JudoJosh
Pro Virili Parte
Effects of a purported aromatase and 5α-reductase inhibitor on hormone profiles in college-age men.
Abstract
The purpose of this study was to determine the effects of an alleged aromatase and 5-α reductase inhibitor (AI) on strength, body composition, and hormonal profiles in resistance-trained men. Thirty resistance-trained men were randomly assigned in a double-blind manner to ingest 500 mg of either a placebo (PL) or AI once per day for 8 wk. Participants participated in a 4-d/wk resistance-training program for 8 wk. At Weeks 0, 4, and 8, body composition, 1-repetition-maximum (1RM) bench press and leg press, muscle endurance, anaerobic power, and hormonal profiles were assessed. Statistical analyses used a 2-way ANOVA with repeated measures for all criterion variables (p ≤ .05). Significant Group × Time interaction effects occurred over the 8-wk period for percent body fat (AI: -1.77% ± 1.52%, PL: -0.55% ± 1.72%; p = .048), total testosterone (AI: 0.97 ± 2.67 ng/ml, PL: -2.10 ± 3.75 ng/ml; p = .018), and bioavailable testosterone (AI: 1.32 ± 3.45 ng/ml, PL: -1.69 ± 3.94 ng/ml; p = .049). Significant main effects for time (p ≤ .05) were noted for bench- and leg-press 1RM, lean body mass, and estradiol. No significant changes were detected among groups for Wingate peak or mean power, total body weight, dihydrotestosterone, hemodynamic variables, or clinical safety data (p > .05). The authors concluded that 500 mg of dailyAI supplementation significantly affected percent body fat, total testosterone, and bioavailable testosterone compared with a placebo in a double-blind fashion.
Background
Researchers wanted to examine the effects of fenugreek as an 5-a reductase inhibitor. Strength, body composition, and hormonal profiles were measured
Study Design
Randomized, double blind, placebo controlled study.
30 resistance-trained men were assigned to either a placebo control group or a fenugreek group. The experimental group took a capsule containing 500mg of fenugreek once per day in the morning on nontraining days and before their workout on training. Duration of the study was 8 weeks. At Weeks 0, 4, and 8 body composition, upper and lower body 1 RM strength, upper and lower body muscle endurance (80% 1RM), anaerobic sprint power, and fasting clinical blood profiles (substrates, electrolytes, muscle and liver enzymes, red cells, white cells) and anabolic hormones (total testosterone, bioavailable testosterone, dihydrotestosterone, estradiol) were all measured. They followed a periodized 4-day/week
resistance-training program, split into two upper and two lower extremity workouts per week.
Notable Results
Testosterone and bioavailable testosterone both increased in the fenugreek group. There was no significant changes in estrogen. The fenugreek group also experienced a decrease in body fat.
Take away
Supplementation with 500mg fenugreek significantly increased total and bioavailable testosterone levels, as well as decreased percent body fat, in conjunction with a resistance-training program.