Dirty Duke
New member
I only have a week left of this run, so will run and access to see if there's any difference. I'm also going to drop the Hup-A before bed and take it during the day instead, as well as taper off the Melatonin.
Mk 677 What's the verdict
- Thread starter Godstrength
- Start date
Mike Arnold
Board Sponsor
Look, if you are one of those guys who refuses to accept that extrapolation can lead to reliable conclusions, there is nothing I can say to you. In this case you might as well argue that GH doesn't increase muscle growth. Actually, you should just take it a step further and argue that SD doesn't build any muscle tissue either. After all, there has never been a single human study showing that SD--or about 200 other steroids--are capable of building muscle mass in humans, yet we know for a fact they do. Obviously, if anecdotal evidence and scientific extrapolation is suitable for drawing conclusions about SD, then it is also possible to do with other drugs.
Now, you could sit here and continue to say "I am going to deny that MK is capable of stimulating tendon regeneration until I see a study specifically showing that it does", but I won't argue about something that doesn't exist. Just like I won't argue with someone who says that I can't claim SD causes muscle growth in humans because no studies exist, neither will argue with someone who says that naturally produced GH (MK-677) doesn't stimulate tendon/connective tissue regeneration--because we already knows that this is one GH's primary functions in the body. .
Now, extrapolation obviously isn't reliable in all cases, but there are times in which it is. In the case of MK-677 I would say it is pretty reliable for multiple reasons, so let's see why.
As you know, studies show that GH can greatly increase collagen synthesis. However, there are multiple types of collagen produced by the body, all of which have different functions. The good news is that GH increases production of the specific type of collagen that assists in the regeneration of tendons. Being that MK also increases GH levels, it is reasonable to conclude that it would increase the production of the same type of collagen and therefore stimulate tendon regeneration...just like exo. GH.
Of course, we also need to look at the amount of GH required to have this effect, to make sure MK-677 is capable of elevating GH levels to the same degree as those seen in the exo. GH studies. How much GH does it take to have this effect? Research has shown that even 1-2 iu of exo. GH significantly increases collagen production...and 3 iu led to a dramatic increase. MK-677 is certainly capable of increasing GH levels the equivalent of 3 iu of exo. GH...and in some cases even more.
You mention the fact that AAS have also been shown to increase collagen production, but comparing AAS to MK-677 is meaningless for a few reasons. For one, not all AAS increase collage synthesis. In fact, many drastically reduce collagen synthesis. Just 300 mg of testosterone/week (I could be off on that number, as it has been year since I read the study, but I know it's close) has been shown decrease collagen synthesis by up to 80%. That is a LOT--similar to an 80 year old man! Furthermore, even if a steroid does increase the production of the right type of collagen, it is not guaranteed to have the same effect. This is because no steroid has, up to this point, been proven to build structurally sound connective tissue like GH does. The only thing we do have proof of is that they can DAMAGE the tendons.
Winstrol is perhaps the most well known example. Although Winstrol has been shown to increase collagen synthesis significantly and build bigger tendons, it causes what is known as cross-linking (improper formation of connective tissue). This causes the tendons to get bigger, but they also become WEAKER and more prone to injury. This is why so many tendon injuries occur while using Winstrol. There is is no denying that Winstrol will build tendon size, but it sure doesn't make them stronger--it makes them weaker by decreasing their structural integrity.
GH does not and has never been shown to have this effect.
So, when you compare AAS to GH you are comparing apples to oranges, but when you compare GH to MK-677, you are comparing apples to apples because both drugs increase the exact same hormone with the exact same functions. Both are human hormones (not synthetic aberrations like AAS, which produce unnatural effects). In fact, MK causes the release of real, naturally produced GH. So, we can reliably conclude that exo. GH and pituitary produced GH (MK-677) both have the same effect, as exo. GH is bio-identical to the GH produced by the pituitary.
In terms of anecdotal evidence, bodybuilders and especially athletes have known for decades that GH promotes tendon regeneration. This is the main reason that athletes use it. It helps keep them in the game longer and increases their chances of remaining injury free. In fact, the real-world evidence for GH's positive effect on tendons/connective tissue is so vast that it is almost impossible to deny. In combination with what science has already revealed about GH and its effects on the tendons, it stands to reason that any drug (MK-677) that substantially increases GH levels would have the same effect.
Lastly, real-world evidence is now showing, with ever increasing frequency, that MK-677 also has this same kind of beneficial effects on connective tissue that GH does. This is not surprising, as MK is easily capable of increasing GH levels to the same degree as that which was seen in the exo. GH studies.
So, while no studies exist showing that MK-677 aides in tendon recovery/growth (just like no studies exist showing it increases muscle fullness or a muscle pump, even though we know it does), we do know that GH (which MK directly increases) does play a role in tendon regeneration. This is one of its main roles in the body. When we evaluate this information in combination with the results that athletes have been experiencing for years, this conclusion is not unreasonable.
Mike Arnold
Board Sponsor
double post
rowz4broz
Well-known member
Im telling you man MK677 was awesome in the 2-3 weeks i was on it i really did feel fuller and now coming off i dont feel as full. Imagine like when you get off creatine. But i was going crazy with a lack of sleep. I didnt come into here to bash MK but sleep is not something that should be ****ed around with. Good thing is usually ppl report better sleep on MK so if thats the case i cant see anything bad about supplementing with it.
The Whizard
Member
Could it have been your source?
rowz4broz
Well-known member
I would highly doubt it. MK does have a % of users who report sleep issues. I think I fell into that percentile.
The Whizard
Member
I ask because you mentioned you’re using a RC quality MK. There is a chance it was contaminated with something else.
rowz4broz
Well-known member
hm... possibly
rascal14
Well-known member
Not likely considering the source I used and got the exact same issue.
fx2050
Member
now i can feel this stuff, lethargy in my arms, damn, i dont want to lift my arms, lethargic head and started eating a bit more
proves how ****e the DNA stuff was, avoid that, severe under dosed. before that was German pharma. similar to this powder but i can tell initially that the powder is purer. def was worth the risk
now to see if i get anything else out of this stuff
proves how ****e the DNA stuff was, avoid that, severe under dosed. before that was German pharma. similar to this powder but i can tell initially that the powder is purer. def was worth the risk
now to see if i get anything else out of this stuff
abformulations
Legend
Wth is lethargic arms, and head? Lmao
Aust
New member
Now this guy is suspect...!,
DemntedCowboy
Well-known member
100% agree. Sounds like he's trying to sell his own stuff
Aust
New member
Looking at his profile and past posts.
banjobounce
Active member
Is it still available to purchase from NP?
Ricky10
Well-known member
Whisky
Well-known member
First week I took it my sleep was all over the place, waking frequently and never feeling like I’d been in a deep sleep. Almost switched dosing to the morning but on day 5 it started to settle down and since then I’m sleeping as well as (if not better) than before.....
Guessing your situation wasn’t improving at all though?
Dirty Duke
New member
About to start up a new cycle tonight. Been sleeping quite well, so will be interesting to see if sleep patterns and cycles are affected.
The Express 42
Well-known member
Similar for me, first week or so sleep was sporadic but I take it about 2 hours before bed now and I’ve been waking up refreshed around 8-9am opposed to groggy 10-11am. Muscle fullness is great. Makes arms look nice and thick but definitely some water retention. Up about 8lbs since starting two weeks ago
Whisky
Well-known member
Yeah also had some weight gain (about 5lbs in 2 weeks) - am on the start of a ph cycle as well but too early for it to likely be those componds....im liking it at the moment
muscleupcrohn
Legend
Fair point, but I think I’d sooner run MK-677 than a lot of PHs. No suppression/shutdown, and actually more human studies that I’m aware of. To each his own though.
Voldyne
Member
That’s a different approach. So I suppose you are not necessarily after the ghrelin/HGH secretion but just like to use it as a sleep aid here and there?
Voldyne
Member
That’s not bad dude, some people say that 2 days off per week is recommended anyway. Six months is a nice run! I think I am heading into my 4th month. Nothing drastic yet, the sides of lethargy have toned down for sure, and hunger is not an issue either. Not seeing too many benefits yet but I just made the switch to PRE brand which seems to gets high marks around here. Hoping I get more tangible benefits at this point.
abformulations
Legend
It’s good stuff. Been on it 3 months now. Perfect to bulk. Hunger is insane not recommended while on a cut though it’ll be rough to keep diet strict
Voldyne
Member
My hunger has not been insane at all. Granted, My diet has been Shytty, but it more has to do with this time of year. It’s not like anyone is going to notice if I eat boiled chicken breast and steamed broccoli every meal when I throw on my winter parka to snow blow the driveway. Not that there would be anything wrong with that...
paul56778
Well-known member
I did PSMF for 1 month straight and hunger was very hard to deal with but i managed by drinking 8+ litres of water per day, also the hunger in the middle of the night early hours when waking was bad.
BBiceps
Well-known member
Nothing? No benefits at all..?
BamBam0319
Well-known member
I’ve used it over a year straight before, on my third month of this run and enjoying it as usual. Seems to help me lean out a little or stay leaner when bulking or not watching my diet as much.
Voldyne
Member
So we are into it about the same length of time... this time around anyway in your case.
I have not noticed anything tangible in terms of benefits. I have been at 12.5mg per day, as I am more interested in increasing HGH as opposed to IGF-1. From what I understand, doses above 12.5mg show more of an increase in IGF-1 while the impact on HGH at a higher dose is negligible.
BBiceps
Well-known member
I have been thinking about using MK677 to heal my body from all the abuse I been putting it through but post like this makes me not want to bother with it...
Not a knock on you at all, happy to read an honest review for once.
Voldyne
Member
I hear ya...maybe it is a brand thing? I started out with Focused Nutrition, then Agressive Labz MK Elite, and now PRE is the latest one for the past 10 days or so...I have been thinking about using MK677 to heal my body from all the abuse I been putting it through but post like this makes me not want to bother with it...
Not a knock on you at all, happy to read an honest review for once.
People seem to rave about Somatozine the most, and I am sure it is a quality product, but I also believe at least one of the 3 I have used have been legit. Maybe the PRE brand will kick in within the next month, and I will feel like a different person..who knows...
Something tells me no..
Voldyne
Member
I should add that I don’t have any chronic pain, so I would not see any difference there anyway..I have been thinking about using MK677 to heal my body from all the abuse I been putting it through but post like this makes me not want to bother with it...
Not a knock on you at all, happy to read an honest review for once.
However, I think I may have experienced improved recovery between workouts when I first started using MK, but now I feel like I can legitimately say that I am at baseline in that regard.
scump
Member
i know a few people who have used focus nutrition products and got no results from them. I mean you will see sheep reviews on here, but thats the same people who think they gained 12lbs in 5 days on muscletech.
Derek Wilson
Active member
Dosage guideline (Proven Peptides): Between 5 to 25 milligrams daily in a 10-week cycle.
Voldyne
Member
Yeah, I had one of the original bottles of FN which mostly had good reviews. Honestly, it felt the most potent of the 3 and had the most blatant typical side effects. Innovative Labz had solid reviews but that felt weaker to me. PRE seemed to hit me more like FN at first, but now it has kind of evened out again. PRE has gotten nothing but solid reviews on here so I have no reason to think that one is not legit. Of course I realize my body is getting used to it by now too, so I have to throw that in the mix.
Syanide
New member
Been running low dose 10mg for almost 3 months now mainly for pain (elbows and back) and it’s been fantastic to be honest. Took 3-4 weeks to kick in and using OL Garine and have mclerage mk-47 to start in a few days.
No real hunger, taking at night 2 hours before bed.. did take massmax with it though for a month and the combination of both made me seriously hungry all of the time. Couldn’t eat enough.
No real hunger, taking at night 2 hours before bed.. did take massmax with it though for a month and the combination of both made me seriously hungry all of the time. Couldn’t eat enough.
Derek Wilson
Active member
Good read
Voldyne
Member
Any experience with MK yourself?
scump
Member
try read the last few pages, heaps of guys on AM run the MAlabs somatazine and love it
if they shipped to australia i definitely would be running it by now lol