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Pattern-Dependent Suppression of Growth Hormone (GH) Pulsatility by Ghrelin and GH-Releasing Peptide-6 in Moderately GH-Deficient Rats -- Thompson et al. 144 (11): 4859 -- Endocrinology
In this study, 7-d intermittent (i.e. every 3 h) infusion of ghrelin, or the GH secretagogue, GH-releasing peptide-6, in the moderately GH- deficient transgenic growth-retarded rat, augmented GH secretion, leading to a sustained acceleration in skeletal growth. In contrast, continuous infusion of ghrelin, or GH-releasing peptide-6, suppressed the amplitude of spontaneous GH secretory episodes and produced only a transient increase in body weight gain.
bottom line being that continuous < intermittent in terms of efficacy. might serve to confirm IM versus subQ adminstration...i reckon IV infusion is FAST, so IM may be the preferred method.
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin -- van der Lely et al. 25 (3): 426 -- Endocrine Reviews
In summary, administration of ghrelin and of at least some of its receptor agonists generates a positive energy balance and increases adiposity in rodents via multiple mechanisms, including increased food intake and reduced fat oxidation, possibly along with decreased locomotor activity and adipocyte-specific effects. In addition, expression of GHS-R in rat adipocytes increases with age and during adipogenesis. Ghrelin in vitro stimulates the differentiation of preadipocytes and antagonizes lipolysis. Ghrelin may therefore play an important role in the process of adipogenesis in rats.
among many other items of interest in that study/review...GHS's might make you fat.
The most representative of these nonpeptidyl GHS that was studied in humans was the spiroindoline L-163,191 (MK-0677) (14, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105). MK-0677 has been shown to possess a high bioavailability and is able to enhance 24-h GH secretion after a single oral administration
wow, that's something to look into, peptide people! here's a full-up study for MK-0677:
Design and Biological Activities of L-163,191 (MK-0677): A Potent, Orally Active Growth Hormone Secretagogue -- Patchett et al. 92 (15): 7001 -- Proceedings of the National Academy of Sciences
big GH spikes from single oral administration, even after 2 hours!
more to come...
In this study, 7-d intermittent (i.e. every 3 h) infusion of ghrelin, or the GH secretagogue, GH-releasing peptide-6, in the moderately GH- deficient transgenic growth-retarded rat, augmented GH secretion, leading to a sustained acceleration in skeletal growth. In contrast, continuous infusion of ghrelin, or GH-releasing peptide-6, suppressed the amplitude of spontaneous GH secretory episodes and produced only a transient increase in body weight gain.
bottom line being that continuous < intermittent in terms of efficacy. might serve to confirm IM versus subQ adminstration...i reckon IV infusion is FAST, so IM may be the preferred method.
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin -- van der Lely et al. 25 (3): 426 -- Endocrine Reviews
In summary, administration of ghrelin and of at least some of its receptor agonists generates a positive energy balance and increases adiposity in rodents via multiple mechanisms, including increased food intake and reduced fat oxidation, possibly along with decreased locomotor activity and adipocyte-specific effects. In addition, expression of GHS-R in rat adipocytes increases with age and during adipogenesis. Ghrelin in vitro stimulates the differentiation of preadipocytes and antagonizes lipolysis. Ghrelin may therefore play an important role in the process of adipogenesis in rats.
among many other items of interest in that study/review...GHS's might make you fat.
The most representative of these nonpeptidyl GHS that was studied in humans was the spiroindoline L-163,191 (MK-0677) (14, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105). MK-0677 has been shown to possess a high bioavailability and is able to enhance 24-h GH secretion after a single oral administration
wow, that's something to look into, peptide people! here's a full-up study for MK-0677:
Design and Biological Activities of L-163,191 (MK-0677): A Potent, Orally Active Growth Hormone Secretagogue -- Patchett et al. 92 (15): 7001 -- Proceedings of the National Academy of Sciences
big GH spikes from single oral administration, even after 2 hours!
more to come...
