Guest viewing limit reached
  • You have reached the maximum number of guest views allowed
  • Please register below to remove this limitation

Maybe there is something to drinking grapefruit juice...

prolangtum

prolangtum

Member
For the past week, I have been eating 1/4 of a grapefruit with each of my two dialy doses of 3mgs of m 4ohn. Either the compound takes a little over a week to kick in, Im am experiencing a placebo affect (although i did not expect much of anything to happen) or the grapefruit greatly enhances the drugs action, as purported by the studies. I did not put much stock in it, but it seems the m 4ohn is working 3-4x better than the first week. Veins are getting more sick everyday, pumps are increasing more and more, and poundages are rising quicker than the first week.
 
Yeah, the active compound in grapefuit juice is something called 6,7-dyhydroxy-bergomottin (DHB). It is supposed to attack 2 enzymes in the liver (CYP and P450) that are responsible for "first pass metoblism" which among other things break down prohormones as they make thier way through the liver. There are several supplement companies that are adding DHB to thier prohormone formulations with the intent of getting more of the intact PH past the liver. How well this compound works in this regard will remain to be seen, but your experience lends some credence to its supposed effects.


:) laterz...
VALIS
 
I always drink grapefruit juice during ephedrine use ... without a doubt it gives me an extra kick than when I'm not drinking it. I noticed this a few years ago but just thought it was my imagination. I dropped the juice for whatever reason and noticed a definate difference. I tried other juices and nothing has the same effect on me during ephedrine use than grapefruit juice.

I'll have to try this with the M14Add ....
 
You have to be careful if you take heart, cholesteror and other types of prescription medication. A friend of mine had a heart attack a few years ago. The doctor was very specific about not eating grapefruit. I really didn't understand why and I don't think my friend understood either so I did a search on google and found a lot of info about DHB and how it affects CYP and P450. Interestingly enough there are some medications that have the same effect as DHB and that is one of the reasons why you can't mix certain medications. DHB can greatly increase the bioavailability of other substances and that can be dangerous, so if you take prescriptionmedications read the insert.
 
Just a 1/4 of the grapefruit? Man how do you do it. When I sit down to eat my grapefruits I have to keep from eating 2, mmm...good!
 
ex_banana-eater said:
Methylated steroids have a very high bioavailability. The increased bioavailability should be unnoticable.
Click to expand...

I don't think its an issue of bioavailability, its more to do with resisting breakdown by the liver so the m4ohn has more time in the body before being broken down.
 
Somebody try grapefuit juice with viagra or cialis. Then we'll know if there's any truth to this...
 
Yeah, that's what you want to do :rolleyes: Give yourself a hard-on that won't go down and cause permanent damage.
 
I have been doing the same thing with my mdien...somewhere between 1/4 to 1/2 grapefruit twice a day usually morning and night. So far I have not really noticed anything different, or anything all that much but its only day 5.
 
you guys think a cup of ice cream could do this also? i would just prefer to take my supps with ice cream
 
sifu said:
And Chocolate syrup with caramel.
Click to expand...

Careful bro, I heard the caramel is good, but the chocolate syrup can decrease absorbtion. Better space it out AT LEAST two hours apart. Also, my friend's cat's brother's uncle got gyno from too much sprinkles.
 
VALIS said:
Yeah, the active compound in grapefuit juice is something called 6,7-dyhydroxy-bergomottin (DHB). It is supposed to attack 2 enzymes in the liver (CYP and P450) that are responsible for "first pass metoblism" which among other things break down prohormones as they make thier way through the liver.............VALIS
Click to expand...

Does anyone know......

Is the reaction between DHB and CYP / P450 and PH/AS specific to androgens, or might it also impact ILGF-L3 ?
 
MarcusG said:
I don't think its an issue of bioavailability, its more to do with resisting breakdown by the liver so the m4ohn has more time in the body before being broken down.
Click to expand...

Yes, it is obviously an issue of oral bioavailability, if you understand what that is. It is the whole reason why we are contemplating grapefruit juice use. Since methylated steroids have a 17alpha alkylation they do not or hardly break down in the sense we are thinking of.
 
PC1 said:
Does anyone know......

Is the reaction between DHB and CYP / P450 and PH/AS specific to androgens, or might it also impact ILGF-L3 ?
Click to expand...

I don't think the reaction between DHB and PH/AS is exclusive since other non androgen medications and such seem to be impacted by consumption of
DHB as they have counterindications against taking them with grapefruit products. As SilverSurfer pointed out, cholesterol medication is one such class. If I'm not mistaken, I think MAOI anti-depressants are another. I'm not familiar with ILGF-L3... What's the story behind this?

Pax :saw:
VALIS
 
VALIS said:
......................... I'm not familiar with ILGF-L3... What's the story behind this?

Pax :saw:
VALIS
Click to expand...

Insulin Like Growth Factor - Long 3. There's a whole new forum dedicated to it/insulin here you can check out. In a layman's nutshell, Growth Hormone causes the liver to produce this, and this is what is responsible for new muscle development (hyperplasia), not the GH itself. I'll be posting a results thread within that forum as I've just started a 4 week cycle of it.

I was just curious if perhaps I should be consuming grapefruit juice in order to get more out of it, although it's supposed to be potent stuff in any event.
 
I think it has more to do with the DHB/ grapefruit priming the stomach or liver lining to use more of it. But this is just a guess on my part.
 
Longdog said:
Somebody try grapefuit juice with viagra or cialis. Then we'll know if there's any truth to this...
Click to expand...


I'm going to try 100mg Viagra with GF juice tonight...lol. I'll keep you all posted. :p
 
OK. I tried 100mg Viagra & GF Juice and couldn't tell any difference. I am 100% sure that I am not responsive to Viagra now...lol. I'll try Cialis & GF juice tomorrow and post the results. :p
 
Bump on this. I was a little skeptical at first. For anyone who doesn't buy into this, eat a grapefruit, wait 1-1.5 hours, down your ECA/ECY (or if you're lucky like me NYCA :cool: ), head to the gym, and have some fun. For added fun listen to Slipknot. If the grapefruit is doing that for your ECA, just think what it's doing for your methylated PH's.
 
I am on day 6 of M4OHN, I've been squirting the liquid into 6oz of grapefruit juice each dose (2x per day). I started at 8mg, & bumped to 12mg today. I haven't noticed anything yet, but it's probably too early for any effects to kick in.
 
Longdog said:
Somebody try grapefuit juice with viagra or cialis. Then we'll know if there's any truth to this...
Click to expand...

I've used grapefruit juice with liquid chems and it's seems to have a better effect and kick in sooner, as a bonus it doesn't taste like ass when you mix it with GF juice! Just my .02
 
I started drinking gf juice with my m1-T this week and can definately feel a difference. Just a mouthful with each of the 3 doses , say 50- ml each time.
 
Also a great source of potassium to help ward off the pumps, cramps, back soreness and tightness, ect. you get from uber potent methyls. Invalid Link Removed Grapefruit juice has a decent amount too, just check out the nutritional info on the label.
 
michaelton said:
I wonder what ever happened to theprolangtum ... :confused:
Click to expand...
He died from his over consumption of grape fruit juice and methylated substances :eek:

No, actually he is still active over at the avant labs forums.
 
It is only one enzyme system involved, the cytochrome P450 (CYP), the specific isozyme is the 3A4. DHB is a 'mechanism based inhibitor' of this system. It prevents oxidative destruction of the drug molecule in question. Not just steroids, a lot of things are metabolized by this enzyme (any CYP3A4 substrate) The metabolic pathways for these substrates include N-oxidation, C-oxidation, N-dealkylation, O-dealkylation, nitro-reduction, dehydration, and C-hydroxylation. The first-pass metabolism during the intestinal absorption process is the likely spot of signifigance, as Sldg suggested earlier. That means higher plasma levels and greater effectiveness of the drug. St. Johns wort is a common herb that has the opposite effect. It induces the enzyme and makes your body detox faster. Serzone is a common anti-dep. med that is a potent inhibitor like GFJ and OJ to a lesser extent. Know these interactions, not just to be safe, but to get the most economy out of the drugs that you use! Use buffers for amines like ephedrine. Chew a couple of tums with it and it will extend the t1/2 due to decreased renal clearance. It also promotes fast stomach absorbtion.
 
Longdog said:
Somebody try grapefuit juice with viagra or cialis. Then we'll know if there's any truth to this...
Click to expand...

By the way, viagra is metabolized by this enzyme so go for it boyeeee
 
You must log in or register to reply here.
Back
Top