If you had to choose between L-Citrulline or Agmatine, what would choose and why?
this, also while sleeping it helps for me get a deeper sleepAgmatine, for its host of other benefits outside of pumps.
Potential nootropic-like effects
Selective nutrient partitioning
Slight mood boost
Potential impact on cAMP and fat loss
Citrulline has human data supporting performance so it's impossible to conclusively say Agmatine is better. Agmatine lacks the human data that a lot of look for to determine efficacy.If there can be only one, Agmatine. It's better at pretty much everything, isn't it? For me at least.
that's fair. i've used both extensively, as i'm sure many others have, and for the sample size of just me and myself it's been pretty conclusive. that said, they're both cheap enough that i doubt i'd ever have reason to do one without the other.Citrulline has human data supporting performance so it's impossible to conclusively say Agmatine is better. Agmatine lacks the human data that a lot of look for to determine efficacy.
Because the thread title is pre workout, my answer was CitrullineSurprised a bit by the overall choice of agmatine. I do remember De__eB liking citrulline better if I'm not mistaken.
I take agmatine in the mornings these days and am generally more interested in other aspects of agmatine than the pump.Surprised a bit by the overall choice of agmatine. I do remember De__eB liking citrulline better if I'm not mistaken.
Agmatine is a pretty weak A2-agonist, though, eh?Agmatine is also possibly counterproductive with a2 stimulants.
It actually has high in vitro binding to the a2 receptor but it's plasma halflife (note: not CNS or tissue) is too short for any appreciable effects to occur. The a2 receptor, which should lower cAMP in vivo, is virtually unaffected in the murine model...in fact, agmatine RAISES cAMP in vivoAgmatine is a pretty weak A2-agonist, though, eh?
Okay cool. Yeah IIRC, Agmatine plasma half life is mere minutes, while CNS and tissue is upwards of 12 hours.It actually has high in vitro binding to the a2 receptor but it's plasma halflife (note: not CNS or tissue) is too short for any appreciable effects to occur. The a2 receptor, which should lower cAMP in vivo, is virtually unaffected in the murine model...in fact, agmatine RAISES cAMP in vivo
Why Cit. Mal instead of just straight Citrulline?Good question.
Assuming this is like all the other questions we pose and price, dose, etc. aren't considered options.
So if I'm answering this specifically focusing on pre-workout use and without a concern of cost, how long it will last based on dose, etc. (e.g. basically I have an unlimited supply of either):
I'm choosing citrulline (preferably as citrulline malate).
I like both for a number of reasons already discussed, but I have blood work from an amino acid profile that showed low arginine levels. I supplemented with citrulline malate, took the test again and was well up into the high end of normal range. My go-to pre-workout for the past year+ doesn't have citrulline in it, so I add 6g citrulline malate and love it. It has 500mg agmatine, but I didn't start using agmatine pre-workout until about that time. I currently take 500mg every morning upon rising as it has cumulative effects. Again, both have a ton of great benefits (which is why I use both), but picking only one to use and specifically pre-workout:
Citrulline >
Not relevant to this discussion, but in general I do love the fact that it makes my pre-workouts taste better lol. It adds the perfect amount of tartness to them to improve them. I've used bulk l-citrulline, too and I don't really know why I'm partial to cit mal unless it's just that.Why Cit. Mal instead of just straight Citrulline?
lol, agreed! I used to go 6g of Cit. Mal with a scoop of Focus XT. Love the taste.Not relevant to this discussion, but in general I do love the fact that it makes my pre-workouts taste better lol. It adds the perfect amount of tartness to them to improve them. I've used bulk l-citrulline, too and I don't really know why I'm partial to cit mal unless it's just that.
Yeah, I saw it last night. I've never heard of that company and the price point isn't as outrageous as I thought it would be considering it's 50 servingsthat's the new version from Dedicated VasoGrow