I think this issue of back-to-back cycles involving designers (as I have seen many other failed cycles involving designers) raises an interesting question. Why is it that back-to-back or lengthy cycles involving esters of Testosterone are successful, but those involving designers are not? If ARs do not downregulate, what intrinsic quality of Testosterone allows it to produce consistent gains over long periods of time, or in a back-to-back fashion? I personally feel it could, and I say could because this is all completely speculative and I could be speaking out of my ass, have something to do with Testosterone's interaction with IGF-1.
I have been reading research lately speculating that because of Testosterone's interaction with IGF, increased amounts of androgens in the bloodstream hypothetically increase the amount of ARs per muscle fiber. This theory would allow for consistent gains to be produced over time, as long as androgens were continually circulating in the bloodstream. If we assume that designers do not have this effect on IGF, which I feel we can safely do, they would in fact not increase the amount of ARs. This would explain why they, in most cases, have hard caps on the amount of time under which they can produce gains.
...Well, what if ARs can not be downregulated, but occupied for finite periods of time? What I mean by this is, what if androgens occupy ARs for periods of time, making them unreceptive to new androgens, but not permanently or even temporarily decreasing their ability to accept androgens in the future once androgen levels in the bloodstream had decreased?
Following in this line of thought, we could assume that Gix's ARs were still being occupied because of the binded Testosterone, and the only way to produce new gains would be to increase the amount of ARs/muscle fibre, something the designer is not doing.