Crazy high ALT, AST from Ostarine

Jinsun

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25mg Ostarine (OL UK), 5 whole weeks in. Bloods:

S-ALT: 5.5 (range: < 0.74)
S-AST: 1.6 (range: < 0.58)
CHOLESTEROL: 5.9 (4.0 - 5.2)
TRIGLICERIDS: 1.0 (0.6 - 1.7)
S-HDL: 0.9 ( > 1.4)
S-LDL: 4.5 (2.0 - 3.5)
S-GGT: 0.23 ( < 0.93)

e2: 10 (11 - 44)
TT: 0.6 (1.42 - 9.23)
LH: 3.03 (0.57 - 12.07)

Prebloods not stellar but mostly in normal range. This was after an Alphmax XT cycle and MK677 (OL UK). Four weeks ago also started taking an SSRI (sertraline, 50mg ed) but this shouldn't have an effect.

e2: 26 (11-44)
TT: 7.22 (1.42 - 9.23)
LH: 3.5 (0.57 - 12.07)
Free T: 22.53 (7 - 22.7)

S-ALT: 0.44 (range: < 0.74)
S-AST: 0.5 (range: < 0.58)
CHOLESTEROL: 5.3 (4.0 - 5.2)
TRIGLICERIDS: 0.7 (0.6 - 1.7)
S-HDL: 1.7 ( > 1.4)
S-LDL: 3.4 (2.0 - 3.5)
S-GGT: 0.28 ( < 0.93)

Somebody care to tell me what the F is going on? My ALT is through the roof. Even if taking methylated PH's or AAS my ALT shouldn't be 8x out of normal range. Needless to say, I'm quitting this Osta cycle and going in to PCT and order a buck loads of tudca. It's a shame.

This is certainly not Ostarine eh? Order from pred.
 
Jinsun

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Also what is weird is my LH is very close to prebloods, but my TT is totally suppressed. It's like the thing shut down my balls. This is very worrisome. There goes my weekend lol.
 
booneman77

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welcome to the world of sarms... so much awful info out there about how osta "isn't suppressive" and ha "no sides'... I had the same experience (in regards to suppression moreso). Hate everything about osta.
 
Chados

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How long since previous cycle? Did you get bloods for that? Seems completly unreasonable for osta to be that toxic.
 
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welcome to the world of sarms... so much awful info out there about how osta "isn't suppressive" and ha "no sides'... I had the same experience (in regards to suppression moreso). Hate everything about osta.
That's strange, could it be that some of us react so different to sarms? How was your dosage and cycle lenght?
 
booneman77

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That's strange, could it be that some of us react so different to sarms? How was your dosage and cycle lenght?
8 weeks at 25mg. by week 4 I felt like absolute death. lethargy, aches, overall mood was awful, etc.
 
Chados

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8 weeks at 25mg. by week 4 I felt like absolute death. lethargy, aches, overall mood was awful, etc.
That's crazy to hear, I did 4 weeks and I felt amazing on it. Maybe there something some people just can't take with osta
 
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booneman77

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That's crazy to hear, I did 4 weeks and I felt amazing on it. Maybe there something some people just can't take with osta
agreed. just like any hormonal product, its very personal how and what is effected
 
Jinsun

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welcome to the world of sarms... so much awful info out there about how osta "isn't suppressive" and ha "no sides'... I had the same experience (in regards to suppression moreso). Hate everything about osta.
Yeah what a nice welcome!

You're saying your LH was also high with TT low?

I mean regarding suppression and osta, seeing as my LH is normal (it usually lowers a bit when I start cutting) technically it didn't shut me down. It looks like it made me primary hipo lol
 
booneman77

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Yeah what a nice welcome!

You're saying your LH was also high with TT low?

I mean regarding suppression and osta, seeing as my LH is normal (it usualy lowers a bit when I start cutting) technically it didn't shut me down. It looks like it made me primary hipo lol
I ran ti right into another cycle so I don't know the exact values... I just know suppression and that was what was going on. I actually felt BETTER when I transitioned right into an actual epi/tren ph cycle ha.
 
Jinsun

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That's crazy to hear, I did 4 weeks and I felt amazing on it. Maybe there something some people just can't take with osta
I don't feel particularity bad tbh. A bit burned out as I'm cutting but nothing out of the ordinary. If I didn't do bloods I would just be thinking that my e2 and dht was low due to maybe 30% suppression...
 
Jinsun

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I ran ti right into another cycle so I don't know the exact values... I just know suppression and that was what was going on. I actually felt BETTER when I transitioned right into an actual epi/tren ph cycle ha.
Oh I see. Well that just seems normal for Osta. Osta is suppressive, that is no mystery :)
 

mase1

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Strange numbers. Did not shut you down, lowered estrogen, and liver through the roof. Luckily osta is great for me. With bloods to confirm.
 
Jinsun

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Okay a serious question: seeing as my LH is normal I'm thinking of not doing a PCT with a serm. Nolva is hepatoxic and all it does (regarding T production) is raise LH, FSH and if my LH is normal then why take it if my liver needs to heal?

My LH is always around 3.0 when I cut and around 3.5 when bulking with high free T and TT.
 

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And this is why I tell people to stay away from sarms and companies pushing them... Ostarine is utter sh1t! I've said it before and I say it again. You're not the first to post bad bloodwork from it. For me it caused gyno and hair loss... And I don't even shed on Masteron or Proviron..
 
Jinsun

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And this is why I tell people to stay away from sarms and companies pushing them... Ostarine is utter sh1t! I've said it before and I say it again. You're not the first to post bad bloodwork from it. For me it caused gyno and hair loss... And I don't even shed on Masteron or Proviron..
Well I've found lots of bloods with normal or slightly suppressed LH and very low TT. But the liver toxicity is apparently hit or miss. At least regarding the intensity.

I wonder what is the deal with LH beeing normal and testosterone beeing 0...
 

mase1

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I have to assume contamination, most companies are capping everything under the sun and putting whatever in it and calling it "ostarine." Not just this sarm or that prohormone, most junk coming from China and not tested so who knows. Everybody's body processes drugs differently but some numbers for sarms especially have been all over the place. My rant is over.
 

user567

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I bought OL UK ostarine not long ago and felt like absolute crap after 2 weeks. I knew it wasnt real Ostarine. Not saying its OL's fault as the company who sold it can simply put whatever they want in the bottle.
 
MrKleen73

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I really don't mean to be dismissive here guys, but keep in mind that your liver values are not just affected by whatever cycle you are on.

ANY toxin you ingest orally goes through your liver and stresses it. Not just whatever gear you are on. This could be as simple as having taken a round of tylenol for a few headaches to having accidentally ingested anything in your food that your body saw as a toxin that needed to be dealt with. Mine shot up one time over me getting a chemical burn from some clothes I picked up from the dry cleaners. Stuff burned my skin a little and when i went to get my blood work and stuff right after my levels were sky high. I was not cycling at the time but the doc said even though I didn't eat that, it still passed through my liver on the 2nd pass and the toxins had lit me up.

I would also inspect your environment and make sure there isn't anything you did recently that might have effected the liver.

Not saying it isn't something else, could be, but don't automatically assume it is the supplement elevating your enzyme levels.
 
Chados

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I really don't mean to be dismissive here guys, but keep in mind that your liver values are not just affected by whatever cycle you are on.

ANY toxin you ingest orally goes through your liver and stresses it. Not just whatever gear you are on. This could be as simple as having taken a round of tylenol for a few headaches to having accidentally ingested anything in your food that your body saw as a toxin that needed to be dealt with. Mine shot up one time over me getting a chemical burn from some clothes I picked up from the dry cleaners. Stuff burned my skin a little and when i went to get my blood work and stuff right after my levels were sky high. I was not cycling at the time but the doc said even though I didn't eat that, it still passed through my liver on the 2nd pass and the toxins had lit me up.

I would also inspect your environment and make sure there isn't anything you did recently that might have effected the liver.

Not saying it isn't something else, could be, but don't automatically assume it is the supplement elevating your enzyme levels.
That makes a lot of sense now when you say it cause I can't imagine an healthy liver being that bad after osta
 
Vikingbro

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I really don't mean to be dismissive here guys, but keep in mind that your liver values are not just affected by whatever cycle you are on.

ANY toxin you ingest orally goes through your liver and stresses it. Not just whatever gear you are on. This could be as simple as having taken a round of tylenol for a few headaches to having accidentally ingested anything in your food that your body saw as a toxin that needed to be dealt with. Mine shot up one time over me getting a chemical burn from some clothes I picked up from the dry cleaners. Stuff burned my skin a little and when i went to get my blood work and stuff right after my levels were sky high. I was not cycling at the time but the doc said even though I didn't eat that, it still passed through my liver on the 2nd pass and the toxins had lit me up.

I would also inspect your environment and make sure there isn't anything you did recently that might have effected the liver.

Not saying it isn't something else, could be, but don't automatically assume it is the supplement elevating your enzyme levels.
Very true. The skin being the largest organ of the body directly draws in and assimilates numerous toxins throughout the day. Pollution, spray deodorant, aftershave, soap/shampoo etc etc. They all have to be passed through the body and cleaned out once ingested. People have no idea how toxic our environment really is. For the record, I try to use minimal products and those I use are natural without a thousand chemicals in them like most shower gels contain. I have used osta twice at 25mg for 10 weeks. Best feel good compound I’ve ever used. Fukk all gains as far as a lot of muscle added, but not a shift at all in ALT/AST over and above normal raises through exercise etc.
 
Jinsun

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Well this conversation is all fine and dandy but has anybody any input on why osta elevated enzymes so much and why TT is zero and LH normal and what to do with PCT???? I mean as much as I appreciate talking about the "weather" this is kinda, khm... serious! :)
 
Vikingbro

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Well this conversation is all fine and dandy but has anybody any input on why osta elevated enzymes so much and why TT is zero and LH normal and what to do with PCT???? I mean as much as I appreciate talking about the "weather" this is kinda, khm... serious! :)
Read my above comment. Are you sure there are no other factors that could have contributed to elevated liver enzymes?
 
Jinsun

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Read my above comment. Are you sure there are no other factors that could have contributed to elevated liver enzymes?
I've taken some aromasin in week 3 and 4, but discontinued after week 4. Aromasin can elevate enzymes but certainly not this much and certainly not after only app 75mg... The only other thing is sertraline, but that also doesn't have indicated hepatoxicity...
 
Chados

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I've taken some aromasin in week 3 and 4, but discontinued after week 4. Aromasin can elevate enzymes but certainly not this much and certainly not after only app 75mg... The only other thing is sertraline, but that also doesn't have indicated hepatoxicity...
We all react differently to compounds and one liver doesn't last as long as the other etc but an healthy liver should not be affected that much with ostarine. It doesn't make sense to me , you should probably completly stay away from alcohol and other things if that's the case. Give some information how you live normally. What do you eat, work with etc. I don't know if mrkleens comment was a longshot but it could make sense to why this happened.
 
Jinsun

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We all react differently to compounds and one liver doesn't last as long as the other etc but an healthy liver should not be affected that much with ostarine. It doesn't make sense to me , you should probably completly stay away from alcohol and other things if that's the case. Give some information how you live normally. What do you eat, work with etc. I don't know if mrkleens comment was a longshot but it could make sense to why this happened.
I agree. A friend is going to take the rest of my osta now and will do bloods. That will clear things if it's only me or if it's the osta.

My life stile is stressful, don't sleep good, etc. I train 3 to 4 times per week and also do cardio app 2 times per week. Don't really drink as alcohol started making me sick more so than when I was young. But this might also be a symptom of me being burned out... But maybe it's my liver that isn't functioning properly... I do have slightly high billirubin, but that I was told is nothing to worry about, but I may dive a bit more into my liver health now.
 

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How long since previous cycle? Did you get bloods for that? Seems completly unreasonable for osta to be that toxic.
My levels are also through the roof after 20mg osta for 6 weeks!
 
Jinsun

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Click on the boxed picture above the text input window :)
 
Chados

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I'm starting to think some of these might not contain ostarine or a mix of something else..
 
Jinsun

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Can you see them?
Yes. Can you explain a bit about your cycle and when the bloods were drawn please.

I see your cholesterol and hdl, ldl were also completely crashed just as mine. Your alt (which I presume is S-ALAT) was on 22.2. almost 5 times out of range.
 

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They were drawn 1 week after i stopped my cycle.....20mg ed for 6 weeks
 
gigante35

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Ol gharine and ostarine are toxic crap, always got elevated liver enzymes AST between 70-100, and ALT between 95-150.
 
Jinsun

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Ol gharine and ostarine are toxic crap, always got elevated liver enzymes AST between 70-100, and ALT between 95-150.
Crazy how I am finding all of this now and not before when I was doing research. Would have just done a primo cycle if I new all of this but no, now my cut is fuc*ed up.

I ran Ghar1ne before I started this cycle and it also skewed my lipid values but not my enzymes.
 
gigante35

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Last time run ol gharine after low back surgeryy l5-s1 for better healing, after digestion tablets everytime i felt in stomach strange pain. After 5 weeks ( 20-30 mg daily) drawn bloods and ast came 83 and alt 140. After over this crap everything came back normal after full month later.
 

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Amazing, so many posts here about how OL UK SARMS and mk-677 is legit and pure. Rep on this board claims they have purity reports. Can’t trust anyone.
 
Jinsun

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Amazing, so many posts here about how OL UK SARMS and mk-677 is legit and pure. Rep on this board claims they have purity reports. Can’t trust anyone.
Well... I'm not sayimg it isn't pure. It might be just how my body reacts to ostarine...
 

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Only osta? Also from OL UK? I see 3 dates on your bloods?
The one with the lowest is from last year cycle with 30mg dbol ed for 4 weeks

The one with the highest is the last day on osta

The third is 6 days later
 
Vikingbro

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Amazing, so many posts here about how OL UK SARMS and mk-677 is legit and pure. Rep on this board claims they have purity reports. Can’t trust anyone.
Let me tell you something. I’ve seen the ‘supposed’ purity report. It is nothing but a bit of paper with writing and a graph. It states nothing about anything. The lab running it, the chemical tested, dates, times, purity etc etc. I could have drawn up a report like this in 5 minutes on my PC. That being said, I still love OLs products and use their osta, LGD, ghar1ne, arm1care pro.
 

Polly1

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Its not the brands it the sarms!They are not as safe as we thought!They need to be used with care!
 

Robert11

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Let me tell you something. I’ve seen the ‘supposed’ purity report. It is nothing but a bit of paper with writing and a graph. It states nothing about anything. The lab running it, the chemical tested, dates, times, purity etc etc. I could have drawn up a report like this in 5 minutes on my PC. That being said, I still love OLs products and use their osta, LGD, ghar1ne, arm1care pro.
I’ve seen many of your posts and know you’re a big OL advocate. I’ve factored this into some decisions made. That said have you ever done bloods while on their lgd or mk? I’d like to hear from some other users showing no impact on enzymes which would suggest this is an isolate user specific case.
 

Robert11

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Its not the brands it the sarms!They are not as safe as we thought!They need to be used with care!
Well I saw something saying these are all made in China and everyone just slaps their name on the packaging. If that’s the case who knows what the **** you’re getting from batch to batch.
 

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Mike Arnold Research sells SARMs. Id be inclined to research with them or PRE, fwiw.
 
Vikingbro

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I’ve seen many of your posts and know you’re a big OL advocate. I’ve factored this into some decisions made. That said have you ever done bloods while on their lgd or mk? I’d like to hear from some other users showing no impact on enzymes which would suggest this is an isolate user specific case.
I have indeed done bloods or to be more specific I have done one blood test post LGD and ghar1ne use. I have no bloods to shed any light on osta though unfortunately. On LGD and ghar1ne my ALT/AST where slightly elevated but nothing more than what is to be expected with heavy exercise. I train lots. Fasted HIIT training every morning and weights later on. 6 days a week without fail. I don’t drink, use drugs and as stated above don’t use any unnecessary chemicals on or in my body which impact liver health. Diet is very clean also. Hope this answers your question.
 

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