How to get BPC157 and TB-500 patches working?

WhyNotHarder

New member
Hi everyone,

I recently bought a bunch of tb and bcp patches to support the healing of my recently operated and torn meniscus. Initially, I was excited, but I haven’t noticed any significant effects so far.

While recovering in the hospital, I had a lot of time on my hands, so I read some papers on the substances in these patches and looked through other forum threads to gather more information.

Here’s what I’ve found:

In theory, patches work by delivering the active ingredients through the skin. However, the outer layer of the skin (the stratum corneum) isn't very permeable. In general, molecules larger than 500 Daltons struggle to passively diffuse through this barrier.

Many studies in mice or rats have shown that when the skin is burned, treatment with BPC-157 helps the wounds to heal more quickly. This suggests that BPC-157 can pass through damaged skin, but I'm not sure if the same is true for TB-500 or intact skin.

In the cosmetic and pharmaceutical industries, this challenge is often overcome by using penetration enhancers such as ethanol or DMSO to help larger molecules cross the skin barrier. Ethanol or DMSO are highly reactive and could alter the peptides by denaturation.

Given this information, I'm considering using sandpaper to lightly abrade the skin and then applying ethanol to increase permeability before applying the patches.

Do any of you have any informed thoughts on whether this approach might be effective or if there are any reasons why it might not work?

Thanks in advance for your insights!
 
I used a transdermal BPC & TB by a board sponsor here, ran it at full dose for 4 weeks and it did sweet **** all. Get the injectables if you actually want to see results
 
Joshlm69 said:
I used a transdermal BPC & TB by a board sponsor here, ran it at full dose for 4 weeks and it did sweet **** all. Get the injectables if you actually want to see results
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Yes you need to inject these peptides, or for gut issues you can take oral bpc but from my understanding it cant work transdermal as its molecular weight is too heavy to pass through the skin. To be fair I have never tried the td but I also dont see a reason to based off feedback like yours and a few others here. A few years back my buddy ran through a few different transdermal brands in the neverending mission to not have to pin lol, I dont believe he found any he liked.

If there is some way that someone has made one that can work td and its 100% legit I'd buy it, I'd love a topical healing agent like that!

If your just dealing with pain and inflammation then topical curcumin works well, I'm using iconic formulations version and it's great for pain relief! I'm combining with peptides soon and il probably log it if anyone is intrested
 
Smont said:
Yes you need to inject these peptides, or for gut issues you can take oral bpc but from my understanding it cant work transdermal as its molecular weight is too heavy to pass through the skin. To be fair I have never tried the td but I also dont see a reason to based off feedback like yours and a few others here. A few years back my buddy ran through a few different transdermal brands in the neverending mission to not have to pin lol, I dont believe he found any he liked.

If there is some way that someone has made one that can work td and its 100% legit I'd buy it, I'd love a topical healing agent like that!

If your just dealing with pain and inflammation then topical curcumin works well, I'm using iconic formulations version and it's great for pain relief! I'm combining with peptides soon and il probably log it if anyone is intrested
Click to expand...

I actually fully 100% healed my shoulder & bicep injuries which I've had for years with CissusXT + Joint Support XT. Within 2 weeks I was at 90% and now 2 months in I'm fully fully healed. Its actually crazy.

I'm half dosing now as maintenance and it continues to feel great while being very cost affordable. Couldn't be happier honestly. I thought I might have to get stem cell or surgery to get fixed but alas, @sns8778 saves the day once again.
 
Any thought on the actual subject of this particular thread, that states clearly the topic: How to get BPC157 and TB-500 patches working?

„
I'm considering using sandpaper to lightly abrade the skin and then applying ethanol to increase permeability before applying the patches.

Do any of you have any informed thoughts on whether this approach might be effective or if there are any reasons why it might not work?
„
 
WhyNotHarder said:
Any thought on the actual subject of this particular thread, that states clearly the topic: How to get BPC157 and TB-500 patches working?

„
I'm considering using sandpaper to lightly abrade the skin and then applying ethanol to increase permeability before applying the patches.

Do any of you have any informed thoughts on whether this approach might be effective or if there are any reasons why it might not work?
„
Click to expand...
No it's not gonna work, and kinda foolish to be honest
 
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WhyNotHarder said:
Any thought on the actual subject of this particular thread, that states clearly the topic: How to get BPC157 and TB-500 patches working?

„
I'm considering using sandpaper to lightly abrade the skin and then applying ethanol to increase permeability before applying the patches.

Do any of you have any informed thoughts on whether this approach might be effective or if there are any reasons why it might not work?
„
Click to expand...

I think using sandpaper on your skin then applying a TD is going to cause some major skin irritation. Just buy BPC-157 and inject it.
 
The idea of using sandpaper to abrade the skin is more likely to cause pain and an infection than it is to increase the likelihood of it working.

I use Joint Support XT for joint issues and Cissus XT for tendons and ligaments.
 
The sandpaper-treated skin is definitely irritated for 2-3 days. It's not the most comfortable feeling.

I've now used a micro-needle pen 2mm to penetrate my skin, instead of using sandpaper. No discomfort so far.

I'm going to try some injectables just to be sure it works. I might also feel a difference.
 
Smont said:
No it's not gonna work, and kinda foolish to be honest
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Wait but why? I am happy to hear your explanation.

I concluded the method carefully from existing literature. I still believe that tiny wounds amplifying the diffusion in general and will make the diffusion of tb or bpc more likely. Can anyone delivering an substantial argument.

here an example argument: It's not going to work because the skin is reacting with thrombozymes, which are basically little clotting factors, and they're going to break down the incoming substances.
 
It is the role of a transdermal carrier to deliver the substance through the skin into the bloodstream.

A good transdermal carrier should have penetration enhancers included in it.

If the ingredient/substance is not an ideal candidate for a transdermal, then intentionally irritating/abrading the skin is not going to help with that because its not going to change the molecular weight or other characteristics of the substance itself to make it any more of a good candidate for td use.

All of the people that I know that are well versed on transdermal delivery, penetration enhancers, etc. have said in the past that it isn't a good candidate for a td product. There's a demand for it, so I'm sure there may be some companies offering it, but unless there is some new development that I'm unaware of, I think that it just simply isn't a good ingredient candidate for a td.

When I was in an accident back in 2022, it destroyed my leg and cause a lot of bone, nerve, and tissue damage. I had looked into making it into a td for personal use and I just don't think it can be done effectively.

The best thing topically/td that I've used for my leg is XPG CurcuPrime Gel, which helped me a lot with the pain and the inflammation.

Tagging @delsolrob for his opinion too on the subject of BPC as a td.
 
WhyNotHarder said:
here an example argument: It's not going to work because the skin is reacting with thrombozymes, which are basically little clotting factors, and they're going to break down the incoming substances.
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Where did you get this from? My understanding was that microneedling (at least in relation to hair restoration) would improve minoxidil absorption, I would guess it would do the same for other transdermals (not talking about BPC or other peptides).
 
I had an interesting conversation with a chemist, about my thoughts. He explained to me that my methods wouldn’t work because:

1a) peptides would be degenerated by the immune system, if not carried to the cell where its needed.
1b) the immune response to any wound would enhance the degenerative factors within the wounded area. Applying through wound could have a contradictory effect on the resorption.
2) for this peptides are very hard to use in pharmacy topicly / transdermal.
 
As already mentioned here unfortunately you were hornswaggled. Not really any way to try to recover this either unless you are able to return the product. I ran a log for a company who had a good rep on here a while back and it was useless. I hated having to say that in a sponsored log but it truly did nothing and all of the literature pretty much says that it won't.
 
AwakeningAlpha said:
Like everyone said, just pin it.

Only exception is anyone suffering with gut issues - the oral version works great.
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This is the best and only real way to get the effects you are looking for. Better to buy the right thing for the right job.
 
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