Unanswered Any natural supplements to reduce prolactin levels?

StarScream66

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I have depression & anxiety and recently my doctor put me on an adjunct drug to help. It's called Rexulti (brexpiprazole). It's classified as an anti-psychotic, but at the low dose I'm taking of 1mg, it doesn't exert those kinds of effects.

Mechanism Of Action
The mechanism of action of brexpiprazole in the treatment of major depressive disorder or schizophrenia is unknown. However, the efficacy of brexpiprazole may be mediated through a combination of partial agonist activity at serotonin 5-HT1A and dopamine D2 receptors, and antagonist activity at serotonin 5-HT2A receptors.

Pharmacodynamics
Brexpiprazole has affinity (expressed as Ki) for multiple monoaminergic receptors including serotonin 5-HT1A (0.12 nM), 5-HT2A (0.47 nM), 5-HT2B (1.9 nM), 5-HT7 (3.7 nM), dopamine D2 (0.30 nM), D3 (1.1 nM), and noradrenergic α1A (3.8 nM), α1B (0.17 nM), α1D (2.6 nM), and α2C (0.59 nM) receptors. Brexpiprazole acts as a partial agonist at the 5-HT1A, D2, and D3 receptors and as an antagonist at 5-HT2A, 5-HT2B, 5-HT7, α1A, α1B, α1D, and α2C receptors. Brexpiprazole also exhibits affinity for histamine H1 receptor (19 nM) and for muscarinic M1 receptor (67% inhibition at 10 βM).

Unfortunately, brexpiprazole increases prolactin levels. I'm going into my doc later this month so I'll have him check my prolactin levels and see where they're at, but my libido is absolutely dead.

Breast cancer, hyperprolactinemia, infertility
Brexpiprazole can cause hyperprolactinemia, likely due to central dopamine D2 antagonism. Elevations in prolactin may result in infertility in either men or women, or other endocrine abnormalities. Close monitoring for adverse endocrine effects is advisable during use of brexpiprazole. Some human breast cancers may be prolactin-dependent and therefore brexpiprazole should be used cautiously in those who have a history of breast cancer.
According to this study,
Effect of Brexpiprazole on Prolactin An Analysis of Short- and Long-Term Studies in Schizophrenia
, the effects on prolactin from brexpiprazole are pretty minimum. But, it's still a concern of mine.

I was thinking of trying bromocriptine with it, but it has a drug interaction warning.

Bromocriptine: (Moderate) The prolactin-lowering effect of bromocriptine at the anterior pituitary may be antagonized by medications that increase prolactin levels, such as the atypical antipsychotics. The atypical antipsychotics elevate prolactin to various degrees. Like other drugs that antagonize dopamine D2 receptors, the elevation in prolactin from atypical antipsychotics can persist during chronic administration. Monitor the patient for reduced response to bromocriptine. Atypical antipsychotic therapy may aggravate diabetes mellitus and cause metabolic changes such as hyperglycemia. If bromocriptine is taken for diabetes, monitor for worsening glycemic control.
So, I was wondering if there are any OTC supplements that can reduce prolactin levels? Any thoughts or suggestions are appreciated.

Thanks,
SS
 
ValiantThor08

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I have depression & anxiety and recently my doctor put me on an adjunct drug to help. It's called Rexulti (brexpiprazole). It's classified as an anti-psychotic, but at the low dose I'm taking of 1mg, it doesn't exert those kinds of effects.



Unfortunately, brexpiprazole increases prolactin levels. I'm going into my doc later this month so I'll have him check my prolactin levels and see where they're at, but my libido is absolutely dead.



According to this study,
Effect of Brexpiprazole on Prolactin An Analysis of Short- and Long-Term Studies in Schizophrenia
, the effects on prolactin from brexpiprazole are pretty minimum. But, it's still a concern of mine.

I was thinking of trying bromocriptine with it, but it has a drug interaction warning.



So, I was wondering if there are any OTC supplements that can reduce prolactin levels? Any thoughts or suggestions are appreciated.

Thanks,
SS
Prolactrone by BLR
Highly effective at reducing prolactin levels and naturally. BLR15 for a discount.
 
cheftepesh1

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I think SNS has one still inhibit p
 
cheftepesh1

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I think SNS has one still inhibit p
 
sdplissken

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Don't take anything natural or not that interacts with dopamine receptors since you are taking Rexulti. Tell your doctor that you have libido issues and ask him to check your prolactin. If it comes high then he will make the right decision regarding your medication.
 
StarScream66

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Prolactrone by BLR
Highly effective at reducing prolactin levels and naturally. BLR15 for a discount.
Looks like it's just l-dopa and green tea extract. Levodopa is on the list of contraindications for anti psychotic medications.
 

Veejay

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Don't take anything natural or not that interacts with dopamine receptors since you are taking Rexulti. Tell your doctor that you have libido issues and ask him to check your prolactin. If it comes high then he will make the right decision regarding your medication.
Awesome to see a reasonable response on here.(y)
Shills have no shame.
 

batmanraider9

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Are you supposed to take L Dopa with P5P? Ive read things that contradict taking it with or without
 

batmanraider9

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Ya. That more than I’m using ON cycle on a combined gram of gear. Not the hugest fan of AI in pct but I did a taper once due to estro rebound.
If I wanted the worlds best pct I’d do that minus the AI and blast a couple thousand hcg over the first week
I have depression & anxiety and recently my doctor put me on an adjunct drug to help. It's called Rexulti (brexpiprazole). It's classified as an anti-psychotic, but at the low dose I'm taking of 1mg, it doesn't exert those kinds of effects.



Unfortunately, brexpiprazole increases prolactin levels. I'm going into my doc later this month so I'll have him check my prolactin levels and see where they're at, but my libido is absolutely dead.



According to this study,
Effect of Brexpiprazole on Prolactin An Analysis of Short- and Long-Term Studies in Schizophrenia, the effects on prolactin from brexpiprazole are pretty minimum. But, it's still a concern of mine.

I was thinking of trying bromocriptine with it, but it has a drug interaction warning.



So, I was wondering if there are any OTC supplements that can reduce prolactin levels? Any thoughts or suggestions are appreciated.

Thanks,
SS
I have schizophrenia bro and also take antipsychotics. Taking L Dopa will be detrimental to your mental health. Every time I take L Dopa I get sick.
 
LeanEngineer

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Already mentioned by inhibit p by sns would an awesome product for this. In stock at strong supplement shop as well.
 
TheVenom

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Awesome to see a reasonable response on here.(y)
Shills have no shame.
Yeah screw everyone else for answering the exact question he asked, right? 🤔🤔
 

aaronuconn

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Yeah screw everyone else for answering the exact question he asked, right?
Given the OP gave substantial background info, you have to look at the question in its full context. I’m aware he came to a supplement forum and asked a question, but it’s general practice to guide an individual back to their physician who prescribed them a medication that is causing issues.
 

aaronuconn

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Yeah screw everyone else for answering the exact question he asked, right?
Given the OP gave substantial background info, you have to look at the question in its full context. I’m aware he came to a supplement forum and asked a question, but it’s general practice to guide an individual back to their physician who prescribed them a medication that is causing issues.
 
TheVenom

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Given the OP gave substantial background info, you have to look at the question in its full context. I’m aware he came to a supplement forum and asked a question, but it’s general practice to guide an individual back to their physician who prescribed them a medication that is causing issues.
The full context implies, to me at least, that OP is an informed adult who understands drugs, both pharma and supplemental. While @sdplissken had a good reply (and i agree with him 100%), it didnt answer the question. And faulting/insulting someone who DID provide the info OP asked for is silly and unhelpful.
 
sdplissken

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Peace guys. We are all on the same iron team. OP is taking an atypical antipsychotic drug which acts on D2 and D3 receptors among others. Every substance natural or not which lowers prolactin acts as a dopaminergic. It could be very risky to suggest anything to him. We don't know even if his prolactin is high or normal. Having said that, prolactrone and inhibit-p are great natural dopaminergic supplements and that's why they are both quite effective in this regard.
 
HIT4ME

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Don't take anything natural or not that interacts with dopamine receptors since you are taking Rexulti. Tell your doctor that you have libido issues and ask him to check your prolactin. If it comes high then he will make the right decision regarding your medication.
This is honestly the best response.

Are there OTC ingredients that are hypothesized to reduce prolactin? Yes. Invariably they effect your dopamine levels and this, as pointed out above, could do more harm than good.

The suggestions above aren't wrong though - L-Dopa and B6 can help reduce prolactin levels, sure. But again, through mechanisms that are potentially hazardous in your situation.

Basically, if it is OTC it won't work or, if it works, it will be powerful enough to potentially interact negatively with your prescriptions.
 
The Express 42

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SNS Inhibit p is a good place to start. Do not use any pharmacy prolactin drugs. I’ve crashed my prolactin on caber after taking 0.25 twice a week for two weeks and it took me months to get my libido/erection quality back
 
stopstalking

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SNS inhibit p.. works very well. With you meds I would talk it over with a Dr.
 
StarScream66

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Thanks for all the replies. I'm going in for blood tests next week and I'll find out my prolactin levels the next week. Hopefully they're not too high.

But, just FYI, I take l-dopa, B6, and most of the other supplements mentioned in this thread (not counting the Vitex) and it doesn't seem to be having any positive effect.
 

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