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Oratropin 1 Info

Quote: EDIT: Yes, IGF can bypass the BBB. However, there is no connection between this method of bypassing the BBB and your technology.[/quote]

Intranasal, pulmonary and sublingual are buccal mucosa targeted drug delivery.
 
jrkarp said:
You have got to be kidding.

First, while the nose and mouth are connected by the same passage, the nerves involved in the transmission that you posted are in the nose only. The substance you are trying to administer has to come in contact with the nasal passages and then goes to the olfactory and trigeminal nerves.

Second, yes, most viruses are inhaled through the nose and mouth. From there they go into the lungs and from the lungs go into the bloodstream, or they cause local infections in the respiratory tract. In any case, they are NOT absorbed through the mouth in the same way as your product.

Finally, you have been caught passing completely bogus and baseless claims in this thread. Don't try to cover that up by talking about how I don't understand your technology. The claims you have been making are insulting to my intelligence and to the intelligence of the other members here.
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The brain contains insulin receptors. Insulin and IGF-1 both bind to the same receptors, they compete. If IGF-1 is receptor mediated, it would cross the BBB much like Insulin does.
Insulin and IGF-1 are very similar in amino acid sequence (hence, "Insulin-Like") not sure about weight in daltons though. The both bind to the same receptors

Insulin passes through the BBB:
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"Insulin and insulin-like growth factor-I (IGF-I) receptors are highly homologous tyrosine kinase receptors that share many common steps in their signaling pathways and have ligands that can bind to either receptor with differing affinities."
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If one were to show how IGF-1/oratropin crosses the BBB originating from the mouth, using intranasal would be a good comparison.
 
jrkarp said:
IGF's molecular weight is about 50% larger than that of Insulin, so I would hardly say that they are almost the same.
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I looked up IGF-1 and insulin in the Merck Index 13th ed. and they are as follows, pretty close in Da:

IGF-1 = 7648Da
Insulin = 6000Da
 
Cap, you seem like a shill, but whatever.

To the Grunt76, the guy who neg repped me for "trying to steal trade secrets," please explain how I was doing that. It's an especially amusing accusation, since intellectual property law is one of my specialties.

I have no hard feelings towards IBE. I think that discussion and debate are healthy and in the end, the information that is obtained only benefits consumers. I stand by most of my points for the time being.
 
Well I thought the explanation given by IBE was crystal clear and needed no further clarification, but you kept on insisting that his EXAMPLES didn't give out the exact process by which Long R3 IGF-1 crosses the BBB, wanting more explanations. I find that downright rude, but then again I'm French-Canadian.
 
His explanation was full of holes. When you make statements about an expensive product with (thus far) no research backing it up, you need to provide at least some solid foundation for those statements.

BTW, if the technology is patented, it cannot be a trade secret. Patents are public documents, and the required disclosure would destroy any trade secret protection.
 
I know, you simply asked him to explain a trade secret and then insist when he's not spelling it out for you. Maybe the technology he uses IS patented and maybe he licenses it and maybe using it in THAT way is a trade secret. Mkay?
 
bioman said:
With alcohol, perhaps it is exerting an insulin-like effect by shuttling the ethanol more quickly into the brain?
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I wonder if leeching all the sugar in the bloodstream that comes to the brain would do that. Kinda the reverse of when you eat, you feel less drunk.

Well of course that's just speculation.
 
Grunt76 said:
I know, you simply asked him to explain a trade secret and then insist when he's not spelling it out for you.
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Actually, looking back, I can't find a post where I asked for an explanation. Can you maybe show me one? Looks to me like all I did was call him out on a few statements.
 
Grunt76 said:
Maybe the technology he uses IS patented and maybe he licenses it and maybe using it in THAT way is a trade secret. Mkay?
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First off, there is no reason to be condescending.

Second, stop guessing about the trade secret thing.
 
Grunt76 said:
Split hairs as long as you want. Good night.
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LOL Split hairs? You accuse me of something and then can't back up your accusation.

That's splitting hairs?
 
JRkarp..chill man. It's very obvious that oratropin works..just look at the feedback, so no reason to doubt every single thing IBE claims.
 
If you read my posts, I said I wasn't questioning its efficacy.

However, the fact that it appears to work does not, by itself, make everything that IBE says true.

And I don't doubt everything he says. This argument was about the IGF from Oratropin crossing the blood brain barrier.
 
No, JKarp brings up some valid questions. Discussions such as these are healthy for this board as long as they remian civil..which they have thus far. It is not rude to dispute claims made by a manufacturer, particularly when they are unable to produce data backing up their claim. This is NOT to say that IBE is being deceptive, rather they may feel the need to keep their trade secrets..secret, or the data is just not there yet.

We all know Oratropin works. Discussing and learning HOW it works is healthy for the consumer and the vendor.

Just continue to be civil and we'll all benefit by learning more as this intellectual debate continues.
 
bioman said:
No, JKarp brings up some valid questions. Discussions such as these are healthy for this board as long as they remian civil..which they have thus far. It is not rude to dispute claims made by a manufacturer, particularly when they are unable to produce data backing up their claim. This is NOT to say that IBE is being deceptive, rather they may feel the need to keep their trade secrets..secret, or the data is just not there yet.

We all know Oratropin works. Discussing and learning HOW it works is healthy for the consumer and the vendor.

Just continue to be civil and we'll all benefit by learning more as this intellectual debate continues.
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:clap2: That's why your name is red ;)
 
jrkarp said:
Cap, you seem like a shill, but whatever.

To the Grunt76, the guy who neg repped me for "trying to steal trade secrets," please explain how I was doing that. It's an especially amusing accusation, since intellectual property law is one of my specialties.

I have no hard feelings towards IBE. I think that discussion and debate are healthy and in the end, the information that is obtained only benefits consumers. I stand by most of my points for the time being.
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A shill?
jrkarp, got no problems with you, just discussing IGF-1 and the BBB.
I posted that the weight in da were similar just to show the close relation of insulin to IGF-1, hence, receptor mediated trancytosis. It's an interesting discussion, IGF-1 and the BBB. IGF-1, if crossing the BBB, can be a treatment for Alzheimers and other linked diseases.
 
capnpappy said:
A shill?
jrkarp, got no problems with you, just discussing IGF-1 and the BBB.
I posted that the weight in da were similar just to show the close relation of insulin to IGF-1, hence, receptor mediated trancytosis. It's an interesting discussion, IGF-1 and the BBB. IGF-1, if crossing the BBB, can be a treatment for Alzheimers and other linked diseases.
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I understand that, but again, as I have said before, the fact that IGF is able to bypass the BBB in some instances does not, by itself, mean that Oratropin does the same thing. There is, up to this point, no connection between the studies that have been posted and Oratropin.

As for the shill comment, well, that remains to be seen, but at this point, you have 8 posts, and 7 of them are defending IBE's claims which, thus far, are largely unsubstantiated.
 
jrkarp said:
I understand that, but again, as I have said before, the fact that IGF is able to bypass the BBB in some instances does not, by itself, mean that Oratropin does the same thing. There is, up to this point, no connection between the studies that have been posted and Oratropin.

As for the shill comment, well, that remains to be seen, but at this point, you have 8 posts, and 7 of them are defending IBE's claims which, thus far, are largely unsubstantiated.
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Intranasal is a good comparison to oral administration, or absorption in the mouth because the mucosa are interconnected. it is a better comparison than injection, that's all I've been alluding to. That was my take on that posted reference that "I POSTED" originally. I am not necessarily dicussing oratropin, discussing IGF-1 in its entirety.
 
btw, jrkarp, I am going to keep arguing with you because I don't think, "Peace" will be in my best interest, considering your avatar.
 
capnpappy said:
Intranasal is a good comparison to oral administration, or absorption in the mouth because the mucosa are interconnected. it is a better comparison than injection, that's all I've been alluding to. That was my take on that posted reference that "I POSTED" originally. I am not necessarily dicussing oratropin, discussing IGF-1 in its entirety.
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Fair enough, if you are not discussing Oratropin. However, when the intranasal involves travel though a nerve found only in the nose, I don't know how useful the comparison is with regards to Oratropin.
 
capnpappy said:
btw, jrkarp, I am going to keep arguing with you because I don't think, "Peace" will be in my best interest, considering your avatar.
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LOL I need to change it, but I haven't found anything. It's getting a bit old. Actually, it means using superior firepower to achieve peace, so maybe surrender would be in your best interest so I don't have to use it.

:icon_lol:
 
jrkarp said:
LOL I need to change it, but I haven't found anything. It's getting a bit old. Actually, it means using superior firepower to achieve peace, so maybe surrender would be in your best interest so I don't have to use it.

:icon_lol:
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LMAO, yeah, maybe!
I've never shot a gun in my life. My brother-in-law is an Army ranger and he almost passed out in laughter when I told him I'm a gun virgin.

The question that i have regarding IGF-1 and the BBB is whether or not IGF-1 receptors in the brain would create an affinity to absorb IGF-1 across the BBB. This signalling occurs with IGF-1 systemically with glucose and other receptors throughout the body. It is interesting and I bet biotech companies like Amgen are studying such mechanism for the BBB. A lot of drugs are in clinicals that work but cannot be administered via injection; ophthalmic (eye) drugs etc.. (they are using eye drops now, but that is limited for obvious reasons). If you could mediate across the BBB via receptor affinity, a lot of diseases would be treated.
 
badbart said:
Does Oratropin 1 make connective tissue stronger, weaker or grow?
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I was wondering the same thing. I have a torn rotator cuff and I didn't know if taking this may speed the healing or if It would be a waste. anythoughts.
 
Gland777 said:
Just for those that are considering buying the Oratropin I would like to say the actual service was VERY SLOW and I had no return calls...,;however, the product seems to be THE REAL DEAL. I have been on the stuff for 1 week and my pumps have been EXCELLENT. I believe this stuff is very anabolic. It is not like anabolic steroids though. My strength is about the same...but my muscles feel hard and ready for intense training. My hands and fingers feel a bit stiff. My appetite is strong. I look forward to the rest of the cycle.
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I tried this around 2 years ago, not even close to injectible IGF-1, i gained 2 lbs during post cycle therapy at the time, but lost it all after i stopped thde oratropin.

I wouldnt be suprised if it was just a little bit of dbol or something in it, as i do not see how IGF-1 can effectivly be absorbed via the oral route, but maybe im wrong, im far from an expert when it comes to delivery application.
 
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