Anyone try both?
Please provide feedback on the comparison between the two.
Thanks
Please provide feedback on the comparison between the two.
Thanks
PowerFull is less dangerous than G. If you use Gen. follow the instructions exactly.
.
What?They are different and both are good.
You need to cycle both. So using one and then the other would work.
PowerFull is less dangerous than G. If you use Gen. follow the instructions exactly.
With PowerFull you can't mess up.
huh? In no way is it dangerous if used correctly.What?
How is GHenerate dangerous?
This I know. I was wondering how one could make such a leap.huh? In no way is it dangerous if used correctly.
Exactly.....strange reasoning. Oh well, lets clear this up. It's NOT dangerousThis I know. I was wondering how one could make such a leap.
GHenerate also doesnt have phenibut, either.
What else have you noticed?I have been taking GHenerate for close to 7 weeks at 8 sprays 2 times a day and have felt no side harsh effects, plus I have noticed I have been getting better sleep while on it. *The rec. dose is 6 sprays*
I started taking GHenerate w/ I-Gh-1 1 week before starting the 'Trifecta Stack' as far as results only from GHenerate goes, I am unsure at the moment. I noticed better sleep as I was not too much of a morning person prior to taking the product due to feeling so tired, but feel well rested each morning. I have been off of the Trifecta Stack for 3 days now and will see if I can notice anything or not with only the GHenerate as the week progresses. I am in a complete off cycle right now and will be able to fully monitor only the GHenerate to get a complete idea on the benefits.What else have you noticed?
Not that i've noticed.GHenerate up the libido?
You could run this long term really using the 5 on 2 off protocol, months really.Not that i've noticed.
It has given me insane pumps during w/o and my shoulder pains went away! So far i really like it and will run again.(FYI-haven't gone above rec. dose)
I was wondering how long i could run this?
You do not have to stack PowerFULL "with all their other stuff", and you do not need three bottles of it to obtain its benefits.Ha no i was just comparing. It is a GH booster is it not? and its natural so yeah its not going to be as good as the real stuff. i did feel better in the gym but to do the cycle as they say, you have to get like 3 bottles of it along with all their other stuff which his what I did and for how much it cost me, I would have been better off just going with PHs. But if you are staying natural then I guess it would give you better workouts than nothing at all!
agreedYou do not have to stack PowerFULL "with all their other stuff", and you do not need three bottles of it to obtain its benefits.
Hydroxy Propyl Beta CyclodextrinThis I know. I was wondering how one could make such a leap.
GHenerate also doesnt have phenibut, either.
Suppressing the ADH? (Anti Diuretic Hormone)Marus Alba chinese herb - promotes urination. Okay that'll be affecting the ah... I forget the hormone.... annoying. Gotta dash. Remembered vasopressin.
Interesting find manInteresting
[Estrogen-like effects of puerarin and total isoflavones from Pueraria lobata]
[Article in Chinese]
Zheng G, Zhang X, Zheng J, Meng Q, Zheng D.
Institute of Metaria Medica, Zhejiang Academy of Medical Sciences, Hangzhou 210013.
OBJECTIVE: To study the estrogen-like effects of puerarin and total isoflavones from Pueraria lobata (TIP) in vivo. METHODS: Puerarin and TIP were orally administrated to ovariectomized rats, infancy or adult mice and estrogen-treated mice at the doses of 150, 300 and 600 mg/kg for 5-9 days. The estrogen-like effects were measured by viginacytology and uterus or ovary weights. RESULTS: Puerarin and TIP significantly promoted uterus growth in ovariectomized rats and infancy mice, increased the ratios of keratocytes in vaginal smear in ovariectomized rats. The sexual cycle was partially recovered in dose-dependent manner. In E2-treated mice, puerarin and TIP obviously inhibited the growth of vigina induced by E2. No obvious effect was observed in normal adult mice. CONCLUSION: The results showed that puerarin and TIP acted as weak estrogen-like effect on estrogen-deficiency animals, while no effect on normal-estrogen level ones, but as antiestrogen-like effect in high-estrogen-level ones. These results suggested that puerarin and TIP possessed property of partial agonist of estrogen receptor.
What are you suggesting?Interesting
[Estrogen-like effects of puerarin and total isoflavones from Pueraria lobata]
[Article in Chinese]
Zheng G, Zhang X, Zheng J, Meng Q, Zheng D.
Institute of Metaria Medica, Zhejiang Academy of Medical Sciences, Hangzhou 210013.
OBJECTIVE: To study the estrogen-like effects of puerarin and total isoflavones from Pueraria lobata (TIP) in vivo. METHODS: Puerarin and TIP were orally administrated to ovariectomized rats, infancy or adult mice and estrogen-treated mice at the doses of 150, 300 and 600 mg/kg for 5-9 days. The estrogen-like effects were measured by viginacytology and uterus or ovary weights. RESULTS: Puerarin and TIP significantly promoted uterus growth in ovariectomized rats and infancy mice, increased the ratios of keratocytes in vaginal smear in ovariectomized rats. The sexual cycle was partially recovered in dose-dependent manner. In E2-treated mice, puerarin and TIP obviously inhibited the growth of vigina induced by E2. No obvious effect was observed in normal adult mice. CONCLUSION: The results showed that puerarin and TIP acted as weak estrogen-like effect on estrogen-deficiency animals, while no effect on normal-estrogen level ones, but as antiestrogen-like effect in high-estrogen-level ones. These results suggested that puerarin and TIP possessed property of partial agonist of estrogen receptor.
You sound defensive for some reason.What are you suggesting?
Not defensive at all. Not an AI product .You sound defensive for some reason.
It is interesting that this is an estrogen receptor agonist with differentiating properties with regard to ones physiology and the idea should be researched more. The compound alone looks like an estrogen receptor agonist. Who knows how this will interact with someones fluctuating hormones from or off a cycle.
I agree. I bring it up because of other factors that come with the population that will be utilizing this. If it is around a cycle, your HPTA is all jacked up and having high estrogen may not exactly respond the same way as an average person would to the compound.Not defensive at all. Not an AI product .
I think it is important to note the conclusion and not just the title.
It was only "pro-estrogen" in the low estrogen condition.Hmm.. pro-estrogen is not cool. Still it is just mice.
I know only very basic Chinese medicine. Is it the berries or the bark that is used in Ghen.? Thats quite important for its properties (wiki)
Again, how many people here have any type of normal hormonal conditions? Look at the structure itself an it looks pro-estrogenic at the receptor.It was only "pro-estrogen" in the low estrogen condition.
Based on the conclusion there is no reason to think that under normal hormonal circumstances this would act as an estrogen agonist.
Maybe someone should PM LG and get him in here.It is a phytoestrogen in itself that up regulates the estrogen receptor. Hence my intrigue on the matter.
I personally was hoping to get the views of someone much smarter than myself, aside from LG. It's like asking AX why Slim-X is safe.Maybe someone should PM LG and get him in here.
So I'm not saying this is necessarily correct but that estrogen like effect study result was from one where they also explained effects on the mice uterus so it may be the case that it has a different function on females but the other conclusion that there was no effect for normal levels would lead me to believe it is not a pro-estrogen.I personally was hoping to get the views of someone much smarter than myself, aside from LG. It's like asking AX why Slim-X is safe.
Yeah, I agree with some of your thoughts, that is why i brought it up.. there is alot of different information on this compound.So I'm not saying this is necessarily correct but that estrogen like effect study result was from one where they also explained effects on the mice uterus so it may be the case that it has a different function on females but the other conclusion that there was no effect for normal levels would lead me to believe it is not a pro-estrogen.
That said, I'm glancing at the other two studies posted and aside from calling it a phyto-estrogen I didn't see it mention estrogenic effects. I will need to do some more research obviously to fully understand but based on the below segment of the write up I would suggest the possibility that it possibly acts as an estrogen receptor antagonist rather than an agonist, meaning it may bind but does not elicit a biological function. I could be totally wrong on this so I'd like a definite answer but describing it as having AI and SERM like activity and studies calling it a phytoestrogen immediately made me think it could be a estrogen receptor antagonist....but like I said, lets get someone who knows for sure to explain
"Puerariae Radix is a plant that has one particular constituent that is set to be the next superstar. It is called puerarin! Puerarin is an amazing nutrient that shows a 520% increase in growth hormone release (1) by stimulating the GHRH receptor. This ingredient was an amazing find but the key is the liquid "under the tongue" bioavailability which makes it biologically active. 520% increase in circulating GH is a HUGE increase and shows that this second pathway is very potent at releasing GH. We use only 98% pure puerarin complexed with cyclodextrin in our formula so it is ultra potent. Puerarin has also been shown to be an anti-aromatase, and a natural SERM, but this is not the main effect, compared to the GHRH stimulation, just a side benefit (3, 4). Finally, this wonder ingredient is a natural phosphoinositol 3 kinase (PI3K) stimulator which is the same anabolic pathway stimulated by IGF-1 and insulin to load the muscle with glycogen. I have to say, even I am impressed by this amazing material. GHRH stimulation, Aromatase Inhibition, natural SERM activity AND PI3K activity! Jackpot!"
repped and yeah I stopped after organic chem 2 and two semesters of biochemistry... was getting to be a little too much for my bio major, hahaYeah, I agree with some of your thoughts, that is why i brought it up.. there is alot of different information on this compound.
I posted the second study that showed when the intestinal flora cleaved the C-glucosyl bond and some other conversion pathway it converted it the estrogenic equol, but again, need someone with some high chemistry background.
Where is Natty when you need him.
Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1.
Hwang YP, Jeong HG.
Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Republic of Korea.
Phytoestrogens are polyphenolic non-steroidal plant compounds with estrogen-like biological activity. The phytoestrogen puerarin, the main isoflavone glycoside found in the root of Pueraria lobata, has been used for various medicinal purposes in traditional Chinese medicines for thousands of years. Recent studies have indicated that the estrogen receptor (ER), through interaction with p85, regulates phosphoinositide 3-kinase (PI3K) activity, revealing a physiologic, non-nuclear function of ER that may be relevant in cytoprotection. In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway. Pretreatment of Hepa1c1c7 and HepG2 cells with puerarin significantly reduced t-BHP-induced caspase-3 activation and subsequent cell death. Also, puerarin up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-BHP. Moreover, puerarin induced Nrf2 nuclear translocation, which is upstream of puerarin-induced HO-1 expression, and PI3K activation, a pathway that is involved in induced Nrf2 nuclear translocation, HO-1 expression and cytoprotection. Puerarin-induced up-regulation of HO-1 and cytoprotection against t-BHP were abolished by silencing Nrf2 expression with specific siRNA. Also, puerarin-mediated increases in PI3K activation and HO-1 induction were reversed by co-treatment with ICI 182,780 and pertussis toxin. Taken together, these results suggest that puerarin augments cellular antioxidant defense capacity through ER-dependent HO-1 induction via the Gbeta1/PI3K/Akt-Nrf2 signaling pathway, thereby protecting cells from oxidative stress.
Good luck with that.I personally was hoping to get the views of someone much smarter than myself, aside from LG.
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