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HMB doesn't work and the science is nonsense - proof inside

EricMarchewitz said:
I absolutely believe this. Lots of anecdotal reports of creatine making kids cranky. Seems pretty common and I would believe that it can impact DHT levels in younger men.
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lol...who cares about younger men, what about older men?:laugh:
 
210LBS said:
Most studies need to be done over and over again to get anything out of them. Anyone remember the creatine study that showed creatine massively increased DHT levels? Like over 50% I think. The first thing I thought was that the creatine used was spiked. But that was it. The study was never followed up again. I think that's a huge find and surprising that it was never followed up. There are too many variables to rely on 1 or 2 studies in a lot of cases.
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100% agree
 
macwad said:
One more recent study (2015):

The efficacy of a β-hydroxy-β-methylbutyrate supplementation on physical capacity, body composition and biochemical markers in elite rowers: a randomised, double-blind, placebo-controlled crossover study
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The results indicate that HMB intake in endurance training has an advantageous effect on the increase in aerobic capacity and the reduction of fat mass. It may also stimulate an increase in peak anaerobic power
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3g HMB, right? I have always wondered if that is with the calcium-salt included? So basically 3g HMB-Ca daily?
 
Pec.Major said:
Ok. so split 3g over the day and one dose 1-5h pre workout? I have always dosed 3g-4g pre and on off days spread out.
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Yeah, if youre wanting to utilise HMBca for muscular purposes and also wish to be pedantic, the PK studies show plasma levels peak just over 2hrs post-ingestion (powder in water), then decline very rapidly over the next 6 hours.
 
Nac said:
Yeah, if youre wanting to utilise HMBca for muscular purposes and also wish to be pedantic, the PK studies show plasma levels peak just over 2hrs post-ingestion (powder in water), then decline very rapidly over the next 6 hours.
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You think there would be any difference between powder and caps?
 
Pec.Major said:
Ok. so split 3g over the day and one dose 1-5h pre workout? I have always dosed 3g-4g pre and on off days spread out.
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Honestly, I just take the 3g once per day. Pre-workout (added to my PWO) if I remember, and just some other time if I don't.
Pec.Major said:
True, chemical warfare in the mouth. But caps are not that expensive.
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I don't think it's all that bad really. Sure, it's not something I'd want to sip on for fun throughout the day when taking it alone in water, but it's very manageable when you add it to something like a flavored pre-workout supplement or a protein shake.

Edit: How expensive are caps? I know you can get the powder for ~$50/year if you buy it in a decent bulk quantity. That's why it's appealing, because it's quite affordable, and seems to have some promising research for performance and for longevity.
 
Pec.Major said:
You think there would be any difference between powder and caps?
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Powder-in-water has "significantly" greater peak plasma levels than caps...but caps have a "significantly" longer half life.

Whether this translates to any practical difference for you and I, Ill leave up to you to decide:

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Scroll down to fig.2a
 
muscleupcrohn said:
Honestly, I just take the 3g once per day. Pre-workout (added to my PWO) if I remember, and just some other time if I don't.

I don't think it's all that bad really. Sure, it's not something I'd want to sip on for fun throughout the day when taking it alone in water, but it's very manageable when you add it to something like a flavored pre-workout supplement or a protein shake.

Edit: How expensive are caps? I know you can get the powder for ~$50/year if you buy it in a decent bulk quantity. That's why it's appealing, because it's quite affordable, and seems to have some promising research for performance and for longevity.
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If I went with powder, I would take it all at once as you. Otherwise I know I will miss or skip a dosing.

True, there is things that are worse, ex; Noopept, berberine (lol at this one), it was capped but I had to taste the powder.

I can get 120 caps at 750mg, for 125sek (14$). If there is a sale, it can be a little bit cheaper. So it is definitely cheaper with powder, but caps are always convenient .
 
Justlooking5 said:
You give my lab grant money, I give you a study that shows your product works?
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Most of the time I think it's more likely that the study simply doesn't get published if the results aren't "favorable," but his studies do seem to get pretty remarkable results, even in the placebo/non-supplemented groups.
 
If your taking Leucine is there any reason to take HMB too? I honestly don't understand besides the fact that they are different compounds how the two differ in what they claim to do and the reasons for incorporating them into your supplementation.
 
GAINZFORDAYZ said:
If your taking Leucine is there any reason to take HMB too? I honestly don't understand besides the fact that they are different compounds how the two differ in what they claim to do and the reasons for incorporating them into your supplementation.
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The main difference is that HMB is a metabolite of Leucine. You would have to ingest quite a lot of Leucine in order to get 3 grams of HMB metabolite. Scenarios where HMB would be beneficial include periods or training harder than usual to the point of over training/reaching, cutting/recomp phases, caloric restriction/deficits, and/or fasted training. Although HMB is not necessary in any of these scenarios, it definitely wouldn't hurt. As many others have pointed out, if bought in bulk it is about $50 per year, and it would be very cheap insurance to help maintain lean mass/strength during such scenarios.
 
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