dsade
NutraPlanet Fanatic
Not a flaming bonfire, but a glowing ember.
As mentioned in the IDRT thread, we are modifying Eviscerate for a mainstream clientele.
The Capsaicin content will be reduced by about 60%, the Raspberry Ketone content increase and the addition of a high potency aloe extract, which in-house experimentation is showing helps alleviate surface burning without reducing that nice deep burn.
IN addition, the aloe extract offers functionality:
FEBS Lett. 2010 Jul 16;584(14):3170-8. Epub 2010 Jun 10.
Aloe emodin glycosides stimulates glucose transport and glycogen storage through PI3K dependent mechanism in L6 myotubes and inhibits adipocyte differentiation in 3T3L1 adipocytes.
Anand S, Muthusamy VS, Sujatha S, Sangeetha KN, Bharathi Raja R, Sudhagar S, Poornima Devi N, Lakshmi BS.
Centre for Biotechnology, Anna University, Chennai, Tamilnadu, India.
Abstract
The present study discusses the efficacy of Aloe emodin-8-O-glycoside (AEG), a plant derived anthroquinone, on alleviating insulin resistance and augmenting glycogen synthesis in L6 myotubes and 3T3L1 adipocytes. Dose-dependent increase in glucose uptake activity (GUA) was observed in both cell lines. Immunoblot analysis revealed an insulin-like glucose transporting mechanism of AEG by activating key markers involved in the insulin signaling cascade such as insulin receptor beta IRbeta, insulin receptor substrate1, 85 phosphatidyl inositol 3' kinase (PI3K) and PKB. Glucose transporter 4 translocation was confirmed by determining the uptake of glucose in the presence of insulin receptor tyrosine kinase and PI3K inhibitors. AEG was found to enhance glycogen synthesis through the inhibition of glycogen synthase kinase 3beta. In conclusion, AEG enhances glucose transport by modulating the proximal and distal markers involved in glucose uptake and its transformation into glycogen.
As mentioned in the IDRT thread, we are modifying Eviscerate for a mainstream clientele.
The Capsaicin content will be reduced by about 60%, the Raspberry Ketone content increase and the addition of a high potency aloe extract, which in-house experimentation is showing helps alleviate surface burning without reducing that nice deep burn.
IN addition, the aloe extract offers functionality:
FEBS Lett. 2010 Jul 16;584(14):3170-8. Epub 2010 Jun 10.
Aloe emodin glycosides stimulates glucose transport and glycogen storage through PI3K dependent mechanism in L6 myotubes and inhibits adipocyte differentiation in 3T3L1 adipocytes.
Anand S, Muthusamy VS, Sujatha S, Sangeetha KN, Bharathi Raja R, Sudhagar S, Poornima Devi N, Lakshmi BS.
Centre for Biotechnology, Anna University, Chennai, Tamilnadu, India.
Abstract
The present study discusses the efficacy of Aloe emodin-8-O-glycoside (AEG), a plant derived anthroquinone, on alleviating insulin resistance and augmenting glycogen synthesis in L6 myotubes and 3T3L1 adipocytes. Dose-dependent increase in glucose uptake activity (GUA) was observed in both cell lines. Immunoblot analysis revealed an insulin-like glucose transporting mechanism of AEG by activating key markers involved in the insulin signaling cascade such as insulin receptor beta IRbeta, insulin receptor substrate1, 85 phosphatidyl inositol 3' kinase (PI3K) and PKB. Glucose transporter 4 translocation was confirmed by determining the uptake of glucose in the presence of insulin receptor tyrosine kinase and PI3K inhibitors. AEG was found to enhance glycogen synthesis through the inhibition of glycogen synthase kinase 3beta. In conclusion, AEG enhances glucose transport by modulating the proximal and distal markers involved in glucose uptake and its transformation into glycogen.
