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Pulse question for Dr. D or any other gurus

you wanted me to fry, admit it

actually i spent a few hours arguing with my dad saying that the athletes should fry, u were being a chemist making a new steroid just like many others i was in awe of it and quite fascinated by "the clear" so i researched as much as i could about it and u and ur trial
 
actually i spent a few hours arguing with my dad saying that the athletes should fry, u were being a chemist making a new steroid just like many others i was in awe of it and quite fascinated by "the clear" so i researched as much as i could about it and u and ur trial


gimme a hug

actually bud selig should fry, but he should only be lightly seared
 
I meant to say antagonist, not agonist. It assuredly is not an agonist since i have data showing it has no anabolic androgenic activity. i can post it if you like, i just have to shrink the jpgs

thought we were having a decent discussion but it appears you had to act like a jerk and ruin it

and please point me to your 6-bromo study. if you want to compare data then have some actual verifiable data to back it up

We shall see, but I can't promise I will always have the grace to overlook your snide, erroneous remarks about me, the companies I work with and the products they sell. We were having a decent discussion, still can too if you like, as long as the tit for tat bs is over now. That's my point. And don't disrespect me with your condescending demeanor either, or else don't cry I'm being a "jerk" later because you get what you give with me.
 
It's not even a substrate for AR much less an agonist or you would not see higher test levels, combined with positive strength and mass gains.

It will be a good day when I see the hypocrisy die. Chemists should not try to be businessmen too, it betrays the science and will backfire in time.


very bold statements you make about 6-bromo. you show me that 6-bromo does not have androgenic activity. activity that would be most assuredly be expressed by its metabolite 6alpha-bromotestosterone. since other 6alpha-halogenated testosterones are quite active, one would anticipate the 6-bromo is as well.

a test such as the attached is what you need to do to demonstrate it. i can get you in touch with Dr. Lyubimov

page one and page seven are attached
 

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We shall see, but I can't promise I will always have the grace to overlook your snide, erroneous remarks about me, the companies I work with and the products they sell. We were having a decent discussion, still can too if you like, as long as the tit for tat bs is over now. That's my point. And don't disrespect me with your condescending demeanor either, or else don't cry I'm being a "jerk" later because you get what you give with me.


snide, condescending???


Moi????
 
Sorry, I misunderstood, that sounds good with the slow, linear T3 ramp. And yes, the plan with Epi looks solid. I can't suggest over 60 because that's the highest I've gone personally, but I have seen guys pulse up to 90 with no adversity.

Cool. I'm ordering phase one right now, actually. any sides at 60 I should be wary of, or perhaps I should stay at 50? Let me know your thoughts. Lookin' like I'll probably get crankin' on this come monday.
 
very bold statements you make about 6-bromo. you show me that 6-bromo does not have androgenic activity. activity that would be most assuredly be expressed by its metabolite 6alpha-bromotestosterone. since other 6alpha-halogenated testosterones are quite active, one would anticipate the 6-bromo is as well.

a test such as the attached is what you need to do to demonstrate it. i can get you in touch with Dr. Lyubimov

page one and page seven are attached

I warned you not to get erroneous with the science again for the sake of sales or egos, didn't I? You know what you just posted is wrong. 6-halogenated androgens are far less active (if active at all) relative to that of testosterone in 99% of documented studies. They are practically anti-androgens in some cases. The ratio of A/A improves in a few examples, but that's about it. As far as brominated subs, I challenge you to show one example of androgenic or anabolic activity, anything at all. You must have some example, unless you do just have business motives to attack it. If your going to say that's what it is, show something to substantiate your opinion.

Besides, your product 6-Oxo converts into 6a-OH-Testosterone! You're throwing stones again when you're selling pro-hormones in a glass house.

Will you not be satisfied until you totally self-destruct and take the best parts of the industry with you? Just give it a rest man!
 
Cool. I'm ordering phase one right now, actually. any sides at 60 I should be wary of, or perhaps I should stay at 50? Let me know your thoughts. Lookin' like I'll probably get crankin' on this come monday.

Some ance, that's my only complaint and it doesn't really start till you exceed 40. ~45mg is the sweet spot with a conventional cycle, 60 if pulsing.
 
Some ance, that's my only complaint and it doesn't really start till you exceed 40. ~45mg is the sweet spot with a conventional cycle, 60 if pulsing.

i commend the doctor. while chemists are debating he is still making it a point to answer questions of the consumer never letting his ego get ahead of himself!:head:
 
I warned you not to get erroneous with the science again for the sake of sales or egos, didn't I? You know what you just posted is wrong. 6-halogenated androgens are far less active (if active at all) relative to that of testosterone in 99% of documented studies. They are practically anti-androgens in some cases. The ratio of A/A improves in a few examples, but that's about it. As far as brominated subs, I challenge you to show one example of androgenic or anabolic activity, anything at all. You must have some example, unless you do just have business motives to attack it. If your going to say that's what it is, show something to substantiate your opinion.

Besides, your product 6-Oxo converts into 6a-OH-Testosterone! You're throwing stones again when you're selling pro-hormones in a glass house.

Will you not be satisfied until you totally self-destruct and take the best parts of the industry with you? Just give it a rest man!

let me handle this one issue at a time. with facts. if you want to counter, then counter with verified facts

6alpha-OH androstenedione has zero androgenic activity according to Vida. if 6alpha-OH testosterone had any activity it would show in the 6alpha-OH androstenedione assay at least somewhat. but it does not. its ZERO

now lets start with our first 6-halogenated androgen - 6alpha-chlorotestosterone (as acetate). According to Vida it has 280% of the anabolic activity of testosterone. thats a whopping number Dr. D

our next 6-halogenated androgen is 6alpha-fluorotestosterone. It has 100-200% the anabolic activity of testosterone. Once again, a strikingly high amount of activity. Oh, and the 6alpha-fluoro methyltestosterone is 230% that of methyltest as well

yes there is no data on 6alpha-brominated testosterones however since activity for halogen substitutions is consistent amongst Cl, F, and Br in other instances there should be a very high amount of confidence that 6alpha-bromotestosterone is also an active anabolic steroids as well

your turn
 
patrick,
you talk of displaying facts only yet you clearly just stated a speculation in saying "there should be a very high amount of confidence that 6alpha-bromotestosterone is also an active anabolic steroids as well" where the hell is the fact on that?
dont make the rules and not follow them
your turn
 
i commend the doctor. while chemists are debating he is still making it a point to answer questions of the consumer never letting his ego get ahead of himself!:head:


Answers are one thing, the truth is another.

People love D cuz he has an answer for everything. The problem is the guy is just another big cat. He pulls stuff out of his ass left and right that is erroneous and baseless just for the sake of having an answer.

Thats why people love him, just like they love big cat. Then when someone like me calls one of them out on something I am the bad guy, the negative guy. I am portrayed as not helping out but just picking on someone

well buddy i am helping out, helping out by setting crap straight. sorry you can't see that.

when i know an answer for a question i give it. when i don't know the answer I SAY I DON'T. And that is how you can tell a true scientist from one playing one on the internet

oh, another way is a true scientist will not hide his identity and credentials
 
DR.D said:
6-halogenated androgens are far less active (if active at all) relative to that of testosterone in 99% of documented studies.

Are there some links to studies that show that available? As patrick is saying that vida says otherwise.
 
patrick,
you talk of displaying facts only yet you clearly just stated a speculation in saying "there should be a very high amount of confidence that 6alpha-bromotestosterone is also an active anabolic steroids as well" where the hell is the fact on that?
dont make the rules and not follow them
your turn


have you ever read a scientific article? they present a hypothesis, they state data, and then at the end they present a conclusion which often includes an educated speculation based upon the data that was uncovered in the article

and that is exactly what i did.

and then doctor d ran off with his tail between his legs
 
patrick,
you talk of displaying facts only yet you clearly just stated a speculation in saying "there should be a very high amount of confidence that 6alpha-bromotestosterone is also an active anabolic steroids as well" where the hell is the fact on that?
dont make the rules and not follow them
your turn

Right! It's also totally absurd to suggest all halogens should react similarly in a class of compound. As if they were interchangeable or something! Try replacing Iodine with Bromine on a molecule of thyroxine and see what happens! It's ridiculous.
 
D has never hid his credentials! and if he prefers to keep his name hidden he has that right as a person. D does not always have the answers and will tell you when he doesnt or if he is uncertain! most of the time however people ask a question specific to him so yea it may appear he has the answers a majority of the time, but ill tel you what he is one of the most honest men i know and if that goes with him being a nice guy so be it.
i am pointing out u said "verified facts" yet you didnt use a verified fact. why? u started assuming, again
 
Are there some links to studies that show that available? As patrick is saying that vida says otherwise.

No, he's right about the chloro and fluoro compounds, that's in the Vida, how it relates to 17-keto structures much less brominated substitutes I have no idea though!

He can't give one example of a 6a or 6b brominated androgen.
 
No, he's right about the chloro and fluoro compounds, that's in the Vida, how it relates to 17-keto structures much less brominated substitutes I have no idea though!

He can't give one example of a 6a or 6b brominated androgen.

Are there any studies showing its AI / testosterone raising capabilities?
 
Osawa Y, Osawa Y, Coon MJ.

A selective inhibitor of aromatase (estrogen synthetase) would be a useful pharmacological tool with potential therapeutic application. We have found that 6 alpha-bromoandrostenedione (6 alpha-BrA) is a competitive inhibitor of human placental aromatase with respect to androstenedione, with an apparent Ki of 3.4 nM, while 6 beta-BrA is a mechanism-based irreversible inhibitor with an apparent Ki of 0.8 microM and a kinact of 0.025 min-1. Aromatase activity was measured by tritium release into water from the 1 beta position of [1(-3)H,4(-14)C]androstenedione in reaction mixtures containing NADPH and the aromatase. Time-dependent inhibition was assessed by preincubation of inhibitors with either the 900 X g placental pellet or placental microsomes in the presence of NADPH. Aliquots were taken at intervals, diluted, and assayed for aromatase activity with androstenedione and additional NADPH. The time-dependent inhibition by 6 beta-BrA was dependent on the concentration of this compound and the presence of NADPH, while the addition of excess substrate in the preincubation mixture hindered the inactivation. Both epimers were ineffective in inhibiting rabbit liver microsomal drug-metabolizing activities in a competitive or time-dependent manner. This indicates a high selectivity of 6-BrA inhibition among P-450 cytochromes. These and other 6-substituted androgens may be useful probes into the nature of the active site and mechanism of action of aromatase.

PMID: 3622372 [PubMed - indexed for MEDLINE]
 
Right! It's also totally absurd to suggest all halogens should react similarly in a class of compound. As if they were interchangeable or something! Try replacing Iodine with Bromine on a molecule of thyroxine and see what happens! It's ridiculous.


we are talking specifically about androgens here D, and the evidence does show halogens can be replaced with one another at positions on the steroid molecule and display comparable activities

case in point:

2-bromo-1-test - anabolic 140

2-chloro-1-test - anabolic 200


you are not arguing with a novice here D.
 
have you ever read a scientific article?

Yes. Perhaps better than you can too, because if you could read them, maybe you could design a decent product. For example, what the H were you thinking with Extreme anyway? Is this the worst anti-estrogen product ever invented or what?!

6-Oxo-Androstenedione 300mg
OK, so over one to eleven weeks I can elevate my DHT levels with a compound that suggestively possesses significant AR binding affinity and experience zero gains in muscle mass while I do it? Ummm, why? No thanks! Why do people still use this junk? Seriously, what's the point if you don't get results in the end?
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Quercetin 600mg
This is a big time phytoestrogen, so what's it doing in this product? The solution is to improve your form of resveratrol to discourage first pass metabolism, not to kill the anti-estrogenic efficacy of your product with dumb ingredients like this. Why even bother to use it after you put trash like this in it?
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Resveratrol 50% 1200mg
There is high estrogenic activity in the cis-isomer (also called the Z-isomer) of resveratrol, which is quite abundant in the 50% extract it seems. 'Superagonists of estradiol' is what this article states! (see link below) Unless this material has been cold processed, stored away from heat and protected from sunlight, you can bet it's not all trans-resveratrol. That means any botanical source likely has high amounts of estrogenic activity from cis isomerization. I'd like to see some data showing the cis/trans ratio and total percentages in this product before I put 1200mg of it in my body.
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Piperine (Black Pepper Extract) 20mg
Severe damage to the seminiferous tubule, decrease in seminiferous tubular and Leydig cell nuclear diameter, desquamation of spermatocytes and spermatids, decrease in intratesticular testosterone, significant reduction in the weights of testis and accessory sex organs! Wow, that sounds like something every man wants... NOT! Piperine's bioavailability is much greater in humans than in mice BTW, and it also greatly retards the breakdown of estradiol. That's really the crucial fact, it extends the half-life of estradiol! Piperine has it's place in moderate doses, but this is not appropriate at all for inclusion in an anti-estrogen product!
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Wow. I don't think this product could have been any more poorly formulated than this. I think a 4'th grader could have grabbed names of ingredients at random out of a shoe box with a blind fold on and done better! In my humble opinion, this is the worse of the worse as far as anti-estrogens available today. I think I'll pass. :run:
 
Inhibition of estrogen synthesis in human breast tumors by testololactone and bromoandrostenedione.
Budnick RM, Dao TL.

The inhibition of aromatase enzyme in human breast tumors by delta 1-testololactone, testololactone, 6 alpha-bromoandrostenedione, and 6 beta-bromoandrostenedione was investigated. Estrone and estradiol synthesis from androstenedione was reduced in 3 tumor incubations by the presence of 0.13 mM delta 1-testololactone and testololactone. 6 alpha- and 6 beta-bromoandrostenedione (2.0 microM) were also shown to block estrogen synthesis in 2 tumors. Furthermore, Lineweaver-Burk plots revealed that all 4 compounds are competitive inhibitors of androstenedione aromatization. An apparent Km of the aromatase enzyme for androstenedione of 0.08 microM and a Vmax of 23 pmol of estrone synthesized/g tumor/hr were determined for one human breast tumor specimen. These results demonstrate that these aromatase inhibitors may be useful for the treatment of breast cancer.

PMID: 7394858 [PubMed - indexed for MEDLINE]

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This indicates a high selectivity of 6-BrA inhibition among P-450 cytochromes

because i'm completely cluless in chemistry but have decent memory, isn't the p-450 path the same one that trisorbagen "touches" ? not really related to this conversation, but how would trisorbagen affect 6-bromo effectiveness?
 
No, he's right about the chloro and fluoro compounds, that's in the Vida, how it relates to 17-keto structures much less brominated substitutes I have no idea though!

]

yet you said minutes earlier

"6-halogenated androgens are far less active (if active at all) relative to that of testosterone in 99% of documented studies. They are practically anti-androgens in some cases."


now theres a typical example of your ass-speak D. always have an answer don't cha. whether its a factual answer is inconsequential
 
because i'm completely cluless in chemistry but have decent memory, isn't the p-450 path the same one that trisorbagen "touches" ? not really related to this conversation, but how would trisorbagen affect 6-bromo effectiveness?

p450 is directly involved in the synthesis and breakdown of androgens and estrogens....among with a million other things. its not something id mess with
 
yet you said minutes earlier

"6-halogenated androgens are far less active (if active at all) relative to that of testosterone in 99% of documented studies. They are practically anti-androgens in some cases."


now theres a typical example of your ass-speak D. always have an answer don't cha. whether its a factual answer is inconsequential

No, I don't have an answer, I don't even understand your question here? You will NOT drag me into another one of these **** flinging fiascoes though. No sir! Goodbye Pat, have fun playing with yourself alone. :)
 
No, I don't have an answer, I don't even understand your question here? You will NOT drag me into another one of these **** flinging fiascoes though. No sir! Goodbye Pat, have fun playing with yourself alone. :)

maybe he will hug himself since i didnt give him a hug
 
(see link below) Unless this material has been cold processed, stored away from heat and protected from sunlight, you can bet it's not all trans-resveratrol. That means any botanical source likely has high amounts of estrogenic activity from cis isomerization. I'd like to see some data showing the cis/trans ratio and total percentages in this product before I put 1200mg of it in my body.
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:



well you just managed to type a whopping amount of misinformation there D. But instead of just ignoring it I will play the game and approach everything one thing at a time

for starters, how about giving a real link so i can read the article you so kindly tried to reference. After that, you can show some evidence that 50% resveratrol from Japanese Knotweed contains substantial amounts of resveratrol.

cold pressed? do you even know what that means? It is a technique used for getting oil out of oilseeds not extracting compounds from plants. oh, and there are no problems with stability of resveratrol like you indicate


Journal of Medicinal Food
Resveratrol and Its Glycon Piceid Are Stable Polyphenols

--------------------------------------------------------------------------------

To cite this paper:
Jiri Prokop, Petr Abrman, Allen L. Seligson, Milos Sovak. Journal of Medicinal Food. 2006, 9(1): 11-14. doi:10.1089/jmf.2006.9.11.

--------------------------------------------------------------------------------



Jiri Prokop
1Interpharma Praha, a.s., Prague, Czech Republic.
Petr Abrman
1Interpharma Praha, a.s., Prague, Czech Republic.
Allen L. Seligson
Biophysica Research, San Diego, La Jolla, California.
Milos Sovak
Biophysica Research and University of California, San Diego, La Jolla, California.
Plant extracts containing phytopolyphenols, including resveratrol, are extensively used as nutraceutical supplements. Recent reports allege their lack of stability at ambient conditions. We have studied the stability of resveratrol and its glycon piceid in a mixture with a whole grape extract for 2 years (long-term stability) under Good Manufacturing Practice pharmaceutical protocols (at 60% humidity and 25°C). The neat compounds were followed for 4 years under conditions of "accelerated stability," at 75% humidity and 40°C, all in the presence of ambient air. Chromatographic analysis did not detect any instability, thus disproving the claims to the opposite. No storage precautions are necessary for these nutritional supplements.
 
No, I don't have an answer, I don't even understand your question here? You will NOT drag me into another one of these **** flinging fiascoes though. No sir! Goodbye Pat, have fun playing with yourself alone. :)



D always plays dumb then cuts and runs

man if you just told the truth and weren't full of crap i probably would be alright with you
 
Some ance, that's my only complaint and it doesn't really start till you exceed 40. ~45mg is the sweet spot with a conventional cycle, 60 if pulsing.

I’m pretty psyched. I’ve been wanting to try both an Epi cycle and a Propadrol cycle, but didn’t want to combine the two because I wanted to take advantage for cutting. Now I can do both!

I’ve ordered the Epi and should be ready to begin on Monday. Thanks for your help!
 
I’m pretty psyched. I’ve been wanting to try both an Epi cycle and a Propadrol cycle, but didn’t want to combine the two because I wanted to take advantage for cutting. Now I can do both!

I’ve ordered the Epi and should be ready to begin on Monday. Thanks for your help!

Sure thing! Others are experimenting with this same combo too and it does sound promising as far as gains and side effect attenuation. I haven't heard any reports yet though. PM if you need any help.
 
Sure thing! Others are experimenting with this same combo too and it does sound promising as far as gains and side effect attenuation. I haven't heard any reports yet though. PM if you need any help.

I will be looking to pulse Epi and SuperDrol.

I plan on doing a 5 day split routine. With training days on days 1, 2, & 4 and off days 3 & 5.

Would a pulse cycle work following the on off days?
 
Resveratrol 50% 1200mg
There is high estrogenic activity in the cis-isomer (also called the Z-isomer) of resveratrol, which is quite abundant in the 50% extract it seems. 'Superagonists of estradiol' is what this article states! (see link below) Unless this material has been cold processed, stored away from heat and protected from sunlight, you can bet it's not all trans-resveratrol. That means any botanical source likely has high amounts of estrogenic activity from cis isomerization. I'd like to see some data showing the cis/trans ratio and total percentages in this product before I put 1200mg of it in my body.
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Dr. D.

There was a critical mistake with the “super-estrogen” resveratrol study (1997) you are referring to. I believe it had something to do with using ethanol as carrier for a cancer cell line, thus distorting the results.

Plus, dozens of studies have been done since then, ultimately disproving the “super-estrogen” potency of resveratrol.

The cis form of resveratrol is simply a weaker form of the trans form. Most of the RESV you find in today supplements (including our Derma Sustain) have 80-90% of the trans form. A minor cis component doesn’t pose any kind of “super-estrogen” threat whatsoever. Besides most of the literature you read about the trans version is simply hype used as marketing tactic. The truth is, cis RESV is just less exciting and less researched, not harmful.

Consider this quote from Russel et al (1999) -

“Also, grapes contain cis- as well as trans-resveratrol. Although the affinity of cis-resveratrol to the estrogen receptor has not been measured, it’s conformation leads one to suspect that the binding will be much weaker than the trans-isomer. The conversion of resveratrol to the cis-isomer is potentiated by heat and UV light and would probably reduce the potential estrogenic activity of this putative phytoestrogen.”

Is Resveratrol an Estrogen Agonist in Growing Rats?
Russell T. Turner, Glenda L. Evans, Minzhi Zhang, Avudaiappan Maran, and Jean D. Sibonga
Endocrinology, Jan 1999; 140: 50.

Kinetics of trans- and cis-resveratrol (3,41,5-trihydroxystilbene) after red wine oral administration in rats.
Bertelli AAE, Giovannini L, Stradi R, Urien S, Tillement JP 1996 Int J Clin Pharmacol Res 16:77–81

Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4,5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats.
Bertelli AAE, Giovannini L, Stradi R, Bertelli A, Tillement J-P 1996
Int J Tissue React 18:67–71



-Pp
 
I will be looking to pulse Epi and SuperDrol.

I plan on doing a 5 day split routine. With training days on days 1, 2, & 4 and off days 3 & 5.

Would a pulse cycle work following the on off days?


steer clear of superdrol. the toxicity is not worth the gains.
 
. Besides most of the literature you read about the trans version is simply hype used as marketing tactic.

I assume you are referring to the BS about instability.

as far as resveratrols benefits go, they are so well substantiated and remarkable that there is no need to exaggerate anything
 
I will be looking to pulse Epi and SuperDrol.

I plan on doing a 5 day split routine. With training days on days 1, 2, & 4 and off days 3 & 5.

Would a pulse cycle work following the on off days?

I do a 5 split also with 3on/2off and it works fine. The 3 consecutive days push the limits of a pulse, but the 2 consecutive offs really help to compensate. Your plan looks good with the 3 & 5 off.
 
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