just as there is a major limitation of extrapolating a view of a handful of biological markers into whole body effects.
however, from all i've seen you only reach a high ketone level when you are on a hypocaloric diet, which althought would stop gluconeogenesis, would also stop fat loss. Unless you mean high creation of keytones rather than a high serum level, which then its possible.
That high ketone level happens when your in consistent ketosis for about 3 weeks, in which insulin and sugars start to rise halting fat loss, however, the carbup/refeeds blunt this action, increase leptin and adiponectin which protects the liver from NAFLD
But the creation of ketones happens daily even on some one not on a diet its a metabolic process. The more fat you eat the more ketones are produced. (well fats oxidized via B-oxidation and forms FFA and acetyl CoA which when over aboundant the liver converts to ketones). so in theory it doesnt matter hypo caloric or hyper caloric, as long as theres an influx of FFA there will be ketone creation.
agreed, but then there should have been at least a few studies that did support it, even if there were many more that didn't. I don't think i've ever found a single one that supported the idea behind increased fat loss with lower muscle loss in vivo.
