J Cardiovasc Pharmacol. 2004 Mar;43(3):471-6.
Development of insulin resistance by nitrate tolerance in conscious rabbits.
Bajza A, Peitl B, Nemeth J, Porszasz R, Rabloczky G, Literati-Nagy P, Szilvassy J, Szilvassy Z.
Clinical evidence has been raised to suggest that transdermal nitroglycerin increases the sensitivity of peripheral tissues to the hypoglycemic effect of insulin. In this study we determined whether development of tolerance to the hypotensive effect of nitroglycerin also resulted in tolerance to the insulin-sensitizing effect in rabbits. Intravenous glucose disposal and hyperinsulinemic euglycemic glucose clamp studies were performed on naive and hemodynamic nitrate tolerant conscious New Zealand white rabbits. These rabbits were exposed to continuous "patch on" with nitroglycerin (0.07 mg/kg/h) or placebo patches over 7 days. Nitroglycerin treatment of 7 days produced a lack of hypotensive response to a single intravenous bolus of 30 microg/kg nitroglycerin, which caused a significant decrease in mean arterial blood pressure in control rabbits. A six-hour exposure to transdermal nitroglycerin significantly increased insulin sensitivity determined by hyperinsulinemic (100 microU/ml) euglycemic (5.5 mmol/l) glucose clamping as compared with that seen in rabbits treated with placebo patches. A significant decrease in insulin sensitivity was observed in the nitroglycerin patch-treated animals both in the presence and after the removal of the last patch when the patches were applied over 7 days. We conclude that acutely nitrate patches improve insulin sensitivity whereas a 7-day chronic treatment schedule that results in hemodynamic nitrate tolerance also produces insulin resistance.
JUST DID MYSELF A HEAP OF ORDERING!
L-Carnitine L-Tartrate, B5, Taurine... all in bulk. Ska-DOOCH.
Also, I found MAN Sport's Blue Print with a FULL GRAM of Agmatine Sulfate and 300mg r-ALA for $19.99 on one of my favorite websites (they just clearanced it)! I bought three bottles.
BOO-TO-THE-YAH!![]()
great stuff here.
Looking forward to your feedback on PsyKo!
I'm a big fan of intras (AM workouts), and I actually liked the old one, InTrain. I think the improved flavor will help during the workout. I've used SizeOn and some of the flavors can be overpowering.
The quaker imitation of Fruit Loops does it too :-/
:dump:
Big O, what is your offseason and competition weight? Height as well if that isn't too intrusive.
So I was researching some studies on all these nutrient partioner ingredients, well this led me to try and find info on the PGG in Banaba (which is impossible to source) and some how came across this and thought I would share it with you guys.
I would apply this to the creatine nitrate. Since it is growing popularity and especially since a couple of you guys got it in bulk the above will apply. It appears in regards to insulin sensitivity nitrates happen to be a double edged sword. Use of the nitrates can improve insulin sensitivity BUT you HAVE to make sure not to build up a nitrate tolerance. If you become tolerant to the nitrate this could lead to insulin resistance which is something nobody wants. So morale of the story is if you are going to be using a nitrate product, especially the bulk form, I would also supplement with NAC & vitamin c to help against building a tolerance.
great deal on blueprint-when joey was running MAN he sent me a couple of bottles to try. i liked it a lot.
I absolutely LOVE recompadrol! Since I started it my BMs are amazing, lol gross sorry but it's so true. I also love the muscle fullness and the ability to eat lots of carbs with no bloat.
Any reason to cycle of this? From what I've read on it I don't see a reason to ever take time off.
Banaba can be found somewhat easily from a few different sites I can think of, but only in very low 1 and 2% Corosolic Extract yields. Recompadrol, one of my absolute favorite GDAs for instance, has 20% Corosolic Acid, which is very hard to find, and very expensive.
Hola. Is anyone aware of known side effects to look out for and monitor that can be caused by Vanadyl Sulfate?
Anyway, yes, I'd say Recompadrol is my favorite GDA overall, because it doesn't focus only on blood sugar, but also on mitigating adipogenesis - it's the perfect cheat meal adjunct.
ALSO... IT HAS JUST BEEN BROUGHT TO MY ATTENTION THAT MROD ISN'T A GUY - ha, sorry! I have all the avatars disabled from showing, since I access the forums from work most of the time, so I have no idea what most of you look like, or at least your avatar![]()
Thats add.. Corosolic Acid is one of the ingredients I was looking into but eary on I found a couple studies that suggested the corosolic acid was essentially worthless and the part of the Banaba that worked was the tannis, specifically the Penta-O-galloyl-glucopyranose (PGG). Although I sort of gave up on corosolic acid after a couple studies that pointed to PGG instead and then moved on to tryna source that which ended up in a dead end
Interested to see if you have anything on Corosolic Acid or are you solely basing its use off of the effects you've felt with it?
I absolutely LOVE recompadrol! Since I started it my BMs are amazing, lol gross sorry but it's so true. I also love the muscle fullness and the ability to eat lots of carbs with no bloat.
Any reason to cycle of this? From what I've read on it I don't see a reason to ever take time off.
Thats odd.. Corosolic Acid is one of the ingredients I was looking into but eary on I found a couple studies that suggested the corosolic acid was essentially worthless and the part of the Banaba that worked was the tannis, specifically the Penta-O-galloyl-glucopyranose (PGG). Although I sort of gave up on corosolic acid after a couple studies that pointed to PGG instead and then moved on to tryna source that which ended up in a dead end
Interested to see if you have anything on Corosolic Acid or are you solely basing its use off of the effects you've felt with it?
Interested in this.. got any more info on it? Which of the ingredients do you attribute this too?
Most of the reading I've done on Banaba has been from slanted sources, such as supplement sites (write ups), Swanson etc. This is news to me, and now I am a little disappointed to hear you say that. Why did Corosolic Acid gain such buzz and notoriety as the GDA of choice, if it wasn't related to any study specific findings?
Hmmm... this is why I just need some 4-Hydoxyisoleucine![]()
- BEST Anabolic Yield
-- Stand Alone Product:IGF1-LR3
--- Stack of 2 ProductsEG MGF /IG1-LR3
- BEST Lipolytic Yield
-- Stand Alone Product: SEMORELIN
--- Stack of 2 Products: HGH FRAG/SEMORELIN
- BEST SYNERGISTIC STACK OF THREE PRODUCTS
Hypertrophy, Body Recomposition, and Tendon/Joint Healing and Skin Health:
IGF1-LR3/SEMORELIN/HEXARELIN.
Great post, thanks for sharing it!
I thought for anabolic stacking RS was a bigger fan of IGF-1 DES rather than LR3, it's stronger and makes it easier to dose with the PEG MGF. I was just reading his stuff on NTBM forums, but I probably misread something. LR3 does have a longer lasting effect, so maybe that's why he recommends that stack.
Good points, I remember him talking about DES a lot too.
Also, I thought MGF couldn't be taken at the same time as IGF-1-LR3?
Right, I think MGF is taken pre workout, then IGF-1 LR3 is taken ~5hrs later. IGF-1 DES can be taken post workout after MGF IIRC.
Russian Star just served up this bit o' great posting I wanted to share with everyone.
I have been curious as to what the most profound research chemicals would be, so I asked about them in a function-specific way:
which would be the best to add to trt?
All of them! :firedevil:
You should try that with a blender, see if you can get an upgrade to a Vita-Mix!
I decided to buy a Vitamix... well, waiting to hear back from their customer service department. I am pretty excited, although something that I fear will be the hardest part, will be finding the fruits (selection I mean, above and beyond basic strawberries and blueberries).
Try Asian markets, they have lots of different fruits and vegetables.
Geeeez racist, it doesn't matter what race the person is who owns the superma..... OHHHHHHHHHHHHHHHHHHH![]()
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Put your zip code in and it will list all the nearby farmers markets and farms. You can also find meat, cheese, eggs, milk, produce, etc
Great resource!
nice to see life here.![]()
Bump!!
I don't know how to act without some outstanding anabolic updates!
Big O, I have a question for you. What compound in GDAs do you think causes the forrest green BMs?
Berberine tears me up, especially the berberine HCL in recompadrol.
Zach should be able to source the 20% HCA for you, he used to have it on his website when he was LeanBodyFormulations.
Wow, sounds awesome. At that point though, why not use regular slin?
Wow, sounds awesome. At that point though, why not use regular slin?
This is not helpful in any way shape or form, but I had to share this for those that are aware:
real slin makes me sexually excited though I will admit.
Recompadrol is back down to 29.99 at NPjust picked up some more. Really wanna try need2slin but simply can not justify the price.
Well, at least you gave it a disclaimer
It was a pretty good weekend overall, super duper mega crushed my chest and arms.
Meh, lackluster. If you're going to get excited about something, it should be Sustanon, Tren Acetate, Anavar, and Masteron. I just put on nine pounds of muscle typing that.
Now... if only... only I knew how to procure and produce said items
Recompadrol WITH Need 2 Slin is like having God peer down through the clouds, make direct eye contact with you, as the universe pauses and slows around you - hearing your creator say to you in a booming yet coddling and satisfyingly soft voice, "You, are the singularity in which I finally realized the absolute apex of my cosmic handiwork."
Recompadrol WITH Need 2 Slin is like having God peer down through the clouds, make direct eye contact with you, as the universe pauses and slows around you - hearing your creator say to you in a booming yet coddling and satisfyingly soft voice, "You, are the singularity in which I finally realized the absolute apex of my cosmic handiwork."
Wow with that description how can I not try recompadrol...
I have it in my cart already and guess its time to pull the trigger on it
As for the need2slin I agree with staked for that price I prolly can piece together the bulk products. Maybe I can get a NTBM rep to hook it up with a discount and I will try the two stacked![]()
Too bad there aren't any NTBM reps around here, those guys are TOOLS anyway! I think there was a 25% off code going around last month, which was basically just the reps screen name with a 25 at the end. When I order I always use Southern15 for a 15% off code, and shipping is free.
I would sincerely like to know if anything close to Need 2 Slin can be pieces together for less, especially when you add in shipping, time to encapsulate, and the capsules themselves. I buy thousands of capsules, size 000, and they are $35 per 1,000, I can usually get free shipping. But, na-r-ala among the other aspects of Need 2 Slin, can get pricey (plus in bulk you'll have to buy a kilogram at a time of some herbs, although na-r-ala can be found for $1 a gram for 100g).
ehh my time is worthless, LOL.. I spend enough time wasting it, its really not a hassle to turn on some netflix and get to capping
I just tried to price it all up only using nutra at a source and I got to $50 for 30 servings and need2slin is $55 for 60 servings! I guess its not too bad of a price considering the ingredients used.
I may have to see if that 25% code still works.. looks like when my custom cap mix is done Ima try this recompadrol/need2slin stack :bling:
Meh, lackluster. If you're going to get excited about something, it should be Sustanon, Tren Acetate, Anavar, and Masteron. I just put on nine pounds of muscle typing that.
Now... if only... only I knew how to procure and produce said items
[/B]
guess I shoulda explained why slin would make me a happy camper. mix it with anadrol and test e would make me like this guy here.
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