I don't believe receptors get downgraded, new receptors are grown every day and all have a half life in the body. What does happen however, is the body responds to long term Androgen therapy by having the liver produce more SHBG.....
Long term prohormone use could have whacked out his liver and kidneys not to mention aggravated the heart and prostate since whatever he may have used would have had considerably different activity in specific tissues than Testosterone will.....
Tell him to stick to Testosterone therapy solo..... He'll probably need it for the rest of his life to keep his natural Androgen levels high, he can still recover his Pituitary, but it may take a year to well over a year for it to function as it did. Most are too impatient to deal with that.
Any more cycles will tax his body in irreversible ways, permanent prostate enlargement, heart strain, and plaque buildup from bad cholesterol can and will kill him in the future.
If you're friend decides to take the gift the doctor gave him, and then abuse it by adding even more T, and other AAS and continue this dangerous path then he is a straight up *******EEEE and will **** his life up!
Point 1: YOU CAN AND WILL make awesome gains and lean out on 150-200mgs of Testosterone a week. If you can't make gains on 150-200mg a week which IMO is considered a weak cycle, then you my friend are a *****. Natural athletes, College and Professional Athletes ALL can get by getting huge on Natural T of 400-750, so why can't you make gains on 900-1200 Total T??? No excuse
Point 2: You need to give your body a clean break from all the excess androgens. Cholesterol must be out of whack, PSA might be elevated, Liver values probably efffed up, and kidney function must be impaired. (remember Kidney damage is different than Liver damage, the kidneys do not really regenerate like the liver)
Point 3: Going back to the cholesterol, which I find a touchy subject because that is the killer in my family. A sloppy diet, combined with 2 years of cycling and even more AAS will clog your arteries! LDL and Lipoprotein levels have probably been consistently high for 2 years, plus even on TRT slightly elevated. He is possibly enducing heart disease which WILL cost him his life and/or quality of life as he gets older. Get him on just TRT, and drink liquid fish oils every day plus lots of healthy cardio RUNNING.
^^^^^ Can't stress this enough
Point 4. Not really a point, but save the damn money! Who has hundreds of dollars to keep spending all the time. Take your kid or wife or gf out to the gym with you instead and use the money to buy them a membership and some protein or good food.
Anyways, just looking out because though I believe modest AAS cycles to be safe. Extended and reckless use will kill you by causing underlying side effects.
God bless, and hope he does the right thing and just do TRT for at least 7-8 months before THINKING of doing anything else.
AND BUY CARLSON'S FISHOILLLLLL Very important he get's his LDL in check
