Mk667- The No BS Straight Scoop ....

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ericos_bob

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LOL it's cool I didn't take your comment to be in any way derogatory.
 
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muchstronger2

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I’m currently dosing 50mg morning + 50 mg evening as studies show no plateau in GH elevation response until 100mg/day.
Will test for IGF-1 levels in 2 months
 
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CatSnake

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Would stacking this with metformin make any sense?
depends.

Metformin can lower T production...

https://www.ncbi.nlm.nih.gov/pubmed/11707532

RESULTS:
Metformin and hypocaloric diets led to decreases in BMI and waist and hip circumferences in both groups. A significant decrease in TT levels in the diabetic group and FT levels in the control group was found, whereas follicle-stimulating hormone, LH, and DHEAS levels were not changed significantly. A significant increase in SHBG levels was observed in the control group but not in the patient group. Leptin levels also decreased after treatment in both groups. Decreased testosterone levels were not correlated to changes in waist and hip circumference, waist-to-hip ratio, BMI, and levels of fasting blood glucose, leptin, SHBG, or DHEAS in the diabetic group. However, a decrease in FT was correlated to changes in the levels of SHBG (r = -0.71, p = 0.001) and LH (r = 0.80, p = 0.001) but not to other parameters.

DISCUSSION:
We conclude that metformin treatment combined with a hypocaloric diet leads to reduced FT levels in obese nondiabetic men and to reduced TT levels in obese men with type 2 diabetes. Increased SHBG levels may account for the decrease in FT levels in the former group.


if you're on cycle/TRT then that's not a concern.



.
 
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muchstronger2

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For those of you wondering why Mk ****s up wity your sleep, here’s a good write up from Reddit:

«*The benefits of using MK-677 will never become comparable to the side effects you're currently experiencing. MK-677 is a ghrelin receptor agonist, so you should probably look up what ghrelin does physiologically to see what you'll experience.

Ghrelin an agonist of the ghrelin receptor. Ghrelin is an orexigenic neuropeptide that inhibits normal cycling between sleep stages, via its tonic and phasic action on the arcuate nucleus of the hypothalamus. Ghrelin release normally follows the circadian rhythm (tonic control), so your body has the lowest amounts before falling asleep, then ghrelin increases steadily before waking up to inhibit sleep. Ghrelin also increases before meal time (phasic control). Basically, if you gave anyone ghrelin, you expect them to be hungry and less able to switch to Slow Wave Sleep, the component of sleep that's important for cognition and memory.

People on here recommend taking MK 677 immidiately before sleep, which goes to show you how broscience dominates bodybuilding. Those people are dumb. If you wanted to enhance the physiological role of ghrelin you'd have to take it a few hours before waking up (like if you go pee in the middle of the night), immidiately upon waking, or before meal times. If you take ghrelin before sleep you WILL have poor quality sleep, fat gain, and arguably a temporary cognitive decline from less SWS. Gastrointestinal distress is the only symptom you're describing that I'd classify as a side effect. The rest is entirely to be expected, and won't go away.

Even if you were to inject yourself with hGH, it'd still take you months to see the positive effects. MK-677 achieves a much more mild increase in growth hormone than hGH injections, so you should expect to wait a few times longer to see an actual benefit besides placebo. MK-677 is effective for weight gain, particularly of fat, but not for anything a bodybuilder would want to use it for.*»
 
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ericos_bob

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Yeah seen that users posts a while back. Makes some valid points and some not so valid point which lend to his bias against MK677 as an effective secretagogue in the face of studies proving otherwise. As for dosing times I always take MK677 early in the AM for this reason due to another study on ghrelin I linked to page 18.
 
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jeffreylawys

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I'm interested in the source for MK-667 that StanleyG mentioned. Sent him a PM but it seems he has not been here for a long time. Can someone send me a PM if they know of that source ? Thanks !

-Jeff
 
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CatSnake

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eh..... I found that it helped my sleep a lot.

Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.
Copinschi G1, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, Van Cauter E.
Author information
Abstract
Previous studies have indicated the existence of common mechanisms regulating sleep and somatotropic activity. In the present study, we investigated the effects of prolonged treatment with a novel, orally active, growth hormone secretagogue (MK-677) on sleep quality in healthy young and older adults. Eight young subjects (18-30 years) followed a double-blind, placebo-controlled, three-period crossover design. Each subject participated in three 7-day treatment periods (with bedtime drug administration), presented in random (Latin square) order, and separated by at least 14 days. Doses were 5 and 25 mg MK-677 and matching placebo. Six older subjects, ages 65-71 years, each participated in two 14-day treatment periods (with bedtime drug administration) separated by a 14-day washout. Doses were 2 and 25 mg MK-677 during the first and second periods, respectively. Baseline sleep and hormonal data were obtained on the 2 days preceding the beginning of the first 14-day treatment period. In young subjects, high-dose MK-677 treatment resulted in an approximately 50% increase in the duration of stage IV and in a more than 20% increase in REM sleep as compared to placebo (p < 0.05). The frequency of deviations from normal sleep decreased from 42% under placebo to 8% under high-dose MK-677 (p < 0.03). In older adults, treatment with MK-677 was associated with a nearly 50% increase in REM sleep (p < 0.05) and a decrease in REM latency (p < 0.02). The frequency of deviations from normal sleep also decreased (p < 0.02). The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence.

https://www.ncbi.nlm.nih.gov/pubmed/9349662
 
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Aeolian251

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So is the CJC-1295 you are stacking with the DAC or no-DAC version?
 
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greg916

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So what’s the consensus on the best way to use this. From what I’ve read, 25mg seems like too much. I don’t want to go over 12.5, especially due to its affect on fasting glucose.

12.5 EOD effective? Dosing morning or maybe mid afternoon?
 
mad_canada

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So what’s the consensus on the best way to use this. From what I’ve read, 25mg seems like too much. I don’t want to go over 12.5, especially due to its affect on fasting glucose.

12.5 EOD effective? Dosing morning or maybe mid afternoon?
No.
25mg is best for muscle gain + fat loss + anti aging.

10mg for primary fat loss.

It's showing to raise GH levels higher at lower Doses and raise igf-1 and growth hormone levels Higher at 25 milligrams per day

The growth hormone increase being responsible for fat loss, while igf-1 being responsible for muscle gain and anti-aging benefits

Of course I 25 mg a day you also get the benefits of elevated growth hormone too.

You must dose it everyday because it has a 24-hour half life so every other day means you will be stopping and starting the process of creating more growth hormone unnecessarily

For more on mk677 you can check out my guide here it's around 2,500 words and goes over pretty much everything

Www.sarminfo.com/mk677guide
 
Toren

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You must dose it everyday because it has a 24-hour half life so every other day means you will be stopping and starting the process of creating more growth hormone unnecessarily[/url]
This information is not true at all. Please do some research for a better understanding on half-lives - biological/terminal as well as blood-plasma. For all intents and purposes most people on these boards are referring to blood plasma half-life. For ease of discussion, just saying half-life is accepted.

If I were to take 25mg of MK for 5 straight days and then abstain from dosing for 2 days, I would still have much of the active compound left in my system - from the last dosage and smaller amounts from previous dosages - and more than enough to elicit a physiological response. Assuming a constant and equal rate of "elimination", which we can only assume for the purpose of this discussion, it would be fair to estimate a remaining dose of ~ 12mg on day 7 of the above-mentioned 5/2 dosing protocol.

Approximate remainging dose after ONE 25mg dose of MK-677 (measured in days): B=25 ...12.5...6.25...3.125...etc. Those amounts would be compounded with repeated daily dosing.

-----------------------------------

I experimented with MK-677 for a year straight and I can say that I "felt" better when I switched from many months of ED dosing (10-30mg) to a few months of the 5on/2off protocol. My skin looked better, my joints felt better, and my product lasted longer as well. I also noticed absolutely no difference in results (fat-loss or muscle gain/maintenance) between the two protocols. People will have to figure out what dosing schedule works best for them but a day or two off from dosing will not STOP pharmacological/physiological effects.
 
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mad_canada

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This information is not true at all. Please do some research for a better understanding on half-lives - biological/terminal as well as blood-plasma. For all intents and purposes most people on these boards are referring to blood plasma half-life. For ease of discussion, just saying half-life is accepted.

If I were to take 25mg of MK for 5 straight days and then abstain from dosing for 2 days, I would still have much of the active compound left in my system - from the last dosage and smaller amounts from previous dosages - and more than enough to elicit a physiological response. Assuming a constant and equal rate of "elimination", which we can only assume for the purpose of this discussion, it would be fair to estimate a remaining dose of ~ 12mg on day 7 of the above-mentioned 5/2 dosing protocol.




-----------------------------------

I experimented with MK-677 for a year straight and I can say that I "felt" better when I switched from many months of ED dosing (10-30mg) to a few months of the 5on/2off protocol. My skin looked better, my joints felt better, and my product lasted longer as well. I also noticed absolutely no difference in results (fat-loss or muscle gain/maintenance) between the two protocols. People will have to figure out what dosing schedule works best for them but a day or two off from dosing will not STOP pharmacological/physiological effects.
The biological half life of hgh secregoges is 24 hours.

All of what I've read says 24 hours, but I'm sure ymmv is a good rule to apply.

https://academic.oup.com/edrv/article/18/5/621/2530767
 
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CatSnake

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No.
25mg is best for muscle gain + fat loss + anti aging.

10mg for primary fat loss.

It's showing to raise GH levels higher at lower Doses and raise igf-1 and growth hormone levels Higher at 25 milligrams per day

The growth hormone increase being responsible for fat loss, while igf-1 being responsible for muscle gain and anti-aging benefits

Of course I 25 mg a day you also get the benefits of elevated growth hormone too.

You must dose it everyday because it has a 24-hour half life so every other day means you will be stopping and starting the process of creating more growth hormone unnecessarily

For more on mk677 you can check out my guide here it's around 2,500 words and goes over pretty much everything

Www.sarminfo.com/mk677guide
huh?

part of the fat loss from hGH is the conversion of insulin to IGF-1 (the other being an increase in conversion of T4 to T3).

you can't differentiate the gains by the dose.... simply how profound they are, and the side effects, as well.
 
mad_canada

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huh?

part of the fat loss from hGH is the conversion of insulin to IGF-1 (the other being an increase in conversion of T4 to T3).

you can't differentiate the gains by the dose.... simply how profound they are, and the side effects, as well.
Sure you can.
The study that did that is located here:

https://www.ncbi.nlm.nih.gov/labs/articles/9329386/

At 10mg, a 52% increase in IGF-I, and 79% increase in GH

At 50mg, a 79% increase in IGF-I, and 82% increase in GH
 
GrizzleB

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I just got some mk in tablet form they're 20mg. Not sure if I should just start at 20 or split them with a cutter and do 10 for the first week...
 
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ericos_bob

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Start at 10mg. If you don't have any sides you can bump the dose. If you find you do experience sides at 10mg stay the course until they subside then bump the dose.
 
GrizzleB

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Start at 10mg. If you don't have any sides you can bump the dose. If you find you do experience sides at 10mg stay the course until they subside then bump the dose.
That's what I was thinking, thanks!
 
YoungThor

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I’m recovering from an injury and would like to dose mk everyday to speed up the process. You mentioned taking two days off. Am I taking a serious risk if I use it everyday? I do take ashwagandha which has been proven to lower cortisol.
 
SBH

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That's what I was thinking, thanks!
I got lethargy from hell running 25 mgs in the morning. Switched to 12.5 at bedtime and had no more problems. Got that sweet high GH release sleep also.
 
Last edited:
NoAddedHmones

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No.
25mg is best for muscle gain + fat loss + anti aging.

10mg for primary fat loss.

It's showing to raise GH levels higher at lower Doses and raise igf-1 and growth hormone levels Higher at 25 milligrams per day

The growth hormone increase being responsible for fat loss, while igf-1 being responsible for muscle gain and anti-aging benefits

Of course I 25 mg a day you also get the benefits of elevated growth hormone too.

You must dose it everyday because it has a 24-hour half life so every other day means you will be stopping and starting the process of creating more growth hormone unnecessarily

For more on mk677 you can check out my guide here it's around 2,500 words and goes over pretty much everything
Well the info on your website is absolutely laughable, the fact you use the work Proven soo many times just shows how little you actually understand about anything you are writing about. Nice plug for your Research Chem store you are clearly trying to push here...are you a board sponsor? Admin
 
mad_canada

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Well the info on your website is absolutely laughable, the fact you use the work Proven soo many times just shows how little you actually understand about anything you are writing about. Nice plug for your Research Chem store you are clearly trying to push here...are you a board sponsor? Admin
Lol. You think I am the company that I have an affiliate account with.
Smart. Very smart.
 
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CatSnake

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Once again you can, they did. See the referenced study.
I didn't see LBM, etc gains in that study... am I missing something?

Side note: I typically try not to reference studies in unhealthy individuals, as it's kinda hard to extrapolate that to healthy men or women. just my .02.
 
50Magnum

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Btw taking 1 baby aspirin with the MK-677 will do nothing for bloat; all that vaso-compress is bullcrap. Go and see other people's results taking mk-677 with the aspirin too; did not work. Some people suggest Clonidine, but that would be too dangerous.
 
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dcoen21

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Is it cjc with dac or without to go along with mk677? Sorry I couldn’t find the specific answer.
 
Old Witch

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Is it cjc with dac or without to go along with mk677? Sorry I couldn’t find the specific answer.
Cjc no dac.

I would prefer hexarelin. I think having a ton of GH floating around all day is no good. Better to use short acting doses, hexarelin is very intense but short acting. Mk677 will intensify it quite a bit. I think for the money you can't get a bigger secretion or dose of GH. 50-100mcg hexarelin plus daily mk677 at 20mg+ would be something close to an 10-12iu GH dose.
 
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danielvp

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When is the best time dose mk-677 relative to hexarelin? Same time?
 
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louisneo7

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Mk677- The No BS Straight Scoop ....



I see so much misinformation on this compound I decided to do a little write up on it to put to rest some misconceptions as far as what it is (and isnt) and what it does (and doesnt do). I will also get into its applications, dosing protocols and stacking it as well.

First of all Mk677 is not a SARM, I repeat Mk677 IS NOT A SARM!! It has been incorrectly marketed as a Sarm and people now actually mistake it for one. A SARM activates the androgen receptor selectively, Mk677 has absolutely no impact on the androgen receptor whatsoever.

So if it isnt a SARM then what is it? t is an oral GHRP (Growth Hormone Releasing Peptide). In other words it is in the same category of compound as GHRP2 and GHRP6 and Ipamorellin except it is orally administered. That factor in and of itself (oral administration) is pretty exciting. One of the hassles with some of the other ghrp's is the frequency with which you have to inject them. An oral compound with the bio-availability necessary to illicit a significant gh release in this category of compound is quite an accomplishment. That being said keep in mind Mk677 is dosed in mg's, the injectable ghrp's are administered in mcg, so obviously a comparatively large amount of mk677 is taken compared to the other ghrps.

Since we have established that Mk677 is a ghrp that immediately helps us to understand better exactly what the compound will do for us. GHRP's act upon the ghrellin receptor eliciting the release of GH. This process is not, however, without a cost. The action upon the ghrellin recptors also elicits an increase in both prolactin and cortisol. There is also an increase in GHIH (growth hormone inhibiting hormone) in the bodies attempt to resume a state of homeostasis. The various ghrp's have differing effects when in comes to the increase in these undesirable hormones. For example GHRP2 causes the most significant increase in them while Ipamorelin causes the least significant increase in them. With the injectable GHRP's there is a direct correlation between the GH release and the increase in undesirable hormone (ie: GHRP= most gh& most undesirable hormones; ipamorelin least gh & least impact on undesirable hormones). This is another exciting thing about Mk677, in addition to oral administration it has a high release of gh with a comparatively low increase in undesirable hormones. Do not get me wrong, there is an increase in these hormones, however compared to the gh release, comparable to other GHRP's, the increase is a low one. In order to offset this increase in Prolactin, Cortisol, and GHIH without taking other compounds the simple protocol of 5 days on, 2 days off administration prevents the build up of these hormones to detrimental levels.

So we now know Mk677 is not a SARM, its an oral GHRP. We also know that it is comparatively speaking a very effective GHRP with a decreased impact on undesirable hormones. So where does it fit in for us and what kind of effects can we expect?

Well where it fits in is anywhere that an increase in GH would be desirable. The thing is this, the increase in GH with Mk677 on its own is high enough to elicit some physical changes and effects. Tats huge. By stacking Mk677 with a GHRH (Growth Hormone Releasing Hormone) such as CJC-1295 or Mod-GRF you can get those GH levels to a very high level. We are talking as high as a moderate dose of actual GH. THAT is huge!! We are talking the equivalent to 4-5iu's of gh daily with a stack of Mk677 (dosed at 25mg/day; 5 days on, 2 off) & CJC-1295 )injected2x/week at a dose of 750mcg/injection). This offers you an infrequent injection, relatively low cost alternative to actual GH. Also with all the bogus GH out there you are much more likely to get legit MK & CJC than legit GH ( I have a solid , reliable source that is a sponsor here- pm me if interested. Rules prevent me from posting their name). Now you could stack Mk677 with another GHRH beside CJC-1295, but the desirable thing abut that GHRH is the infrequent injection schedule which is why I prefer it. BTW I am not pulling these numbers and comparisions to actual GH out of a hat. These are based on my expereince WITH BLOOD WORK to support them.

So I said it is useful wherever GH would be useful. For Example, healing, anti aging and when combined with an anabolic stack increased muscle growth. Will it provide an increase in muscle mass on its own, yes, but no where near where you see some people reporting. There is a lot of BS hype and shilling going on since MK was at one time available as a supplement. This lead to BS and false claims as to its effects and then the"fit in crowd"posted they were getting the same results. (The fit in crowd are the ones that say **** just to fit in). The fact is on its own MK is not extremely anabolic per se, but it is extremely effective (just as effective as GH ) and when combined WITH anabolics it becomes and extremely anabolic addition. Thats the whole premise of GH use in bodybuilding guys. GH in and of itself is not extremely anabolic , especially when compared to steroids. However when added TO steroids, look out!!

Now lets talk a bit abut side effects. I see a ton of people talking about bloat with Mk677. There is a lot of confusion as to why this occurs and how to prevent it. Many people drop the dosage however by doing so you directly impact the potency and effectiveness of Mk. The optimal dose for Mkk677, without a doubt, is 25mg/day. The bloat is caused by an effect in the kidneys caused by the increase in GH on vasopressin. This can easily be offset by the addition of a simple low dose daily aspirin protocol. Thats right, one 82mg aspirin/day with impact ADH (anti dieuretic hormone or vasporessin) to the point where it eliminated the bloat associated with Mk677.

I think that abut covers it. I covered all the main points. Mk is not a SARM, it will not put 10-15bs of muscle on you, it does not drastically increase prolactin or cortisol, and it does not have to cause water retention. Mk677 is, IMO, a god send. It has allowed me too, by stacking it with CJC-1295, be on what is essentially an affordable, infrequent injection, Moderate Dose, GH protocol and I am reaping all the benefits that come with that. Increased sense of well being; improved skin, hair and nails; decreased bodyfat; an increase in muscle mass (that is drastically magnified when on an anabolic of some kind). Overall I think MK is an awesome, albeit misunderstood compound. Most of the misunderstanding has spawned from BS marketing and shilling. My goal was to set the record straight on MK and put the truth out there. What I really dont understand is the compound is awesome enough based on the truth. They never really needed to over-hype it but sadly thats how some industries work.

Anyway I hope this helps someone and feel free to ask any questions on MK you would like. I will answer to the best of my ability based on my knowledge and first hand experience.
StanG
Could you let me know if I could use Ipamorelin & MK677 safely & effectively?
 
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jim2509

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So is there something in the 5 on 2 off protocol with MK677 rather than on 7 days a week??
 
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Does mk677 also effect testosterone or estrogen levels?

I used mk677 a while back, not too long after my pct from a cycle.

I ran it along side a test booster which had an AI, prolactin and cortisol control, and I had no issues, got good pumps.

I ran the mk again from the same company but without a test booster and got gyno after the 2nd week. I stopped the cycle and came back to it a while later at half the dose along side a test booster this time and again, gyno came back with bloating. Maybe that 2nd bottle of mk was something else?
 
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This may be a stupid question, but if I were to get the CJC, how much would I need to run it for 6 months along with the MK. Not familiar with peptides or pinning. Cause I see on a suppliers site they’re 2 mg vials, how many doses is that? If I need 2500mcg a dose? What does that measure up to in a syringe?
 
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So 12 vials of cjc w dac at 2mg/vial and 1200mcg/week being good starter dose would yield a 12 week run as an example. This is a middle of the road dose
So you’re saying I’d need 12?
 
Old Witch

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You only need 2mg a week, or really every six days.
 
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NGtrains

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Yeah unless you can get 5mg vials, then you’d only need five.
Fuck that’s pricey especially since I wouldn’t start the run til I had it all. I planned on running this combo once I start PCT, Looks like I’ll be saving til then
 
Cgkone

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Does mk677 also effect testosterone or estrogen levels?

I used mk677 a while back, not too long after my pct from a cycle.

I ran it along side a test booster which had an AI, prolactin and cortisol control, and I had no issues, got good pumps.

I ran the mk again from the same company but without a test booster and got gyno after the 2nd week. I stopped the cycle and came back to it a while later at half the dose along side a test booster this time and again, gyno came back with bloating. Maybe that 2nd bottle of mk was something else?
Mk677 has no effect on test or estro
 
Cgkone

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This may be a stupid question, but if I were to get the CJC, how much would I need to run it for 6 months along with the MK. Not familiar with peptides or pinning. Cause I see on a suppliers site they’re 2 mg vials, how many doses is that? If I need 2500mcg a dose? What does that measure up to in a syringe?
At least 2mg a week. 5mg would be better
 

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