My theory, and it is just that theory is that as the liver produces bile that is needed in the small intestine for breakdown of fat molecules then if you hinder bile production , which strong orals do, then you limit your body's ability to process fats. Bile is stored in the gall bladder and is released when needed for digestion, it also cleans out the liver of toxic salts that accumulate. So as orals hinder bile production thus, in turn, salts accumulate in the liver causing cholestasis or decreased liver function and ultimately irriversable liver tissue death. TUDCA is the ONLY liver supp that directly stimulates bile production and is therefore really the only one worth taking!
So the way I look at it is take my TUDCA and other supps a while ( atleast an hour ) before I take my orals so that bile production has been stimulated and therefor fat breakdown in the small intestine can occur, then that way I won't matter what food I eat with my orals!! The pancreas is responsible for producing The digestive enzymes responsible for breaking down proteins and carbs, so not so much to worry about!!
Anyway just my theories! Could be correct could be TOTALLY wrong!? Would be good to get some input?