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MK-677

The_Old_Guy said:
Water Retention, Carpal Numbness, Hunger due to Ghrelin stimulation.
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i'm on mk long time use 4 differents brands Olympus / nutraplanet / focused / Chemtech-lab never had Those sides either,,, except water retention in carb day {them on keto most of the year} the negative sides are sleepless and if take before the bed mk gives me a boost of energy for a few hours ... positive fulnes solid muscle pump in the gym better recowery thats it .... i would say stop to chase the sides
 
Many of the sides experienced on MK are not from increased IGF-1 anyway. Hunger is due to MK acting as a ghrelin mimetic. Low blood sugar symptoms are also related to this effect if I'm not mistaken. There are ghrelin receptors in other areas of the brain on which MK has stimulatory effects. This is touched on in the post on long acting ghrelin mimetics being brain detrimental. I'd imagine this is the most likely cause some people will experience insomnia at high doses or anxiety (heightened fear learning) The only sides you could attribute to increased GH are ofcourse those typical of high GH sides but then again we are not seeing that with MK either. Low doses of HGH often won't illicit any sides at all. I mean most of us had higher natural GH levels during puberty than we will ever see with MK at any dose and experienced no sides. Sounds like you may be golden but as you say tests are going to be needed to confirm.
 
ericos_bob said:
Many of the sides experienced on MK are not from increased IGF-1 anyway. Hunger is due to MK acting as a ghrelin mimetic. Low blood sugar symptoms are also related to this effect if I'm not mistaken. There are ghrelin receptors in other areas of the brain on which MK has stimulatory effects. This is touched on in the post on long acting ghrelin mimetics being brain detrimental. I'd imagine this is the most likely cause some people will experience insomnia at high doses or anxiety (heightened fear learning) The only sides you could attribute to increased GH are ofcourse those typical of high GH sides but then again we are not seeing that with MK either. Low doses of HGH often won't illicit any sides at all. I mean most of us had higher natural GH levels during puberty than we will ever see with MK at any dose and experienced no sides. Sounds like you may be golden but as you say tests are going to be needed to confirm.
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I had insomnia at 40mg and 30 does make me tad bit hungrier. Dropped down to 20, as I am in a maintenance / recomp phase right now.
 
The_Old_Guy said:
I wasn't being literal. FDA approved Vioxx killed 55,000 people. I was merely pointing out that this wasn't a "supp" - it's an experimental drug still in Phase Trials.
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I took vioxx for 5 years eons ago and never had a single issue though. I mean if you take 4 and 5 times the prescribed amount of hydrocodone you can expect horrific results as well.
 
I'd be interested to know if anyone has experienced an increase in IGF-1 levels when surpassing 25mg ED? From studies I've seen it sounds like 25mg is the sweet spot.
 
ericos_bob said:
Many of the sides experienced on MK are not from increased IGF-1 anyway.
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I know. But the only way to be sure it is working, is to check IGF-1 levels. Serum GH is too pulsatile/tory for the average Joe to measure at LabCorp. IGF-1 on the other hand, stays elevated. I'm sure you know how GH and IGF-1 interact.
 
hardknock said:
I took vioxx for 5 years eons ago and never had a single issue though. I mean if you take 4 and 5 times the prescribed amount of hydrocodone you can expect horrific results as well.
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And a broken clock is right twice a day. Are you saying that all the deaths that caused a massive recall and lawsuit payout - were because they took 4 and 5 times the prescribed amount of Vioxx? Seems Merck wouldn't have had to pay if that was the case?
 
The_Old_Guy said:
I know. But the only way to be sure it is working, is to check IGF-1 levels. Serum GH is too pulsatile/tory for the average Joe to measure at LabCorp. IGF-1 on the other hand, stays elevated. I'm sure you know how GH and IGF-1 interact.
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I look forward to your results if you do get your levels tested. I may do the same at some point but at the moment the benefits I'm seeing are enough to keep me satisfied.
 
Mate of mine woke up with numb hands on his first cycle, but has been on it close to a year but 10mg pre bed. He says it keeps his inquiry's at bay and allows him to have a little less pain.
 
The_Old_Guy said:
And a broken clock is right twice a day. Are you saying that all the deaths that caused a massive recall and lawsuit payout - were because they took 4 and 5 times the prescribed amount of Vioxx? Seems Merck wouldn't have had to pay if that was the case?
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No what I am saying is I took vioxx eons ago for 5 years and never had any single issue. I am also saying that not every death was related to normal usage of vioxx as is Tylenol, hydrocodone, oxy, morphine, etc etc etc.
Ive had to use celebrex, vioxx, oxy, morphine, tramadol, hydrocodone, for the past 19 years for ruptured disc and torn ligaments, from powerlifting and I have yet to have any issues. I get constantly blood tested and mri's twice a year but thus far nothing notable.

Lets get one thing perfectly straight before this goes down the wrong path. I was merely stating facts from those reports. Obviously people die from even normal usage and that is unfortunate so I am not advocating all deaths are from idiotic use. If thats what you thought then I should have made my statement more clear.
 
Great thread. Read through a good chunk of it but did not find answer to the question I have. I have been on mk for about a month now at 25mg before bed. Water retention/gut has been a big problem. Diet and other supps are on point but I'm looking and feeling fatter than I should. Has anyone had any success in results and dropping some of this retention by lowering the dosage? Thinking about going to 12.5mg.
 
good source for mk677 caps?

i am using line one nutrition and they are legit. I can compare to ghar1ne when they were on market available still
 
Got blood results, run 2 months gharine 30 mg every night before sleep. Estradiol low, shbg high, test in middle range, free test low, igf 1 high, lh and fsh in range but in high border. I suppose something difficult they put in caps, or some mix. Mk 677 must elevated estradiol not drop in low.
 
gigante35 said:
Got blood results, run 2 months gharine 30 mg every night before sleep. Estradiol low, shbg high, test in middle range, free test low, igf 1 high, lh and fsh in range but in high border. I suppose something difficult they put in caps, or some mix. Mk 677 must elevated estradiol not drop in low.
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what brand ?
 
gigante35 said:
Got blood results, run 2 months gharine 30 mg every night before sleep. Estradiol low, shbg high, test in middle range, free test low, igf 1 high, lh and fsh in range but in high border. I suppose something difficult they put in caps, or some mix. Mk 677 must elevated estradiol not drop in low.
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Did you gain weight?
 
Yes i went from 98 to 102 kg and body fat stay on same level. In muscles i can see big nitrogen retention and pumps on traning are just amazing. Drawn blood before cycling everything was in perfect state, without free test witch was law. On the start cycle i run three weeks 3 gr daa and throw in folidrone 2.0 last 7 days. So i cant connect low estradiol levels and pretty high shbg ( 2 times higher than max. Allowed level) with gharine. Tommorow i will get complete panel of blood work, including liver, kidney values and etc. This is cap version gharine so no liver toxicity must be expect. I have some suspicion that producer put some prohormones in mix, tomorrow will get those numbers and get conclusion.
 
Yes from uk. Green and white combo pills, legit definitely by olympus labs. I run it few times before so in term legit or not, 100 % legit pills.
 
how useful would Mk be for a 21 year old?

Ran it for like a few days got bloated AF and tired and didn't want to run it any longer because of school and other time commitments. Thoughts and suggestions?
 
I ran MK-677 for over a year during the ages 20-21 and had great results. If it gives you bad side effects, though, obviously don't use it.
For me, I slept better, had a better appetite, skin was healthier, and I had more energy throughout the day. Like a poor man's HGH.
 
I don't see negatives for a 21 year old either, if it increases your natural production then it'll increase your production no matter if your already producing a lot or a little.

I personally love the stuff, although I have had varying effects from different suppliers.
 
BamBam0319 said:
I ran MK-677 for over a year during the ages 20-21 and had great results. If it gives you bad side effects, though, obviously don't use it.
For me, I slept better, had a better appetite, skin was healthier, and I had more energy throughout the day. Like a poor man's HGH.
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didn't you said in one of your post in the past that alongside with mk you been running so many compounds that you do not feel the difference?
 
bobi593 said:
didn't you said in one of your post in the past that alongside with mk you been running so many compounds that you do not feel the difference?
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bobi593 said:
to really say something about this stuff you have to run mk solo....
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You think I was taking steroids for over a year straight?
Don't worry, I'm not an idiot. I can say things about MK because I've ran it solo....
 
BamBam0319 said:
You think I was taking steroids for over a year straight?
Don't worry, I'm not an idiot. I can say things about MK because I've ran it solo....
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unfortunately you produce so many posts that I do not want and do not have time to find this statement..... but I'm pretty sure that you said that it's was not mk solo run , anyway I will give you the benefit of the doubt ;-)
 
bobi593 said:
unfortunately you produce so many posts that I do not want and do not have time to find this statement..... but I'm pretty sure that you said that it's was not mk solo run , anyway I will give you the benefit of the doubt ;-)
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There have been several occasions where MK was not the only thing I was using. However, I used MK on AND off cycle, and as a result I can say what I observed when using it solo. So yes, you're right; I didn't use MK-677 by itself for over a year. But there were many months throughout that year where I was NOT using steroids, and only MK-677.
You must have misunderstood my statement, whenever I said it, so I don't need your benefit of the doubt lol. I'm glad I could clear this up for you, though.
 
dental420gene said:
So MK would provide what benefits to a 21 year old with already high GH / IGF levels? What would supraphysiological GH do for me..?
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Mostly effects like overgrowth of various organs, water retention, faster aging, growth hormone gut, faster tumor growth.. all the good stuff. Probably none of the bad stuff like increased strength and muscle growth though.
 
NoAddedHmones said:
Mostly effects like overgrowth of various organs, water retention, faster aging, growth hormone gut, faster tumor growth.. all the good stuff. Probably none of the bad stuff like increased strength and muscle growth though.
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do you refer your post to his age or to mk in general ?
 
farshad040 said:
i thought it was gonna fix my fatigue which I suffer from and give me energy. I know its still early gonna give it up to a month.
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When's the last time you've had a full blood panel done? Address the underlying effect first before applying some kind of fix. Giving MK 677 a month may not give you what you are looking for.

How is your sleep hygiene? When until when?

I have been going to bed about 9pm and waking at 3am feeling great.
Last night I was up late, so it was 11pm until 5am. I just wake up like I have been awake for an hour already. At one point during my last run, I never felt like I needed much sleep, but my wife said, 5 minutes after hitting the pillow, the lights were out, and I was dead to the world until waking. This compound is amazing to me. I look forward to studying the long-term effects.
 
farshad040 said:
i dont look different its been 5 days I just feel more tired... when does it work (25mg)
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...it's been 5 days and you expect to see changes in your physique? From a GH related compound?
You do realize you have to take actual HGH for at least 3 months to notice ANYTHING. Why would you expect a compound that causes your body to release more of its own GH to work any faster than that?
farshad040 said:
Yada yada yada

doesent matter what causes my fatigue , HGH fixes any types of fatigue no matter what causes it because its a HEALING substance.
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And....wrong. Explain to me how HGH or MK-677 supplementation would fix a condition of low testosterone. Or diabetes?
 
farshad040 said:
i thought it was gonna fix my fatigue which I suffer from and give me energy. I know its still early gonna give it up to a month.
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It shouldn't take more than a month or 60 days to see results of what you are seeking. This based on a majority.
 
hardknock said:
It shouldn't take more than a month or 60 days to see results of what you are seeking. This based on a majority.
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Yep it took around 2 months to see certain benefits. Improved pumps were noticed after just a week, but the rejuvenating effects took a couple months to become evident. Changes in body composition despite making no changes to my diet were noticed around the 4-6 month mark for me. Dose was 20-25mg ED.
 
ericos_bob said:
Yep it took around 2 months to see certain benefits. Improved pumps were noticed after just a week, but the rejuvenating effects took a couple months to become evident. Changes in body composition despite making no changes to my diet were noticed around the 4-6 month mark for me. Dose was 20-25mg ED.
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The pumps are just crazy.

Body composition has gotten better without gaining much weight.
 
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