Just wondering what the closest supplement to HCG is or what alternatives there are?
Thinking DAA or HCGenerate. Would love to know if any supps like trib or tongkat ali have positive effects on LH.
DAA will have an effect somewhat like what you describing- this is from the Lit-Up Tech Write-Up- this gives an overview of the physiology of the response:
"•When the NMDA binding sites are triggered in the hypothalamus by DAA and its co-agonist (in this case N-Methyl Glycine), there is an increase in cyclic guanosine monophosphate (cGMP) activity in the pituitary. cGMP is classified as a second messenger, meaning that it exerts its effects by acting in a manner secondary and in response to a first messenger signaling molecule. When the first messenger signaling molecules bind to a receptor (in this case, D-Aspartic Acid and its co-agonist bind to NR-1 and NR-2), the secondary pathway is activated that increases cGMP production. The heightened levels of cGMP in the pituitary correspond to an increased production of gonadotropin releasing hormone (GnRH), and growth hormone releasing hormone (GHRH). The resulting increase in GHRH from stimulation of the NMDA receptor also allows increased amounts of growth hormone (GH) to be secreted from the pituitary, while an increase in GnRH subsequently signals the pituitary to release luteinizing hormone (LH), and follicle stimulating hormone (FSH) (see figure 2). This increase in LH and FSH allows for an increase in steroidogenesis in the testes, which subsequently allows for the production of increased amounts of testosterone, as explained below ((1-3,10-13,43,45,59-60,75-77).
•Luteinizing Hormone, via receptors found on the surface of Leydig cells (a type of cell that helps produce testosterone) in the testes, controls the production and secretion of testosterone. The subsequent binding of LH with its receptor on the Leydig cell allows a signal to be sent through the cyclic AMP (another type of second messenger) pathway. Once this signaling occurs, the protein kinase A pathway is then activated, and this ultimately allows for the release of testosterone after 30-60 minutes of LH stimulation (42-43,108-109).
• Similarly, increases in cGMP from Lit-Up™ also enhance phosphorylation (a fancy word for activation via attachment of a phosphate group) of the steroidogenic acute regulatory protein (StAR), a Leydig cell cholesterol transfer protein that provides the building blocks for testosterone synthesis. This is important for increasing endogenous testosterone production, in that StAR activation is necessary for the stimulation of steroidogenic enzymes involved in the transfer of cholesterol to testosterone. These results suggest that increases in cGMP correlate to increases in basal steroidogenesis in the Leydig cells of the testes through the protein kinase G (PKG, or a type of enzyme that cGMP interacts with)-dependent modification of the StAR protein and interaction with LH. To summarize, Lit-Up™ increases LH, cGMP, and StAR activity, all of which can significantly up the amount of testosterone produced in the body (42-43,108-109)."
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