Depends, not everyone has larger gaps between meals pending their meal frequency. I know you fast almost an entire day, so for you, multiple doses would not be an issue. Not everyone stretches out meals very far apart based off their lifestyle and preference so there is no clear cut answer
If someone eats every 3 hours per se, Dosing between meals still may not be fully fasted compared to first thing in the morning... where it would be more optimal and have more pros than cons.
Kind of a self-experiment situation. If you do take it first thing after sleeping (Assuming 6-8-10 hours of sleep) there would be the greatest chance of being fasted and no insulin present from food or other supplements a user may be taking.