X-Gels always did seem like they gave me some good mass, I'm a little scared to try it with my joints now lol
I posted this on another board:
They checked for inflammation markers:
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The third placebo-controlled study on Arachidonic Acid (ARA) supplementation in resistance-trained subjects has just been published (1). For those unfamiliar, ARA is a polyunsaturated fatty acid from the omega-6 family. It is considered the most important of its class, and is involved in various...
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3. No/Reduced Inflammation.
Arachidonic acid is a substrate used by the body to make eicosanoids, which are involved in inflammation. This has lead to a popular misconception; ARA supplementation must promote inflammation. Numerous other studies have examined this, and come to similar conclusions. It doesn’t. Inflammation is a tightly regulated biological response, that is not simply initiated by consuming ARA. However, the misconception persists. Leaving almost no stone unturned, the Auckland study addresses this in extensive detail by looking for changes in a wide range of immune cell surface markers (ITGAM, ELANE, CEACAM8, CD68, CD163, CD206) and inflammatory cytokines (IL1B, IL6, CCL2, TNF), at both the systemic and local level. The result:
there was no evidence of elevated inflammation with ARA supplementation in any marker tested, at either the systemic or tissue level. In fact, there was a modest reduction in blood monocyte counts, as well as PBMC mRNA expression of (ELANE) and CD66b (CEACAM8). As the researchers pointed out,
“These changes would appear to reflect, if anything, a reduced basal systemic inflammatory response… These findings do not support the common assertion that heightened dietary intake and tissue abundance of ARA will promote chronic inflammation in otherwise healthy individuals.”
I have plenty of injuries and chronic pain and as long as I take x-gels preworkout only I have had zero systemic pain or joint issues. In the beginning, the developer,
William Llewellyn, suggested no omega-3 intake while supplementing with ARA. I never abided by this and simply took them at different times of the day and the ARA only on workout days. I think the combination of significant strength gains(for a natural supplement) combined with daily dosing(as originally suggested to do) and the removal of all omega-3's and joint supplements(also originally suggested to do) is what caused some to initially report issues with joint pain.
1 whole egg has about 75mg of ARA, depending on size, and I believe this played a role in the success of high egg diets as prescribed by the likes of Vince Gironda and company. The combination of high-quality protein and an anabolic fatty acid was, and is, a pretty potent combination considering you can get them at the grocery store lol. ARA is also mandated by law to be in baby formula and that's when we make the best gains of our lives so it has to work right??? LOL