I ran a bottle of shift with an eca stack and e and alphamine, depending on the day. I pretty much took all on an empty stomach, then did a fasted cardio session. I dropped around 5 pounds. cant say what it really contributed as ECA is very effective imo, and almost impossible to beat with supps from what ive experienced. I cant tell you that it did not give me any issues. Even when i took 2 scoops alphamine as a caffiene source, 1 bronkaid, and 81 aspirin, plus the shift i had no issues. However i will not reccommend doing it, its alot going on at once and after about a week i decided i might be risking too much since its alot of stims.