Curcumin

Powercage

Powercage

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Hey PA,
How do you recommend dosing your Curcumin and piperine (bioperine)? Currently using LE Super Bio-Curc

Thanks
 
Powercage said:
Hey PA,
How do you recommend dosing your Curcumin and piperine (bioperine)? Currently using LE Super Bio-Curc

Thanks
Click to expand...

i havent taken it in a while. when i did, i followed the popular protocols.

its a promising compound, however i only bother to take so many pills a day and lately i have cut curcumin out of the mix
 
Powercage said:
Hey PA,
How do you recommend dosing your Curcumin and piperine (bioperine)? Currently using LE Super Bio-Curc

Thanks
Click to expand...

Just buy some turmeric at the local whole foods store and add it to your food, that way you don't have the additives from caps.
 
I like everything about curcumin except the fact it is very strongly activates AMPK, which shuts off mTOR in skeletal muscle. Although I am interested in what pat thinks of this.

A number of good ingredients have shown to increase AMPK a good amount. Berberine for example does, and also has data showing it caused mild muscle atrophy which could ahve been caused from the fact it inhibited mTOR via AMPK activation.

The study said the atrophy was caused by atrogin-1 stimulation. AMPK activation causes atrogin-1 stimulation.

So lots of negatives regarding muscle growth and AMPK activation
 
nattydisaster said:
I like everything about curcumin except the fact it is very strongly activates AMPK, which shuts off mTOR in skeletal muscle. Although I am interested in what pat thinks of this.

A number of good ingredients have shown to increase AMPK a good amount. Berberine for example does, and also has data showing it caused mild muscle atrophy which could ahve been caused from the fact it inhibited mTOR via AMPK activation.

The study said the atrophy was caused by atrogin-1 stimulation. AMPK activation causes atrogin-1 stimulation
Click to expand...

There are a couple different AMPK isoforms. Which if i remember correctly are tissue specific. Might be worth looking into.
 
nattydisaster said:
I like everything about curcumin except the fact it is very strongly activates AMPK, which shuts off mTOR in skeletal muscle. Although I am interested in what pat thinks of this.

A number of good ingredients have shown to increase AMPK a good amount. Berberine for example does, and also has data showing it caused mild muscle atrophy which could ahve been caused from the fact it inhibited mTOR via AMPK activation.

The study said the atrophy was caused by atrogin-1 stimulation. AMPK activation causes atrogin-1 stimulation
Click to expand...


ursolic acid reduces atrogin-1 expression

"As discussed above, atrogin-1 and MuRF1 are transcriptionallyupregulated by atrophy-inducing stresses (Sacheck et al.,
2007; and Figure 1B), and they are required for muscle atrophy
(Bodine et al., 2001a). Moreover, in our studies of fasted mice,
we found that ursolic acid reduced atrogin-1 and MuRF1 mRNAs
(Figure 2H). Consistent with that finding, the arrays indicated
that dietary ursolic acid reduced atrogin-1 mRNA, which was
the most highly repressed mRNA measured on the array"

i understand the ampk - mTOR seesaw issue. but i dunno if its something that you should base everything on when it comes to compounds like curcumin with such a wide array of effects
 
0071982WC said:
Magnesium sterate....
Click to expand...

magnesium is a mineral most athletes are deficient in

stearic acid is one of the most common dietary fatty acids found in food

but those are moot points anyone because the amount of mag stearate used for excipient purposes is trivial

try again
 
0071982WC said:
No point, I obviously cannot debate on your level of intellect ......
Click to expand...

its not really about intellect, its about knowledge. i am really kinda dumb, i just know alot of stuph


i was that kid that sat in the corner of homeroom and rocked back and forth
 
Patrick Arnold said:
magnesium is a mineral most athletes are deficient in

stearic acid is one of the most common dietary fatty acids found in food

but those are moot points anyone because the amount of mag stearate used for excipient purposes is trivial

try again
Click to expand...

Just playing Devils advocate here. Titanium dioxide could possibly raise concern, however as with mag stearate quantities used in caps are most likely trivial. However, with the amount of caps some people consume who knows. Particularly if they were ultrafine particles.
 
broons said:
Just playing Devils advocate here. Titanium dioxide could possibly raise concern, however as with mag stearate quantities used in caps are most likely trivial. However, with the amount of caps some people consume who knows. Particularly if they were ultrafine particles.
Click to expand...

are you talking about mag or tit?
 
broons said:
Tit dioxide. As I said, just playing devils advocate
Click to expand...


well when its used its used in very small amounts. Its considered to be non-toxic at that dose. of course on the internetz you can always find someone who is crying about the toxicity of whatever

titanium is found in the soil everywhere i believe. you probably ingest it all the time when eating fruits and veggies
 
Patrick Arnold said:
well when its used its used in very small amounts. Its considered to be non-toxic at that dose. of course on the internetz you can always find someone who is crying about the toxicity of whatever

titanium is found in the soil everywhere i believe. you probably ingest it all the time when eating fruits and veggies
Click to expand...

Yes, I would agree with you. I brought it up for the sake of discussion only. The IARC has classified it as "possibly carcinogenic to humans" due to some rat studies and industrial observations but the amounts involved are exponentially larger than what's in a few caps.

Anyways, this thread was about curcumin I apologize for derailing it a little bit there.
 
Turmeric is a good seasoning but damn it's terrible for your breath.

Caps with Bioperine is the way to go I suppose.
 
Powercage said:
Hey PA,
How do you recommend dosing your Curcumin and piperine (bioperine)? Currently using LE Super Bio-Curc

Thanks
Click to expand...
I prefer taking mine in Pork Vindaloo
 
Curcumin from what I gather is an inhibitor of tgf-b. There is a thread on the site which makes a connection between ursolic acid, tgf-b and myostatin. Maybe this is why there are studies which have shown curcumin and muscle tissue regeneration.
 
Patrick Arnold said:
its not really about intellect, its about knowledge. i am really kinda dumb, i just know alot of stuph


i was that kid that sat in the corner of homeroom and rocked back and forth
Click to expand...
Well I guess that makes 2 of us. And it takes more than 2 to tango... or something like that?
 
What about this form of curcumin?

Invalid Link Removed

AOR uses it and supposedly it is much better.
 
PuZo said:
What about this form of curcumin?

Invalid Link Removed

AOR uses it and supposedly it is much better.
Click to expand...
AOR is all I needed to see to validate the legitimacy of a quality company. Thanks for the link as well!
 
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i dont pay attention to other supplement companies or their products anymore. maybe thats good, maybe thats bad. 95% of the stuff out there is crap so i figure i save alot of frustration by just minding my own bizness
 
Patrick Arnold said:
i dont pay attention to other supplement companies or their products anymore. maybe thats good, maybe thats bad. 95% of the stuff out there is crap so i figure i save alot of frustration by just minding my own bizness
Click to expand...

It is/was arguably the best multi on the market...

[TABLE="width: 552, align: left"]
[TR="bgcolor: #EAE9EB"]
[TD]Vitamins[/TD]
[TD="align: right"] [/TD]
[TD="align: right"] [/TD]
[/TR]
[TR]
[TD]Vitamin A Complex[/TD]
[TD="align: right"] [/TD]
[TD="align: right"] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] -Retinol (Palmitate)[/TD]
[TD="align: right"]200mcg/110 mcg RAE[/TD]
[TD="align: right"] [/TD]
[/TR]
[TR]
[TD]Natural-Source Mixed Carotenoids:
[/TD]
[TD="align: right"] [/TD]
[TD="align: right"] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] Beta-carotene[/TD]
[TD="align: right"]1.8 mg[/TD]
[TD="align: right"] [/TD]
[/TR]
[TR]
[TD] Cryptoxanthin[/TD]
[TD="align: right"] 250mcg[/TD]
[TD="align: right"]208 IU[/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] Lutein[/TD]
[TD="align: right"]6.8mg[/TD]
[TD="align: right"] [/TD]
[/TR]
[TR]
[TD] Astaxanthin[/TD]
[TD="align: right"]2mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] Lycopene[/TD]
[TD="align: right"]5mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Vitamin B Complex[/TD]
[TD="align: right"] [/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] B1 (Thiamine)[/TD]
[TD="align: right"]9mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] B2 (Riboflavin)[/TD]
[TD="align: right"]2.5mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] B3 (Niacin)(as 126 mg Inositol Hexanicotinate)[/TD]
[TD="align: right"]115mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] B5 (d-Ca Pantothenate)[/TD]
[TD="align: right"]100mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] B6 (Pyridoxal 5' Phosphate)[/TD]
[TD="align: right"]100mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] B12 (Methylcobalamin)[/TD]
[TD="align: right"]647mcg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] Folic Acid (5-methyltetrahydrofolate)[/TD]
[TD="align: right"]800mcg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Biotin[/TD]
[TD="align: right"]300mcg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] Choline (from Bitartrate)[/TD]
[TD="align: right"]100mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Inositol[/TD]
[TD="align: right"]100mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] Vitamin C Complex[/TD]
[TD="align: right"] [/TD]
[TD] [/TD]
[/TR]
[TR]
[TD]-Vitamin C (as Magnesium Ascorbate)[/TD]
[TD="align: right"]120mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD]-Mixed Citrus Bioflavonoids[/TD]
[TD="align: right"]25mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD]Vitamin D3 (Cholecalciferol)[/TD]
[TD="align: right"]25mcg[/TD]
[TD="align: right"]1000 IU[/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD]Vitamin E Complex[/TD]
[TD="align: right"][/TD]
[TD][/TD]
[/TR]
[TR]
[TD]Mixed Tocopherols:[/TD]
[TD="align: right"] 99.6mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD]RRR-Alpha-Tocopherol[/TD]
[TD="align: right"]13.8mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD]Gamma-Tocopherol[/TD]
[TD="align: right"]58.2mg[/TD]
[TD="align: right"] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD]Delta-Tocopherol[/TD]
[TD="align: right"]27.6mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD]Mixed Tocotrienols:[/TD]
[TD="align: right"]10mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] alpha-tocotrienol[/TD]
[TD="align: right"]3mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] gamma-tocotrienol[/TD]
[TD="align: right"]5.5mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] delta-tocotrienol[/TD]
[TD="align: right"]1.5 mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD]Vitamin K2 Menatetrenone[/TD]
[TD="align: right"]120mcg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD]MINERALS[/TD]
[TD="align: right"] [/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Boron (Citrate)[/TD]
[TD="align: right"]700mcg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD="align: left"] Calcium (Calcium carbonate, Citrate-Malate, d-Ca Pantothenate)[/TD]
[TD="align: right"]300mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Chromium (Picolinate)[/TD]
[TD="align: right"]100mcg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] Copper (Citrate)[/TD]
[TD="align: right"]1.5mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Iodine (Potassium Iodide)[/TD]
[TD="align: right"]150mcg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD="align: left"] Magnesium (Aspartate, Oxide, Ascorbate, Chlorophyllin)[/TD]
[TD="align: right"]210mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Potassium (Chloride)[/TD]
[TD="align: right"]50mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] Manganese (Bisglycinate)[/TD]
[TD="align: right"]2.3mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Molybdenum (Na Molybdate)[/TD]
[TD="align: right"]45mcg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] Selenium (Selenomethionine)[/TD]
[TD="align: right"]55mcg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Silicon (Na Metasilicate)[/TD]
[TD="align: right"]25mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] Vanadium (Citrate)[/TD]
[TD="align: right"]18mcg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Zinc (Citrate)[/TD]
[TD="align: right"]11mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD]Phytonutrients & Antioxidants[/TD]
[TD="align: right"] [/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Trans-Resveratrol[/TD]
[TD="align: right"]1.8mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD="align: left"] Grape Seed Extract (85% Oligomeric proanthocyanidins)[/TD]
[TD="align: right"]100mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Alpha-Lipoic Acid[/TD]
[TD="align: right"]150mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Co-EnzymeQ10 (ubidecarenone)[/TD]
[TD="align: right"]30mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Green Tea Extract (45% EgCG)[/TD]
[TD="align: right"]140mg[/TD]
[TD] [/TD]
[/TR]
[TR="bgcolor: #EAE9EB"]
[TD] N-Acetylcysteine (NAC)[/TD]
[TD="align: right"]200mg[/TD]
[TD] [/TD]
[/TR]
[TR]
[TD] Quercetin (dihydrate)[/TD]
[TD="align: right"]65mg[/TD]
[TD] [/TD]
[/TR]
[/TABLE]
 
i will just stick with my generic store bought vitamin and mineral. if i want 1.8mg of trans-resveratrol I'll eat a grape
 
Patrick Arnold said:
i will just stick with my generic store bought vitamin and mineral. if i want 1.8mg of trans-resveratrol I'll eat a grape
Click to expand...

I'd be more concerned if you bought a multi solely for the trans-resveratrol...
 
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