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Blood sugar lowering agents

Without taking this thread in a different direction, don't you care "WHERE" these blood sugars go "when lowered" (Adipocytes, liver, fat cells, etc)?

JudoJosh said:
This is strictly an informational thread so please keep product pimping down to a minimum as well as anecdotal remarks such as "XX product made me swole bro!".

Statements made in this are expected to be, at the very least based using some objective reasoning, but preferably if you have a reference, please share.
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In. but my contribution will have to wait until I get to a computer. Great thread I wish we had threads like this for other topics.
 
Uh oh... Not looking good for bitter melon

Testicular oxidative stress in Sprague-Dawley rats treated with bitter melon (Momordica charantia): the effect of antioxidant supplementation

Abstract

Objective: An important mediator of testicular injury is oxidative stress; the implicating pathway has been pointed at a free radical mechanism by researchers. This article, investigates the effect of bitter melon (Momordica charantia) (MC) seed extract and antioxidant supplementation in the testes of Sprague-Dawley (S-D) rat.

Methodology: Ninety male S-D rats, weighing between 110- 214 g, were assigned randomly into six main Groups A to F. Group A was administered 50 mg/100 g of MC extract orally, between 6 to 16 weeks. Group B were pre-treated with ascorbic acid (AA) 0.01mg/kg, three days/week, α-tocopherol (AT) 20 mg/kg, five days/week and both test solutions (TS) i.e. AA and AT; 0.01 and 20 mg/kg, three and five days/week for 8 weeks. This was followed by administration of the extract at dose and duration as in A. Group C received the extract for 8 weeks and afterwards post-treated for another 8 weeks with AA, AT and both TS (as above). Group D in addition to the extract administration were treated with AA, AT and both TS in dose and duration similar to B above. Group E had AA, AT and both TS alone for 8 weeks. Group F served as the control subjects. The animals testicular tissues were processed for malondialdehyde (MDA) and AA concentrations. Serum testosterone (TT) assay was done from left ventricular blood.

Results: The extract administered for 6, 8 and 16 weeks produced significantly (p < 0.05) increased testicular MDA (1.74 ± 1.15, 1.84 ± 0.38 and 2.38 ± 0.40) compared to control (0.38 ± 0.02, 0.38 ± 0.03 and 0.35 ± 0.02) and decreased AA (0.01± 0.02, 0.01± 0.01 and 0.00± 0.01) compared to control (0.15 ± 0.02, 0.12 ± 0.02 and 0.13 ± 0.02). There was also an associated significant decrease (p < 0.05) in peripheral TT levels compared to control. The extract produced responses that showed no prophylactic rather modulatory effect with TS.

Conclusion: These findings suggest that the extract resulted in changes in the testicular oxidative status. This may play a role in testicular dysfunction that may compromise fertility.
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Effect of graded doses of Momordica charantia seed extract on rat sperm: scanning electron microscope study.

Morphological changes in sperm of albino rats observed under scanning electron microscopy illustrate the disturbance in the plasma membrane as well as in the acrosomal membrane on treatment with effect of graded doses of alcohol seed extract from Momordica charantia. Considerable changes in the shape and size of the sperm head were observed, with the middle region of the sperm head being slightly constricted dorsoventrally. Most sperm appeared morphologically abnormal in the mid-region of the tail, with formation of a balloon-like cytoplasmic droplet. The results of this study suggest that such effects may have resulted from a general disturbance in proteins and an alteration in the cauda epididymal milieu, probably due to androgen deficiency consequent to the anti-androgenic property of Momordica charantia seeds.
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so if your testicular health is dear to your heart, I would think twice before messing with bitter melon
 
I found a PDF document on the Web that lists numerous herbs which may lower blood sugar levels - several of them have already been named here. However, the author does not provide primary research references, so you would have to check PubMed on your own to verify the claims. Thought it might be useful anyway.

www . aaimedicine.com / jaaim / sep06 / Blood_Sugar.pdf

(I can't post regular links yet. So, in order to get the link for the PDF document, remove all spaces from the address above.)
 
This isn't a substance but diabetics work out a lot since working out causes the insertion of GLUT4 into the plasma membrane of muscle fibers and allows the uptake of glucose from the blood. Normally insulin causes the insertion of GLUT4 onto many cell surfaces but for various reasons it doesn't work for type 2 diabetics so they exercise to insert it into some of their cells. Maybe some sort of supplement that helps with GLUT4 insertion would work to lower blood sugar.
 
wujustyle said:
This isn't a substance but diabetics work out a lot since working out causes the insertion of GLUT4 into the plasma membrane of muscle fibers and allows the uptake of glucose from the blood. Normally insulin causes the insertion of GLUT4 onto many cell surfaces but for various reasons it doesn't work for type 2 diabetics so they exercise to insert it into some of their cells. Maybe some sort of supplement that helps with GLUT4 insertion would work to lower blood sugar.
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The proper term is translocation and that's actually how most of these products work (vicariously through AMPK) :)
 
guys need some add advice. im new and im getting to learn alot from you guys... im trying to cut on my bf and was recommended this stack:
Alpja Lipoic acid - 1 pill every 4hrs
Cinamon 100mg- 1 pill int the morn 1 pill eight hrs later
Chromium picolinate- 3 polls per day (1 every 5hrs)

i wanted to know if this is safe? does this HARM my body at all or potentially harm my body in the future? i read something about GDA supps related to cancer? is this the same? sorry if these are dumb questions but again im a novice thanks
 
Murda_sheRote said:
guys need some add advice. im new and im getting to learn alot from you guys... im trying to cut on my bf and was recommended this stack:
Alpja Lipoic acid - 1 pill every 4hrs
Cinamon 100mg- 1 pill int the morn 1 pill eight hrs later
Chromium picolinate- 3 polls per day (1 every 5hrs)

i wanted to know if this is safe? does this HARM my body at all or potentially harm my body in the future? i read something about GDA supps related to cancer? is this the same? sorry if these are dumb questions but again im a novice thanks
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I dont think that those ingredients gonna harm u.
I was using same stuff as you but I also add something extra and everything go well.
 
Murda_sheRote said:
guys need some add advice. im new and im getting to learn alot from you guys... im trying to cut on my bf and was recommended this stack:
Alpja Lipoic acid - 1 pill every 4hrs
Cinamon 100mg- 1 pill int the morn 1 pill eight hrs later
Chromium picolinate- 3 polls per day (1 every 5hrs)

i wanted to know if this is safe? does this HARM my body at all or potentially harm my body in the future? i read something about GDA supps related to cancer? is this the same? sorry if these are dumb questions but again im a novice thanks
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I have not read anything linking to cancer, though rala is going to be better than ala, and ala has been linked to higher mortality rates compared to rala.

I would dose these 20-45 mins before high carb meals rather than spaced out during the day. Honestly at those levels I don't think its going to make much of a difference one way or another
 
Murda_sheRote said:
guys need some add advice. im new and im getting to learn alot from you guys... im trying to cut on my bf and was recommended this stack:
Alpja Lipoic acid - 1 pill every 4hrs
Cinamon 100mg- 1 pill int the morn 1 pill eight hrs later
Chromium picolinate- 3 polls per day (1 every 5hrs)

i wanted to know if this is safe? does this HARM my body at all or potentially harm my body in the future? i read something about GDA supps related to cancer? is this the same? sorry if these are dumb questions but again im a novice thanks
Click to expand...

I'd go with chromium polynicotate over picolinate. Safer and more effective.
 
saggy321 said:
Mr Cooper, I'm not sure if you're at liberty to say, but is AP the only GDA that enacts this selectively in muscle cells?
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Mr Cooper can better elaborate but from what I've seen in research, corosolic acid, found in banaba, is the only gda that selectively translocates glucose to muscle. Some argue the tanins in banaba play a role as well but I believe it's the high amounts of CA.

Anabolic Pump's crape mertel extract seems to contain high amounts of CA which is why I love it for pumps and fantastic glycogen insertion in muscles.
 
Clemenza said:
Mr Cooper can better elaborate but from what I've seen in research, corosolic acid, found in banaba, is the only gda that selectively translocates glucose to muscle. Some argue the tanins in banaba play a role as well but I believe it's the high amounts of CA.

Anabolic Pump's crape mertel extract seems to contain high amounts of CA which is why I love it for pumps and fantastic glycogen insertion in muscles.
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Is it selective to muscle cells? I was unaware of this. Source?

Anabolic pump is a solid formula composed of two highly studied GDA/mimics, I was unaware that we could select muscle and not select adipose GLUT4 translocation.
 
rob112 said:
Is it selective to muscle cells? I was unaware of this. Source?

Anabolic pump is a solid formula composed of two highly studied GDA/mimics, I was unaware that we could select muscle and not select adipose GLUT4 translocation.
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There are only two that I have found. One you have never heard of before. The other is high-dosed TUDCA.
 
mr.cooper69 said:
There are only two that I have found. One you have never heard of before. The other is high-dosed TUDCA.
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Very interesting. Is the other every gonna see the light of day?
 
Clemenza said:
Mr Cooper can better elaborate but from what I've seen in research, corosolic acid, found in banaba, is the only gda that selectively translocates glucose to muscle. Some argue the tanins in banaba play a role as well but I believe it's the high amounts of CA.

Anabolic Pump's crape mertel extract seems to contain high amounts of CA which is why I love it for pumps and fantastic glycogen insertion in muscles.
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Interesting.. anabolic pump always worked the best for me.

So for carb loading for a bodybuilding show, force feed muscles with carbs.. the new AP would make a solid choice, correct? No blocking of carb uptake? I am looking for something, that does something similar as insulin, obviously not that strong though, to force feed muscle cells..
 
why not just get insulin humulin R can be ordered from any online veterinary med supplier without a prescription just tell them its for your diabetic cat
 
Oscar said:
why not just get insulin humulin R can be ordered from any online veterinary med supplier without a prescription just tell them its for your diabetic cat
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or, you can just walk in to the pharmacy and ask for it, as it does not require a perscription. I've played with slin like a 5 year old with lego's, but that doesn't mean I want to use it everyday, all year round. It has a purpose, to combat hyperglycemia related to high doses of certain, growth factors, but I don't need that support around the clock.

Mike
 
criticalbench said:
or, you can just walk in to the pharmacy and ask for it, as it does not require a perscription. I've played with slin like a 5 year old with lego's, but that doesn't mean I want to use it everyday, all year round. It has a purpose, to combat hyperglycemia related to high doses of certain, growth factors, but I don't need that support around the clock.

Mike
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You are on another level compared to most on this forum though. Slin would be highly risky for the average member here.
 
AZMIDLYF said:
You are on another level compared to most on this forum though. Slin would be highly risky for the average member here.
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haha thanks.. IMO, slin has very little use to building muscle.. its more to combat dangerous side effects of the drugs needed to build muscle.

Mike
 
fightbackhxc said:
Apple Cider Vingear Organic with the Mother. Cheap and effective.
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Have experience with it?

I have read about it but never got around to trying it

If I remember correctly it works by slowing the gastric emptying


Edit: added references
 
A 60-g test drink consumed prior to meals contained either distilled water and 1 tsp saccharine, or 20 g apple cider vinegar with 5% acetic acid, 40 g distilled water, and 1 tsp saccharine. Sweetened water was consumed for the control and peanut treatments, and the sweetened vinegar drink was consumed for the vinegar treatments. For the peanut treatments, peanut butter (25 g) was substituted for butter in the bagel meal, and roasted peanuts (25 g) were substituted for butter in the chicken meal. These changes did not alter mealtime glycemic load or energy content
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Vinegar or peanut ingestion significantly reduced 60-minute glucose response to the bagel meal (-54% and -56%, respectively
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The above uses 20g 5%acetic acid and I believe vinegar is 5% acetic acid so 4 teaspoons should have you covered.
 
JudoJosh said:
Invalid Link Removed

The above uses 20g 5%acetic acid and I believe vinegar is 5% acetic acid so 4 teaspoons should have you covered.
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It's tasty man
 
mr.cooper69 said:
There are only two that I have found. One you have never heard of before. The other is high-dosed TUDCA.
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I never saw an answer, so im bumpin.
You holdin Coop!? If you don't tell me, I can't verify I havent heard of such things ;)
Whats interesting when you mention TUDCA is the effect of taurine on glucose levels.
Taurine at dosages around 4-6g have shown profound lowering of basal glucose in my personal lab rat, with the added benefit of serious energy boost.
The other things that have made a difference in my personal observation (10+ glucose evaluations/day):
Berberine
Anacyclus
HCA
Gymnema
Banaba
Black Cumin Seed
RCE
Na-r-ala

Still to test:
Rock Lotus
Gynostemma
C-3-G
TUDCA
I need to look at ginseng again, as a few models show ginseng working thru multi pathways.

Side note: Does anyone have the study showing beta cell restoration in Alloxan induced diabetic models, with DHEA supplementation?
 
Clemenza said:
I've run blood glucose tests using just about every gda we've mentioned and haven't found anything close to being as effective as Vanadyl Sulfate. It is overlooked IMO and if you dig deep in the research you will find it is not toxic in recommended dosing.
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What other herbs/ingredients have you used the glucose test on for example Na-rala Banaba etc. Would be interested to hear your findings on them.
Also what is recommended dosing for Vanadyl sulfate?

Thanks
 
Alasel said:
What other herbs/ingredients have you used the glucose test on for example Na-rala Banaba etc. Would be interested to hear your findings on them.
Also what is recommended dosing for Vanadyl sulfate?

Thanks
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Banaba
Gymnema
Momordica
Cissus Quadrangularis
Phellodendron
 
Alasel said:
What other herbs/ingredients have you used the glucose test on for example Na-rala Banaba etc. Would be interested to hear your findings on them.
Also what is recommended dosing for Vanadyl sulfate?

Thanks
Click to expand...

Banaba
Gymnema
Momordica
Cissus Quadrangularis
Phellodendron
 
Alasel said:
What other herbs/ingredients have you used the glucose test on for example Na-rala Banaba etc. Would be interested to hear your findings on them.
Also what is recommended dosing for Vanadyl sulfate?

Thanks
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50-100mg has been studied for up to 30 months on diabetes and was deemed safe with no tox issues.

I'd just run recompadrol. All bases covered otherwise

10mg will work but I personally like 50mg -150mg a day.
 
EBF Inc said:
50-100mg has been studied for up to 30 months on diabetes and was deemed safe with no tox issues. I'd just run recompadrol. All bases covered otherwise 10mg will work but I personally like 50mg -150mg a day.
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Do you have an idea of how much VS per cap Recompadrol has?
 
EBF Inc said:
50-100mg has been studied for up to 30 months on diabetes and was deemed safe with no tox issues.

I'd just run recompadrol. All bases covered otherwise

10mg will work but I personally like 50mg -150mg a day.
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I found 10mg plenty 4 to 6x a day with each 40 to 80g carb meal.

But I would just go with Recompadrol. Its extremely effective
 
Pounditz said:
I never saw an answer, so im bumpin.
You holdin Coop!? If you don't tell me, I can't verify I havent heard of such things ;)
Whats interesting when you mention TUDCA is the effect of taurine on glucose levels.
Taurine at dosages around 4-6g have shown profound lowering of basal glucose in my personal lab rat, with the added benefit of serious energy boost.
The other things that have made a difference in my personal observation (10+ glucose evaluations/day):
Berberine
Anacyclus
HCA
Gymnema
Banaba
Black Cumin Seed
RCE
Na-r-ala

Still to test:
Rock Lotus
Gynostemma
C-3-G
TUDCA
I need to look at ginseng again, as a few models show ginseng working thru multi pathways.

Side note: Does anyone have the study showing beta cell restoration in Alloxan induced diabetic models, with DHEA supplementation?
Click to expand...

These all have some pretty good data so I believe it. Is RCE red clover extract?

You should try testing salacia reticulata. As for your question, I haven't seen the DHEA study, but I know gymnema has this effect
 
mr.cooper69 said:
These all have some pretty good data so I believe it. Is RCE red clover extract?

You should try testing salacia reticulata. As for your question, I haven't seen the DHEA study, but I know gymnema has this effect
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Salacia reticulata and salacia oblonga work extremely well

Recompadrol anyone? It has salacia also! What a coincidence
 
Great thread.
 
Pounditz said:
Maral Root. Rhaponticum Carthamoides Extract.

What is the main difference in the reticulata vs oblonga?

I love me some Recompadrol :)
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There's not much as constituents within the species are similar

Just the kinds of extracts you can find.

Oblonga extracts are usually full spectrum at up to 20:1 from when I was looking at them.

Or mangeferin at a low dose vs reticulata finding the saponins
 
Mainevant said:
Highly recommend C3G.
Little bit expansive but worth it.
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Pounditz said:
Can you elaborate on this? Immediate effects (in the GDA department) or a build up?Thanks!
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I concur. Tried a few bottles of Indigo 3g last summer and was extremely impressed. Absolutely makes every other GDA product look like a joke. Doesn't appear to be a build up, effect is noticeable right away. I got more comments about my physique while using it than any other product I've used. I wish I had the money to make it a staple. The price has come down significantly since it was first introduced, but it is still way too steep for me to use regularly. I've never tried any other Biotest products but this one was a winner.
 
Mainevant said:
Works good for me.
Try it for yourself.

Check out this article as well:
Invalid Link Removed
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First of all it's way to expensive and there's not much research on it

These cyandins usually are found when certain flavonoids/glycosides are broken down.

Anthocyanosides from bilberry work well.

Also that article takes about fat cell inflammation

Wow. Can they skew research well whoever wrote that

First of all inflammation yes does cause faulty signals and essentially the reduction in inflammation more then likely is coming from these effects in the fat cells

PPARy and Akt/Pi3k as these seem to have anti inflammatory effects on fat cells. But this causes differentiation

Fully differentiated mature cells have the ability for cAMP stimulated lipolysis as opposed to pre adipocytes

So you can see where it's good.

But; inflammation in the fat cells cause INCREASES in lipolysis and PREVENTs adipocytes from differentiation and guess what else apoptosis through caspase 3 and 9 and through increases in BAX/BCL-2 ratio.

So while you can see reducing inflammation is good it prevents other things as well

You want how can i say, selective inflammation at certain times.

Oh and I'm working on that for you guys
 
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