This extract from the book will explain best.
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POMEGRANITE™
The pomegranate is a fruit that was held sacred by many of the world's major religions. It is a symbol of hope, one of the ‘three blessed fruits’ in Buddhism, and a symbol of resurrection in Christianity. The pomegranate’s medicinal properties were already recognised in antiquity. The pomegranate is said to be the Tree of Life, and speculated as being the forbidden fruit in the Garden of Eden. Its Latin name Punica granatum literally means ‘seeded apple’ Invalid Link Removed.
The pomegranate fruit is used in medicine as a symbol of persistence of life, fertility, and regeneration, originating from the Greek myth of Persephone. It is present in the coat of arms of The British Medical Association, The Royal College of Physicians, The Royal College of Midwives, and The Royal College of Obstetricians and Gynaecologists Invalid Link Removed.
The punicalagin polyphenols present in PJE have clinically shown to be a potent endothelial nitric oxide synthase (eNOS) activators Invalid Link Removed.
The endothelial was once considered as a simple barrier between the blood and vessel wall, but now we know that it plays a more important role being a dynamic organ which lines the entire vascular system. Endothelial cells line the inner walls of the arteries and control vascular functions such as vasomotion (which controls blood flow) and inflammation Invalid Link Removed.
Nitric oxide (NO) is an endothelium-dependent vasodilator (Casino et al. 1993) and is created when the enzyme nitric oxide synthase (NOS) converts the amino acid L-arginine Invalid Link Removed.
NO is produced in three ways, known as the three isoforms of NOS.
The first is neuronal nitric oxide synthase (nNOS) which produces NO to act as a neuronal messenger that regulates synaptic neurotransmitter release Invalid Link Removed.
The second is macrophage or inducible nitric oxide synthase (iNOS), which is only expressed in cells that activate the macrophages after injury or inflammation Invalid Link Removed.
The third, and where pomegranate juice extract comes into effect, is endothelial nitric oxide synthase (eNOS), which produces NO in blood vessels Invalid Link Removed.
Through the eNOS isoform PJE relaxes the inner muscles of the blood vessels (endothelial relaxation) Invalid Link Removed, causing the vessels to vasodilate, further promoted by an increase in nitric oxide synthases (NOS) Invalid Link Removed.
NO increases blood flow allowing for improved oxygen and nutrient transport and in this way, PJE also increases oxygenation which improves endurance Invalid Link Removed.
PJE not only increases NO levels but it also protects it by inhibiting superoxide anion, a NO modulator that decreases its bioavailability Invalid Link Removed. PJE does this by promoting the release of an enzyme from the mitochondria called superoxide dismutase (SOD) which acts as an anti-inflammatory by neutralising the highly reactive superoxide anion radical, breaking it down into oxygen and hydrogen peroxide.
When you have an infection, the immune system deploys superoxide from the mitochondria to hunt down the invading microorganisms and destroys them. Once this has been completed, then SOD is released to neutralise superoxide, keeping balance. This balance however shifts as we age and the endothelial lining thins, becoming less optimal at releasing enough SOD, leading to overproduction of superoxide, causing oxidative stress Invalid Link Removed. SOD is important as it also repairs cells damaged by the superoxide anion radical Invalid Link Removed.
Another way PJE protects NO levels is by inhibiting arginase, the enzyme involved in the breakdown of nitric oxide Invalid Link Removed. By inhibiting arginase and the superoxide anion, more NO circulates the body, prolonging muscle pump.
Not only is the muscle pump compromised by these radicals, but actual energy levels too. When a cell is inflamed at the cell membrane (the outer cell wall) and the inner mitochondrial membrane (where energy is produced), nutrients cannot get into the cell and energy cannot escape the cell, causing fatigue Invalid Link Removed.
There are other herbal extracts that work in a similar way protecting NO, such as grape seed extract, but PJE has shown to be superior Invalid Link Removed. A study published in the "Journal of Agricultural and Food Chemistry" in 2000 reported that pomegranate juice has more than twice the antioxidant content of green tea Invalid Link Removed and grapeseed extract Invalid Link Removed.
By consuming PJE high in punicalagins you will improve endothelial function and improve the benefits that come with it Invalid Link Removed.
Most commercial extracts of pomegranate have been found to be lacking true pomegranate polyphenols, having been adulterated with cheaper and lower quality polyphenol content Invalid Link Removed, however The Anomaly™ uses PomeGranite™ PJE, a high quality 80% standardised extract of punicalagins, unique to the pomegranate alone Invalid Link Removed."
Regarding PA safety, it is very safe.
Regarding myostatin inhibition, supplements do not compare to pharma grade follistatin but they can help with natural progression. Just as how Mediator hasn't made waves in the industry because the clinical dosage is 1.5g, not 750mg like most brands who use it seem to like to say (Mediator is 50% PA), extracts like laxogenin and epicatechin don't deliver because of poor bioavailbility. These ingredients need me to microencapsulated to survive your stomach and get to the intestine to be absorbed.
It is a case of good ingredients but poor technology and I have gone further using TPGS micelle delivery.
