any REAL vasodilator supps?

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    Quote Originally Posted by grngoloco View Post
    I take it for the bp lowering effect primarily and as a gh booster secondarily
    And it fulfills neither of those roles.

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    Quote Originally Posted by rms80 View Post
    Quick List of Vasodilators:
    insulin/high glycemic carbs
    icariin
    AAKG
    Ag Sulfate
    osthole (makes some people ill though)
    olive leaf extract
    citrulline
    cre nitrate or any other nitrate
    fish oil
    PDE5 Inhibitors (Cialis, Viagra, etc.)
    forskolin (even though it counteracts insulin @ cellular level)
    grape seed extract
    pycogenol
    arginine in general
    L-Norvaline
    Niacin
    Arginine and AAKG increase muscle blood volume, not vasodilation. Pump =/= vasodilation...same applies for other ingredients on your list.
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    i really appreciate all the help guys. ive honestly never looked into agmatine nor really knew what it was before you guys mentioned it. also, i remember hearing some stuff about 'dangers' of nitrates in creatine and stuff but, again, didnt do my own research until now.

    im thinking i may give c4 a shot as it has nitrates and it serves my energy need, throw some agmatine into it for even better pumps/dilation, then run about 3g of taurine a day alongside some olive leaf extract.

    thanks again for the help
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    Quote Originally Posted by mr.cooper69

    And it fulfills neither of those roles.
    I have high blood pressure 150+/90+ then take 20g of arginine and it drops to 124/70 .... I'd say that proves the BP lowering effect,,, and read many articles in Google scholar that report significant gh blood level boosts when taken in a 2:1 ratio with ornithine at levels over
    15g a day..... I'll believe Google scholar over tests done by sites selling stuff
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    http://www.vrp.com/amino-acids/growt...the-literature

    Skip down to the paragraph on arginine and ornithine ... arginine by itself has mixed results,,, but when stacked 2:1 with ornithine you get results
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    How many articles should I post? There are over 50 years worth!
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    Quote Originally Posted by grngoloco View Post
    I have high blood pressure 150+/90+ then take 20g of arginine and it drops to 124/70 .... I'd say that proves the BP lowering effect,,, and read many articles in Google scholar that report significant gh blood level boosts when taken in a 2:1 ratio with ornithine at levels over
    15g a day..... I'll believe Google scholar over tests done by sites selling stuff
    Ok, 20g/day may have an effect on vasodilation by working against its low oral bioavailability. Most people dose 3-6g/day which does nothing.

    However, arginine attenuates the GH response to exercise.
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    Oh, and all of your articles lack scientific relevance. If you'd like see the effects of arginine on NO in exercising individuals...well, you'll find one study in favor and a TON against.
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    I am new to the body building scene, but I've studied health and nutrition for 20+ years..... my main focus, until recently, was noottopics and growth hormone for the anti aging effects.
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    Show me the articles,,, show me proof
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    Hello my old nemesis lol. How can you say arginine does not induce vasodilation? Vasodilation via arginine is pretty much the only reason we have eNOS. I would agree that many preparations of arginine would upset your stomach by the time it was beneficial, but it will induce vasodilation.

    Quote Originally Posted by mr.cooper69 View Post
    Arginine and AAKG increase muscle blood volume, not vasodilation. Pump =/= vasodilation...same applies for other ingredients on your list.
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    Psst....run!

    Quote Originally Posted by grngoloco View Post
    Show me the articles,,, show me proof
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    I'm always up for real discussions ... these sites frustrate me when people say someone is wrong without backing it up
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    Quote Originally Posted by Aleksandar37 View Post
    Hello my old nemesis lol. How can you say arginine does not induce vasodilation? Vasodilation via arginine is pretty much the only reason we have eNOS. I would agree that many preparations of arginine would upset your stomach by the time it was beneficial, but it will induce vasodilation.
    Ok, context here. Supplemental, oral arginine in reasonable doses does not induce vasodilation. Obviously one of arginine's primary roles in the body is to serve as a NO precursor, but again: context. Anyway, I won't continue this debate, because you and I could go on forever about this, and it's been done before . How's your research coming along?

    Quote Originally Posted by grngoloco View Post
    I'm always up for real discussions ... these sites frustrate me when people say someone is wrong without backing it up
    It's because I have backed it up in countless threads on various boards. The information is out there, and many of the texts are free and do not require a subscription.
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    The upset stomach can be avoided by gradually increasing dosage up to 20g a day
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    As with any supplement,,, it won't work if you don't take enough,,,, or if not taken in the proper synergistic balance with other nutrients....which is why multiple sources of info need to be cross referenced
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    Go to google scholar,,, it is free and has a larger majority of actual research articles minus the commercialization of marketing
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    I understand that and I'm pro-arginine to the point that I agree there are other options that work too, but don't think it is fair to say that arginine does not induce vasodilation at all. The problem, in my opinion, is that many products don't do it correctly and you get GI problems.

    Cooper is the real deal though and he will back it up. In the future though, could you please at least summarize the studies that you are using? Nobody has the time to click on every site you post up.

    Quote Originally Posted by grngoloco View Post
    I'm always up for real discussions ... these sites frustrate me when people say someone is wrong without backing it up
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    Indeed and I was just saying hi Things are going well. Doing more downstream stuff after NO activates sGC. PDE inhibitors and that fun stuff.

    Quote Originally Posted by mr.cooper69 View Post
    Ok, context here. Supplemental, oral arginine in reasonable doses does not induce vasodilation. Obviously one of arginine's primary roles in the body is to serve as a NO precursor, but again: context. Anyway, I won't continue this debate, because you and I could go on forever about this, and it's been done before . How's your research coming along?



    It's because I have backed it up in countless threads on various boards. The information is out there, and many of the texts are free and do not require a subscription.
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    Quote Originally Posted by Aleksandar37 View Post
    Indeed and I was just saying hi Things are going well. Doing more downstream stuff after NO activates sGC. PDE inhibitors and that fun stuff.
    Awesome my friend, and glad to see you're with PES. Definitely let me know when the research is available online, I'd love to see what you've been working on
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    Cool deal..... will do.... I do love to debate and always look for more info,,, and will absolutely admit when it turns out I am wrong.... two major reasons arginine doesn't work for people is, like cooper said, it has poor absorption requiring high dosages and two,,, it needs to be taken alone on an empty stomach so it doesn't need to compete for receptors ..... anyway guys,,, I'm off to the gym...... I'd love to pick your brains about aas,,, they're new to me and right now I'm doing test cyp and adex with hcg and injectable b12 in the mail on it's way ......
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    Fyi, my arginine supplementation is as follows:
    20g arginine powder
    10g ornithine powder
    5g lcar
    5g creatine
    1 single pack pedialyte powder
    Mixed with water and drank on an empty stomach first thing in the morning ...
    I wait 30 minutes then drink a protein shake and eat breakfast
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    Who here has used HemaVol?


    It is hands down the highest praised pump/vasodilator.
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    Quote Originally Posted by monstermash View Post

    I think he was just kidding but if not, i wouldn't do mix viagra w/ CN either. Sounds like a brew for a massive headache, fainting spell or in fl3x's case FACE EXPLOSION.
    ..Yes and possibly death due to an unsafe drop in blood pressure. The commercials even warn you about not taking nitrates with viagra. very dangerous.

    And besides most guys under the age of 70 don't have prescriptions for V or C anyway so not sure how this would be beneficial to most.
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    Quote Originally Posted by VaughnTrue View Post
    Who here has used HemaVol?


    It is hands down the highest praised pump/vasodilator.
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    out of curiosity, how do you dose your arginine? i know you said 20g, but do you do 2 servings of 10, 4 of 5, etc?

    thanks!
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    Quote Originally Posted by bill86
    out of curiosity, how do you dose your arginine? i know you said 20g, but do you do 2 servings of 10, 4 of 5, etc?

    thanks!
    I buy the bulk powder and do all 20g in one dose in the regimine I mentioned above ... can't remenber, ,, think it's @ two teaspoons
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    Arginine does not increase NO...but does help produce pumps.


    Agmatine + Cit Malate + Norvaline + GMS + Alpha-GPC + Vitamin C + Rutacaerpine + Epimedium = win.
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    I don't know how your body works, but every other animal on the planet produces NO from arginine through one of three enzymes (nNOS, eNOS, and iNOS).

    Quote Originally Posted by VaughnTrue View Post
    Arginine does not increase NO...but does help produce pumps.


    Agmatine + Cit Malate + Norvaline + GMS + Alpha-GPC + Vitamin C + Rutacaerpine + Epimedium = win.
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    Quote Originally Posted by Aleksandar37 View Post
    I don't know how your body works, but every other animal on the planet produces NO from arginine through one of three enzymes (nNOS, eNOS, and iNOS).
    I don't know how your body works, however orally ingested Arginine does not make it to your blood stream where NO is actually created.

    This is why Citrulline Malate increased NO, in that it converts to Arginine in your blood...which then raises no.



    Arginine is a great NO booster if you're injecting it...are you injecting yours?
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    1: J Nutr Biochem. 2008 Aug 15. [Epub ahead of print]
    Liu TH, Wu CL, Chiang CW, Lo YW, Tseng HF, Chang CK.
    No effect of short-term arginine supplementation on nitric oxide production, metabolism and performance in intermittent exercise in athletes.

    Arginine supplementation has been shown to alleviate endothelial dysfunction and improve exercise performance through increasing nitric oxide production in patients with cardiopulmonary diseases. In addition, arginine supplementation could decrease accumulations of lactate and ammonia, metabolites involved in development of muscular fatigue. The aim of this study was to investigate the effect of short-term arginine supplementation on performance in intermittent anaerobic exercise and the underlying mechanism in well-trained male athletes. Ten elite male college judo athletes participated with a randomized crossover, placebo-controlled design. The subjects consumed 6 g/day arginine (ARG trial) or placebo (CON trial) for 3 days then performed an intermittent anaerobic exercise test on a cycle ergometer. Blood samples were collected before supplementation, before and during exercise and 0, 3, 6, 10, 30 and 60 min after exercise. ARG trial had significantly higher arginine concentrations than CON trial at the same time point before, during and after exercise. In both trials, nitrate and nitrite concentration was significantly higher during and 6 min after exercise comparing to the basal concentration. The increase in nitrate and nitrite concentration during exercise in both trials was parallel to the increase in plasma citrulline concentrations. There was no significant difference between the 2 trials in plasma nitrate and nitrite, lactate and ammonia concentrations and peak and average power in the exercise. The results of this study suggested that short-term arginine supplementation had no effect on nitric oxide production, lactate and ammonia metabolism and performance in intermittent anaerobic exercise in well-trained male athletes.


    Int J Sport Nutr Exerc Metab. 2009 Aug;19(4):355-65.
    Bescós R, Gonzalez-Haro C, Pujol P, Drobnic F, Alonso E, Santolaria ML, Ruiz O, Esteve M, Galilea P.
    Effects of dietary L-arginine intake on cardiorespiratory and metabolic adaptation in athletes.

    To assess the effect of diet enrichment with L-arginine or supplementation at high doses on physiological adaptation during exercise, 9 athletes followed 3 different diets, each over 3 consecutive days, with a wash-out period of 4 d between training sessions: control diet (CD), 5.5 +/- 0.3 g/d of L-arginine; Diet 1 (rich in L-arginine food), 9.0 +/- 1.1 g/d of L-arginine; and Diet 2 (the same as CD but including an oral supplement of 15 g/d), 20.5 +/- 0.3 g/d of L-arginine. Plasma nitrate levels of each participant were determined on the day after each treatment. Participants performed a submaximal treadmill test (initial speed 10-11 km/hr, work increments 1 km/hr every 4 min until 85-90% VO2max, and passive recovery periods of 2 min). Oxygen uptake and heart rate were monitored throughout the test. Blood lactate concentration ([La-]b) was determined at the end of each stage. Repeated-measures ANOVA and paired Student's t tests were used to compare the various physiological parameters between diets. The level of significance was set at p < .05. [La-]b showed a significant effect at the 5-min time point between CD and Diet 2 (CD 3.0 +/- 0.5 mM, Diet 2 2.5 +/- 0.5 mM, p = .03), but this tendency was not found at higher exercise intensities. No significant differences were observed in any of the cardiorespiratory or plasma nitrate levels. In conclusion, dietary L-arginine intake on the days preceding the test does not improve physiological parameters during exercise.


    Circulation. 2007 Jul 10;116(2):188-95. Epub 2007 Jun 25.
    Wilson AM, Harada R, Nair N, Balasubramanian N, Cooke JP.
    L-arginine supplementation in peripheral arterial disease: no benefit and possible harm.

    BACKGROUND: L-arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodilator. L-arginine supplementation improves vascular reactivity and functional capacity in peripheral arterial disease (PAD) in small, short-term studies. We aimed to determine the effects of long-term administration of L-arginine on vascular reactivity and functional capacity in patients with PAD. METHODS AND RESULTS: The Nitric Oxide in Peripheral Arterial Insufficiency (NO-PAIN) study was a randomized clinical trial of oral L-arginine (3 g/d) versus placebo for 6 months in 133 subjects with intermittent claudication due to PAD in a single-center setting. The primary end point was the change at 6 months in the absolute claudication distance as assessed by the Skinner-Gardner treadmill protocol. L-arginine supplementation significantly increased plasma L-arginine levels. However, measures of nitric oxide availability (including flow-mediated vasodilation, vascular compliance, plasma and urinary nitrogen oxides, and plasma citrulline formation) were reduced or not improved compared with placebo. Although absolute claudication distance improved in both L-arginine- and placebo-treated patients, the improvement in the L-arginine-treated group was significantly less than that in the placebo group (28.3% versus 11.5%; P=0.024). CONCLUSIONS: In patients with PAD, long-term administration of L-arginine does not increase nitric oxide synthesis or improve vascular reactivity. Furthermore, the expected placebo effect observed in studies of functional capacity was attenuated in the L-arginine-treated group. As opposed to its short-term administration, long-term administration of L-arginine is not useful in patients with intermittent claudication and PAD.


    I agree that Arginine is the precursor to NO...however it's not when it's in your belly.
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    That is not what you said the first time. Just trying to keep comments honest and accurate. All of these other supps are ways of getting arginine to convert to NO, so to make a general statement that "Arginine does not increase NO" is not correct when arginine is the common denominator. Neither is saying that orally ingested arginine does not make it into the blood stream. You're suggesting that none at all does when citrulline mallate simply has better bioavailability.

    Quote Originally Posted by VaughnTrue View Post
    I don't know how your body works, however orally ingested Arginine does not make it to your blood stream where NO is actually created.

    This is why Citrulline Malate increased NO, in that it converts to Arginine in your blood...which then raises no.



    Arginine is a great NO booster if you're injecting it...are you injecting yours?
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    Quote Originally Posted by Aleksandar37 View Post
    That is not what you said the first time. Just trying to keep comments honest and accurate. All of these other supps are ways of getting arginine to convert to NO, so to make a general statement that "Arginine does not increase NO" is not correct when arginine is the common denominator. Neither is saying that orally ingested arginine does not make it into the blood stream. You're suggesting that none at all does when citrulline mallate simply has better bioavailability.
    No...the way you read something and the way I wrote it are two different things.


    This thread is talking about dietary supplements(thus things that must be ingested orally). If Arginine comes up in the conversation, it is already assumed people are referring to it as a supplement than can boost NO through oral supplementation.

    We both know this to not be the case.

    Citrulline Malate doesn't have "better absorption", its actually able to increase Arginine levels...but Arginine cant!
  

  
 

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