Bet you cant tell what those estrogen are. What there affinity for the receptors are. Which receptors they have a higher affinity for. What thise receptors do. And if serms effect more cell types other than breast tissue. Jesus vhrist you are dumb.
no you misconstrued what I said, I said serms used by bodybuilders were designed for women with breast cancer, and torem decreased the risk of cancer it does not stop it, good article tho
I tried to keep it civil and maybe we could learn something from each other, the whole purpose of these forums is to exchange knowledge, I'm out.
But if it only effect breast tissue how does it effect prostate, bones, and prevent diabetes. See my point the serm attach to all estrogen receptors. This protects you from the negatives effect of estrogen even if the levels are high. As wstrogen has no where to bind to thus making it no matter what the blood levels of estrogen are.
You were in to learn anything. I provided real science. You ignored it while shouting out brolore. As you have no idea about basic anatomy or how anything causes an effect in the body.
this is pretty interesting, I wonder how it effects insulin use during cycle or PCT, altho it was testing in specific rats and they are trying to correlate it to women with breast and uterus cancer, it says it effects beta cells
have no idea what you are arguing now, can we just agree to disagree, I promise to help you in your gyno threads
Uh shut up i don't have no gyno nor will i ever.
The fact that you dont know what im talking about proves how you dont understand sh!t. As no receptors to bind to means that substance cant have an effect. They do this to mice all the time. They bread them without receptors to test and isolated the mechanism of actions outside of the receptors they knocked out.
by far your most informative post, I can tell you help a lot of people here. BTW i didnt see you contribute in any of the posts here where people have gyno, is that cause you only know how to get gyno?
Actually i have helped people with gyn. Alot!
Agreed. Im done arguing with him. I should have not started this to begin with. I actually just blocked him. Im want to apologize to you and the others in this thread for this. I know better than to agrue like this.
this is true, and mainly why clomid is used for pct, it is known to be a poor serm, nolva is much better
Yes. They have a higher affinity for certain cell types(ie receptor types) than others. This does not mean it has less affinity than estrogen necessarily. Matter of fact I think it's would be better to assume it still higher, in most cells than estrogen. Saying it can effect bone, pancreatic, prostate, hypothalamic, pituitary, and breast cells with a stronger affinity than estrogem. Now this changes depending on serm and steriods being used. If it is a methylated steriods that can lead to a methyl estrogen it may definitely have a higher affinity than the serm. This is untest here.
Also no serm is an antagonist. They are reverse agonist. Transcribing the opposite signal of estrogen. While aslo being agonist at ER-b. This is all varying degrees depending on the serm and cell type.
Would say it's a poor serm. It's a great serm depending on the goal. Ie cells you want to target. So you want to target hypothalamic and pituitary it's a great serm. Anything else not so much
I agree, I have been on several threads here helping people with their issues and basically it started from them not using an AI to start with. my one and only disagreement with the clomid use is its better to prevent elevated estrogen then try to block it with clomid. and for PCT most people use both clomid and nolva, for the exact reason you stated it is poor at blocking gyno.
Antagonist and reverse agonist are not the same. On means it block the signal, while the other means it transcibes the opposite signal it normally would.
Yes. For the first part this is true. But cell types typically have I higher amount of certain types of receptors. And that is what I was implying. I should have clarified more.
I didnt think I could do that here, it would be from another forum, I'll pm you the article
Torem is the preferred SERM because of clomid side effects (in some)
that was one of the first things I said, if your going to use it long term it should be under doctor supervision. I have used clomid alot for pct but now I blast and cruise
Actually most enzymes work both ways. But thats not my point though. It does not need to go other way with enzymes to turn it into one thing or an other to be converted to estrogen. It goes directly from trest(7a-methyl-19-nortestosterone) to estrogen. It just does not do this through aromatase. Its actually other enzymes in the liver that reduces it to estrogens. All 19nors are this way. So AIs do sh!t to protect you. 2kvette can explains this way better though
Thats wrong. To imply this its reverse agonist a ER-a while agonist at ER-b. Not certian cells. Its has a higher affinity for certian cells than other though.
Also the dmz is probably partnof the reason for lack of estrogen side. Moreso than the ai. I dont have time to go in depth as to whh though.
You can cite sources. As long as you arent tell use where to to buy illegal things.
Sorry but hcg leads to more problems than it solves. Ill go into why whenni get off work
First part is true. I didn't touch on this as this is not my point. So i didnt want to go down this path. But i agree.
Without a doubt. Clomid can be quite toxic
