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MK-677

all I can say is i tried it twice.
and don't care for it anymore I sold my last bottle of OL gharine .
it's pretty good for ppl who r bulking as you will eat like a mad man.
 
I dose before bed.. Avoids lethargy. But I also just got use to it and it didn't affect me any more. I'm creeping on 4 months on mk677. I'll run it thru current cycle of epiandro 4andro and Ostarine. Then up my dose to25mg for pct.
 
Decided to give this a miss, cant risk being to tired in my job. Have 2 bottles of OL Gharn1ne left too. PM me guys :)
 
Running it now on 10mg / day. I noticed no lethargy at all - in fact I feel like I have more energy. It could be because I sleep better (deeper sleep). I dose in the morning because I heard it negatively affects sleep otherwise. I am only a few days in so I will report back or create a separate post of my results.
 
Cycloman said:
Running it now on 10mg / day. I noticed no lethargy at all - in fact I feel like I have more energy. It could be because I sleep better (deeper sleep). I dose in the morning because I heard it negatively affects sleep otherwise. I am only a few days in so I will report back or create a separate post of my results.
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Everybody is different......literally!!
 
So, nowadays which are the better MK677 brands?

It´s a shame OL stopped it.. It was really good.

I´m able to find MK677 in some online stores but most of them are from companies i´ve never heard before. I guess most of them are crap.

By the way, if anyone from Europe, have a spare Ghar1n that want´s to sell, pm me.

Edit: Found it in a UK store... Don´t know if it´s an error or not since it has been out of stock for a long time... But i already bought a bottle. Lets see what will happen.
 
I hear ppl on it for 6 months but I really am not hearing any results to be honest. I used it before,can eat a ton of food always hungry? Guess that helps. Not hearing any leaning out or joint repair. No skin tightening or anti-aging. Really my experience and what I am reading-makes you extremely hungry and keeps body fat from increasing on bulk. Good pump in gym and some that don't sleep well can benefit from improved sleep.
 
mase1 said:
I hear ppl on it for 6 months but I really am not hearing any results to be honest. I used it before,can eat a ton of food always hungry? Guess that helps. Not hearing any leaning out or joint repair. No skin tightening or anti-aging. Really my experience and what I am reading-makes you extremely hungry and keeps body fat from increasing on bulk. Good pump in gym and some that don't sleep well can benefit from improved sleep.
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The published data show subjects putting on a small amount of LBM with no change in bodyfat. It looks pretty disappointing, to be honest.
 
I'd been on it since January and recently stopped it. I didn't think it did much until I went off it. When I went off, I found my recovery after workouts was slower and had some old joint pains return. I'm back on it now.
I think for older lifters like me it's great but for younger people not sure you would get much out of it.
 
It increases GH and IGF to high normal (10/310 are the one set of blood numbers I've seen - not mine). So that's what it will do, nothing like many iu's exogenously. I think Pete is right, older people may notice it more. I'm going on my 5th month 10, 20, and now 30mg. Problem is, I can't remember what I felt like before taking it (other than I always feel great) :D But it sure as heck didn't heal Elbow Tendonitis.
 
Upon looking into it some people feel it hurts their libido.
That's interesting because some people say it may initially raise prolactin.
You can Google search mk677 and find where some people say it lowered their testosterone.
Literally dozens of different results.
 
Cgkone said:
Upon looking into it some people feel it hurts their libido.
That's interesting because some people say it may initially raise prolactin.
You can Google search mk677 and find where some people say it lowered their testosterone.
Literally dozens of different results.
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I wonder if some of those results are due to "contamination" (accidental, or otherwise) with an oral DS/PH. Hard to imagine why this would suppress T otherwise.
 
adobepot said:
I wonder if some of those results are due to "contamination" (accidental, or otherwise) with an oral DS/PH. Hard to imagine why this would suppress T otherwise.
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Don't know. But also blood test are hard to come across.
Some that I have found mention lowered T.
 
When is the best time to take mk677 morning or night? I took it for the first time last night. Vivid dreams but woke up 5 times. Still woke up very fresh and full of energy. Felt like i slept deeply
 
Danielgoodwin said:
When is the best time to take mk677 morning or night? I took it for the first time last night. Vivid dreams but woke up 5 times. Still woke up very fresh and full of energy. Felt like i slept deeply
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Lots of opinions on this. Try both and see which works better for you.
 
Danielgoodwin said:
When is the best time to take mk677 morning or night? I took it for the first time last night. Vivid dreams but woke up 5 times. Still woke up very fresh and full of energy. Felt like i slept deeply
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Mike Arnold just did a good run down of MK-677 on the new Performance Enhancement Radio on Iron Radio. It binds to a GH receptor (GHR-1 or GSR-1, I forget) for ~24 hours, and increases the frequency and amplitude of natural GH pulses. I don't think it matters when you take it. I take it before bed with no problems - stopped Huperzine with it though, that messed with my sleep. Control other things like fluid intake a few hours before, and lay off the Taurine in the evening too.
 
So I'm coming up to my 4 months on mk677 12.5 mg ED.
I'm going to stop for 5 weeks and come back on during my PCT.
I feel like I'll benefit more then.
I also feel the initial 6 -10 weeks was the most positive in results.
I also was expecting it to be way more synergistic with epiandro 4andro and Ostarine.
Not so much.
I'm interested in how coming off will help my diet and libido.
I have a shadow of a doubt that it effects libido ( in me) negatively .
The initial hunger is good for pct.
I'll keep posted.
 
Cgkone said:
So I'm coming up to my 4 months on mk677 12.5 mg ED.
I'm going to stop for 5 weeks and come back on during my PCT.
I feel like I'll benefit more then.
I also feel the initial 6 -10 weeks was the most positive in results.
I also was expecting it to be way more synergistic with epiandro 4andro and Ostarine.
Not so much.
I'm interested in how coming off will help my diet and libido.
I have a shadow of a doubt that it effects libido ( in me) negatively .
The initial hunger is good for pct.
I'll keep posted.
Click to expand...
Libido drop was more likely due to shutdown from the andros.
 
My libido is ok. 500mg of 4andro and 1000 epiandro.
But a significant slow decline since initial mk677.
I'm not even sure the mk677 is to blame but it's interesting to research the cases where mk677 has possibly lowered T.
I'm still very much pro mk677. I love the results off cycle and in pct.
 
Thanks for the advice. I've just started taking cardarine at 5pm as well. I think the cardarine is messing with my sleep. Going to start taking it in the mornings. Cardarine seems to have a stim effect on me after 2 hours of ingestion
 
bump for the question,
has anyone experienced muscle spasm on mk677?
i've started experiencing some painful spasms mostly in legs (vastus medialis) if i stand for longer than a few minutes and then try to bend a knee or raise up a leg i get painful spasms in wave form that starts from the knee and up.
in arms and shoulders too (brachioradialis, front delts) when brushing hear
i've added potassium gluconate, magnesium, taurine and still get the spasms... any ideas?
current dosing 10 mg in the morning and 20 mg before bed
 
Vict I once noticed muscel spasm in the left shoulder for serveral minutes, which was in my opinion random and has nothing to do with MK-677 (which I'm taking for the 11th week now, mostly 25mg/ed, went up to 50mg/ed for some days as a test). Use magnesium (watch out for too high doses, otherwise you can get diarrhea) or use taurine, I would say. But according to your post, you are already taking them without any effect. How about your blood sugar? MK-677 can lead to temporary decrease in insuline sensitivity which also may have an impact on these spasm.

I don't know you daily intake on vitamines and minerals but while using a GHS like MK-677 I recommend using higher doses of "everything".

I have honestly no idea in your case. What you can try:
- reduce the dosage (20mg/ed or less, even 10mg/ed had nice effects in studies)
- intake scheme to pre-bed
- ensure to take enough minerals and vitamines, split during the day
 
sanmarino said:
Vict I once noticed muscel spasm in the left shoulder for serveral minutes, which was in my opinion random and has nothing to do with MK-677 (which I'm taking for the 11th week now, mostly 25mg/ed, went up to 50mg/ed for some days as a test). Use magnesium (watch out for too high doses, otherwise you can get diarrhea) or use taurine, I would say. But according to your post, you are already taking them without any effect. How about your blood sugar? MK-677 can lead to temporary decrease in insuline sensitivity which also may have an impact on these spasm.

I don't know you daily intake on vitamines and minerals but while using a GHS like MK-677 I recommend using higher doses of "everything".

I have honestly no idea in your case. What you can try:
- reduce the dosage (20mg/ed or less, even 10mg/ed had nice effects in studies)
- intake scheme to pre-bed
- ensure to take enough minerals and vitamines, split during the day
Click to expand...
sanmarino can you expand on your reference to blood sugar? It seems I am sensitive to being hypoglycemic. I found out when I replaced sugar with Splenda, but I had to stop because it made me hypoglycemic. After I stopped using it, everything went back to normal.
So quite curious as to these effects as I am planning to start with some MK-677.
 
UncleSarm said:
sanmarino can you expand on your reference to blood sugar? It seems I am sensitive to being hypoglycemic. I found out when I replaced sugar with Splenda, but I had to stop because it made me hypoglycemic. After I stopped using it, everything went back to normal.
So quite curious as to these effects as I am planning to start with some MK-677.
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when you switched, did you sick in anyway or headaches etc?
 
smith_69 said:
when you switched, did you sick in anyway or headaches etc?
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While taking Splenda, I would get headaches from the sugar crashes. My doc sent me for a sugar test and I was diagnosed as hypoglycemic and was recommended to carry a packet of sugar or a candy bar with me all the time ... "no cure for it". This was at around 35 years old and it freaked me out, so I did some research. I found that some people became hypoglycemic after starting to use Splenda and, less so, other sugar sweeteners, so all the places I replaced sugar with Splenda, I just went without. It take awhile to get used to coffee and tea without sugar, for sure, but I haven't had sugar problems since I quit that junk.
 
UncleSarm said:
While taking Splenda, I would get headaches from the sugar crashes. My doc sent me for a sugar test and I was diagnosed as hypoglycemic and was recommended to carry a packet of sugar or a candy bar with me all the time ... "no cure for it". This was at around 35 years old and it freaked me out, so I did some research. I found that some people became hypoglycemic after starting to use Splenda and, less so, other sugar sweeteners, so all the places I replaced sugar with Splenda, I just went without. It take awhile to get used to coffee and tea without sugar, for sure, but I haven't had sugar problems since I quit that junk.
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I have the same problem ..
 
Personally I've used MK-677 for 9 months now I believe, anywhere from 10mg to 50mg, and haven't had any issues to speak of. Lethargy at the very beginning and anytime I bump from 10 to 20 or 30, but since I've experimented and found that I enjoy 10mg just fine, I see no need to go higher anymore. Plus, it's much easier on my poor anorexic wallet.
 
When I was using it a 10mg daily, if I had any glycemic level issues it was a positive - less low blood sugar
 
UncleSarm said:
sanmarino can you expand on your reference to blood sugar? It seems I am sensitive to being hypoglycemic. I found out when I replaced sugar with Splenda, but I had to stop because it made me hypoglycemic. After I stopped using it, everything went back to normal.
So quite curious as to these effects as I am planning to start with some MK-677.
Click to expand...

I will post a quote:

The increase in fasting and postprandial (Sustacal) insulin concentrations, and less marked but still statistically significant increases in postprandial glucose concentrations, are consistent with the known effect of GH to enhance insulin resistance.[...]GH therapy in GH-deficient subjects has been reported to increase insulin resistance at 6 weeks, but have a diminished effect at 26 weeks when significant decreases of body fat have occurred (42). - See more at: Invalid Link Removed

Despite the subject in this studie were people with a GH-deficit other studies have shown that the same effect can also expected in healthy younger and elder people while using a GHS like MK-677.
 
sanmarino said:
I will post a quote:

The increase in fasting and postprandial (Sustacal) insulin concentrations, and less marked but still statistically significant increases in postprandial glucose concentrations, are consistent with the known effect of GH to enhance insulin resistance.[...]GH therapy in GH-deficient subjects has been reported to increase insulin resistance at 6 weeks, but have a diminished effect at 26 weeks when significant decreases of body fat have occurred (42). - See more at: Invalid Link Removed

Despite the subject in this studie were people with a GH-deficit other studies have shown that the same effect can also expected in healthy younger and elder people while using a GHS like MK-677.
Click to expand...

So if I understand correctly, MK-677 has shown to increase insulin resistance, which means more insulin is produced. In turn this excess insulin can crash your blood sugars and if you're sensitive to hypoglycemia, it can bring it on. Am I interpreting this correctly sanmarino?
So that means that I will need to be careful if I decide to take MK-677.
 
UncleSarm said:
So if I understand correctly, MK-677 has shown to increase insulin resistance, which means more insulin is produced. In turn this excess insulin can crash your blood sugars and if you're sensitive to hypoglycemia, it can bring it on. Am I interpreting this correctly sanmarino?
So that means that I will need to be careful if I decide to take MK-677.
Click to expand...

If I understand correctly, if using on a cut it should actually be beneficial - "GH therapy in GH-deficient subjects has been reported to increase insulin resistance at 6 weeks, but have a diminished effect at 26 weeks when significant decreases of body fat have occurred " Did I understand that correctly?
 
Tank999 said:
If I understand correctly, if using on a cut it should actually be beneficial - "GH therapy in GH-deficient subjects has been reported to increase insulin resistance at 6 weeks, but have a diminished effect at 26 weeks when significant decreases of body fat have occurred " Did I understand that correctly?
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Invalid Link Removed
 
Been taking mk677 and cardarine for 6 days now. Ive noticed something that worries me a little... the smell of my urine is different, i dont put my head in the bowl to notice it either! It has a sweet smell to it... ive never had this before. not sure if its the cardarine or mk677. Mk677 can mess with blood sugar which ive heard can give this sympton
 
Danielgoodwin said:
Been taking mk677 and cardarine for 6 days now. Ive noticed something that worries me a little... the smell of my urine is different, i dont put my head in the bowl to notice it either! It has a sweet smell to it... ive never had this before. not sure if its the cardarine or mk677. Mk677 can mess with blood sugar which ive heard can give this sympton
Click to expand...
Smelling sweet is okay, it's only when it tastes sweet that you have an issue.
 
PeteRyde said:
Just wondering what was the reason you increased the dose and why you then reduced it.
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Because I wanted to experiment and see if higher doses would benefit me enough to continue at higher dosages, which it did not enough for me to reasonably spend that much money on it, so, I reduced it back to the lowest effective dosage that works personally for me. I think I already explained this in another post in this thread.
 
BamBam0319 said:
Personally I've used MK-677 for 9 months now I believe, anywhere from 10mg to 50mg, and haven't had any issues to speak of. Lethargy at the very beginning and anytime I bump from 10 to 20 or 30, but since I've experimented and found that I enjoy 10mg just fine, I see no need to go higher anymore. Plus, it's much easier on my poor anorexic wallet.
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PeteRyde looks like it was in the same post that you quoted half of. Did you read the rest of my post, or just that first sentence? Lol
 
PeteRyde said:
Too lethargic from the mk677 to read it all
(I thought there may have been a reason you weren't happy with the lower dose to want to increase it.)
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Just wanted to see what would happen, and just not enough benefits at a higher dose to make sense financially. I am, after all, a college student so making money and staying up in grades is a hard combination to juggle.
 
UncleSarm said:
So if I understand correctly, MK-677 has shown to increase insulin resistance, which means more insulin is produced. In turn this excess insulin can crash your blood sugars and if you're sensitive to hypoglycemia, it can bring it on. Am I interpreting this correctly sanmarino?
So that means that I will need to be careful if I decide to take MK-677.
Click to expand...

A reduction in insulin sensitivity means that you need more action to reach the same reaction a before. There are a lot of factors which influence the insulin senitivity (age, training, bodyfat, stress, lifestyle, nutrition, etc.). The older you get the lower your insulin sensitivity will be (in other words: your insulin resistance increases). Also the body fat has influence as you have seen.

As you know insulin is muscle- and fat-anabolic. It nothing other than a "defense-action": the body tries to protect us from getting more fat when we are already obese and eating more pizza and fast food. If he - the body - won't decrease the sensitivity we would be getting fat in a linear way. But due to this defense-mechanisme it's going to be a logarithmic function (you need now much more calories to gain weight).

Nevertheless, this defense-mechanism has also its side effects which will happen in a long-term view: heart attack, diabetes, high blood pressure, depression etc.).

Regarding to hypoglycemia you are correct: higher level of insulin can lead to hypoglycemia. It is the same reaction like a person with diabetes injects a too high dose of insulin.

It's never a bad idea to have a carb-bar with you. It sounds worser than it is, actually. Also keep in mind, that these observations were made primarily with elder people (which do not excercise). But also in younger persons this reaction - like in any increase of the human growth hormone - were observed.
The conclusion is: the longer the time horizon of application is the more stable are such reactions. But also keep in mind that the body has it's own defensive mechanism agains higher growth hormone levels. The longer the run with endogen-boosters are (not the same as exogenic STH) the higher the probability that this level will return to the natural baseline.

Of couse: after two years of testing the GH and IGF-1 values were approx. 70% higher than normal. The real question is, how long can such a booster be run without reaching a benefit of 0%. But I think, as an anti-age drug MK-677 is quite a good choice for elder people to improve their quality of life.

[hmm, I digressed again, sorry for that]
 
Danielgoodwin said:
Been taking mk677 and cardarine for 6 days now. Ive noticed something that worries me a little... the smell of my urine is different, i dont put my head in the bowl to notice it either! It has a sweet smell to it... ive never had this before. not sure if its the cardarine or mk677. Mk677 can mess with blood sugar which ive heard can give this sympton
Click to expand...

You don't happen to also be taking anything with Fenugreek in it, are you?
 
sanmarino said:
A reduction in insulin sensitivity means that you need more action to reach the same reaction a before. There are a lot of factors which influence the insulin senitivity (age, training, bodyfat, stress, lifestyle, nutrition, etc.). The older you get the lower your insulin sensitivity will be (in other words: your insulin resistance increases). Also the body fat has influence as you have seen.

As you know insulin is muscle- and fat-anabolic. It nothing other than a "defense-action": the body tries to protect us from getting more fat when we are already obese and eating more pizza and fast food. If he - the body - won't decrease the sensitivity we would be getting fat in a linear way. But due to this defense-mechanisme it's going to be a logarithmic function (you need now much more calories to gain weight).

Nevertheless, this defense-mechanism has also its side effects which will happen in a long-term view: heart attack, diabetes, high blood pressure, depression etc.).

Regarding to hypoglycemia you are correct: higher level of insulin can lead to hypoglycemia. It is the same reaction like a person with diabetes injects a too high dose of insulin.

It's never a bad idea to have a carb-bar with you. It sounds worser than it is, actually. Also keep in mind, that these observations were made primarily with elder people (which do not excercise). But also in younger persons this reaction - like in any increase of the human growth hormone - were observed.
The conclusion is: the longer the time horizon of application is the more stable are such reactions. But also keep in mind that the body has it's own defensive mechanism agains higher growth hormone levels. The longer the run with endogen-boosters are (not the same as exogenic STH) the higher the probability that this level will return to the natural baseline.

Of couse: after two years of testing the GH and IGF-1 values were approx. 70% higher than normal. The real question is, how long can such a booster be run without reaching a benefit of 0%. But I think, as an anti-age drug MK-677 is quite a good choice for elder people to improve their quality of life.

[hmm, I digressed again, sorry for that]
Click to expand...

Thanks for the thorough explanation sanmarino. That means I will need to be careful and monitor my body's response.
 
Lack of sleep stinks!!
 
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