Mulletsoldier
Binging on Pure ****ing Rage
How Anabolic Pump Works
I would just like to preface this by stating this is not the official write-up by any means, just a little diddy I wrote to satiate the masses.
How Does Anabolic Pump Work To Build Muscle?
Before we delve into this, we should first distinguish how the GLUT group of isoforms operates as it pertains to glucose regulation. There have been 5 functional GLUTs identified, with the GLUT4 isoform being the major-insulin responsive glucose transporter predominantly restricted to striated muscle and adipose. For this first segment, we will focus mainly on striated muscle.
There are three sites of regulation of intracellular glucose uptake in skeletal muscle: glucose delivery to the skeletal muscle cells, surface membrane permeability to glucose (i.e., glucose transport), and flux through intracellular metabolism. The site most pertinent to Anabolic Pump, is the second mentioned. GLUT4, dormant within vesicles of adipose and striated muscle cells, translocates to the plasma membrane of cells in the presence of Insulin as a result of Insulin activating protein cascades. Anabolic Pump exponentially increases the amount of GLUT4 translocation in skeletal muscle cells, causing the membrane to be supraphysiologically permeable to glucose. Thereby greatly increasing the amount of glycogen stored within muscle cell mitochondria.
This process is being undertaken by two mechanisms; both currently unknown.
How Does Anabolic Pump Induce Fat Loss?
Where Anabolic Pump gets very interesting however, is by inhibiting this same insulin-reactive cascading process in adipocytes. In order to understand this, just as above, we must define a key process inherent within Anabolic Pump’s effects. In this case, we must distinguish the PPAR family, specifically PPAR Gamma 2 and its role in the regulation of adipocyte cells. PPAR Gamma 2 is believed to modulate genes within adipose cells that are responsible for the regulation of certain lipid-binding proteins, proteins that bind to fat, basically. Anabolic Pump is inhibiting PPAR Gamma 2 within adipose cells by two mechanisms which, at this point, are unknown.
In much simpler terms, Anabolic Pump preventing inherent survival traits within Adipose cells to bind to FFAs and circulating blood lipids. This prevents the chronic accumulation of adipose cells by removing their survival mechanism. As a result, lipoylsis is induced and FFAs are metabolized into the bloodstream to used as fuel. Conveniently, striated muscle cells will be 'super-charged' so to speak with glycogen, and with a proper diet and training routine these FFAs will most likely not be re-deposited.
I would just like to preface this by stating this is not the official write-up by any means, just a little diddy I wrote to satiate the masses.
How Does Anabolic Pump Work To Build Muscle?
Before we delve into this, we should first distinguish how the GLUT group of isoforms operates as it pertains to glucose regulation. There have been 5 functional GLUTs identified, with the GLUT4 isoform being the major-insulin responsive glucose transporter predominantly restricted to striated muscle and adipose. For this first segment, we will focus mainly on striated muscle.
There are three sites of regulation of intracellular glucose uptake in skeletal muscle: glucose delivery to the skeletal muscle cells, surface membrane permeability to glucose (i.e., glucose transport), and flux through intracellular metabolism. The site most pertinent to Anabolic Pump, is the second mentioned. GLUT4, dormant within vesicles of adipose and striated muscle cells, translocates to the plasma membrane of cells in the presence of Insulin as a result of Insulin activating protein cascades. Anabolic Pump exponentially increases the amount of GLUT4 translocation in skeletal muscle cells, causing the membrane to be supraphysiologically permeable to glucose. Thereby greatly increasing the amount of glycogen stored within muscle cell mitochondria.
This process is being undertaken by two mechanisms; both currently unknown.
How Does Anabolic Pump Induce Fat Loss?
Where Anabolic Pump gets very interesting however, is by inhibiting this same insulin-reactive cascading process in adipocytes. In order to understand this, just as above, we must define a key process inherent within Anabolic Pump’s effects. In this case, we must distinguish the PPAR family, specifically PPAR Gamma 2 and its role in the regulation of adipocyte cells. PPAR Gamma 2 is believed to modulate genes within adipose cells that are responsible for the regulation of certain lipid-binding proteins, proteins that bind to fat, basically. Anabolic Pump is inhibiting PPAR Gamma 2 within adipose cells by two mechanisms which, at this point, are unknown.
In much simpler terms, Anabolic Pump preventing inherent survival traits within Adipose cells to bind to FFAs and circulating blood lipids. This prevents the chronic accumulation of adipose cells by removing their survival mechanism. As a result, lipoylsis is induced and FFAs are metabolized into the bloodstream to used as fuel. Conveniently, striated muscle cells will be 'super-charged' so to speak with glycogen, and with a proper diet and training routine these FFAs will most likely not be re-deposited.
aka Ziri Jr
