j3ffbeck
New member
hey guys, got a lil bit of a problemo here.
As I was wrapping up a 5wk PCT with nolva/clomid (20/20/20/10/10 and 50/50/50/25/25). I started getting nipple pain a couple days after PCT ended and now, there's a pea to peanut sized lump. Painful to touch etc. Lil bit of milk when squeeze, very very little. Have been trying not to **** with it though so I've only squeezed it once. The cycle was hdrol at 75mg for 6wks with the last week and a half at 100. I had zero problems on cycle, not itch/puffy nips, nothing. At first I didn't know if it was progesterone receptor related from the nolva, or if i got bunk pharma tabs and PCT just failed.
I just got my bloodtest back (about a week after PCT ended) and it seems like I got legit nolva/clomid tabs.
Bloodwork results
First the good:
Testosterone, serum was 1027 (ref 280-800)
Pre-cycle was at 480 so, yeah the tabs were good.
IGF-1 was normal 204 (ref 117-329)
Also, pretty much everything else was normal including lipids and liver values
Now the bad:
Estradiol was 52.4 (ref 7.6-42.6)
Pre-cycle was not even detectable (<7.6)
Dunno about progestrone as there wasn't an option for it
Long version and rationale:
I've hopped back on the nolva while i wait for ancillaries to arrive. I'm looking to hit the gyno with the standard letro up/down taper, but with Exemestane at the end for a week or 2 to help reduce any estrogen rebound from the letro. The reason I want to do Aromasin/Exemestane is nolva doesn't control estrogen and it seems that's what my problem is.
I know nolva is usually recomended after letro for rebound, but here's my issue with that. The nolva does nothing to prevent estro rebound, but just stops the estro from binding receptors. In my case, this sort of approach appears to already have resulted high circulating estrogen which, unfortunately for me, wants to stay around even after the nolva has left my system. Hence, the gyno after coming off nolva.
On the other hand, the high estrogen might be more so from the clomid as I've read a couple studies (a couple in women, and another in alcoholic but otherwise healthy males without cirrhosis) that showed clomid increased circulating estrogen and SHBG production. I dunno if nolva has the same effect. So, nolva following letro might be OK if the problem was clomid, but I'm still pretty concerned about estrogen remaining high during and after the post letro nolva phase.
This is why I'm thinking to follow letro with Aromasin/Extremestane instead. It seems like that could actually prevent estro rebound following the letro. My understanding is that letro is a competitive inhibitor of aromatase and that results in upregulation of aromatase production hence estrogen rebound after coming off the lestro. Aromasin/Extremestane, on the other hand, is a suicidal inhibitor and therefore, aromatase enzyme activity can only be restored when new enzyme is made. I'm hoping that that will result in a slower return of estrogen and help my body normalize.
Again though, I really know very little about this sort of thing and there are probably so important points that I'm missing here. I'd really appreciate any help with how to dose the Aromasin/Exemestane as I'm coming off the letro, but I welcome any comments/thoughts on this sensitive (lol, punny) issue.
Cliffs:
May have overdone the PCT and now have high testosterone and high estrogen. Lumps in right nip, probably estro related. Gonna run letro/Exemestane taper to kill it. Need help with Exemestane dosage.
As I was wrapping up a 5wk PCT with nolva/clomid (20/20/20/10/10 and 50/50/50/25/25). I started getting nipple pain a couple days after PCT ended and now, there's a pea to peanut sized lump. Painful to touch etc. Lil bit of milk when squeeze, very very little. Have been trying not to **** with it though so I've only squeezed it once. The cycle was hdrol at 75mg for 6wks with the last week and a half at 100. I had zero problems on cycle, not itch/puffy nips, nothing. At first I didn't know if it was progesterone receptor related from the nolva, or if i got bunk pharma tabs and PCT just failed.
I just got my bloodtest back (about a week after PCT ended) and it seems like I got legit nolva/clomid tabs.
Bloodwork results
First the good:
Testosterone, serum was 1027 (ref 280-800)
Pre-cycle was at 480 so, yeah the tabs were good.
IGF-1 was normal 204 (ref 117-329)
Also, pretty much everything else was normal including lipids and liver values
Now the bad:
Estradiol was 52.4 (ref 7.6-42.6)
Pre-cycle was not even detectable (<7.6)
Dunno about progestrone as there wasn't an option for it
Long version and rationale:
I've hopped back on the nolva while i wait for ancillaries to arrive. I'm looking to hit the gyno with the standard letro up/down taper, but with Exemestane at the end for a week or 2 to help reduce any estrogen rebound from the letro. The reason I want to do Aromasin/Exemestane is nolva doesn't control estrogen and it seems that's what my problem is.
I know nolva is usually recomended after letro for rebound, but here's my issue with that. The nolva does nothing to prevent estro rebound, but just stops the estro from binding receptors. In my case, this sort of approach appears to already have resulted high circulating estrogen which, unfortunately for me, wants to stay around even after the nolva has left my system. Hence, the gyno after coming off nolva.
On the other hand, the high estrogen might be more so from the clomid as I've read a couple studies (a couple in women, and another in alcoholic but otherwise healthy males without cirrhosis) that showed clomid increased circulating estrogen and SHBG production. I dunno if nolva has the same effect. So, nolva following letro might be OK if the problem was clomid, but I'm still pretty concerned about estrogen remaining high during and after the post letro nolva phase.
This is why I'm thinking to follow letro with Aromasin/Extremestane instead. It seems like that could actually prevent estro rebound following the letro. My understanding is that letro is a competitive inhibitor of aromatase and that results in upregulation of aromatase production hence estrogen rebound after coming off the lestro. Aromasin/Extremestane, on the other hand, is a suicidal inhibitor and therefore, aromatase enzyme activity can only be restored when new enzyme is made. I'm hoping that that will result in a slower return of estrogen and help my body normalize.
Again though, I really know very little about this sort of thing and there are probably so important points that I'm missing here. I'd really appreciate any help with how to dose the Aromasin/Exemestane as I'm coming off the letro, but I welcome any comments/thoughts on this sensitive (lol, punny) issue.
Cliffs:
May have overdone the PCT and now have high testosterone and high estrogen. Lumps in right nip, probably estro related. Gonna run letro/Exemestane taper to kill it. Need help with Exemestane dosage.
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