HAN SWOLO FAQ-

brundel

brundel

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HAN SWOLO
QUICK REFERENCE

Vasodilation
Anti inflammatory
Prevents oxidative stress
Prevents muscle atrophy
Reduces blood glucose
Reduces bodyfat
Increases insulin sensitivity
Increases energy output

LIGUSTRAZINE PHOSPHATE
Ligustrazine is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong), which has been extensively used for medicinal purpose for more than 2000 years. Ligustrazine was firstly isolated in 1957 and has been increasingly studied for its action on myocardial and cerebral infarction since 1970s. In the past decades, researchers explored other pharmacological capabilities of Ligustrazine in various diseases, such as coronary heart disease, diabetes, cancers, and liver injury. Accordingly, laboratory study verified the regulation ability of this agent in multiple molecular targets, such as anti-inflammation, antioxidant, antiplatelet, and antiapoptosis. The pharmacology of Ligustrazine has been well reviewed.

The cardiovascular pharmacological effects of Ligustrazine aroused widespread interest among researchers in recent years. There are considerable documents supporting the view that this monomer can be a promising botanical remedy for cardiovascular diseases. The possible mechanism of its action might include modulating ion channels, stimulating the release of NO production, inhibiting vascular smooth muscle cell proliferation and migration, scavenging ROS, regulating inflammation and apoptosis, and preventing platelet aggregation.

Bioavailability
Ligustrazine has a bioavailability of around 10% and experiences rapid clearance giving it a very short half life. This makes is unsuitable for supplemental usage without modification. The phosphate addition increases bioavailability to around 87% vs 10% and the inhibitor quercetin co crystals prevents its rapid metabolism increasing half life many times over.
Combined this makes our Ligustrazine phosphate the strongest version available and makes this stuff one hell of a vasodilator and performance enhancer.

Ligustrazine phosphate is a fantastic nitric oxide booster but works in multiple ways to open blood vessels. Testing indicates it is effective even in the presence of stimulants. It is also slightly anabolic and prevents muscle atrophy. Ligustrazine reduces oxidative stress and reduces inflammation making it a fantastic addition.

OSTHOLE CYCLODEXTRIN COMPLEX
Osthole is a coumarin commonly found in Cnidium monnieri. Cnidium has been used for thousands of years in Chinese medicine for anti-viral properties, skin rashes and breakouts, as pro-erectile agents, anti-osteoporotic as well as anti-diabetic and sometimes anti-inflammatory. Studies indicate that if bioavailability is enhanced osthole can be an exceptional vasodilator and will work in spite of CNS stimulant useage.

Osthole has been around in the supplement industry for as long as I can remember, and, considering how great it looks on paper I was always curious why its effects were so dismal.

Bioavailability.
Osthole has a somewhat low oral bioavilability along with a very low water solubility and experiences rapid first pass metabolism. A limited percentage is absorbed and of this limited percentage 40% is gone at 5 min and at least 80% of that osthole is metabolized within 20 min. As such we have taken steps to ensure the our osthole actually works. We have employed an osthole cyclodextrin complex with the addition of a strong metabolic inhibitor (quercetin niacin co crystals). Our bioavailable Quercetin has a strong inhibitory effect against CYP2D6 and a moderate effect against CYP2C19 and CYP3A4 helping to prevent the rapid metabolism plaguing normal osthole. As a result we see massively increased bioavailability, water solublity and major inhibition of first pass metabolism. Black lion Research Osthole has fantastic bioavilability with a long half life.
Bioavailability was the limiting factor for osthole and the reason it has such lackluster effects. BLR Osthole cyclodextrin is some awe inspiring stuff.
Lets explore how it works and what else aside from vasodilation it does.

Vasodilation
Osthole has the capability to dilate blood vessels and arteries in the presence of CNS stimulants.
It is concluded that osthole relaxes rat thoracic aorta by virtue of its Ca(2+)-channel blocking properties and by elevating cGMP levels in vascular smooth muscle. Osthole has also been shown to work well in the presence of stimulants so if you do choose to add some stims to your pre workout mix you will still get great vasodilation and pump.

Additional benefits
-AMPK
-GLUT4
-Insulin sensitivity
-Helps reduce fat
-Helps increase energy output


AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. Activation of AMPK in skeletal muscles, the liver, and adipose tissues results in a favorable metabolic milieu for decreased levels of circulating glucose, plasma lipids, and ectopic fat accumulation and enhanced insulin sensitivity. Osthole increases AMPK and increases GLUT4 expression which helps keep glucose down, insulin sensitivity up and fat loss at a maximum level.

Osthole is a also dual PPAR agonist and improves glucose and lipid metabolism via modulation of PPARα/γ-mediated target gene expression in liver, adipose tissue, and skeletal muscle. During a 9 week treatment with osthole emulsion, Lipid levels in serum and liver were decreased by 37.9–67.2% and 31.4–38.5% for triglyceride, 33.1–47.5% and 28.5–31.2% for free fatty acid, respectively, the fasting blood glucose, fasting serum insulin, and homeostasis modelassessment of IR were also decreased by 17.2–22.7%, 25.9–26.7%, and 37.5–42.8%, respectively.
Osthole has been shown to improve glucose and lipid metabolism and exert a significant effect on fat loss.

Testosterone
Osthole has once been implicated in increasing testosterone, as well as luteinizing hormone and FSH.

Quercetin Niacin co crystals
Everyone knows about quercetin and niacin but quercetin has very poor oral bioavailability ~1% and niacin causes severe flushing at decent doses. Bonding the molecules together increases the absorption of Quercetin many times over ~40-70%, and prevents the Niacin flush. Quercetin is an exceptional vasodilator as is Niacin and quercetin has been studied for everything from endurance and an increase in VO2 Max, fat loss, its strong antioxidant effect, and its antiviral power, however, for our purpose we added it for more than just vasodilation.
Both Ligustrazine and Osthole have exceptionally rapid first pass metabolism giving them very short half lives. Quercetin has been shown to inhibit the metabolism of both giving them decent half lives and all the horsepower we need for powehouse training.





REFS:










 
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ValiantThor08

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Great write up for Han Swolo!
 
3clipseGT

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Lots of excellent info on the ingredients in Han Swolo. I am chomping at the bit to get more!
 

_Endure_

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Us reps have tested it out, and it works very well, even in the presence of a lot of stimulants.
What was your take on these highlights below? Reads to help with recovery overall but a lot of supplements make that claim. Not saying it does or doesn't but I think when a pump product is released everyone tends to just focus on the pump aspect. Just curious if anyone specifically did feel it was of overall recovery benefit.

Anti inflammatory
Prevents oxidative stress
Prevents muscle atrophy
 
3clipseGT

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What was your take on these highlights below? Reads to help with recovery overall but a lot of supplements make that claim. Not saying it does or doesn't but I think when a pump product is released everyone tends to just focus on the pump aspect. Just curious if anyone specifically did feel it was of overall recovery benefit.

Anti inflammatory
Prevents oxidative stress
Prevents muscle atrophy
I know for myself I wasn’t looking to gauge Anti inflammatory or the others you listed but just merely the pump.
 
brundel

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What was your take on these highlights below? Reads to help with recovery overall but a lot of supplements make that claim. Not saying it does or doesn't but I think when a pump product is released everyone tends to just focus on the pump aspect. Just curious if anyone specifically did feel it was of overall recovery benefit.

Anti inflammatory
Prevents oxidative stress
Prevents muscle atrophy
One of the great things about this blend is each ingredient is much more than a vasodilator.
For example quercetin is a senolytic and combined with dasatinib has been shown to reverse biological aging.
It has strong antiviral properties and strongly defends against present health threats.
antioxidant, antihistamine etc etc etc etc.

And the other 2 are no less impressive. I could put out an entire separate write up not mentioning vasodilation at all.

This stuff is VERY pro cardiac health but also helps the body cope with the stress of training.
PUMP, yes but so much more.
 

Resolve10

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One of the great things about this blend is each ingredient is much more than a vasodilator.
For example quercetin is a senolytic and combined with dasatinib has been shown to reverse biological aging.
It has strong antiviral properties and strongly defends against present health threats.
antioxidant, antihistamine etc etc etc etc.

And the other 2 are no less impressive. I could put out an entire separate write up not mentioning vasodilation at all.

This stuff is VERY pro cardiac health but also helps the body cope with the stress of training.
PUMP, yes but so much more.
Testers/reps notice any effects on blood glucose? That and the PPAR angle seem quite interesting.
 
3clipseGT

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Testers/reps notice any effects on blood glucose? That and the PPAR angle seem quite interesting.
I didn’t test BG but I definitely can when I get another bottle. I will say though that even when using a GDA I don’t ever get “hypo” or feel as though my blood glucose is getting low. Granted my BG is typically in the 90s fasted so it’s not like I am anywhere close to hypo lol.
 
brundel

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Testers/reps notice any effects on blood glucose? That and the PPAR angle seem quite interesting.
I honestly dont know how strong the combined effects are on glucose.
In the study I quoted the change was 17.2–22.7%, but they used regular osthole. So the effects of the osthole cyclodextrin and Quercetin inhibitor combo may be several times stronger. I would be interested in seeing some BG tests.
 
ValiantThor08

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Testers/reps notice any effects on blood glucose? That and the PPAR angle seem quite interesting.
I train fasted, but knowing it may have positives on BG, I may have some quick carbs with it pre workout.
 

_Endure_

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One of the great things about this blend is each ingredient is much more than a vasodilator.
For example quercetin is a senolytic and combined with dasatinib has been shown to reverse biological aging.
It has strong antiviral properties and strongly defends against present health threats.
antioxidant, antihistamine etc etc etc etc.

And the other 2 are no less impressive. I could put out an entire separate write up not mentioning vasodilation at all.

This stuff is VERY pro cardiac health but also helps the body cope with the stress of training.
PUMP, yes but so much more.
Not trying to slag your product so won’t take it as such but papers are sometimes just papers and the rep above mentioned he was really only logging the pump aspect. Hopefully as this product comes out some might be able to chime in on that.
 
brundel

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Not trying to slag your product so won’t take it as such but papers are sometimes just papers and the rep above mentioned he was really only logging the pump aspect. Hopefully as this product comes out some might be able to chime in on that.
Of course. One thing I can absolutely guarantee is this product is an exceptional vasodilator. I know because we tested it for over a year with dozens of testers, multiple trials and multiple trial testing goals.
As a GDA for example I really dont know how strong it is only that there is research stating it should do xxx.
 
3clipseGT

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Not trying to slag your product so won’t take it as such but papers are sometimes just papers and the rep above mentioned he was really only logging the pump aspect. Hopefully as this product comes out some might be able to chime in on that.
Actual experiences are always beneficial but without papers on effects, a majority of products wouldn’t see the market. In general this is a pump product so that aspect is most important, IMO, with the other possible effects being extra benefits. Ill be checking BG when I get more in to see how I respond and will report with photos in these threads.
 

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What is the maximum amount of capsules that someone can take a day. Any pro erectile effects. I take 5mg a day of cialis wondering if that could cause any problems.
 
ValiantThor08

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What is the maximum amount of capsules that someone can take a day. Any pro erectile effects. I take 5mg a day of cialis wondering if that could cause any problems.
If you are already taking Cialis, I would only take the vaso pre workout. Nothing is going to Trump Cialis for Cialis intended purpose. If you take liquid Cialis, take between 1 and 2mg a day. You will find it is just as good as 5mg, with less side effects
 
brundel

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What is the maximum amount of capsules that someone can take a day. Any pro erectile effects. I take 5mg a day of cialis wondering if that could cause any problems.
Should absolutely have pro erectile effects. Injectable Osthole is a fantastic ED solution and this oral version will stay active hours longer than the IV version. Do you have a Blood pressure cuff?
I would test before, take half a cap (just shoot down with some juice or something, will taste bad) Then test BP at 30 and 60 min.
If its no real change do the same with 1 cap. Should be fine but with a prescription PED inhibitor its probably best to give it a test.

I dont suggest taking 2 at a time ever. You dont want to pass out lol
 
JeremyNG25

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Should absolutely have pro erectile effects. Injectable Osthole is a fantastic ED solution and this oral version will stay active hours longer than the IV version. Do you have a Blood pressure cuff?
I would test before, take half a cap (just shoot down with some juice or something, will taste bad) Then test BP at 30 and 60 min.
If its no real change do the same with 1 cap. Should be fine but with a prescription PED inhibitor its probably best to give it a test.

I dont suggest taking 2 at a time ever. You dont want to pass out lol
So I’m guessing this is not something we should take with other pump products or is that ok?
 
3clipseGT

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So I’m guessing this is not something we should take with other pump products or is that ok?
What other pump products are you thinking of? If it’s something like citrulline or agmatine I dont see an issue with it. With that being said, I also don’t think you would need it given how effective Han Swolo is at inducing pumps. My advice would be to test Han Swolo by itself for multiple workouts and get a feel for it, then add in Citrulline etc if necessary. Brundel may have some better info on this. I will say though id stay away from Nitrates, again Brundel may have some better thoughts on this though.
 
brundel

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If its glycerpump or creatine then its fine. I cant imagine any circumstance where you'll need or want more vasodilation than from this. If its in a high stim pre then its probably OK.
 

Z28Luver7777

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Is this something you take daily or only prior to lifting for best effects?
 
3clipseGT

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Is this something you take daily or only prior to lifting for best effects?
Given the other benefits papers have reported you could take it every day but it’s main use is as a preworkout pump product.
 

Z28Luver7777

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So effects would be noticed if dosed like half an hour prior to lifting?
 

Z28Luver7777

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Do we know when it’ll be shipped? I purchased during the Labor Day sale
 

Z28Luver7777

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Does this supplement have any synergism when stacked with anything else?
 
Rocket3015

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I am really looking forward to this !!
 
Rocket3015

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If its glycerpump or creatine then its fine. I cant imagine any circumstance where you'll need or want more vasodilation than from this. If its in a high stim pre then its probably OK.
The Vasodilation is what really has me intrigued !!
 
ValiantThor08

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Of course I already had my morning stim when I read it so focus was on point lol

I know you are well versed with Stims. Have you tried it yet?
No, have not yet, but it is coming, it will be tested, and we believe everyone will love it. :)
 
Ricky10

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I have to reload up on lots of supplements right now, but this one definitely caught my eye.

I love the name, as well as the novel approach with ingredients I have been fond of in the past.

This will definitely be part of my arsenal sooner than later!
 
ELROCK

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I have to reload up on lots of supplements right now, but this one definitely caught my eye.

I love the name, as well as the novel approach with ingredients I have been fond of in the past.

This will definitely be part of my arsenal sooner than later!
Looking jacked bro
 
Ptlhains

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I am one of the first people to make an - a large order on Labor day - order 12079.
When is it being shipped???
 
brundel

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I am one of the first people to make an - a large order on Labor day - order 12079.
When is it being shipped???
The majority are on trucks for shipping so they will go today. You should have already received a confirmation with tracking.
Unless you ordered Exotherm in which case it will ship I think tues.
There were so many packs I had to use my vehicle as well. Front to back packed.
 
rubberring

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The majority are on trucks for shipping so they will go today. You should have already received a confirmation with tracking.
Unless you ordered Exotherm in which case it will ship I think tues.
There were so many packs I had to use my vehicle as well. Front to back packed.
I have received no tracking number, and I only ordered the HS. Order #12099
 

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