Because of its affects on inflammation. Would this be a bad thing to stack with ArA
Others can speak to this more certainly but I would imagine like with fish oil or cissus type products, just dose as far away from eachother as possible, like at least 4 hours apartBecause of its affects on inflammation. Would this be a bad thing to stack with ArA
I work out first thing in the AM and then dose my EP with my first meal post as per the label directions. Would it be acceptable to dose the EP before bed?Others can speak to this more certainly but I would imagine like with fish oil or cissus type products, just dose as far away from eachother as possible, like at least 4 hours apart
Stacks fine sir. It's not about inflammation, it's about a specific type that you want to avoid: COX-2. This does not act thereBecause of its affects on inflammation. Would this be a bad thing to stack with ArA
Thanx coopStacks fine sir. It's not about inflammation, it's about a specific type that you want to avoid: COX-2. This does not act there
Could anyone ask this question one more time?So...if arimistane is a slightly better AI than this new ingredient, why did PES make the switch? Am I missing something?
I hadn't seen it asked before, and it hasn't been asked in this thread. I take it that no one has given a satisfactory answer yet?Could anyone ask this question one more time?
Well, arimistane had side effects in a lot of users that the new compound apparently doesn't have. They included more of it (100mg instead of 75mg of arimistane) so it should be a great option to ppl who had sides from the old formula.I hadn't seen it asked before, and it hasn't been asked in this thread. I take it that no one has given a satisfactory answer yet?
Gotcha. I appreciate it.Well, arimistane had side effects in a lot of users that the new compound apparently doesn't have. They included more of it (100mg instead of 75mg of arimistane) so it should be a great option to ppl who had sides from the old formula.
Arimistane is slightly more potent in vitro. Read the OP. This new compound has demonstrated bioavailability in vivo (something arimistane didn't have as per studies, but the anecdote strongly supported it) and it comes with the nice "side effect" of multi PPAR agonism and fat lossSo...if arimistane is a slightly better AI than this new ingredient, why did PES make the switch? Am I missing something?
It wasnt DSHEA compliant. It's supposed to getting pulled but many still use it. Apparently studies show abieta is more potent AI without the sides.. So in PES' eyes, it was a non issue and better productI understand for Abieta for some people that don't want sore joints.
But why couldn't PES make both versions?
Why not make the more joint friendly for those and the Arimistane version for those that DIDN'T suffer from joint pain?
I'm just askin. I'm in the process of giving Abieta a shot at the moment. But I was just thinking why this couldn't be a possibility.
Actually it less potent than on if you look at studies. Neither is compliant but it was better for them to dc the OF and go with another since I'm sure it's caught the attention of the fda by now seeing so many companies use itIt wasnt DSHEA compliant. It's supposed to getting pulled but many still use it. Apparently studies show abieta is more potent AI without the sides.. So in PES' eyes, it was a non issue and better product
How was the original not compliant if it is a metabolite of dhea and that is compliant? How is the new one not compliant?Actually it less potent than on if you look at studies. Neither is compliant but it was better for them to dc the OF and go with another since I'm sure it's caught the attention of the fda by now seeing so many companies use it
I think the compliance issue is just rumors and speculation. PES hasn't said anything about it and I think the change is unrelated. I would guess they changed it because so many other products use arimistane and they wanted to have an answer for people who can't use arimistane because of joint issues. It makes sense when you think about it from their perspective. They want new, cutting edge stuff that isn't offered widely. I just wish they kept both EPro formulas as I am in week 3 of my first EPro run and I haven't been this dry and vascular in...ever. maybe AS can release that extra extract in EPro as a solo product? That with Alphamax together would be insane for people who can tolerate arimistane!How was the original not compliant if it is a metabolite of dhea and that is compliant? How is the new one not compliant?
Interesting. Great feedback. Noticing some leaning now around week 3.5, almost week 4 and on a bulk. Only allotted myself 4 weeks but I will run for 8 next time, on a cut as well. But those numbers are great... Guess this is a true 8 week productAs an FYI, the new formula works very well. Im currently on the second bottle of the new EPro. Although the results took longer, I am very impressed with the weight loss benefits. I am stacking it with the new ABE and aRa. Started my phat routine at 256. I am now sitting at 244. This is on a bulk. However by upper body is definitely thicker than before. Have gotten several compliments from almost everyone. The recomp affects are amazing. Arimistane does work faster and might have been stronger but it always kinda peaked at the third week for me. This new formula has continued to bring results
Interesting question. However there is a guy who commented that he dosed one cap of the new formula reg erase along side new EPro , and he noted that the results kicked in faster and they were comparable to ArimistaneSo with these results and it taking longer for things to kick in, I'm wondering whether this product should or could be run longer?. Even longer than 8 weeks since people seem to say it kicks in at around week 3 and beyond.
Up for being a test dummy.So with these results and it taking longer for things to kick in, I'm wondering whether this product should or could be run longer?. Even longer than 8 weeks since people seem to say it kicks in at around week 3 and beyond.
Interesting question. However there is a guy who commented that he dosed one cap of the new formula reg erase along side new EPro , and he noted that the results kicked in faster and they were comparable to Arimistane
Sounds like a solid approach IMO. Perhaps the solo erase could be dosed higher then.. 4 caps daily instead if 3 for 8 weeks and accelerated results. I would try it but my bottle is almost gone so it wouldn't be worth it/show a differenceUp for being a test dummy.
Depending on rep feedback on that idea
Well it takes longer to kick in, but the effects also last longer than a typical product once you've discontinued use. Something to think aboutSo with these results and it taking longer for things to kick in, I'm wondering whether this product should or could be run longer?. Even longer than 8 weeks since people seem to say it kicks in at around week 3 and beyond.
Interesting.. Is abieta suicidal like erase was?Well it takes longer to kick in, but the effects also last longer than a typical product once you've discontinued use. Something to think about
I've been using 3 caps a day for the last two weeks with 3 DAA and 1 extra pump of androgel. This would usually cause nipple activity but so far it has not at all.Interesting.. Is abieta suicidal like erase was?
Do you think the possibility exists for 4 caps a day like some dosed erased?
I don't know anyone who ever ventured over 4 capsules per day.I'm doing 5 caps a day atm with original Erase.
I don't know anyone who ever ventured over 4 capsules per day.
Most people found 3 of the original more than enough with some even running it lower.
Edit: with the exception of Rosie who ran it at 5-6 caps per day apparently lol.
Your first clue should have been the NO response from the reps.No its not suicidal.
Your first clue should have been the NO response from the reps.
EVERYONE has been asking this question since it's been out. No answer.
This question has been answered already. A simple search in the supp company section will provide the amswer. Post number 10 in the Erase Pro thread. Coop answered it himself.
Your reply would could come across as negative when im sure it wasn't meant to. The PES guys are all good people, so Im sure they would not intentionally ignore someone's request for information
This is not entirely true as there are multiple ways allosteric inhibition can occur in a competitive fashion. I generally enjoy PES products quite a bit, but there seems to be uncertainties regarding the new erase compound... I would feel more comfortable if there were more definites/positive reviews and less speculation, especially regarding something as important as MOA.To be perfectly clear, the reps don't know the answer. I, however, did answer in another thread. Twice, actually. The available data and testing shows allosteric inhibition (vs competitive) due to what we observe with "upping the dose." As it is, allosteric inhibitors are synonymous with suicidal inhibitors in the AI category. It is possible this is an exception (the first one), but a great confirmation that it's suicidal would be people posting bloodwork 2-3 weeks after their cycle. This is a relatively new product so give it time.
No, allosteric inhibition cannot be competitive. You are thinking of partial agonists acting as antagonists, or of allosterism occurring in the absence of bound substrate...this is not what I'm talking about.This is not entirely true as there are multiple ways allosteric inhibition can occur in a competitive fashion. I generally enjoy PES products quite a bit, but there seems to be uncertainties regarding the new erase compound... I would feel more comfortable if there were more definites/positive reviews and less speculation, especially regarding something as important as MOA.
I am now taking 4 caps of Erase and may have to bump it up myself to either 5 or like in your case..6.Sighs.
I guess we need to see still.
ERASE PRO has been out long enough.
I'll give my opinion on it once I'm done with this first bottle.
But to be honest, I went from taking 4 caps of regular ERASE to now 6! A day!!!
If that doesn't tell you I don't know what will.
PRO will have its chance starting this Friday. By week 4 if nothing then I'll have to unfortunately give a brutal honest opinion.
Might go back to the competitor. Sighs.
Nothing made me piss more and dry out more noticeably than MAN: Nolvadren XT
My pee at times was ORANGE! stuff worked!
But something about them pissed me off. Might just have to get over it.
I shouldn't have to be taking 6 Erase pills a day in hopes to see something.
Pro has that extra ingredient. Last chance. Hoping it delivers.
Yes they canNo, allosteric inhibition cannot be competitive. You are thinking of partial agonists acting as antagonists, or of allosterism occurring in the absence of bound substrate...this is not what I'm talking about. The MOA is allosteric aromatase inhibition. This compound has MORE definitives and scientific data than the previous compound. And as with the previous compound, repeated bloodwork is necessary to determine the MOA. That one was also allosteric but we did not know it was suicidal until quite a bit later. Preliminary studies will often examine kinetics of enzyme activity, which tells us competitive vs allosteric vs other mechanisms. Whether it's suicidal or not is typically determined in vivo unless there is already a high suspicion of suicidal activity, in which case they may radiolabel each constituent and see what pops
Which part is this referring to lolYes they can
I remember my old biochem prof saying it was a common misconception that allosteric inhibitors are only non competitive. To the point where people refer to them incorrectly. Most of the rest of your post was over my head.Which part is this referring to lol If this is with respect to an allosteric inhibitor causing competitive inhibition, please post a (realistic/real-life) example that isn't a partial agonist or present only when the substrate is unbound
Your professor is right. But what I'm referring to is binding "patterns." Allosterism is not the same as the binding pattern known as "allosteric inhibition." The binding pattern we observe with this compound is allosteric inhibition, regardless of whether or not there is a mild competitive component that gets overwhelmed in the processI remember my old biochem prof saying it was a common misconception that allosteric inhibitors are only non competitive. To the point where people refer to them incorrectly. Most of the rest of your post was over my head.
Yeah . Let me know if it's working for you.I am now taking 4 caps of Erase and may have to bump it up myself to either 5 or like in your case..6.
Sure will my friend.Yeah . Let me know if it's working for you.
I'm looking forward to seeing what Erase Pro does differently from Regular Erase.
That's because the new version takes longer to kick in then the old.... Which has been stated numerous times.Yeah . Let me know if it's working for you. I'm looking forward to seeing what Erase Pro does differently from Regular Erase. I haven't really been on regular Erase long enough. But by now the old version would've kicked in. I have to wait...
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