Contaygious
Active member
Cool glad I saw this so I can start early and not chalk up to rad accidentally
i ordered a few cognitive boosters
Oxiracetam , phenibut, more noopept ( which seems to be less effective over time)
hopefully these will help with mental energy
hit hard o not I use iforce maxout as a preworkout and that shiat gets me up n running .I'm starting to see a lot of talk on Internet about lethargy and crappy workouts with 677. How long until it passes? Thinking of starting ghari1ne first before the rad
I was wondering if we could get someone on the formulation side to comment. I've been going on label instructions which are listed here:
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and that is to dose with a meal -- not an empty stomach.
Now my initial thought would have been empty stomach, pre-bed, but I've followed the label.
Should I be dosing empty stomach?
To be honest, because of it's mechanism of action, it shouldn't matter how it is taken. It should be effective regardless. Now, whether taking it 'with food' is optimal compared to taking it on an 'empty stomach', my personal recommendation would be on an empty stomach. However, considering the versatility of MK-677, it is recommended for those cutting and bulking. So for those bulking, taking it with a meal may be unavoidable if your stomach is rarely ever empty. It's also recommended to dose more than once per day if bulking, making it even more difficult to take it on an empty stomach. Yet there are logs out there of people bulking on MK-677 with success, so if that is an indication of anything, it's that it doesn't inhibit it's effectiveness. So while I cannot say why the label indicates taking it with a meal, I can assure you the product should remain effect regardless of when you take it.
I would think if you can't rearrange you meal schedule, early morning on an empty stomach is your other option.
How does this affect how you feel during the day? Does it make you sleepy and so forth during the day if you take it in the morning? Never taken this before obviously, and I suppose you could say I'm "bulking" as I'm pretty much eating constantly from before my first class to before I go to bed.
So I'm trying to figure out the best time to take my doses. I can always experiment and mess around with dosing times and conditions regarding meals and so forth but it's always good to get others' experiences as well and determine the best route to maybe start with.
From what I've seen so far its hit or miss.. People getting tired throughout the day even with night time dosage.
Agreed. Growth hormone in the body has always been really interesting to me.
I may do a log just for sh*ts and giggles. Already got a log going but maybe will do one for this too
Another thought I had was increased prolactin; has anyone had any issues with this in regards to MK 677 supplementation? I already have pramipexole on hand from back in the day (last year...) when trenavar was still on the market. Lol. So I may run that at a low dose during this MK cycle.
I am already using letrozole to combat some gyno issues I'm currently having and once that clears up I also have aromasin and nolvadex on hand.
Also, just my 2 cents after reading a small portion of this thread: I have never taken a BLR product (and I have taken a few) and thought, "Wow! That worked really well!" But I have never taken their letrone product so I don't have an opinion on how well that works.
I look forward to hearing some feedback! Thanks guys.
I believe I'm pretty sensitive to prolactin-related sides, since Ive had painful nipples coming off of stuff that is not supposed to even be "hormonal". I been on mk-677 for about 6 weeks and haven't had any of these sides.
I know that's why you said it, I'm just inquiring because I may run into the same problem, as I am almost always eating when I am awake.
I was just wondering if taking it in the morning would make you want to sleep all day, or if you would still only notice that effect at night and just experience increased hunger during the day regardless of when you take your dose.
UPDATE:
1) I'm at 7 weeks, 4 or 5 weeks (I'd have to check) @ 30 Mg.
2) I gave up on the pre-bed huperzine a while back (or huperzine, period); it just had too many side effects for me, maybe because I jack with my acetylcholine levels enough without the huperzine.
3) I then found that a 10 Mg. dose of melatonin approximately doubled the GH response to GHRP (presumably because it inhibits somatostatin), so I figured I'd give it a try.
4) the melatonin worked well for about the first week, but then I started waking a little too frequently, having a little too restless of sleep.
5) last night I decided to leave off the melatonin. Well, I got an incredible sleep: much deeper, less waking to pee, and very tingly hands again!
I think the problem may lie in the form of melatonin used. Regular quick release melatonin has a very short half-life--about 2.5 hours--often causing a disturbance in the sleep cycle. Researchers suggest using time release melatonin In order to more closely mimic the body's natural release pattern.
I've also found claims that large bolus doses of melatonin may desensitize the brain to melatonin's effects.
6) I will be trying time release to see if it works better. Part of the problem is there is actually very little in the way of studies on the effects of chronic dosing of melatonin, in whatever dose.
7) in the meantime, I'll be looking into other natural somatostatin inhibitors.
Great feedback, especially on the Melatonin. I know I build a tolerance pretty quickly to it. I might look into time released options as well.
As for other somatostatin inhibitors look at CDP-choline:
Administration of CDP-choline in healthy elderly adults resulted in a four-fold increase in serum GH levels, compared with baseline values.
Ceda GP, Ceresini G, Denti L, et al. Effects of cytidine 5'-diphosphocholine administration on basal and growth hormon< -releasing honnone-induced growth homione secretion in elderly subjects. Acta Endocrino! {Copenhl. 1991 May;124(5):5I6-20.
Yeah, the problem with the CDP choline is that I take Alpha-Gpc pre-training. Again, I'm hesitant to Jack with acetylcholine levels too much.
I also use Biotest Brain Candy often (though not always) before my morning walks-- it contains CDP choline.
Understandable. I'm going to be looking into alternative somatostatin inhibitors anyway so I'll likely post back here with a list of what I found.
Coming late to the party. Started reading yesterday just now finished. I will be starting ghar1ine Friday night. It seems for the most part nobody really noticed bloating until 20mg or higher. Did anyone notice bloating with around 10mg doses?
Yes.
I am water logged and bloated . On 10mg only . Lethargy is worst side ....makes me want to stop using
It will get better brother. Just stick with it. Lethargy was the worst I have ever felt, and like you was only 10mg. Lasted about 3 weeks. Im up to 20 now and haven't had any lethargy since it initially presented itself
Bro its been about 5 wks and no change![]()
my preworkout takes care of lethargy when I had it!I am water logged and bloated . On 10mg only . Lethargy is worst side ....makes me want to stop using
I am water logged and bloated . On 10mg only . Lethargy is worst side ....makes me want to stop using
Bro its been about 5 wks and no change![]()
You are on a lot of other compounds as well still, right? Having made several changes as well, correct? This MIGHT impact your lethargy. Or even be more of the cause, depending on a multitude of factors. Lay it all out, maybe we can help get your energy back.
Olympus UK has a lot of interesting stuff I'm interested in, yet vaguely scared of. After reading this thread, Ghar1ne looks interesting. For the least amount of side effects, I assume the best thing to do is dose it near bed, and on an empty stomach? I'm trying to avoid all of those hunger issues/lethargy issues that people are talking of in this thread. Also, in someone who's "younger" (26), would this stuff be useful or not?
Olympus UK has a lot of interesting stuff I'm interested in, yet vaguely scared of. After reading this thread, Ghar1ne looks interesting. For the least amount of side effects, I assume the best thing to do is dose it near bed, and on an empty stomach? I'm trying to avoid all of those hunger issues/lethargy issues that people are talking of in this thread. Also, in someone who's "younger" (26), would this stuff be useful or not?
All my doses have been pre bed and the lethargy still hit like a brick wall
That didn't work either. My pre workout at the time was a full scoop of Stimul8 around 11am. Only difference was the addition of Ghar1ne. Between the hrs of 4 and 6, lethargy would come crashing down. Never failed.
All my doses have been pre bed and the lethargy still hit like a brick wall
Olympus UK has a lot of interesting stuff I'm interested in, yet vaguely scared of. After reading this thread, Ghar1ne looks interesting. For the least amount of side effects, I assume the best thing to do is dose it near bed, and on an empty stomach? I'm trying to avoid all of those hunger issues/lethargy issues that people are talking of in this thread. Also, in someone who's "younger" (26), would this stuff be useful or not?