Mk667- The No BS Straight Scoop ....

StanleyG

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Mk677- The No BS Straight Scoop ....



I see so much misinformation on this compound I decided to do a little write up on it to put to rest some misconceptions as far as what it is (and isnt) and what it does (and doesnt do). I will also get into its applications, dosing protocols and stacking it as well.

First of all Mk677 is not a SARM, I repeat Mk677 IS NOT A SARM!! It has been incorrectly marketed as a Sarm and people now actually mistake it for one. A SARM activates the androgen receptor selectively, Mk677 has absolutely no impact on the androgen receptor whatsoever.

So if it isnt a SARM then what is it? t is an oral GHRP (Growth Hormone Releasing Peptide). In other words it is in the same category of compound as GHRP2 and GHRP6 and Ipamorellin except it is orally administered. That factor in and of itself (oral administration) is pretty exciting. One of the hassles with some of the other ghrp's is the frequency with which you have to inject them. An oral compound with the bio-availability necessary to illicit a significant gh release in this category of compound is quite an accomplishment. That being said keep in mind Mk677 is dosed in mg's, the injectable ghrp's are administered in mcg, so obviously a comparatively large amount of mk677 is taken compared to the other ghrps.

Since we have established that Mk677 is a ghrp that immediately helps us to understand better exactly what the compound will do for us. GHRP's act upon the ghrellin receptor eliciting the release of GH. This process is not, however, without a cost. The action upon the ghrellin recptors also elicits an increase in both prolactin and cortisol. There is also an increase in GHIH (growth hormone inhibiting hormone) in the bodies attempt to resume a state of homeostasis. The various ghrp's have differing effects when in comes to the increase in these undesirable hormones. For example GHRP2 causes the most significant increase in them while Ipamorelin causes the least significant increase in them. With the injectable GHRP's there is a direct correlation between the GH release and the increase in undesirable hormone (ie: GHRP= most gh& most undesirable hormones; ipamorelin least gh & least impact on undesirable hormones). This is another exciting thing about Mk677, in addition to oral administration it has a high release of gh with a comparatively low increase in undesirable hormones. Do not get me wrong, there is an increase in these hormones, however compared to the gh release, comparable to other GHRP's, the increase is a low one. In order to offset this increase in Prolactin, Cortisol, and GHIH without taking other compounds the simple protocol of 5 days on, 2 days off administration prevents the build up of these hormones to detrimental levels.

So we now know Mk677 is not a SARM, its an oral GHRP. We also know that it is comparatively speaking a very effective GHRP with a decreased impact on undesirable hormones. So where does it fit in for us and what kind of effects can we expect?

Well where it fits in is anywhere that an increase in GH would be desirable. The thing is this, the increase in GH with Mk677 on its own is high enough to elicit some physical changes and effects. Tats huge. By stacking Mk677 with a GHRH (Growth Hormone Releasing Hormone) such as CJC-1295 or Mod-GRF you can get those GH levels to a very high level. We are talking as high as a moderate dose of actual GH. THAT is huge!! We are talking the equivalent to 4-5iu's of gh daily with a stack of Mk677 (dosed at 25mg/day; 5 days on, 2 off) & CJC-1295 )injected2x/week at a dose of 750mcg/injection). This offers you an infrequent injection, relatively low cost alternative to actual GH. Also with all the bogus GH out there you are much more likely to get legit MK & CJC than legit GH ( I have a solid , reliable source that is a sponsor here- pm me if interested. Rules prevent me from posting their name). Now you could stack Mk677 with another GHRH beside CJC-1295, but the desirable thing abut that GHRH is the infrequent injection schedule which is why I prefer it. BTW I am not pulling these numbers and comparisions to actual GH out of a hat. These are based on my expereince WITH BLOOD WORK to support them.

So I said it is useful wherever GH would be useful. For Example, healing, anti aging and when combined with an anabolic stack increased muscle growth. Will it provide an increase in muscle mass on its own, yes, but no where near where you see some people reporting. There is a lot of BS hype and shilling going on since MK was at one time available as a supplement. This lead to BS and false claims as to its effects and then the"fit in crowd"posted they were getting the same results. (The fit in crowd are the ones that say **** just to fit in). The fact is on its own MK is not extremely anabolic per se, but it is extremely effective (just as effective as GH ) and when combined WITH anabolics it becomes and extremely anabolic addition. Thats the whole premise of GH use in bodybuilding guys. GH in and of itself is not extremely anabolic , especially when compared to steroids. However when added TO steroids, look out!!

Now lets talk a bit abut side effects. I see a ton of people talking about bloat with Mk677. There is a lot of confusion as to why this occurs and how to prevent it. Many people drop the dosage however by doing so you directly impact the potency and effectiveness of Mk. The optimal dose for Mkk677, without a doubt, is 25mg/day. The bloat is caused by an effect in the kidneys caused by the increase in GH on vasopressin. This can easily be offset by the addition of a simple low dose daily aspirin protocol. Thats right, one 82mg aspirin/day with impact ADH (anti dieuretic hormone or vasporessin) to the point where it eliminated the bloat associated with Mk677.

I think that abut covers it. I covered all the main points. Mk is not a SARM, it will not put 10-15bs of muscle on you, it does not drastically increase prolactin or cortisol, and it does not have to cause water retention. Mk677 is, IMO, a god send. It has allowed me too, by stacking it with CJC-1295, be on what is essentially an affordable, infrequent injection, Moderate Dose, GH protocol and I am reaping all the benefits that come with that. Increased sense of well being; improved skin, hair and nails; decreased bodyfat; an increase in muscle mass (that is drastically magnified when on an anabolic of some kind). Overall I think MK is an awesome, albeit misunderstood compound. Most of the misunderstanding has spawned from BS marketing and shilling. My goal was to set the record straight on MK and put the truth out there. What I really dont understand is the compound is awesome enough based on the truth. They never really needed to over-hype it but sadly thats how some industries work.

Anyway I hope this helps someone and feel free to ask any questions on MK you would like. I will answer to the best of my ability based on my knowledge and first hand experience.
StanG
 
B5150

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Any references to support quantatively the increase of GH and other markers above baseline?

Any references to support or discredit the unwanted GH side of the proliferation of cancer cells in those predisposed or with history of such?
 
StanleyG

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Any references to support quantatively the increase of GH and other markers above baseline?

Any references to support or discredit the unwanted GH side of the proliferation of cancer cells in those predisposed or with history of such?
My personal blood work in which i had boh igf and gh tested......

I never mentioned anything about possible gh side of the proliferation of cancer cells??????
 
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My personal blood work in which i had boh igf and gh tested......
It would be great if you posted your bloodwork so we could see its efficacy.

never mentioned anything about possible gh side of the proliferation of cancer cells??????
I never said you did. It's a reasonable assumption that elevated levels of growth hormone indiscriminately potentiate cell proliferation of all kind including cancer. Do you have any reference that MK-667 does not present this risk?

Both statements/queries are intended to allow an intelligent person to make an informed decision regarding the risk to reward (efficacy) of using suck a product.

Thanks
 
StanleyG

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It would be great if you posted your bloodwork so we could see its efficacy.

I never said you did. It's a reasonable assumption that elevated levels of growth hormone indiscriminately potentiate cell proliferation of all kind including cancer. Do you have any reference that MK-667 does not present this risk?

Both statements/queries are intended to allow an intelligent person to make an informed decision regarding the risk to reward (efficacy) of using suck a product.

Thanks

I had baseline blood was drawn 6 weeks pre :

IGF Baseline Test: 193.4 , this draw: 273.2 (flag:High)
HGH Baseline Test: 1.9, this draw: >3.0 (flag:High) ref range up to 3.0

A more specific GH Only test run 10 weeks post baseline showed these results:
HGH Baseline Test: 1.9, this draw: 4.8

I'm sorry usually when someone requests references re: a write up I have done I would assume it is on something I stated within the write up. You know, to support a contention I have made or stated. However if you are simply asking my opinion or if I have come across any such information in my research or experience I would answer as follows:
I found no indicative literature stating mk677 presents any risk whatsoever as far as cancer cell proliferation. That being said if we are going to deal in assumptions and more specifically multiple assumptions I would present this as my opinion. If you are one that assumes gh potentiates cancer cell proliferation I would think it safe to say or to also assume mk677 would present such a risk as well given its effects on endogenous gh production.

I hope both of the above help someone to make an informed decision re mk677. I also hope that anyone with cancer ATM is doing well and doing their best to take care of themselves, receiving proper treatment, and I wish them all the best for hopefully a speedy recovery or at least remission and a good quality of life.
 
StanleyG

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I'm surprised you haven't said anything about using huperzine with mk677
We can certainly discuss it. Some even like green tea extract and horny goat weed in lieu of huperazine. A 5 on/ 2 off dosing protocol with Mk677 minimizes the necessity for all the aforementioned IME, however that does not mean one cannot benefit from them for sure.
 
Dma378

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Subbed for more discussion.

Just purchased several weeks worth of CJC 1295 DAC that I will start in a couple weeks. This isn't the first mention I've seen on combining it with MK. And I like the idea because I don't want the frequent injections of the other peptides. So I think I will add it in for increased effects.

This is the first time I've ever heard mention of GH's relation to cancer cell growth, so I would be interested in finding out more about this.
 
Brick Tannen

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I really like the 5 on 2 day off protocol for reducing cortisol and prolactin levels. What do u think of inhibit-p, for this as well. I take inhibit-p every night before bed reguardless of any other supps.
 
Joedoubledose

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Subbed , just started mk never thought of using cjc in conjunction but it's a good idea
 
Dma378

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Subbed , just started mk never thought of using cjc in conjunction but it's a good idea
Just grabbed 2 bottles of MK. 1 bottle of Focused and 1 bottle from the same source as my CJC. Along with 5 more vials of CJC yeah buddy!! Can't wait to get this rockin'
 

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We can certainly discuss it. Some even like green tea extract and horny goat weed in lieu of huperazine. A 5 on/ 2 off dosing protocol with Mk677 minimizes the necessity for all the aforementioned IME, however that does not mean one cannot benefit from them for sure.
hmm what benefits do green tea extract & horny goat weed provide? I know huperzine is used to combat somatostatin.
 
Joedoubledose

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Just grabbed 2 bottles of MK. 1 bottle of Focused and 1 bottle from the same source as my CJC. Along with 5 more vials of CJC yeah buddy!! Can't wait to get this rockin'
I got one of focused :p
 

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Mk677 gives me a massive thirst for water, personally I like to dose it in the morning and deal with the lethargy on the days it comes.
Night time doses mess with my sleep!

It's no miracle drug but it's good and I will keep using it.

Currently using and liking FN
 

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Can it be stacked with Andro 1, Andro 4 and M1D ANdro. Or should I use it after I do the Andro cycle with PCT.
 
Smont

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It can be stacked with anything and continued through pct
 
goodvibes

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Great write up StanleyG. Thoughts on the constant stress it produces in our brain (relative also to cortisol increase) and the possible negative eff3cts especially with the long half life. 5 days on is still very long. I saw your post on the other thread but don't you think there is a possibility there?
 
Joedoubledose

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Also lets talk about somatostatin inhibitors such as hupA and melatonin aswell as pairing them with green tea
 
rtmilburn

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Pyrostigmine showed doubled the amount a of ghrp-2 induce hgh release
 
UncleSarm

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This was a great writeup, thanks for taking the time to do it.

It would be awesome if you could get into detail with the following:
- What are your options to reduce prolactin, cortisol, and GHIH while on MK-677? You mentioned 5on/2off, what alternatives are there?
- What are your options for bloat, other than daily aspirin?
- You mention that added to anabolics, it becomes even more anabolic. Is this the same with SARMs (Osta & LGD)?
 
GreenMachineX

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Great write up StanleyG. Thoughts on the constant stress it produces in our brain (relative also to cortisol increase) and the possible negative eff3cts especially with the long half life. 5 days on is still very long. I saw your post on the other thread but don't you think there is a possibility there?
What do you mean by constant stress it produces?
 
StanleyG

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Great write up StanleyG. Thoughts on the constant stress it produces in our brain (relative also to cortisol increase) and the possible negative eff3cts especially with the long half life. 5 days on is still very long. I saw your post on the other thread but don't you think there is a possibility there?
Im not sure, I mean thats the only thing I have ever seen on such an effect. Also duration of use if I recall was a main factor or at least question when it came to that effect as well.
 
StanleyG

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This was a great writeup, thanks for taking the time to do it.

It would be awesome if you could get into detail with the following:
- What are your options to reduce prolactin, cortisol, and GHIH while on MK-677? You mentioned 5on/2off, what alternatives are there?
- What are your options for bloat, other than daily aspirin?
- You mention that added to anabolics, it becomes even more anabolic. Is this the same with SARMs (Osta & LGD)?

TY for the kind words.
1- Horny Goat Weed and Grren Tes Extract help and the most effective tool is huperazine. Also a dopamine agonist will help as well with the PRL

2- Keep diet in check and also if on an aromatizing anabolic be sure e2 is properly managed

3- I have not personally stacked it with a SARMs only anabolic stack so I cannot say 100% for certain but I would suspect so, yes.
 
Smont

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So combining green tea and horny goat weed with mk would amplify its effects?
 
solidsnake

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Good write up buddy, subbed for the info
 
StanleyG

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I really like the 5 on 2 day off protocol for reducing cortisol and prolactin levels. What do u think of inhibit-p, for this as well. I take inhibit-p every night before bed reguardless of any other supps.
Know nothing about it......
 

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I really like the 5 on 2 day off protocol for reducing cortisol and prolactin levels. What do u think of inhibit-p, for this as well. I take inhibit-p every night before bed reguardless of any other supps.
Those are non-issues with MK-677. Even the literature ranging from 6-12 months do not suggest that those levels are affected by MK-677.

The elevation of GH and IGF-1 are also not high enough for the bodybuilding purpose of anabolism. It's simply nowhere near the range it needs to be to really proliferate new muscle cells.

General health though, MK-677 IMHO is beneficial.
 
StanleyG

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starting age,

how old do you have to be to start using this product in your opinion?

thank you :)
Well I will say this, this is not like aas with the hpta but it is a hormonal product. I kind of look at it like this. I think people considering using it need to decide for themselves. I have a personal rule that I went by for myself which was do not use hormonal products of any kind until age 25. I feel that served me well but does that mean that thats the best or only way? No not at all.
I do think that regardless of age you should have a firm foundation as far as diet,rest and training before considering using this or any product along these lines.
I know Im not giving a firm answer but you asked for my opinion so here it is. I think it best based based on my personal experience to be 25 or older before using an hormonal products. That being said I am far more ok with someone between the ages of 21-25 telling me they are using this that using a product that would shut down their hpta. So to sum it up, my opinion, 25 is optimal but at least 21.
 
StanleyG

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thank you for the response,

what about GW-501516?
I avoid prar agonists and prars in general. While there is some debate re gw and causing cancer there is NO debate that PRARS definitely increase the proliferation and growth of cancer cells. It is in no way worth it to me to even begin to take such a risk for what I actually perceive to be minimal benefit to a bodybuilder (the benefits of gw & sr9009).
 
rtmilburn

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I avoid prar agonists and prars in general. While there is some debate re gw and causing cancer there is NO debate that PRARS definitely increase the proliferation and growth of cancer cells. It is in no way worth it to me to even begin to take such a risk for what I actually perceive to be minimal benefit to a bodybuilder (the benefits of gw & sr9009).
Never heard this. Ive actually heard the opposite. Working out heavily effects PRARs, and people have theorized that this is one of the ways working out help prevent cancer, and slows aging (age is a major cause of cancer). Could you link me to where to heard this i would love to read it.
 
rtmilburn

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i dont expect you to know this but,
do YOU think that supplementing with GW-501516 (20mg a day 8on/4off) is alot worse than smoking cigarettes (cancer wise) ?

(this is just to compare it to something)

thanks[/QUOTE]

After reading how prar does have an effect on cancer i really really doubt that its even close to smoking
 
rtmilburn

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After reading how prar does have an effect on cancer i really really doubt that its even close to smoking
so you belive smoking is worse, right?[/QUOTE]

Yes
 

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There's going to be a dose X length effect on cancer. Even then I'm not sure if it is carcinogenic or if it just speeds up cancer which is already present.

At the doses people are using GW at though, it's a decent calculated risk imho. In other words, chances are quite slim most likely.
 
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Back to the age question. GH tends to work better for the older crowd so I would assume someone that is healthy and under 25 maybe even 30 would not benefit much from a gh booster. Any1 have any info on this. The reason I bring it up so younger guys aren't out wasting there money.
 
rtmilburn

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Back to the age question. GH tends to work better for the older crowd so I would assume someone that is healthy and under 25 maybe even 30 would not benefit much from a gh booster. Any1 have any info on this. The reason I bring it up so younger guys aren't out wasting there money.
Mk alone i would agree. But mk and cjc stack now we are talking about relevent amounts hgh being released that will make a difference for anyone, especially if using anabolic along with it. Even more so if using mk, cjc, Pyrostigmine(or hup-a if you can't source Pyrostigmine), horny goat weed extract(epimedium), green tea, melatonin, and ldopa, that will significantly increase hgh probably get close to 6 uis. As mk and cjc has shown 4 by its self.
 

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Mk677 solo tests seem to show it pushes GH to the upper limits of natural ranges and can push IGF slightly above natural ranges.

Not truly supra physical but better than nature seems to provide most of us
 

dynamo

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Mk677 solo tests seem to show it pushes GH to the upper limits of natural ranges and can push IGF slightly above natural ranges.

Not truly supra physical but better than nature seems to provide most of us
Thus good for overall health benefits. It's VERY roughly ~1-2 IUs equivalent of GH. This is not anywhere near bodybuilding levels.

PCT is a good time to run it as well because that's when your IGF-1 levels tank so in PCT you're trying to keep your levels up.
 
rtmilburn

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Thus good for overall health benefits. It's VERY roughly ~1-2 IUs equivalent of GH. This is not anywhere near bodybuilding levels.

PCT is a good time to run it as well because that's when your IGF-1 levels tank so in PCT you're trying to keep your levels up.
Actually igf-1 levels wont tank pct unless you use nolva. Nolva is what causes decrease in igf-1 and IMHO there are much better option for pct then nolva. Cough cough clomid cough cough
 

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Actually igf-1 levels wont tank pct unless you use nolva. Nolva is what causes decrease in igf-1 and IMHO there are much better option for pct then nolva. Cough cough clomid cough cough
It actually does tank regardless. Remember, PCT we are both trying to recover and hold on to as much for as long as possible. You come off a cycle your IGF-1 levels will drop significantly (since they were raised significantly whilst on cycle).
 

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