Great, tnx

it seems like we have some reading to do on alpha and beta er receptors.
From wiki:
"ERα plays a role in the physiological development and function of a variety of organ systems to varying degrees, including the reproductive, central nervous, skeletal, and cardiovascular systems.[11] Accordingly, ERα is widely expressed throughout the body, including the uterus and ovary, male reproductive organs, mammary gland, bone, heart, hypothalamus, pituitary gland, liver, lung, kidney, spleen, and adipose tissue."
That's a lot of "stuff". Surely affecting all of this for the duration of the whole cycle, plus some time after cycle, can't be without sides?