Vitamin C to Bowel Tolerance

GreenMachineX

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Does anyone else use vitamin c to bowel tolerance when they get ill? 12g is the most I’ve needed to get the “gurgleguts” and saw drastic improvement in flu and cold. Anyone else try it or consistently do it?
 
ValiantThor08

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Does anyone else use vitamin c to bowel tolerance when they get ill? 12g is the most I’ve needed to get the “gurgleguts” and saw drastic improvement in flu and cold. Anyone else try it or consistently do it?
A couple weeks ago I felt real bad. I took 3g every 20 min for like 5 hours, then bowel tolerance hit. I stopped. I did the same thing each day. Each day toward the end of the day I felt notably better.
 
rob112

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I know of people that swear by this but I never could actually find stuff to back up the claims. If you found any I would be very interested. That said I do still appreciate anecdotal feedback like this.
 
GreenMachineX

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I know of people that swear by this but I never could actually find stuff to back up the claims. If you found any I would be very interested. That said I do still appreciate anecdotal feedback like this.
Nope, I never found any peer reviewed literature on it but I didn’t look too hard. It was first recommended by an MD on a different forum years ago, and it turns out it works really well.
 
ValiantThor08

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I wouldn’t know when I hit my threshold. Having the shyts is my new norm in 2020
You would know with C. Your stomach begins to make loud noises, so even if you were having some issues, this would be noticeable. And using to bowel tolerance is only if you think you have caught a virus or infection.
 
ValiantThor08

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I know of people that swear by this but I never could actually find stuff to back up the claims. If you found any I would be very interested. That said I do still appreciate anecdotal feedback like this.
Don't think there are any specific bowel tolerance studies performed.
 
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I do my own personal experimenting, and have done that, and in my opinion it makes me go from feeling like crap to significantly better by end of day, and then a progression of feeling better from that day on forward if I continue protocol next day.
Study completed @rob112 :)
 

Mixelflick

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Does anyone else use vitamin c to bowel tolerance when they get ill? 12g is the most I’ve needed to get the “gurgleguts” and saw drastic improvement in flu and cold. Anyone else try it or consistently do it?
I do, and my experience mirrors yours insofar as feeling better.

If you play around with Vitamin C, you'll notice something curious: Your body uses a hell of a lot more of it when you're sick, it soaks it up like a sponge. For example, if I dose 2 grams an hour when feeling fine, I reach bowell tolerance within 3 - 4 hours. When I get sick, it takes the better part of a day (late in the day, after about 10-12 hours).

They say more than 250mg at a time and anymore is just excreted. But that statement is missing context. If you're sick (like, really sick) I think that figure jumps considerably. Linus Pauling was right about Vit C, you'll learn a lot reading his stuff...
 
GreenMachineX

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I do, and my experience mirrors yours insofar as feeling better.

If you play around with Vitamin C, you'll notice something curious: Your body uses a hell of a lot more of it when you're sick, it soaks it up like a sponge. For example, if I dose 2 grams an hour when feeling fine, I reach bowell tolerance within 3 - 4 hours. When I get sick, it takes the better part of a day (late in the day, after about 10-12 hours).

They say more than 250mg at a time and anymore is just excreted. But that statement is missing context. If you're sick (like, really sick) I think that figure jumps considerably. Linus Pauling was right about Vit C, you'll learn a lot reading his stuff...
Definitely agree.
 
HIT4ME

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I take 6 grams a day about everyday. I have done this since my early 20's and have had periods where I stopped because I convinced myself there was no science behind it and it is probably quackery. In my subjective experience I get sick much more easily when I am not using it all the time at 5-6 grams.

After taking breaks 2-3 times for even a couple years I decided it is obvious it helps. I am not immune to getting suck, but am pretty darned resilient and can spend time with sick people without worrying.

A few years ago I had my mom, dad, girlfriend and her family all get a cold. They were all in bed for a week and sick for 2 weeks with this thing.

One afternoon I was out and started feeling really sick. I always thought the bowel tolerance stuff was quackery too...but decided what the heck. I took 50 grams all at once and kept taking it. Yeah, I was crapping water like a fire hose. But I woke up the next morning almost fine. I continued with mega doses and was 100% the next morning.

I have taken doses up to 100 grams/day since all with relatively similar results...sometimes less effective but obviously effective in my mind.

Maybe I am a quack...but I am not sick. Haha
 
GreenMachineX

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I take 6 grams a day about everyday. I have done this since my early 20's and have had periods where I stopped because I convinced myself there was no science behind it and it is probably quackery. In my subjective experience I get sick much more easily when I am not using it all the time at 5-6 grams.

After taking breaks 2-3 times for even a couple years I decided it is obvious it helps. I am not immune to getting suck, but am pretty darned resilient and can spend time with sick people without worrying.

A few years ago I had my mom, dad, girlfriend and her family all get a cold. They were all in bed for a week and sick for 2 weeks with this thing.

One afternoon I was out and started feeling really sick. I always thought the bowel tolerance stuff was quackery too...but decided what the heck. I took 50 grams all at once and kept taking it. Yeah, I was crapping water like a fire hose. But I woke up the next morning almost fine. I continued with mega doses and was 100% the next morning.

I have taken doses up to 100 grams/day since all with relatively similar results...sometimes less effective but obviously effective in my mind.

Maybe I am a quack...but I am not sick. Haha
What brand and product do you use for those doses?
 
HIT4ME

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What brand and product do you use for those doses?
I just get powder...a kg is normally around $30. Bronson, bulk supps, nutricost, even some evay stuff...it is all about the same. I have a scoop that gives 5-6 grams and I just make a gallon jug of water with 1 large pack of crystal light and a scoop of Vitamin C every day and drink it throughout the day.
 
GreenMachineX

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I just get powder...a kg is normally around $30. Bronson, bulk supps, nutricost, even some evay stuff...it is all about the same. I have a scoop that gives 5-6 grams and I just make a gallon jug of water with 1 large pack of crystal light and a scoop of Vitamin C every day and drink it throughout the day.
Do you drink that around your workouts too?
 
HIT4ME

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Do you drink that around your workouts too?
Yeah, sometimes - I know people freak about Vitamin C and antioxidants around workouts...but whatever. I don't like to oversimplify stuff like that to "good or bad". Generally though, that's my normal drink with meals/throughout the day. I drink A LOT. My normal intake is around 2 gallons/day and sometimes I may not drink a full gallon of the Crystal Light concoction, some days I may drink 1.5 gallons, but on average it's around 1 gallon as a regular drink when I have meals or between meals. It just makes getting my vitamin C easy without thought involved. I've considered adding other ingredients as well....like betaine, etc. but then I get into making it complicated :)
 
GreenMachineX

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Yeah, sometimes - I know people freak about Vitamin C and antioxidants around workouts...but whatever. I don't like to oversimplify stuff like that to "good or bad". Generally though, that's my normal drink with meals/throughout the day. I drink A LOT. My normal intake is around 2 gallons/day and sometimes I may not drink a full gallon of the Crystal Light concoction, some days I may drink 1.5 gallons, but on average it's around 1 gallon as a regular drink when I have meals or between meals. It just makes getting my vitamin C easy without thought involved. I've considered adding other ingredients as well....like betaine, etc. but then I get into making it complicated :)
Gotcha. Makes sense. I take all my doses with food, usually 2g per meal totaling 6g per day when healthy. Occasionally a little extra here or there, but for me dosing with food even when ill (just a lot more at a time) seems to be just right without the runs.
 

Mixelflick

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I take 6 grams a day about everyday. I have done this since my early 20's and have had periods where I stopped because I convinced myself there was no science behind it and it is probably quackery. In my subjective experience I get sick much more easily when I am not using it all the time at 5-6 grams.

After taking breaks 2-3 times for even a couple years I decided it is obvious it helps. I am not immune to getting suck, but am pretty darned resilient and can spend time with sick people without worrying.

A few years ago I had my mom, dad, girlfriend and her family all get a cold. They were all in bed for a week and sick for 2 weeks with this thing.

One afternoon I was out and started feeling really sick. I always thought the bowel tolerance stuff was quackery too...but decided what the heck. I took 50 grams all at once and kept taking it. Yeah, I was crapping water like a fire hose. But I woke up the next morning almost fine. I continued with mega doses and was 100% the next morning.

I have taken doses up to 100 grams/day since all with relatively similar results...sometimes less effective but obviously effective in my mind.

Maybe I am a quack...but I am not sick. Haha
100g/day!?!?!

Wow. Good thing its water soluble, and any excess is just excreted LOL. Vitamin C is an overlooked nutraceutical IMO, and capable of much more than just optimizing immune function. Consider for example, that just 1,500mg/day resulted in lower levels of cortisol and inflammation in athletes*.

Also, there appears to be a link between Vitamin C levels and muscle, as evidenced by this study**. A deficiency of such caused both muscle atrophy and a noted decrease in performance.


* https://www.ncbi.nlm.nih.gov/pubmed/11590482
** https://www.nature.com/articles/s41598-019-41229-7
 
manifesto

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This is great info....I recently started taking 2g's recently
 
HIT4ME

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100g/day!?!?!

Wow. Good thing its water soluble, and any excess is just excreted LOL. Vitamin C is an overlooked nutraceutical IMO, and capable of much more than just optimizing immune function. Consider for example, that just 1,500mg/day resulted in lower levels of cortisol and inflammation in athletes*.

Also, there appears to be a link between Vitamin C levels and muscle, as evidenced by this study**. A deficiency of such caused both muscle atrophy and a noted decrease in performance.


* https://www.ncbi.nlm.nih.gov/pubmed/11590482
** https://www.nature.com/articles/s41598-019-41229-7
Yup. I mix it in drinks so strong it burns going down and is tough to drink. But sucking it down and having uncontrollable water flowing out my bowels for a day beats the heck out if some ding a week in bed sick. Plus, the toilet runs aren't painful (just inconvenient) and sometimes I will start feeling better, literally, in hours.
 
ValiantThor08

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Just found you can purchase injectable vitamin C online. Game changer.
 
HIT4ME

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HIT4ME

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Can inject IM. Just google search it. Shows right up. And cheap.
Just because you can doesn't mean you should. I am guessing the small amount if Vitamin C you would be getting IM would not be worth it. It looks like the vials that come up are about 250 my/ml - so even at 6 ml that is just 1.5 grams. 6 ml would be a heck of a painful injection and, as stated above, Vitamin C itself burns anyway and can leave your muscle sore for days.

When injecting IV in hospital settings it is often in 10, 20 or even 25 gram doses over time. This will significantly elevate peak plasma levels vs. Oral - but I am not sure IM injection will have the same benefits.
 
ValiantThor08

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Just because you can doesn't mean you should. I am guessing the small amount if Vitamin C you would be getting IM would not be worth it. It looks like the vials that come up are about 250 my/ml - so even at 6 ml that is just 1.5 grams. 6 ml would be a heck of a painful injection and, as stated above, Vitamin C itself burns anyway and can leave your muscle sore for days.

When injecting IV in hospital settings it is often in 10, 20 or even 25 gram doses over time. This will significantly elevate peak plasma levels vs. Oral - but I am not sure IM injection will have the same benefits.
I'm not sure of IM benefits either, just interesting. I am greatly interested in IV C administration.
 

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I just picked up 2lbs of bulk powder. Perhaps not as efficacious as IM or IV, but according to the Dr. in that presentation - still gets the job done. Just takes a little longer..

People using 250-500mg/day.... doesn't surprise me they don't think it works. High dose C though, is an entirely different ballgame. Down enough to saturate, and you start noticing good things - both when you're healthy and coming down with something..
 
GreenMachineX

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I just picked up 2lbs of bulk powder. Perhaps not as efficacious as IM or IV, but according to the Dr. in that presentation - still gets the job done. Just takes a little longer..

People using 250-500mg/day.... doesn't surprise me they don't think it works. High dose C though, is an entirely different ballgame. Down enough to saturate, and you start noticing good things - both when you're healthy and coming down with something..
Agreed!
 
HIT4ME

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I'm not sure of IM benefits either, just interesting. I am greatly interested in IV C administration.
Yeah, but IV has some risks that make it not really worth it for typical use this way. I do wish hospitals were a little more aware of this type of thing or that you could ask for it and not be laughed at in most hospitals - but that's a different story.

It does make me want to learn to give myself an IV on some level. It is definitely interesting. But the logic in me doesn't allow me to try it. I'd probably F it all up and kill myself or cause an ER visit for some Vitamin C. How embarrassing would that be?

Nurse: "What is the nature of your visit today?"
Me: "I, um, injected Vitamin C and it didn't go well."
Nurse: "Why did you do that?"
Me: "um....it was interesting?"

I just picked up 2lbs of bulk powder. Perhaps not as efficacious as IM or IV, but according to the Dr. in that presentation - still gets the job done. Just takes a little longer..

People using 250-500mg/day.... doesn't surprise me they don't think it works. High dose C though, is an entirely different ballgame. Down enough to saturate, and you start noticing good things - both when you're healthy and coming down with something..
Yes! This is my big thing with the studies. The "perception" of what high dose is. They do meta studies and find minimal results - but these studies include 500 mg - 1 g doses as the high dose groups a lot of the time. Sometimes it may be 2 grams which is much better. But N-Acetylcysteine won't reverse acetaminophen toxicity if you take 2 grams either. If they did studies on NAC for this and included every patient who got 1 gram of NAC to determine if it helped with APAP poisoning, of course the results would be that it isn't useful.

The pharmacodynamic studies I have seen have shown that 1 gram seems to be the point of diminishing returns for saturation, but I'm not sure this is accurate. It may be accurate for single dose per day administration, but I really think part of the reason for this limitation is the GI effects of large doses. IV will achieve saturation levels as high as 13,000 um/ml at 50 grams, while 1-2 grams of Vitamin C orally seems to reach 200-300 um/ml. My thinking here is that if you took a dose anywhere near the level needed (50 grams) to reach 13,000 um - you would end up crapping out a bunch of it because of the GI effects. But large doses over time may be of benefit. I also wonder if the GI "side effects" of Vitamin C may actually have a positive effect on gut health.

Of course this is all speculation...
 

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There's no doubt high dose (25, 50, even 100g/day) orally has its benefits. And yes, I do think that extends to even when you excrete it. The entire body benefits, and as the Dr. lecturing here said it's been proven to benefit the immune system in 20 different ways - with no toxicity. As in, ZERO.

In many respects, these studies looking at maybe 1-2 grams are analagous to the first studies on anabolics. 50mg/week of Deca isn't going to do jack. So that's what they said. For years, Rx steroids came with an insert saying they won't increase physical performance. Believe it or not, most of the medical community actually believed it.

It's a shame they don't perform these studies with a much higher dose. Part of me thinks they're afraid of what they'll find...
 
HIT4ME

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There's no doubt high dose (25, 50, even 100g/day) orally has its benefits. And yes, I do think that extends to even when you excrete it. The entire body benefits, and as the Dr. lecturing here said it's been proven to benefit the immune system in 20 different ways - with no toxicity. As in, ZERO.

In many respects, these studies looking at maybe 1-2 grams are analagous to the first studies on anabolics. 50mg/week of Deca isn't going to do jack. So that's what they said. For years, Rx steroids came with an insert saying they won't increase physical performance. Believe it or not, most of the medical community actually believed it.

It's a shame they don't perform these much higher dose studies. Part of me thinks they're afraid of what they'll find...
In fairness, I think the higher dose studies could have some issues. Some underlying diseases could be made worse with large doses of vitamin c IN THEORY and adherance to such a protocol can be difficult. I mean, getting your typical person to suddenly start consuming 20 grams of Vitamin C is going to have some issues, including the bathroom time and many people will just stop taking it and fall out of the study at that point.

But yeah, it would be nice to see a couple studies with 5, 10 up to 20 grams to see what happens.
 
HIT4ME

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I have never experimented with liposomal C. Partially because of the hype - partially because of the expense. Plain old regular ascorbic acid is cheap and it seems to work fine for me. I guess part of it is that I really like Vitamin C but I don't see it as some magical substance - and at some point that is where the hype leads. Sure, maybe if there was some reason I needed even higher levels of vitamin C in my blood stream...like an adjunct treatment for cancer (not a cure itself)....I would consider it. But for $30 I can get 5 grams/day for 200 days and it seems to work very well for me.
 
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I have never experimented with liposomal C. Partially because of the hype - partially because of the expense. Plain old regular ascorbic acid is cheap and it seems to work fine for me. I guess part of it is that I really like Vitamin C but I don't see it as some magical substance - and at some point that is where the hype leads. Sure, maybe if there was some reason I needed even higher levels of vitamin C in my blood stream...like an adjunct treatment for cancer (not a cure itself)....I would consider it. But for $30 I can get 5 grams/day for 200 days and it seems to work very well for me.

If you Google, apparently you can make your own and it makes it more affordable.
 
HIT4ME

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I have never experimented with liposomal C. Partially because of the hype - partially because of the expense. Plain old regular ascorbic acid is cheap and it seems to work fine for me. I guess part of it is that I really like Vitamin C but I don't see it as some magical substance - and at some point that is where the hype leads. Sure, maybe if there was some reason I needed even higher levels of vitamin C in my blood stream...like an adjunct treatment for cancer (not a cure itself)....I would consider it. But for $30 I can get 5 grams/day for 200 days and it seems to work very well for me.
If you Google, apparently you can make your own and it makes it more affordable.
Oh yeah...and a third factor...I am lazy :)
 

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I have never experimented with liposomal C. Partially because of the hype - partially because of the expense. Plain old regular ascorbic acid is cheap and it seems to work fine for me. I guess part of it is that I really like Vitamin C but I don't see it as some magical substance - and at some point that is where the hype leads. Sure, maybe if there was some reason I needed even higher levels of vitamin C in my blood stream...like an adjunct treatment for cancer (not a cure itself)....I would consider it. But for $30 I can get 5 grams/day for 200 days and it seems to work very well for me.


Oh yeah...and a third factor...I am lazy :)
I’m a big proponent of C... although I don’t dose as high as you. What benefits can you attribute to the high dose C? Generally curious- as I’ve thought about increasing my dose.
 
HIT4ME

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I’m a big proponent of C... although I don’t dose as high as you. What benefits can you attribute to the high dose C? Generally curious- as I’ve thought about increasing my dose.
This is tough - because this gets into territory with little scientific backing. For me, I honestly just have 20 years of history with vitamin C where I can subjectively say that when I have had years where I stopped taking it for a while, I can get sick a couple times a year. Maybe I get sick once some years, sometimes twice, sometimes even 3 times.

At 1-2 grams a day this is impacted, sure, and I "feel" like I don't get sick as often and that probably drops to 0-2 times/year. But at 5 grams/day - this drops to 0-1x per year and that is with me hanging out with sick people and just not caring about it. I am often around my parents, my girlfriend and her family, when they are all sick and I get nothing or if they are REALLY sick I get it for around a day. It's not bulletproof and it may be skewed by belief or placebo - but it's a level I've really come comfortable with.

There should also be some reduced cortisol and improved health parameters around redox reactions, but again, a lot of this is hard to really pin down. I will say that Vitamin C is the one supplement that I have taken pretty often/regularly (with some breaks) over the past 20 years and I sometimes wonder if it is the reason that so many people act so shocked when I tell them I am 40 years old. I saw someone from high school a year ago after not seeing them for 20 years and he literally brought me over to his mother and was like - he looks like he hasn't aged a day! ....Which if I was a woman and people were trying to make me feel good, I would discount, but sometimes it is just strange. I certainly ACT like I haven't aged a day, but that's another story I think.
 
GreenMachineX

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Results: Overall, reported flu and cold symptoms in the test group decreased 85% compared with the control group after the administration of megadose Vitamin C.

Conclusion: Vitamin C in megadoses administered before or after the appearance of cold and flu symptoms relieved and prevented the symptoms in the test population compared with the control group.”

Interesting study here! I’ll be keeping my doses near bowel tolerance for the next several months.
 
HIT4ME

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Results: Overall, reported flu and cold symptoms in the test group decreased 85% compared with the control group after the administration of megadose Vitamin C.

Conclusion: Vitamin C in megadoses administered before or after the appearance of cold and flu symptoms relieved and prevented the symptoms in the test population compared with the control group.”

Interesting study here! I’ll be keeping my doses near bowel tolerance for the next several months.
I like that - and on the bottom of that page is this article, which is a Cochrane review and finds that phophylaxis with Vitamin C is not warranted - and that doses up to 4 grams do not seem to improve outcomes when introduced during the onset of colds.

But, in the same conclusion it states that it does show benefit to individuals exposed to breif periods of severe exercise or cold, it does play a role in respiratory defense mechanisms, and that one large study did show that 8 grams equivocally improved outcomes when introduced during the onset of colds (as opposed to 4 grams having no effect - which demonstrates the possible benefit of larger doses).

https://pubmed.ncbi.nlm.nih.gov/15495002/

Also, liked your study at least using 1 gram/hour and then 3 grams/day. Good finds.
 
GreenMachineX

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I like that - and on the bottom of that page is this article, which is a Cochrane review and finds that phophylaxis with Vitamin C is not warranted - and that doses up to 4 grams do not seem to improve outcomes when introduced during the onset of colds.

But, in the same conclusion it states that it does show benefit to individuals exposed to breif periods of severe exercise or cold, it does play a role in respiratory defense mechanisms, and that one large study did show that 8 grams equivocally improved outcomes when introduced during the onset of colds (as opposed to 4 grams having no effect - which demonstrates the possible benefit of larger doses).

https://pubmed.ncbi.nlm.nih.gov/15495002/

Also, liked your study at least using 1 gram/hour and then 3 grams/day. Good finds.
National vitamin C shortage coming soon 😂

I have another I’ll post soon as well...
 
HIT4ME

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How about this? Unfortunately a review and my a study, but Vitamin C reduced ventilation times for the most critically ill patients by 25%. Still, with only the abstract I cannot analyse whether or not death rates were a factor.

 
GreenMachineX

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How about this? Unfortunately a review and my a study, but Vitamin C reduced ventilation times for the most critically ill patients by 25%. Still, with only the abstract I cannot analyse whether or not death rates were a factor.

Can’t answer that, but I wonder what 12g would have done!
 
GreenMachineX

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Check this one out...


“Vitamin C (ascorbic acid) possesses anti-viral activity. It has been shown that vitamin C is an essential factor in the production of the anti-viral immune response during the early phase of viral infection through the production of type I interferons (Kim et al. 2013), which up-regulates Natural killer (NK) cell and cytotoxic T-lymphocyte activity (Madhusudana et al. 2004). Also, studies have indicated that ascorbic acid can be used as an inactivating agent for both RNA and DNA viruses, lessening viral infectivity (Jariwalla and Harakeh, 1996; Byun and Jean,2011). In addition, ascorbic acid can detoxify viral products that produce pain and inflammation (Harakek et al .1990). High dose IV Vitamin C has been shown to be effective against viral infections such as the common cold rhinovirus (Hemila and Herman,1995); avian virus H1N1 (Ely,2007;) Chikungunya (Gonzalez et al. 2014; Marcial-Vega et al,2015); Zika (Gonzalez et al 2016) and influenza (Zarubaeva et al.2017). Also oral supplementation with vitamin C (doses over 3g) appears to be able to both prevent and treat respiratory and systemic infections (Carr and Maggini, 2017).”
 
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There are reports of China shipping LARGE quantities of Vitamin C into the Wuhan area...

I'm surprised Vitamin C isn't sold out everywhere online...I just ordered a large quantity.

People need to stop fighting over toilet paper, and focus on health.
 
ValiantThor08

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There are reports of China shipping LARGE quantities of Vitamin C into the Wuhan area...

I'm surprised Vitamin C isn't sold out everywhere online...I just ordered a large quantity.

People need to stop fighting over toilet paper, and focus on health.
Vitamin C is not sold out cause the WHO dismissed vitamin c publicly. Now if they said it may provide benefits, people would be hoarding C, then they would have a need for all that TP xD
 
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Haha yup.

I've tried to speak to people about the importance of vitamins right now, and I feel like it's going through one ear, and it the other....SMH
 

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