Lower doses or the incorrect extraction process has been shown to be ineffective so the extraction process is very important with EJ. So lets dig into whats inside the plant itself.
Just a short list of the chemical constituents of EJ-
Epicatechin
Ursolic acid
Chlorogenic acid
Corosolic acid
Oleanolic acid
Caffeic acid
Procyanidin B2
Protocatechuic acid
Ferulic acid
Tormentic acid
Naringenin
Ellagic acid
EGCG
Quercetin
This is a pretty impressive list of actives. Lets take a look at what some of these do.
Epicatechin.
EJ doesnt have as much epicatechin as something like cocoa or green tea but there is still a decent amount. Its estimated that there is about 150mg per 100g in cocoa and there is about 60mg in EJ so a little less than half. None the less there is enough that epicatechin will be active especially with Narinigenin, EGCG and quercetin in the mix as these all increase the absorption of epicatechin. Lets think of epicatechin as sort of a bonus.
Ursolic acid.
There is a decent dose in here at upwards of 150mg estimated per daily dose of our EJ extract but Ursolic acid is also a major constituent of another of Vectors ingredents giving us approx 300mg + of Ursolic acid per dose. Ursolic acid orally has been show in studies to increase muscle mass, Increase strength, Increase brown fat, Increase glucose utilization and increase exercise capacity. Its been stated that UA is not viable orally but I think I disagree and it seems as though studies also indicate that it is orally active although it has a very poor absorption rate. High doses are required and studies indicate 300+ should be enough orally to produce the desired results.
Corosolic acid.
Corosolic acid is a GDA generally extracted from Banaba (lagerstroemia speciosa) but a significant amount is present in Eribotrya J. Corosolic acid works orally at relatively low doses and has some interesting effects. Even doses of 10mg are viable to display its impressive effects. Most people have heard of Corosolic acid for its glucose effects as it is a major GDA. Corosolic acid can help to keep glucose down with multiple mechanisms of action. Glut4 translocation, reduced insulin resistance as well as all kinds of enzymatic suppression and or expression.
-Corosolic acid has been shown to reduce cholesterol levels and enhance lipid metabolism.
-Corosolic acid is also a great fat burner not only through antidiabetic effects but also by retarding absorption of fatty acids.
-Corosolic acid is a potent and selective inhibitor of the enzyme (11-beta hydroxysteroid dehydrogenase type 1) that converts inactive cortisone to active cortisol. Therefore, corosolic acid may prevent excessive cortisol production.
Overall Corosolic acid is one of Vectors great components. Increased Glucose uptake into muscles, decreased blood sugar, increased insulin sensitivity, increased fat utilization and decreased fat diposition plus decreased cortisol make Corosolic a powerhouse.
Oleanolic acid
Oleanolic acid (OA) is a constituent of Olea Europea, Viscum Album and Eriobotrya japonica as well as others.
Its long been used in Chinese medicine for treatment of liver disorders and other ailments. OA increases glucose utilization, is a solid vasodilator and increases expression of the AKT pathway.
Protocatechuic acid
Insulin like activity by activating PPAPy.
Decreases ROS
Antiageing
Anti inflammatory
Antiseptic
analgesic
GLUT4 upregulation
Antioxidant
Protects the testes from damage and stress
Cardio protective
Caffeic acid
Increased exercise capacity
Reduced Blood Lactate
Increased fat loss
Endurance
Ferulic acid, 4-hydroxy-3-methoxycinnamic acid, is one of the most ubiquitous phenolic acids, found in the
bran of grasses such as wheat, rice, and oats. It belongs to the family of plant hydroxycinnamic acids, which
include caffeic acid, sinapic acid, and p-coumaric acid. Recent studies have provided evidence that ferulic acid reduces the risk of disease, including
Alzheimer’s disease, cardiovascular disease, diabetes, and colon cancer. Currently, ferulic acid is used to enhance athletic
performance, both in humans and racehorses. Supplementation by it has been found to increase muscle strength in weight lifters.
In one animal study a single acute administration of Ferulic acid increased swimming time by 170%.
Ferulic acid prevented the decrease in catalase, superoxide dismutase and protected against the depletion of GST activity induced by exhaustive
exercise.
Exercise can be associated with oxidative stress. Thus exercise can act as a powerful source of Reactive Oxygen Species, depending on duration and intensity. During exhaustive exercise, fat is typically used as the primary energy source, thus sparing glycogen stores, which in turn retards fatigue. However, during strenuous exercise substantial production of ROS occurs via beta oxidation during the utilization of fat.
In addition, a dramatic increase in oxygen consumption in the body creates an imbalance between ROS and the antioxidant defense system resulting in fatigue.
Acute adminstration of Ferulic acid prevents fatigue, increases endurance and protects the body during exhaustive exercise.
Chlorogenic acid
CA often reffered to as green coffee extract is widely known for its antiobesity effects via PPARa agonism and by preventing proliferation of new fat cells. CA can increase muscular glucose uptake both by stimulating Non insulin dependent AMPK as well as stimulating pAKt. Great for keeping bodyfat off while promoting muscle growth.
Tormentic acid
Anti diabetic
Glut4
AMPK
REFS:
1.Loquat leaf extract enhances myogenic differentiation, improves muscle function and attenuates muscle loss in aged rats.
https://www.ncbi.nlm.nih.gov/m/pubmed/26178971/
2.Loquat (Eriobotrya japonica) extract prevents dexamethasone-induced muscle atrophy by inhibiting the muscle degradation pathway in Sprague Dawley rats.
https://www.ncbi.nlm.nih.gov/m/pubmed/26004741/?i=2&from=/26178971/related
3.Effect of Loquat Leaf Extract on Muscle Strength, Muscle Mass, and Muscle Function in Healthy Adults: A Randomized, Double-Blinded, and Placebo-Controlled Trial
https://www.hindawi.com/journals/ecam/2016/4301621/
4.Ethanol Extract of Eriobotrya japonica Leaves Enhanced Swimming Capacity in Mice
http://pubs.sciepub.com/jfnr/5/6/8/index.html
5.Cell Suspension Culture of Eriobotrya japonica Regulates the Diabetic and Hyperlipidemic Signs of High-Fat-Fed Mice
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&********web&cd=13&ved=0ahUKEwjF363a_uvXAhVKqVQKHQnWCw0QFghbMAw&url=http://www.mdpi.com/1420-3049/18/3/2726/pdf&usg=AOvVaw3tsGlnXSZOftlHTKRGxosJ
6.Tormentic Acid, a Major Component of Suspension Cells of Eriobotrya japonica, Suppresses High-Fat Diet-Induced Diabetes and Hyperlipidemia by Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation
7.
http://pubs.acs.org/doi/abs/10.1021/jf503334d
8.
http://pubs.acs.org/doi/abs/10.1021/jf503334d
9.
http://www.mdpi.com/1420-3049/18/3/2726/htm
10.
https://www.spandidos-publications.com/10.3892/ijmm.2015.2286
11.
https://www.ncbi.nlm.nih.gov/pubmed/15485899
12.
http://dev.biologists.org/content/132/12/2685
13.
https://www.nature.com/articles/srep31142
14.
https://www.ncbi.nlm.nih.gov/pubmed/25564701
15.
http://journals.plos.org/plosone/article?****10.1371/journal.pone.0039332