KANNA: enhances mental capacity?

EMPIREMIND

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Below is a wrote up on Kanna, an herb which is shown to enhance mental capacity and cognitive abilty.

INGREDIENT OVERVIEW: KANNA
Posted by Ed Shanks


Mental and cognitive enhancement is quickly becoming one of the biggest trends in the supplement industry. After the release of the movie Limitless, countless people have been searching for NZT, or a viable replacement. Unfortunately, there isn’t yet a drug that can enhance cognitive abilities to the degree depicted in the movie. However, there are several herbs that can enhance your natural mental capacity. One of those herbs is Kanna, otherwise known as Sceletium Tortuosum. Keep reading to see why we choose to use Kanna in Bacchus (click here for Bacchus info), our newest Neuro Manager.



HOW DOES KANNA WORK?

Two key components of Kanna are mesembrine and mesembrenone. They are both PDE4 Inhibitors. Not to be confused with PDE5 Inhibitors (Viagra, Cilas, Levitra, etc.), they have strong pro-cognitive effects. Including long-term memory improvement. Your long-term memory works by storing, and categorizing, short term memories through the hippocampus. Once this process is completed (sometimes it takes several times), you form a memory, and the rest is history.



NEURO-PROTECTIVE

A breakdown in the memory storage process is associated with Alzheimer’s disease, and other forms of dementia. However, new research is showing a correlation with these two cognitive disorders and plaque deposits in the brain. These plaque deposits destroy the brain in several ways, most noticeably through inflammation and decreased blood flow. PDE4 Inhibitors have strong neuro-protective qualities, such as protecting the brain from hypoxic and inflammatory damage.



KANNA HELPS WITH ENDURANCE

Kanna has been used for centuries to help with endurance. The San hunters and gatherers used Kanna to help with their hunting trips. They used Kanna to endure the heat of the Kalahari Desert, and to help prevent dehydration. It also gave them the ability to stay calm and vigilant during periods of high stress. Modern day users of Kanna have found the herb to increase endurance, help prevent muscle cramps, and provide an analgesic effect that can allow athletes to train, and compete, beyond their pain threshold.


SOCIAL EUPHORIANT

You might be the smartest individual in the world, but what happens when you can’t communicate your ideas to others? Your world-changing ideas will remain in your head forever. However, Kanna can help you communicate better. Kanna helps to calm your mind when you are in social settings. This calmness can lead to greater confidence, and a greater bonding experience with those individuals. Kanna has been known to be one of the best “ice-breaking” herbs available (dating, presentations, sales, etc.).



SO WHY DO YOU NEED KANNA IN YOUR LIFE?

Kanna just might be the most potent neuro-enhancing herb available. Not only does it help with calming and relaxing the brain, it has strong neuro-protecting properties. Add in the athletic, memory, and social euphoriant improving potential, and Kanna should be one of your go-to, daily supplements.


Kanna will be included in the new product BACCHUS from Chaos and Pain, COMING VERY SOON!




pyrobatt BloodManor
 
bwdill

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Very interesting. You fellas have any favorites for current nootropics?
 
EMPIREMIND

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Very interesting. You fellas have any favorites for current nootropics?
I'm curious to hear from people as well, I haven't really had many. Some focus product and preworkouts which have nootropics, but some guys are very well versed in this arena... I also wonder if any of these guys are familiar with Kanna?
 
BloodManor

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Bacchus really has me intrigued
Love how we go from extreme energy and power supps to extreme relaxation supps
Gonna be a fun ride
 

BBiceps

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Interesting, want to hear from someone that have experience with this?
 
soxbsbll05

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I never tried that, was it good?
It's only my favorite pre-workout ever! The focus and mind/muscle connection is definitely present when you take it which is what the Kanna helps with.
 
thebigt

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It's only my favorite pre-workout ever! The focus and mind/muscle connection is definitely present when you take it which is what the Kanna helps with.
x2 on the reign!!!
 
EMPIREMIND

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Bacchus really has me intrigued
Love how we go from extreme energy and power supps to extreme relaxation supps
Gonna be a fun ride
Tell me about it, going to be a nice change of pace!
 

BBiceps

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It's only my favorite pre-workout ever! The focus and mind/muscle connection is definitely present when you take it which is what the Kanna helps with.
After taken a look at the ingredients I’m interested to try it, looks good, thanks!
 
muscleupcrohn

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I'm curious to hear from people as well, I haven't really had many. Some focus product and preworkouts which have nootropics, but some guys are very well versed in this arena... I also wonder if any of these guys are familiar with Kanna?
Sceletium is a good but often subtle nootropic that I, and others, find actually goes well with other more "stimulating" or "energizing" nootropics/stims. It is good for reducing stress/anxiety and improving mood, but I would NOT expect actual "euphoria" from it. I've been using it daily in NootropiMax for a long time now, as well as using various bulk sources prior to NootropiMax's release (which means that NootropiMax contains seletium, of course). If you just want bulk sceletium to try as opposed to just bulk powder, but prefer an extract that is essentially identical to Zembrin for a fraction of the price of Zembrin, PM me.
OL's preworkout Re1gn has Kanna in it
It's actually this extract, which is made by Afrigetics (which confuses me a little bit, as their bottle says it's a registered trademark of Afrigetics, which it is, but their writeup on their website says that they, OL, trademarked it).

Also, could someone from C&P post up some links to the endurance studies they're referring to in their writeup?
 
bigbeaph

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About 10 years ago I used to buy these things called "bliss shot" that had kanna in it. It was really awesome....it would kick in 20-30 min after ingestion. It would make you very relaxed and similar to a drunk feeling. But a clean drunk - motor skills seemed fine and I never got sleepy. Good for any time of day. One of the cool things was no matter how I tried it, it was once a day max. The second time I'd take it even 12 hrs apart it just had very little or more often no seeming effect. Great if your like me and tend to get carried away with these types of things. It would have been very addicting without that "built in safety measure." I've been looking at kanna again recently - cant wait to try this. Hope they need a bunch of loggers!
 
pyrobatt

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EMPIREMIND

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Also, could someone from C&P post up some links to the endurance studies they're referring to in their writeup?
As requested bro

https://www.ncbi.nlm.nih.gov/pubmed/23441963 subjective well being

https://www.ncbi.nlm.nih.gov/pubmed/25389443 a good one

https://www.ncbi.nlm.nih.gov/pubmed/21798331 ped4 inhibitor which equals increased bmr, anabolic properties, release of fatty acids, the ability to combat diet induced obesity .
 
muscleupcrohn

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https://www.ncbi.nlm.nih.gov/pubmed/23441963 subjective well being

https://www.ncbi.nlm.nih.gov/pubmed/25389443 a good one

https://www.ncbi.nlm.nih.gov/pubmed/21798331 ped4 inhibitor which equals increased bmr, anabolic properties, release of fatty acids, the ability to combat diet induced obesity .

I could go on.... and on...

I'm such a dork, hahahahahaha
I’m fully aware of the cognitive and mood benefits of sceletium, I was asking if there was any actual research showing increased endurance, which it seems there is not. And don’t go thinking I’m knocking the ingredient; I’ve used it for years and included it in NootropiMax as well. I was genuinely curious if there was some new research I haven’t seen showing increased endurance. Either way, it’s worth using just for its mood benefits anyway IMO.
 
pyrobatt

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I’m fully aware of the cognitive and mood benefits of sceletium, I was asking if there was any actual research showing increased endurance, which it seems there is not. And don’t go thinking I’m knocking the ingredient; I’ve used it for years and included it in NootropiMax as well. I was genuinely curious if there was some new research I haven’t seen showing increased endurance. Either way, it’s worth using just for its mood benefits anyway IMO.
Maybe I Should have explained more clearly. Sometimes I'm bad at that.

ped 4 inhibitor= increased CAMP = increased endurance.

Specific studies on ped 4 inhibition and studies on increasing cAMP in relation to endurance are what I would look for if you're looking into the specific mechanisms behind why kana increases endurance.

No specific studies on endurance but if you follow the trail, you'll find that through the mechanisms it does increase endurance.
 
BloodManor

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^^ mirin knowledge
I agree not everything can be read in a study and most are controlled a certain way.
 
muscleupcrohn

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Maybe I Should have explained more clearly. Sometimes I'm bad at that.

ped 4 inhibitor= increased CAMP = increased endurance.

Specific studies on ped 4 inhibition and studies on increasing cAMP in relation to endurance are what I would look for if you're looking into the specific mechanisms behind why kana increases endurance.

No specific studies on endurance but if you follow the trail, you'll find that through the mechanisms it does increase endurance.
I know I’m probably beating a dead horse at this point, but I figured since you’re the one making the claims, you’d be able to provide at least one study to support your claims instead of telling me to look it up.
 
pyrobatt

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I know I’m probably beating a dead horse at this point, but I figured since you’re the one making the claims, you’d be able to provide at least one study to support your claims instead of telling me to look it up.
No need to get hostle.

https://en.m.wikipedia.org/wiki/Phosphodiesterase-4_inhibitor

Look under mode of acrion.

https://en.m.wikipedia.org/wiki/Cyclic_adenosine_monophosphate

Look under functions on the camp wiki.

The info is there and open to the public to read.

Long story short ped4 inhibition = more cAMP. cAMP is an ATP derivative and more of it is responsible for a host of benefical effects including increased endurance via the upregulation of skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1α.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666691/ This study goes into pgc-1a and how it literally controls whole body lactate thresh hold. This brings us back around to endurance.

You can read up more about pgc-1a here: https://en.wikipedia.org/wiki/PPARGC1A#cite_note-pmid23650363-15
Under regulation you can see How significant this can be for endurance athletes and strength athletes.
 
muscleupcrohn

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No need to get hostle.

https://en.m.wikipedia.org/wiki/Phosphodiesterase-4_inhibitor

Look under mode of acrion.

https://en.m.wikipedia.org/wiki/Cyclic_adenosine_monophosphate

Look under functions on the camp wiki.

The info is there and open to the public to read.

Long story short ped4 inhibition = more cAMP. cAMP is an ATP derivative and more of it is responsible for a host of benefical effects including increased endurance via the upregulation of skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1α.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666691/ This study goes into pgc-1a and how it literally controls whole body lactate thresh hold. This brings us back around to endurance.

You can read up more about pgc-1a here: https://en.wikipedia.org/wiki/PPARGC1A#cite_note-pmid23650363-15
Under regulation you can see How significant this can be for endurance athletes and strength athletes.
I’m not being hostile, I’m stating the universal fact/rule in scientific literature that the burden of proof rests with the person making the claim; if you’re making the claim, you should also provide the evidence, not simply tell other people to look it up. I’d assume you agree with this, or why even have a write-up in the first place? I read through your write-up and it didn’t provide any answers, which is why I asked here. That’s hostile? Also, there are a few significant assumptions here. We know that sceletium is an effective PDE4 (not PED4, I assume that’s just your autocorrect though) inhibitor, but can we inherently conclude that this PDE 4 inhibition will increase cAMP to such a degree that it will in turn increase endurance via the other MoAs proposed? I’d say the best we can say is that sceletium may increase endurance, and that we have a proposed MoA for it, but to state that it DOES increase endurance without so much as a rodent study on the topic, or even a study measuring increases in cAMP (we need to know the magnitude of the effects, not just the effect itself) in humans, is disingenuous.
 
pyrobatt

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I’m not being hostile, I’m stating the universal fact/rule in scientific literature that the burden of proof rests with the person making the claim; if you’re making the claim, you should also provide the evidence, not simply tell other people to look it up. I’d assume you agree with this, or why even have a write-up in the first place? I read through your write-up and it didn’t provide any answers, which is why I asked here. That’s hostile? Also, there are a few significant assumptions here. We know that sceletium is an effective PDE4 (not PED4, I assume that’s just your autocorrect though) inhibitor, but can we inherently conclude that this PDE 4 inhibition will increase cAMP to such a degree that it will in turn increase endurance via the other MoAs proposed? I’d say the best we can say is that sceletium may increase endurance, and that we have a proposed MoA for it, but to state that it DOES increase endurance without so much as a rodent study on the topic, or even a study measuring increases in cAMP (we need to know the magnitude of the effects, not just the effect itself) in humans, is disingenuous.
Man, someone has a thing for chaos and pain. We love you too boo.

I stated the reasoning behind the claim and if you find that disingenuous...I mean, you can buy from another company. I've done everything I can to answer your question and provide you with the information you're seeking but something tells me no matter what I say, It's never going to be enough. We can't please everyone.

Unless you want hugs. We have those in overstock.
 
BloodManor

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Man, someone has a thing for chaos and pain. We love you too boo.

I stated the reasoning behind the claim and if you find that disingenuous...I mean, you can buy from another company. I've done everything I can to answer your question and provide you with the information you're seeking but something tells me no matter what I say, It's never going to be enough. We can't please everyone.

Unless you want hugs. We have those in overstock.
I’m great at giving hugs
Big guys give the best ones
 

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