BlackWinging
New member
Are there any effective OTC COMT inhibitors that could allow N-Coumaroyldopamine to stay active longer to exert it's benefits? I know EGCG and quercetin both inhibit it to some degree but aren't overly potent at doing so.
COMT inhibition and N-Coumaroyldopamine
- Thread starter BlackWinging
- Start date
mr.cooper69
Legend
The kinetics of NCD aren't as simple as initially thought. While it is indeed a substrate for COMT, the testing of myself and others (i.e. BK) with pure NCD (tough to find) shows that its effects persist much longer than predicted.
EGCG and quercetin won't appreciably affect COMT though, to your point
EGCG and quercetin won't appreciably affect COMT though, to your point
BlackWinging
New member
Interesting. At the very least its good to know that it's not just a expensive waste. I guess we'll just have to wait for more studies. Thanks Coop.
RecompMan
Well-known member
I use that **** for my runs
BlackWinging
New member
I've seen rhodiola mentioned as a COMT inhibitor a few times, but never any concrete evidence that shows it actually works as one. Specifically I've seen different sites state it inhibits COMT up to 60% but they don't link to anything to back that up.
Whacked
Well-known member
I hope this doesnt break any board rules but when I read this thread, I wanted to learn more about COMT.
I stumbled across this informative thread. It discussed Warrior vs Worrier. Man, that is so me any more. Need to get to the bottom of this. Coop, can I hire you as my Doc and you fix me?
My anxiety is off the charts anymore as are my seemingly LOW dopamine levels.
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I stumbled across this informative thread. It discussed Warrior vs Worrier. Man, that is so me any more. Need to get to the bottom of this. Coop, can I hire you as my Doc and you fix me?
My anxiety is off the charts anymore as are my seemingly LOW dopamine levels.
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3clipseGT
On my grind
I hope this doesnt break any board rules but when I read this thread, I wanted to learn more about COMT.
I stumbled across this informative thread. It discussed Warrior vs Worrier. Man, that is so me any more. Need to get to the bottom of this. Coop, can I hire you as my Doc and you fix me?
My anxiety is off the charts anymore as are my seemingly LOW dopamine levels.
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Very interesting and a lot of what is said seems to apply to me. Definitely subbed for more info
JudoJosh
Pro Virili Parte
This paper Invalid Link Removed mentions it may inhibit COMT and uses this as a reference
Stancheva SL, Mosharrof A. Effect of the extract of Rhodiola rosea L. on the content of the brain biogenic monamines. Med Physiol 1987;40:85-87
Which I cant seem to find but it appears that they gave r. Rosea to rats and observed changes in monoamine levels and hypothesized the changes were the result of r. Rosea inhibiting COMT. Hardly says much though since r. Rosea is a MAO inhibitor (both A and B) Invalid Link Removed which can explain the changes they observed.
3clipseGT
On my grind
Whats all this mean in laymen terms? If you have high COMT then you are hungrier and burn more fat?
Would NCD increase COMT ? All this stuff kind of loses me.
RecompMan
Well-known member
Whoops sorry thought we were talking about the CART system. My fault
RecompMan
Well-known member
I was thinking we were talking about the effects of CART disregard statement
BlackWinging
New member
Yeah I saw this being discussed on another forum before. The discussion basically went "rhodiola isn't a COMT inhibitor, the study was done before the one finding it was an MAO inhibitor which would explain the increase in serotonin". Still looks like a great herb, and I'm planning on getting some for when I do a caffeine tolerance break.
I've never heard of the CART system before, care to do a basic overview?
RecompMan
Well-known member
Here's the info you want on comt sorry for confusion,again.
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RecompMan
Well-known member
Better then explaining because there are multiple regulators of this gene like leptin npy agouti and pomc
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Now pomc
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Relationship between pomc leptin and cart
Maybe coops corner on this one. Can be very in depth
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Below shows a chart of relationship
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BlackWinging
New member
Looks like I have my reading for day. Thanks, always happy to learn.
RecompMan
Well-known member
There is a lot of overlapping information. It's basically leptin activates these systems to increase fat burning an reduce hunger
Mch3/4 in the pomc system are more related to feeding and burning as well