of something major enjoy your writing and waiting on your innovation.
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These are prime growth pathways, apart from androgenic and mTOR mediated pathways, which makes them all the more exciting. The results from BMP (while it was out) are nothing short of miraculous. Again, restock is TOP priority.

Hoping to have some time to spend on 9 ad 14, as those are both excellent targets to solve major health problems (weak/broken bones, aging connective tissue and joints) that we'll be hitting like nobody else in the industry (even my surgeon wasn't entirely up to speed) ever has.

Sure, you'll see plenty of copies, but I am not going to mention any names.
 
I'm look forward to when you become a millionaire ? I just hope you remember us poor guys over here. Lol

Stuff like this makes me want to completely change my major and go into bioengineering or something.
 
I don't care about being a millionaire. Literally the only pleasure I get out of life is researching and designing.
 
Keep at it man, we appreciate it for sure
 
hsk said:
Wanted to try the OG version but wasn't able t get around to it. Will be grabbing some 2.0 for sure once its out. Any ETA?
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Just waiting for delivery.
 
Beta said:
Excited for 2.0! What are the main changes?
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I'm holding off the changes for until we do a full run of capsules. Even getting the existing powder done is proving a mighty task itself.
 
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