Just what he said really - your androgen receptors have never seen an outside source, they're virgin. You know how any drug you have to keep cranking the dose up to see the same results, or use harder drugs? Same thing here - think how drunk someone can get so easily the first time they drink, with zero tolerance.
If you really do your research, buy the supports, the research chems, know what to dose when & why, have a basic understanding of all the hormones you're playing with and how these drugs & your chems work in the body - and are willing to be a man and tough the sides - I say go straight for the throat and use something like Super DMZ 2 with both Msten and DMZ and start eating/lifting.