PhosphatidylSerine Benefits

MattPorter

MattPorter

Banned
I am really fascinated with Phosphatidyl Serine and it's ability to attenuate the negative effects of exercise induced cortisol.

I am also seeing a correlation with naturally high cortisol levels and environmentally provoked high cortisol levels and lowered Testosterone production.

It would seem that PhosphatidylSerine would be ideal in a Post Cycle Therapy as an "indirect T booster" via -->cortisol lowering pathways.

It also looks like phospholipids will serve as a major catalyst in the biosynthesis of cholesterol-->testosterone conversion.

Invalid Link Removed became 'sexy' to me again....just kind of forgot about it.

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-Matt
 
What if I told you that exercise-induced cortisol is correlated with increased LBM and may actually be a beneficial adaptation for hypertrophy? Would you still be so staunchly behind the effects of PS (which I love by the way, but definitely not for the reasons you mentioned)?
 
Much like administering antioxidants periworkout to reduce exercise-induced ROS, I think it would be a rather dumb idea to use an anti-cortisol supplement around workout times: Invalid Link Removed. If not for that reason, then because exercise is a great time for lipolysis to occur, a process which will be blunted if you reduce cortisol prematurely. Conversely, in muscle tissue, cortisol is really only catabolic to muscle protein in a chronically elevated, unnatural state.

So while Matt is correct in saying PS is a pretty versatile ingredient, he likes it for all the wrong reasons.
 
Sub'd for more info. Subject has always kind of interested me. In general I always felt that these things may be detrimental for reasons posted in link, etc.

Coop I know you like Anabeta Elite, so do the same ideas hold for dosing of that and Reduce XT around workouts (or I guess not around them)?
 
Reduce XT and Anabeta Elite do not reduce cortisol, but rather have an impact on an enzyme related to cortisol predominantly in adipose, resulting in fat deposition/adipogenesis. See the link above: Invalid Link Removed.
 
mr.cooper69 said:
Reduce XT and Anabeta Elite do not reduce cortisol, but rather have an impact on an enzyme related to cortisol predominantly in adipose, resulting in fat deposition/adipogenesis. See the link above: Invalid Link Removed.
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Figured I was missing the concept somewhat. Thanks will read up on this more now. :thumbsup:
 
Subbng for info because I feel PS is highly underrated for its benefits partially because the know abouts aren't out in the open.

OS-Team App Nut
 
Movin_weight said:
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Really awesome thread.

I like where the discussion is going on stress induced cortisol vs. Exercise induced.
 
mr.cooper69 said:
Much like administering antioxidants periworkout to reduce exercise-induced ROS, I think it would be a rather dumb idea to use an anti-cortisol supplement around workout times: Invalid Link Removed. If not for that reason, then because exercise is a great time for lipolysis to occur, a process which will be blunted if you reduce cortisol prematurely. Conversely, in muscle tissue, cortisol is really only catabolic to muscle protein in a chronically elevated, unnatural state.

So while Matt is correct in saying PS is a pretty versatile ingredient, he likes it for all the wrong reasons.
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i missed where he said ingesting PS periWO??
yes he mentions exercise-induced cortisol but i don't think that specific timing scenario is what he had in mind..just one of the many benefits, to wipe out any worry when PS supplementation is incurred on a daily basis..
i also thoroughly enjoy this for pct - matt you know i love EndoAMP and TRS. :yup:
 
snagencyV2.0 said:
i missed where he said ingesting PS periWO?? yes he mentions exercise-induced cortisol but i don't think that specific timing scenario is what he had in mind..just one of the many benefits, to wipe out any worry when PS supplementation is incurred on a daily basis..i also thoroughly enjoy this for pct - matt you know i love EndoAMP and TRS. :yup:
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The effect of PS is acute. If you want to mitigate exercise-induced cortisol, then by default the dose would have to be periworkout.
 
mr.cooper69 said:
The effect of PS is acute. If you want to mitigate exercise-induced cortisol, then by default the dose would have to be periworkout.
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Makes sense... cortisol peaks mid workout. It's really THAT acute of effects for PS that a pre/post dosage would be ineffective?
 
OrganicShadow said:
Makes sense... cortisol peaks mid workout. It's really THAT acute of effects for PS that a pre/post dosage would be ineffective?
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I never said that. Cortisol peaks about 45 minutes into an intense training session. I've been saying periworkout (pre/post/intra) is not a good idea for optimizing body composition.
 
Ohhh I misread that.
 
mr.cooper69 said:
What if I told you that exercise-induced cortisol is correlated with increased LBM and may actually be a beneficial adaptation for hypertrophy? Would you still be so staunchly behind the effects of PS (which I love by the way, but definitely not for the reasons you mentioned)?
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I was mostly concerned with its use as a PCT adjunct. Also, perhaps making steroids work better.

What references do you have the show cortisol promotes hypertrophy or anabolism? This is good info coop.

I definitely understand cortisol effects that come about in natural 'acute' ways like through exertion through exercise and its ability

to promote lipolysis ,, but how does this affect LbM accrual? I am more concerned about tipping the favor of utmost muscle growth , rather than oxidizing fatty acids.

-Matt
 
This is something I have never understood. Why would cortisol spike after your body was in such an anabolic state?
 
AZMIDLYF said:
This is something I have never understood. Why would cortisol spike after your body was in such an anabolic state?
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If your referring to heavy weight training it would be more so catabolic as you are breaking down muscle tissue during that time period.

-Matt
 
But you are breaking down muscle tissue whether on cycle or off cycle. I just never grasped why everyone always said your cortisol spikes when coming off a cycle.
 
AZMIDLYF said:
But you are breaking down muscle tissue whether on cycle or off cycle. I just never grasped why everyone always said your cortisol spikes when coming off a cycle.
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SOmething like trenbolone is a glucocorticoid antagonist so that is a much different scenario than being UN assisted and breaking down muscle tissue with only endogenous levels

-Matt
 
MattPorter said:
I was mostly concerned with its use as a PCT adjunct. Also, perhaps making steroids work better.

What references do you have the show cortisol promotes hypertrophy or anabolism? This is good info coop.

I definitely understand cortisol effects that come about in natural 'acute' ways like through exertion through exercise and its ability

to promote lipolysis ,, but how does this affect LbM accrual? I am more concerned about tipping the favor of utmost muscle growth , rather than oxidizing fatty acids.

-Matt
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Someone actually posted a link to the study in this thread, right after I made the post. Exercise-induced cortisol increases are correlated with higher LBM and lower fat mass.
 
Well some catabolism needs to happen in order to drive anabolism.
 
OrganicShadow said:
Well some catabolism needs to happen in order to drive anabolism.
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Yes -- just like inflammation is crucial in muscle growth and why nsaids and fishoil etc need to be in check.

Would be cool to see more studies than the one that was posted.

I like using PS (endoamp) upon rising with my carbless breakfast

-Matt
 
MattPorter said:
Yes -- just like inflammation is crucial in muscle growth and why nsaids and fishoil etc need to be in check.

Would be cool to see more studies than the one that was posted.

I like using PS (endoamp) upon rising with my carbless breakfast

-Matt
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Do you keep your carbs fairly low offseason even?
 
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