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Coop's Corner #1: Forskolin + B-agonists

mr.cooper69

Legend
This will be the first of a series of interesting studies and analysis. It's posted here rather than the science section because I think everyone can benefit from knowing this stuff.

Today's topic is how forskolin synergizes with B-agonists in actual humans for the purpose of fat loss.

Here is the paper I'm referencing: Invalid Link Removed.

Forskolin, by acting downstream of the b-adrenergic receptor, increases adenyl cyclase activity and thus elevates cAMP. This amplifies the intracellular signal saying "burn fat," such that the body interprets normal B-receptor stimulation as something greater. The combination will maximize fat loss in a given period of time.

B-Agonists you can use: ECA stack, Alphamine, Alpha-T2
Forskolin products you can use: Forskolin-95, Primaforce Forskolin, PNI Paragon

Happy fat loss everyone!
 
mr.cooper69 said:
This will be the first of a series of interesting studies and analysis. It's posted here rather than the science section because I think everyone can benefit from knowing this stuff.

Today's topic is how forskolin synergizes with B-agonists in actual humans for the purpose of fat loss.

Here is the paper I'm referencing: Invalid Link Removed.

Forskolin, by acting downstream of the b-adrenergic receptor, increases adenyl cyclase activity and thus elevates cAMP. This amplifies the intracellular signal saying "burn fat," such that the body interprets normal B-receptor stimulation as something greater. The combination will maximize fat loss in a given period of time.

B-Agonists you can use: ECA stack, Alphamine, Alpha-T2
Forskolin products you can use: Forskolin-95, Primaforce Forskolin, PNI Paragon

Happy fat loss everyone!
Click to expand...

Waiting to stack it with versa1 n compound 20 at double dose. So we will see.
 
Good info.. will be following! You should re-write the studies in cliff form to make it easier for us lazy guys :D

Mike
 
criticalbench said:
Good info.. will be following! You should re-write the studies in cliff form to make it easier for us lazy guys :D

Mike
Click to expand...

Here's the basic rundown:

A activates B. B activates C. C activates D. D activates fat burning.

A B-agonist increases levels of A. More A means more B. More B means more C.

Forskolin further increases levels of C. So you have way, way more C, which activates D. D activates way, way more fat burning.
 
mr.cooper69 said:
Here's the basic rundown:

A activates B. B activates C. C activates D. D activates fat burning.

A B-agonist increases levels of A. More A means more B. More B means more C.

Forskolin further increases levels of C. So you have way, way more C, which activates D. D activates way, way more fat burning.
Click to expand...

LOL

I think following that confused me more than the original post haha :D
 
mr.cooper69 said:
Here's the basic rundown:

A activates B. B activates C. C activates D. D activates fat burning.

A B-agonist increases levels of A. More A means more B. More B means more C.

Forskolin further increases levels of C. So you have way, way more C, which activates D. D activates way, way more fat burning.
Click to expand...

Now to get this effect whats the min and max dosage?
 
Coop had answered a q I had about forsk dose timing related to fast loss...as I dose most of my forsk preWO, then some postWO...he said it didn't...wondering if forsk activates all these things and is further potentiated by the listed stims, if dosing most preWO wouldn't be the most beneficial for fat loss...hmmmm...
 
Love this thread. I usually dose at least 25mgs of Forskolin-95 with each of my Alphamine doses. :D
 
Guess I'll do my dosing of F95: 1 cap preworkout with my AT2 + preworkout/Alphamine, 1 cap post workout, 1 cap on the second dose of AT2+Shift, 1 cap before bed with Shift.
 
500mg of 10% is the studied dose so 50mg of 95% should yeild equivalent results
 
mr.cooper69 said:
Here's the basic rundown:

A activates B. B activates C. C activates D. D activates fat burning.

A B-agonist increases levels of A. More A means more B. More B means more C.

Forskolin further increases levels of C. So you have way, way more C, which activates D. D activates way, way more fat burning.
Click to expand...

I love it when my "d" gets active.
 
mr.cooper69 said:
I dose 1-2 forskoin-95 caps with each scoop of alphamine. It totals to 50-150mg daily
Click to expand...

So you're usually dosing the F95 on an empty stomach? I've been trying to dose mine 15-20 min before breakfast & dinner. But I didn't know if it makes a difference.
 
mr.cooper69 said:
I dose 1-2 forskoin-95 caps with each scoop of alphamine. It totals to 50-150mg daily
Click to expand...

50mg Being the least and 150mg being the most. Now does the dose depend on body weight? If it doesn't than whats the difference in terms of effects?
 
I've been stacking Pure Forskolin with Compound 20 with a great results in the past. with added Alphamine it would be a killer stack
i find that 75mg of Forskolin (pure) is the perfect spot. really enjoy the benifets of forskolin!
 
ddfox said:
So you're usually dosing the F95 on an empty stomach? I've been trying to dose mine 15-20 min before breakfast & dinner. But I didn't know if it makes a difference.
Click to expand...

With or without meals won't matter with the 95%. Forskolin has pretty decent retention time too

halfhuman said:
50mg Being the least and 150mg being the most. Now does the dose depend on body weight? If it doesn't than whats the difference in terms of effects?
Click to expand...

The studies don't titrate according to bodyweight, but I'd say yes, the effects are weight-dependent. Lower doses create subtler body composition changes, while higher doses have your thyroid output, testosterone production, lipolysis, anabolic signaling, and vasodilation maxed out.
 
Some sweet info in this thread. I'll definitely be picking up some forskolin to go with my next alphamine run.
 
mr.cooper69 said:
The studies don't titrate according to bodyweight, but I'd say yes, the effects are weight-dependent. Lower doses create subtler body composition changes, while higher doses have your thyroid output, testosterone production, lipolysis, anabolic signaling, and vasodilation maxed out.
Click to expand...
So would the effects of forskolin be "extra" noticeable or good in someone with an under active thyroid?
 
doggy_dog said:
Does Forskolin offer any benefits in relation to lean body mass increase or is it more towards fat loss?
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I read a study a while back where it suggest that forskolin did offer benefits in relations to increased lean body tissue, but I believe the study was done on untrained individuals (female and males I believe). I'd have to try and find the study.
 
mpaquett said:
I read a study a while back where it suggest that forskolin did offer benefits in relations to increased lean body tissue, but I believe the study was done on untrained individuals (female and males I believe). I'd have to try and find the study.
Click to expand...

It activated glp-1 as well
 
How should forskolin be cycled? I've been using 100mg analyzed Supplements Forskolin 95 a day with OG Anabeta for July and August. Can I continue to run it or should I give it s month break and then get back on it?
 
Clemenza said:
How should forskolin be cycled? I've been using 100mg analyzed Supplements Forskolin 95 a day with OG Anabeta for July and August. Can I continue to run it or should I give it s month break and then get back on it?
Click to expand...


I've asked Cooper this question and he told me 12 weeks and then cycle off for a month. Cooper, is that correct?
 
It was taken for 3 months in the study so thats what I would do
 
A Coop thread? Sub'd for sum learninnn
 
1) I understand the utility of diminishing returns but Is there any value using the "more is better" principle with a product like Forskolin?
I tend to need more than the average Joe for many products.

2) PES T2: What is the ingredient that is a beta-2 agonist?

3) Wouldnt adding an α-1 antagonists (Rauwolscine/isoyohimbine/α-yohimbine) make this even SICKER :)

4) Would un-sexy old-school green tea supps add another punch to this (synergyistically) due to it's COMT inhibition (via catechins) thus allowing for epinephine to be more active? This lending itsefl to more fa- burning (more pronouced effects of the other items mentioned)? I've never seen green tea do jack on it's own but perhaps this is where it can shine?

mr.cooper69 said:
Here's the basic rundown:

B-Agonists you can use: ECA stack, Alphamine, Alpha-T2

A activates B. B activates C. C activates D. D activates fat burning.

A B-agonist increases levels of A. More A means more B. More B means more C.

Forskolin further increases levels of C. So you have way, way more C, which activates D. D activates way, way more fat burning.
Click to expand...
 
Whacked said:
1) I understand the utility of diminishing returns but Is there any value using the "more is better" principle with a product like Forskolin?
I tend to need more than the average Joe for many products.

2) PES T2: What is the ingredient that is a beta-2 agonist?

3) Wouldnt adding an α-1 antagonists (Rauwolscine/isoyohimbine/α-yohimbine) make this even SICKER :)

4) Would un-sexy old-school green tea supps add another punch to this (synergyistically) due to it's COMT inhibition (via catechins) thus allowing for epinephine to be more active? This lending itsefl to more fa- burning (more pronouced effects of the other items mentioned)? I've never seen green tea do jack on it's own but perhaps this is where it can shine?
Click to expand...

1. Yeah, I use about 100mg myself.

2. higenamine

3. Those are alpha 2 antagonists, and yes, they further synergize (hence the alphamine/T2 recommendations)

4. Green Tea does not physiologically inhibit COMT. You'd need several grams...like 5g EGCG.
 
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